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Map Adverse Drug Events (ADEs) mentioned in text data to their most relevant Preferred MeDDRA terms.
CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.
Anti-neutrophil cytoplasmic antibody positive vasculitis
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OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Anti-neutrophil cytoplasmic antibody positive vasculitis
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Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.
Anti-neutrophil cytoplasmic antibody positive vasculitis
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RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.
Hypoacusis
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The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.
Hypoacusis
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Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.
Optic neuritis
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During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.
Visual impairment
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In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.
Visual impairment
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Flucloxacillin-induced aplastic anaemia and liver failure.
Aplastic Anaemia
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It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.
Drug-induced Liver injury
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We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.
Aplastic Anaemia
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Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.
Bronchospasm
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Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.
Hypocalcaemia
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This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.
Systemic lupus erythematosus
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Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.
Mucosal Pigmentation disorder
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The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.
Pigmentation disorder
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We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.
Pigmentation disorder
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Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.
Lymphoma
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Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).
Tardive Dyskinesia
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Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.
Respiratory Dyskinesia
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The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.
Dyskinesia
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In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.
Nervous system disorder
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To date, there have been few reports of visual disturbances associated with BTX-B use.
Visual impairment
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Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.
Nervous system disorder
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Enalapril-induced anemia in two kidney transplant recipients.
Anaemia
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Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.
Anaemia
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A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.
Myalgia
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Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.
Rhabdomyolysis
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We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.
Rhabdomyolysis
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Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.
Hypersensitivity
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However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.
Apnoea
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Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.
Hypersensitivity
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We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.
Hypersensitivity
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TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.
Cholestasis
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Chronic fentanyl application induces adrenocortical insufficiency.
Adrenocortical insufficiency acute
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We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.
Adrenocortical insufficiency acute
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Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.
Neuroleptic malignant syndrome
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OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.
Neuroleptic malignant syndrome
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Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.
Eosinophilia
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We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.
Eosinophilia
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We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.
Eosinophilia
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Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.
Interstitial lung disease
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We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.
Interstitial lung disease
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CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.
Corneal deposits
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Corneal endothelial deposits associated with rifabutin use.
Corneal deposits
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PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.
Corneal deposits
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RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.
Corneal deposits
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CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.
Uterine cancer
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CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.
Uterine cancer
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Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.
Uterine cancer
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We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.
Uterine cancer
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Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.
Neutropenia
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Mycophenolate mofetil-induced neutropenia in liver transplantation.
Neutropenia
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The mean time from starting MMF to the development of neutropenia was 4 months.
Neutropenia
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The side effects of MMF, such as bone marrow toxicity, have been reported.
Myelosuppression
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A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.
Haemoglobinaemia
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Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.
Haemoglobinaemia
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That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).
Disseminated intravascular coagulation
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The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.
Disseminated intravascular coagulation
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This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.
Haemoglobinaemia
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After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).
Neutropenia
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Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.
Agranulocytosis
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These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.
Agranulocytosis
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However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.
Myelosuppression
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Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.
Myelosuppression
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A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.
Endometrial stromal sarcoma
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High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.
Endometrial stromal sarcoma
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In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.
Endometrial stromal sarcoma
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After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.
Heart rate decreased
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Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.
Cardiotoxicity
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Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.
Cardiotoxicity
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Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.
Atrioventricular block second degree
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Falling backward in two elderly patients taking bupropion.
Fall
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RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.
Fall
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The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.
Visual impairment
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Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.
Visual field defect
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BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.
Retinal exudates
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Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.
Macular oOedema
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CONCLUSION: During and after IFN therapy, OCT is a useful examination technique for revealing macular edema in patients who have decreased vision.
Visual impairment
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Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.
Hypoalbuminaemia
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The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.
Visual acuity reduced
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With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.
Macular oOedema
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Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.
Diabetes mellitus
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OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.
Diabetes mellitus
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Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.
Skin necrosis
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Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.
Skin necrosis
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We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.
Rash
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We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.
Skin necrosis
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Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.
Colitis ischaemic
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Tegaserod-associated ischemic colitis.
Colitis ischaemic
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We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.
Irritable bowel syndrome
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A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.
Diarrhoea
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Lansoprazole-associated collagenous colitis: a case report.
Colitis microscopic
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The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.
Colitis microscopic
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46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.
Ulcer
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Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.
Ulcer
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Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.
Neurotoxicity
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Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.
Neurotoxicity
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Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.
Areflexia
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CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.
Cerebral haemorrhage