prognosis/cardio-docs-qa · Datasets at Hugging Face

What are ACE inhibitors and ARBs fetotoxic in the second and third trimesters of pregnancy?

not approved for use during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors and ARBs fetotoxic in the second and third trimesters of pregnancy?. ### Response: not approved for use during pregnancy.

What may cause adverse effects in the first trimester of pregnancy?

hypertension or the medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause adverse effects in the first trimester of pregnancy?. ### Response: hypertension or the medication.

What may be secondary to hypertension or the medication?

Adverse effects in the first trimester of pregnancy

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Adverse events in the later trimesters have been suggested by observation data and meta-analyses?

S10.2.2-4

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For ARBs, case reports with effects similar to ACE inhibitors have been published.

fetotoxic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For ARBs, case reports with effects similar to ACE inhibitors have been published.. ### Response: fetotoxic.

What has been published?

case reports with effects similar to ACE inhibitors

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What are the recommendations for treatment of hypertension in older persons summarized in Online Data Supplement 54?

References that support recommendations

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What is recommended for noninstitutionalized ambulatory community-dwelling adults (65 years of age) with an average SBP of 130 mm Hg or higher?

Treatment of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for noninstitutionalized ambulatory community-dwelling adults (65 years of age) with an average SBP of 130 mm Hg or higher?. ### Response: Treatment of hypertension.

S10.3.1-1IIa C-EO2 for older adults with hypertension and a high burden of comorbidity and limited life expectancy?

clinical judgment, patient preference, and a team-based approach to assess risk/benefit is reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S10.3.1-1IIa C-EO2 for older adults with hypertension and a high burden of comorbidity and limited life expectancy?. ### Response: clinical judgment, patient preference, and a team-based approach to assess risk/benefit is reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs.

What is reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs?

high burden of comorbidity and limited life expectancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs?. ### Response: high burden of comorbidity and limited life expectancy.

Why is hyper -tension a leading cause of preventable morbidity and mortality?

extremely high prevalence in older adults

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What is a leading cause of preventable morbidity and mortality?

hyper -tension

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What is under-recognized as a major contributor to premature disability and institutionalization?

hyper -tension

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When do SBP and DBP increase linearly?

up to the fifth or sixth decade of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When do SBP and DBP increase linearly?. ### Response: up to the fifth or sixth decade of life.

What is the predominant form of hypertension in older persons?

hyper -tension

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What is DBP gradually decreasing after?

the fifth or sixth decade of life

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SBP continues to rise after what?

fifth or sixth decade of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SBP continues to rise after what?. ### Response: fifth or sixth decade of life.

Prior mitral valve surgeryComorbidities Severe COPD or home oxygen therapyPulmonary hypertensionSevere RV dysfunction Hepatic dysfunction Frailty*Serious COPD OR Home oxygen therapy Pulmonary HypertensionSerioase RV dysfunctionHepatic functionFrailty *Severate COPD Or Home oxygen Therapy Pulmonaria hypertensionHepatia dysfunctionFraily*Futility STS score >15 What is the comorbidity score for a prior Mitral valve operation

Pulmonary hypertension Severe RV dysfunction Hepatic dysfunction Frailty*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prior mitral valve surgeryComorbidities Severe COPD or home oxygen therapyPulmonary hypertensionSevere RV dysfunction Hepatic dysfunction Frailty*Serious COPD OR Home oxygen therapy Pulmonary HypertensionSerioase RV dysfunctionHepatic functionFrailty *Severate COPD Or Home oxygen Therapy Pulmonaria hypertensionHepatia dysfunctionFraily*Futility STS score >15 What is the comorbidity score for a prior Mitral valve operation. ### Response: Pulmonary hypertension Severe RV dysfunction Hepatic dysfunction Frailty*.

What type of therapy is used to treat Pulmonary hypertension?

home oxygen

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What is the value of a frailty score?

Katz Activities of Daily Living Score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of a frailty score?. ### Response: Katz Activities of Daily Living Score.

What is the Katz Activities of Daily Living Score?

Validated frailty scores

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COPD indicates what?

chronic obstructive pulmonary disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: COPD indicates what?. ### Response: chronic obstructive pulmonary disease.

SAVR indicates what type of valve replacement?

surgical aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SAVR indicates what type of valve replacement?. ### Response: surgical aortic.

STS stands for Society of Thoracic Surgeons.

STS, Society of Thoracic Surgeons

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What is the acronym for transcatheter edge-to-edge repair?

TEER

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What is another name for tricuspid regurgitation?

TR

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When was the STS Adult Cardiac Surgery Database released?

2019

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What is the acronym for coronary artery bypass graft surgery?

CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for coronary artery bypass graft surgery?. ### Response: CABG.

What does STS stand for?

Society of Thoracic Surgeons

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When was this article downloaded?

April 27, 2023

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What is the name of the trial that compares dabi-gatran and warfarin in patients with atrial fibrillation and valvular heart disease?

RE-LY Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that compares dabi-gatran and warfarin in patients with atrial fibrillation and valvular heart disease?. ### Response: RE-LY Trial.

Who is the author of the RE-LY Trial?

Ezekowitz MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the RE-LY Trial?. ### Response: Ezekowitz MD.

Atrial fibrillation and valvular heart disease: the RE-LY Trial.

Comparison of dabi-gatran and warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation and valvular heart disease: the RE-LY Trial.. ### Response: Comparison of dabi-gatran and warfarin.

Circulation. 2016;134:589–98.

2016

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What is the name of the Randomized Evaluation of Long-Term Anticoagulant Therapy?

RE-LY Trial

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What is a systematic review and meta-analysis of valvular heart disease?

Effects of non-vitamin K antagonist oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of valvular heart disease?. ### Response: Effects of non-vitamin K antagonist oral anticoagulants.

What is Floyd CN, Ferro A. Indications for anticoagulant and antiplatelet combined therapy?

CHA2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Floyd CN, Ferro A. Indications for anticoagulant and antiplatelet combined therapy?. ### Response: CHA2DS2-VASc score.

What is the Euro Heart Survey on Atrial Fibrillation based on?

risk factor

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What score is used for refining stroke risk stratification in patients with atrial fibrillation with CHA2DS2-VASc?

CHADS2 score 0–

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How is stroke risk stratified in atrial fibrillation patients?

novel risk factor-based approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is stroke risk stratified in atrial fibrillation patients?. ### Response: novel risk factor-based approach.

What is the CHADS2 score 0-1?

refining stroke risk stratification

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How is the impact of CHA2DS2-VASc score on anticoagulation recommendations?

Impact

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What is the name of the disease that causes atrial fibrillation?

valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes atrial fibrillation?. ### Response: valvular heart disease.

What are the names of the two drugs used to treat atrial fibrosis?

non-vitamin K antagonist oral anticoagulants

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Which drug is better for patients with a heart condition?

warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug is better for patients with a heart condition?. ### Response: warfarin.

In what year did N Engl J Med publish a report on the effectiveness of rivaroxaban versus warfarin?

2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did N Engl J Med publish a report on the effectiveness of rivaroxaban versus warfarin?. ### Response: 2011.

What is the name of the drug used in nonvalvular atrial fibrillation?

Rivaroxaban

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When was the N Engl J Med 365:883-91?

2011

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What is edoxaban versus warfarin in patients with atrial fibrosis?

non-vitamin K antagonist oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is edoxaban versus warfarin in patients with atrial fibrosis?. ### Response: non-vitamin K antagonist oral anticoagulants.

What is the difference between edoxaban and warfarin in atrial fibrillation patients?

non-vitamin K antagonist oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between edoxaban and warfarin in atrial fibrillation patients?. ### Response: non-vitamin K antagonist oral anticoagulants.

What was the N Engl J Med 2013:369:2093–104?

Edoxaban

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How did home testing of international normalized ratio affect clinical events?

Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did home testing of international normalized ratio affect clinical events?. ### Response: Effect.

When did N Eng J Med 2010:363:1608–20?

2010

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What is the importance of moni-toring?

Initiating and maintain-ing patients on warfarin anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the importance of moni-toring?. ### Response: Initiating and maintain-ing patients on warfarin anticoagulation.

What is part 2 of the guide to anticoagulant therapy?

oral anti-coagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 2 of the guide to anticoagulant therapy?. ### Response: oral anti-coagulants.

Who is the author of the Guide to Anticoagulant Therapy?

Hirsh J, Fuster V

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the Guide to Anticoagulant Therapy?. ### Response: Hirsh J, Fuster V.

What is the name of the multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical heart valves?

AREVA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical heart valves?. ### Response: AREVA.

What is the name of the multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical prosthetic heart valves?

AREVA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical prosthetic heart valves?. ### Response: AREVA.

What is gical repair in fixed subaortic stenosis?

S4.2.3-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is gical repair in fixed subaortic stenosis?. ### Response: S4.2.3-6.

When did J Am Coll Cardiol. 30:1835-42?

1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 30:1835-42?. ### Response: 1997.

What is the developmental complex of?

parachute mitral valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the developmental complex of?. ### Response: parachute mitral valve.

What is supravalvular ring of left atrium, subaortic stenosis, and coarctation of aorta?

The developmental complex of “parachute mitral valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supravalvular ring of left atrium, subaortic stenosis, and coarctation of aorta?. ### Response: The developmental complex of “parachute mitral valve.

When was the Am J Cardiol.11:714–25.

1963

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What was the 2014 AHA/ACC guideline for?

management of patients with valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2014 AHA/ACC guideline for?. ### Response: management of patients with valvular heart disease.

What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines recommend for the management of patients with valvular heart di-sease?

AHA/ACC guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines recommend for the management of patients with valvular heart di-sease?. ### Response: AHA/ACC guideline.

What did Brodyn NE, Haft JI, describe as a result of membranous sub-aortic stenosis?

Chest pain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Brodyn NE, Haft JI, describe as a result of membranous sub-aortic stenosis?. ### Response: Chest pain.

What type of stenosis in young women is a multicentre study?

balloon aortic valvu-loplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis in young women is a multicentre study?. ### Response: balloon aortic valvu-loplasty.

What is the morphology of bi-cuspid stenosis?

Morphology of bi-cuspid aortic valve in children and adolescents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the morphology of bi-cuspid stenosis?. ### Response: Morphology of bi-cuspid aortic valve in children and adolescents.

What is prevalent in relatives of bicuspid aortic valve patients?

Aortopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prevalent in relatives of bicuspid aortic valve patients?. ### Response: Aortopathy.

What is the name of the disease in children and adolescents?

valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease in children and adolescents?. ### Response: valvular heart disease.

When was the J Am Coll Cardiol.44:1648-51?

2004

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What is the name of the prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve in newborns by echocardiographic screening?

J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve in newborns by echocardiographic screening?. ### Response: J Am Coll Cardiol.

What is the frequency of familial clustering of congenital bicuspid aortic valve?

S4.2.4-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of familial clustering of congenital bicuspid aortic valve?. ### Response: S4.2.4-5.

What was the J Am Coll Cardiol. 1997;30:1809-12?

A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 1997;30:1809-12?. ### Response: A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve.

Who wrote the 2014 AHA/ACC guideline?

Nishimura RA, Otto CM, Bonow RO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2014 AHA/ACC guideline?. ### Response: Nishimura RA, Otto CM, Bonow RO.

What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

management of patients with valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: management of patients with valvular heart disease.

What was the name of the task force on practice guidelines?

American College of Cardiology/American Heart Association

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When was the document downloaded from the AHAjournals website?

April 28, 2023

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Who is a founding KDIGO Co-Chair?

David C Wheeler, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a founding KDIGO Co-Chair?. ### Response: David C Wheeler, MD.

What is the name of the MD who was a co-chair?

David C Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MD who was a co-chair?. ### Response: David C Wheeler.

Who is an MD who has a PhD?

Adrian Covic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an MD who has a PhD?. ### Response: Adrian Covic.

Which MD has an appointment as a board member?

Garabed Eknoyan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which MD has an appointment as a board member?. ### Response: Garabed Eknoyan.

MBA, FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD?

Fred Brown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MBA, FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD?. ### Response: Fred Brown.

PhDRicardo Correa-Rotter, MDAdrian Covic, MD and PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAna Figueiredo, RN, MSc, PhDMohammed Benghanem Gharbi, BSc, FRCPCDavid

ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PhDRicardo Correa-Rotter, MDAdrian Covic, MD and PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAna Figueiredo, RN, MSc, PhDMohammed Benghanem Gharbi, BSc, FRCPCDavid. ### Response: ﬁ.

What is the title of the doctoral candidate who earned his PhD?

Angela Yee-Moon Wang

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the doctoral candidate who earned his PhD?. ### Response: Angela Yee-Moon Wang.

Who is the professor of medicine who received his MSc?

Ana Figueiredo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine who received his MSc?. ### Response: Ana Figueiredo.

Who is the MD, FRCP, FACPZhi-Hong Liu, MDPeter A McCullough, MPH, FACC, FACPRafique Moosa, MDMiguel C Riella, MDAdibul Hasan Rizvi, MBBS, FRCPBernardo Rodriquez-Iturbe, MD, PhD?

Philip K-T Li

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, FRCP, FACPZhi-Hong Liu, MDPeter A McCullough, MPH, FACC, FACPRafique Moosa, MDMiguel C Riella, MDAdibul Hasan Rizvi, MBBS, FRCPBernardo Rodriquez-Iturbe, MD, PhD?. ### Response: Philip K-T Li.

Who is the Senior Vice-President for Scientific Activities?

Kerry Willis, PhD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior Vice-President for Scientific Activities?. ### Response: Kerry Willis, PhD.

What is Michael Cheung's profession?

MA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael Cheung's profession?. ### Response: MA.

What does e564S Antithrombotic Therapy for Atrial Fibrillation not apply to?

patients already receiving warfarin for AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does e564S Antithrombotic Therapy for Atrial Fibrillation not apply to?. ### Response: patients already receiving warfarin for AF.

There are no studies comparing warfarin plus aspirin to what?

triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no studies comparing warfarin plus aspirin to what?. ### Response: triple therapy.

What is a triple therapy?

warfarin, aspirin, and clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a triple therapy?. ### Response: warfarin, aspirin, and clopidogrel.

Recent ACS.

12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent ACS.. ### Response: 12 months.

What would be appropriate if the risk reduction in MI and stroke achieved by adding the second antiplatelet agent is greater than the increase in bleeding risk?

Use of triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be appropriate if the risk reduction in MI and stroke achieved by adding the second antiplatelet agent is greater than the increase in bleeding risk?. ### Response: Use of triple therapy.

What are patients who are not under-going stent placement?

Patients With AF and ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who are not under-going stent placement?. ### Response: Patients With AF and ACS.

What is the principle to fi rst do no harm?

mindful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the principle to fi rst do no harm?. ### Response: mindful.

Why do we not advocate the use of triple therapy?

Given the lack of direct evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do we not advocate the use of triple therapy?. ### Response: Given the lack of direct evidence.

What type of stent is not used in patients with AF with ACS?

intracoronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stent is not used in patients with AF with ACS?. ### Response: intracoronary.

What are patients who place a high value on on MI and stroke reduc-tion and a low value on avoiding bleeding likely to opt for?

triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who place a high value on on MI and stroke reduc-tion and a low value on avoiding bleeding likely to opt for?. ### Response: triple therapy.

How long is the initial period of triple therapy?

3-6 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the initial period of triple therapy?. ### Response: 3-6 months.