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|---|---|---|---|---|---|---|---|
Comment 6: EPS vs. EPSs in plural form should be consistent throughout.
| null | null |
Comment 15: l. 169-170: “thirty” instead of “thirteen”?
| null | null |
biom12060834_makarova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
481-482: “spectrum” Answer 33: Suggestion has been included in the revised version of the manuscript Comment 34: I.
| null | null |
biom12060834_makarova
| 0 |
The evidences for the partial structure given are not convincing.
| null | null |
Also, β-glucopyranose and β-galactopyranose structures were identified and the acetylation was confirmed.
| null | null |
biom12060834_makarova
| 0 |
Answer 1: To better understand EPS chemical structure, further 2D NMR experiments were performed and results are presented inside the manuscript.
| null | null |
Comment 19: l. 247: Volume of 0.2 mM ethanolic DPPH solution?
| null | null |
biom12060834_makarova
| 0 |
Author Response Please see the attachment to see the responses.
| null | null |
(I was referring to peak intensities that are not uniform.
| null | null |
biom12060834_makarova
| 0 |
Comment 32: l. 480: Why was linkage analysis not performed?
| null | null |
Probably, to establish its structure, it is necessary to use chemical methods (hydrolysis, methylation, etc.
| null | null |
biom12060834_makarova
| 0 |
These results suggest they are the prevailing units of the EPS backbone making it a branched one.
| null | null |
Comment 6: EPS vs. EPSs in plural form should be consistent throughout.
| null | null |
biom12060834_makarova
| 0 |
Comment 14: l. 165: Table 2 where Table 1 expected Answer 14:
| null | null |
Chatterjee, S., Mukhopadhyay, S. K., Gauri, S. S., & Dey, S. (2018).
| null | null |
biom12060834_makarova
| 0 |
Comment 6: EPS vs. EPSs in plural form should be consistent throughout.
| null | null |
Units are not specified on the axes labels or in the legend.
| null | null |
biom12060834_makarova
| 0 |
→ Comment 2: The following comments were not addressed correctly: Why was linkage analysis not performed?
| null | null |
Comment 1: Unfortunately, its structure was not fully determined.
| null | null |
biom12060834_makarova
| 0 |
Comment 28: Figure 4; This figure is redundant as it gives the same information as Figure 3.
| null | null |
50-51: “improvement of rheological” Answer 8:
| null | null |
biom12060834_makarova
| 0 |
It is advisable, in my opinion, to provide information on the content of heavy metals in the EPS, since the authors plan to offer this product for the food industry in the future.
| null | null |
Comment 28: Figure 4; This figure is redundant as it gives the same information as Figure 3.
| null | null |
biom12060834_makarova
| 0 |
), as well as two-dimensional NMR spectroscopy.
| null | null |
The authors used the RSM based on central composite design technique to maximize the EPS production by B. haynesii, and also conducted a diverse study of the EPS properties.
| null | null |
biom12060834_makarova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
EPC is isolated from a thermal spring of volcanic origin, which contains a set of various elements, including heavy metals.
| null | null |
biom12060834_makarova
| 0 |
TOCSY and HMBC are mentioned in methods, but no results are presented.
| null | null |
Articles (mostly definite, but also indefinite) are often missing and sometimes superfluous.
| null | null |
biom12060834_makarova
| 0 |
528 and 531: “radical” Answer 36: Suggestion has been included in the revised version of the manuscript Comment 37: l. 535 and 536: “activity” Answer 37: Suggestion has been included in the revised version of the manuscript Comment 38: l. 537: No section 3.6.2 Answer 38:
| null | null |
Comment 3: Optimization of production constitutes an important part not mentioned in the title.
| null | null |
biom12060834_perova
| 0 |
The new spectra emphasize this even more: for example, I count at least 10 H1/H2 cross peaks of different intensities on the COSY.)
| null | null |
528 and 531: “radical” Answer 36: Suggestion has been included in the revised version of the manuscript Comment 37: l. 535 and 536: “activity” Answer 37: Suggestion has been included in the revised version of the manuscript Comment 38: l. 537: No section 3.6.2 Answer 38:
| null | null |
biom12060834_perova
| 0 |
Comment 2: The manuscript is very long: it contains a lot of information and many references not always pertinent to EPS characterization.
| null | null |
Probably, to establish its structure, it is necessary to use chemical methods (hydrolysis, methylation, etc.
| null | null |
biom12060834_perova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
biom12060834_perova
| 0 |
Comment 42: l. 683-684: Food-grade oils are not aliphatic and aromatic hydrocarbons.
| null | null |
The authors used the RSM based on central composite design technique to maximize the EPS production by B. haynesii, and also conducted a diverse study of the EPS properties.
| null | null |
biom12060834_perova
| 0 |
This EPS was carefully purified according to standard purification protocols for EPS.
| null | null |
Answer 29: As per the suggestion given by the reviewer, section numbering has been checked thoroughly in the revised version of the manuscript Comment 30: l. 442: “C), whereas the” Answer 30: Suggestion has been included in the revised version of the manuscript Comment 31: l. 471, 600, 678, and 718: Reference format is different; corresponding references could be missing in the list.
| null | null |
biom12060834_perova
| 0 |
Comment 43: l. 711: “to be significantly” Answer 43: Suggestion has been included in the revised version of the manuscript Comment 44: l. 725: “possibility of future” Answer 44: Suggestion has been included in the revised version of the manuscript
| null | null |
Basically, the work was done at a fairly high professional level, the material is presented clearly, well structured, the data obtained are discussed with the previously obtained literature data.
| null | null |
biom12060834_perova
| 0 |
These results suggest they are the prevailing units of the EPS backbone making it a branched one.
| null | null |
Probably, to establish its structure, it is necessary to use chemical methods (hydrolysis, methylation, etc.
| null | null |
biom12060834_perova
| 0 |
Comment 4: Acceptability for food applications was not discussed.
| null | null |
(I was referring to the chemical method by methylation.)
| null | null |
biom12060834_perova
| 0 |
There are inconsistencies in singular- plural concordance between subject and verb as well as noun and pronoun.
| null | null |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
biom12060834_perova
| 0 |
The presented manuscript is related to the study of an exopolysaccharide isolated from the extremophilic microorganism Bacillus haynesii CamB6.
| null | null |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
biom12060834_perova
| 0 |
(I was referring to the chemical method by methylation.)
| null | null |
→ Comment 2: The following comments were not addressed correctly: Why was linkage analysis not performed?
| null | null |
biom12060834_perova
| 0 |
Answer 29: As per the suggestion given by the reviewer, section numbering has been checked thoroughly in the revised version of the manuscript Comment 30: l. 442: “C), whereas the” Answer 30: Suggestion has been included in the revised version of the manuscript Comment 31: l. 471, 600, 678, and 718: Reference format is different; corresponding references could be missing in the list.
| null | null |
The authors used the RSM based on central composite design technique to maximize the EPS production by B. haynesii, and also conducted a diverse study of the EPS properties.
| null | null |
biom12060834_perova
| 0 |
Also, β-glucopyranose and β-galactopyranose structures were identified and the acetylation was confirmed.
| null | null |
Also, β-glucopyranose and β-galactopyranose structures were identified and the acetylation was confirmed.
| null | null |
biom12060834_perova
| 0 |
Articles (mostly definite, but also indefinite) are often missing and sometimes superfluous.
| null | null |
The authors added a COSY spectrum but did not analyze it.
| null | null |
biom12060834_perova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
→ Comment 1: The English language was improved, but there are still errors.
| null | null |
biom12060834_perova
| 0 |
→ Comment 2: The following comments were not addressed correctly: Why was linkage analysis not performed?
| null | null |
Manuscript biomolecules-1691308 In this manuscript, the exopolysaccharide from Bacillus haynesii CamB6 was exhaustively characterized.
| null | null |
biom12060834_perova
| 0 |
(I was referring to the chemical method by methylation.)
| null | null |
Comment 1: Unfortunately, its structure was not fully determined.
| null | null |
biom12060834_perova
| 0 |
Figure 6: Bacterial EPSs are normally composed of repeating units.
| null | null |
Figure 6: Bacterial EPSs are normally composed of repeating units.
| null | null |
biom12060834_perova
| 0 |
According to the 1H NMR spectrum, it can be assumed that EPS has a complex branched structure.
| null | null |
According to the 1H NMR spectrum, it can be assumed that EPS has a complex branched structure.
| null | null |
biom12060834_perova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
According to the 1H NMR spectrum, it can be assumed that EPS has a complex branched structure.
| null | null |
biom12060834_perova
| 0 |
The studied EPS showed promising properties to use in the food industry.
| null | null |
These results suggest they are the prevailing units of the EPS backbone making it a branched one.
| null | null |
biom12060834_perova
| 0 |
Units are not specified on the axes labels or in the legend.
| null | null |
The presented manuscript is related to the study of an exopolysaccharide isolated from the extremophilic microorganism Bacillus haynesii CamB6.
| null | null |
biom12060834_perova
| 0 |
In combination with a high yield of polysaccharide from the bacterial mass, this makes it attractive for practical use.
| null | null |
The authors used the RSM based on central composite design technique to maximize the EPS production by B. haynesii, and also conducted a diverse study of the EPS properties.
| null | null |
biom12060834_perova
| 0 |
The studied EPS showed promising properties to use in the food industry.
| null | null |
Tick label values for glucose and yeast extract are different.
| null | null |
biom12060834_perova
| 0 |
Comment 15: l. 169-170: “thirty” instead of “thirteen”?
| null | null |
Tick label values for glucose and yeast extract are different.
| null | null |
biom12060834_perova
| 0 |
Comment 17: l. 228: GPC defined on l. 231 (check) Answer 17:
| null | null |
Comment 21: l. 284: No section 2.6.3 Answer 21:
| null | null |
biom12060834_perova
| 0 |
Units are not specified on the axes labels or in the legend.
| null | null |
Comment 22: Figure 1: What is the significance of the tick mark labels on the maps?
| null | null |
biom12060834_perova
| 0 |
Answer 25: Suggestion has been included in the revised version of the manuscript Comment 26: Figure 3: Units are not specified on the axes labels or in the legend.
| null | null |
50-51: “improvement of rheological” Answer 8:
| null | null |
biom12060834_perova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
Comment 7: Use a consistent abbreviation (l or L) for liter (including milliliter and microliter) throughout.
| null | null |
biom12060834_perova
| 0 |
Comment 17: l. 228: GPC defined on l. 231 (check) Answer 17:
| null | null |
Comment 19: l. 247: Volume of 0.2 mM ethanolic DPPH solution?
| null | null |
biom12060834_perova
| 0 |
There are inconsistencies in singular- plural concordance between subject and verb as well as noun and pronoun.
| null | null |
481-482: “spectrum” Answer 33: Suggestion has been included in the revised version of the manuscript Comment 34: I.
| null | null |
biom12060834_perova
| 0 |
It is advisable, in my opinion, to provide information on the content of heavy metals in the EPS, since the authors plan to offer this product for the food industry in the future.
| null | null |
TOCSY and HMBC are mentioned in methods, but no results are presented.
| null | null |
biom12060834_perova
| 0 |
Comment 39: l. 581: “Table S1A” Answer 39: Suggestion has been included in the revised version of the manuscript Comment 40: l. 603: “Figure S1” Answer 40: Suggestion has been included in the revised version of the manuscript Comment 41: l. 636: “Glc and Gal” Answer 41:
| null | null |
Comment 4: Acceptability for food applications was not discussed.
| null | null |
biom12060834_perova
| 0 |
This EPS was carefully purified according to standard purification protocols for EPS.
| null | null |
The studied EPS showed promising properties to use in the food industry.
| null | null |
biom12060834_perova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
Units are not specified on the axes labels or in the legend.
| null | null |
biom12060834_perova
| 0 |
Answer 25: Suggestion has been included in the revised version of the manuscript Comment 26: Figure 3: Units are not specified on the axes labels or in the legend.
| null | null |
The presented manuscript is related to the study of an exopolysaccharide isolated from the extremophilic microorganism Bacillus haynesii CamB6.
| null | null |
biom12060834_perova
| 0 |
Author Response Thank you so much dear reviewer for your positive comments regarding the revised version of our manuscript.
| null | null |
Comment 35: l. 500 : The chemical shift range is more than from 1 to 5.
| null | null |
biom12060834_perova
| 0 |
Comment 28: Figure 4; This figure is redundant as it gives the same information as Figure 3.
| null | null |
Comment 32: l. 480: Why was linkage analysis not performed?
| null | null |
biom12060834_perova
| 0 |
This EPS was carefully purified according to standard purification protocols for EPS.
| null | null |
Comment 17: l. 228: GPC defined on l. 231 (check) Answer 17:
| null | null |
biom12060834_perova
| 0 |
Author Response Please see the attachment for the responses.
| null | null |
Author Response Please see the attachment to see the responses.
| null | null |
biom12060834_perova
| 0 |
Author Response Thank you so much dear reviewer for your positive comments regarding the revised version of our manuscript.
| null | null |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
biom12060834_perova
| 0 |
In combination with a high yield of polysaccharide from the bacterial mass, this makes it attractive for practical use.
| null | null |
A 2D COSY spectrum would be necessary to confirm the assignments made on the 1D: e.g., H2- Man is not normally found in the range 3.2-3.5 ppm (the statement ll.
| null | null |
biom12060834_perova
| 0 |
Comment 4: Line 526-527: The proposal should be reformulated.
| null | null |
Comment 43: l. 711: “to be significantly” Answer 43: Suggestion has been included in the revised version of the manuscript Comment 44: l. 725: “possibility of future” Answer 44: Suggestion has been included in the revised version of the manuscript
| null | null |
biom12060834_perova
| 0 |
It could be argued that some RNA is hydrolyzed during extraction, but for this to be the case, one should assume that the cells were not well washed after being pelleted by centrifugation, which is not the case.
| null | null |
Author Response Author’s Response: We appreciated the reviewers’ comment.
| null | null |
biomedicines10030600_makarova
| 0 |
https://www.sciencedirect.com/science/article/abs/pii/S0960894X08011086?via%3Dihub
| null | null |
The authors presented the paper "Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport".
| null | null |
biomedicines10030600_makarova
| 0 |
They actually show that adding these components to the growth medium does not modify the bactericidal nature of the action of the antibiotic.
| null | null |
The authors presented the paper "Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport".
| null | null |
biomedicines10030600_makarova
| 0 |
Author Response Author’s Response: We appreciate the reviewers’ comment and the suggestion.
| null | null |
Author Response Author’s Response: We appreciated the reviewers’ comment.
| null | null |
biomedicines10030600_makarova
| 0 |
https://www.sciencedirect.com/science/article/abs/pii/S0960894X08011086?via%3Dihub
| null | null |
We agree that confirming that the effect of cefiderocol is bactericidal under the conditions tested is important.
| null | null |
biomedicines10030600_makarova
| 0 |
3) A scheme summarizing how different molecular defects can converge on similar NMDAR-mediated EPSCs would be helpful in the discussion 4) A small commentary on the possible functional significance of the identified mutation properties for the pathogenesis of certain diseases would be interesting.
| null | null |
2) Please add a chart about tau changes in Figure 3.
| null | null |
brainsci12060789_makarova
| 0 |
These findings highlight the complexity of interpreting effects of disease-causing NMDA receptor missense mutations in the context of neuronal function.
| null | null |
Particularly, GluN2B GoF and LoF mutants show similar phenotypes in the presence of GluN1/2A/2B triheteromers, while the LoF mutation, C456Y, shows much less rescue effect than GoF mutation in the absence of both GluN2A and GluN2B.
| null | null |
brainsci12060789_makarova
| 0 |
The results presented are convincing and I only have a few minor comments.
| null | null |
These findings highlight the complexity of interpreting effects of disease-causing NMDA receptor missense mutations in the context of neuronal function.
| null | null |
brainsci12060789_makarova
| 0 |
The abstract is too long, which does not actually abstract the whole content very well.
| null | null |
There are also a number of sentences that are so complicated for easy read.
| null | null |
brainsci12060789_makarova
| 0 |
1) Since mutations can affect NMDA receptor localization, data on whether AMPA/NMDA ratios changed would be informative.
| null | null |
In the absence of both native GluN2A and GluN2B subunits, functional incorporation into synaptic NMDA receptors was attenuated for GoF mutants, or almost eliminated for LoF GluN2B mutants.
| null | null |
brainsci12060789_makarova
| 0 |
The authors conclude that the presence of triheteromeric NMDA receptors, and the types of the mutated GluN2 subunit are all important factors that can influence the function of the NMDA variants.
| null | null |
The results presented are convincing and I only have a few minor comments.
| null | null |
brainsci12060789_makarova
| 0 |
Please verify if the time scale is correct in Fig. 3А.
| null | null |
Finally, we show that having a single null Grin2b allele has only a modest effect on NMDA-EPSC decay kinetics.
| null | null |
brainsci12060789_makarova
| 0 |
Mechanistic insight was gained from experiments in HEK293T cells, which revealed that GluN2B GoF mutants slowed deactivation in diheteromeric GluN1/2B, but not triheteromeric GluN1/2A/2B receptors.
| null | null |
The abstract is too long, which does not actually abstract the whole content very well.
| null | null |
brainsci12060789_makarova
| 0 |
Please find below our point-by-point response.
| null | null |
The authors conclude that the presence of triheteromeric NMDA receptors, and the types of the mutated GluN2 subunit are all important factors that can influence the function of the NMDA variants.
| null | null |
brainsci12060789_perova
| 0 |
In the present study, the authors revealed how some mutations from patients with GRIN2B-related disorders result in defective synaptic transmission.
| null | null |
Using molecular replacement experiments in cultured hippocampal slices and functional properties for diheteromeric and triheteromeric NMDA receptors expressed in HEK293T cells, the authors demonstrated effects of GoF and LoF mutations.
| null | null |
brainsci12060789_perova
| 0 |
1) Since mutations can affect NMDA receptor localization, data on whether AMPA/NMDA ratios changed would be informative.
| null | null |
Author Response Thank you to the reviewer for their comments and helpful suggestions.
| null | null |
brainsci12060789_perova
| 0 |
There are also a number of sentences that are so complicated for easy read.
| null | null |
Using molecular replacement experiments in cultured hippocampal slices and functional properties for diheteromeric and triheteromeric NMDA receptors expressed in HEK293T cells, the authors demonstrated effects of GoF and LoF mutations.
| null | null |
brainsci12060789_perova
| 0 |
Please find below our point-by-point response.
| null | null |
Please find below our point-by-point response.
| null | null |
brainsci12060789_perova
| 0 |
Even though fig.2aiii shows a comparable relative peak amplitude, which indicates both GOF and LOF rescue NMDA-EPSC in Grin2b-/- neurons, it looks to me that the absolute amplitude in fig.2aii shows a quite big difference in un-transferred groups which are supposed to be comparable, not as consistent as shown in fig.1ci.
| null | null |
The abstract is too long, which does not actually abstract the whole content very well.
| null | null |
brainsci12060789_perova
| 0 |
Please find below our point-by-point response.
| null | null |
1) Since mutations can affect NMDA receptor localization, data on whether AMPA/NMDA ratios changed would be informative.
| null | null |
brainsci12060789_perova
| 0 |
The discussion interprets the results as supporting evidence of exercise-induced hypoalgesia (EIH) in the patients with FM.
| null | null |
The results are clearly reported and adequately discussed.
| null | null |
brainsci6010008_makarova
| 0 |
Following exercise in FM patients, activity was transiently increased in anterior insula and dorsolateral prefrontal cortex (DLPFC) while activity was transienly decreased following rest.
| null | null |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
brainsci6010008_makarova
| 0 |
Author Response We would like to thank the reviewer for their positive and critical review of our work.
| null | null |
The methodology is sound and the manuscript is well-written.
| null | null |
brainsci6010008_makarova
| 0 |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
We have addressed each concern below and made changes in the manuscript accordingly.
| null | null |
brainsci6010008_makarova
| 0 |
Author Response We would like to thank the reviewer for their positive and critical review of our work.
| null | null |
Author Response We would like to thank the reviewer for their positive and critical review of our work.
| null | null |
brainsci6010008_makarova
| 0 |
I am uncertain why the authors only report the effect sizes of group differences in the first run.
| null | null |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
brainsci6010008_makarova
| 0 |
The results are clearly reported and adequately discussed.
| null | null |
The methodology is sound and the manuscript is well-written.
| null | null |
brainsci6010008_makarova
| 0 |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
The results are clearly reported and adequately discussed.
| null | null |
brainsci6010008_makarova
| 0 |
Following exercise in FM patients, activity was transiently increased in anterior insula and dorsolateral prefrontal cortex (DLPFC) while activity was transienly decreased following rest.
| null | null |
We have addressed each concern below and made changes in the manuscript accordingly.
| null | null |
brainsci6010008_makarova
| 0 |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
The results are clearly reported and adequately discussed.
| null | null |
brainsci6010008_makarova
| 0 |
The methodology is sound and the manuscript is well-written.
| null | null |
However, in the latter case the authors need to address the issue of multiple correlations.
| null | null |
brainsci6010008_makarova
| 0 |
Considering discussion the results in relation to previous studies on exercise and neuroimaging.
| null | null |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
brainsci6010008_makarova
| 0 |
“ Each temperature was applied twice so I assume averages were used, but the authors should clarify.
| null | null |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
brainsci6010008_makarova
| 0 |
“ Each temperature was applied twice so I assume averages were used, but the authors should clarify.
| null | null |
We have addressed each concern below and made changes in the manuscript accordingly.
| null | null |
brainsci6010008_makarova
| 0 |
Considering discussion the results in relation to previous studies on exercise and neuroimaging.
| null | null |
The methodology is sound and the manuscript is well-written.
| null | null |
brainsci6010008_perova
| 0 |
Elevations should be revised to higher so that readers do not erroneously believe that a pre-scan application of heat stimuli was administered.
| null | null |
Elevations should be revised to higher so that readers do not erroneously believe that a pre-scan application of heat stimuli was administered.
| null | null |
brainsci6010008_perova
| 0 |
In paralell pain sensitivity to heat was decreased by exercise.
| null | null |
Changes in pain sensitivity after exercise vs. quiet rest were significantly correlated with changes in activity in the DLPFC (exercise vs. rest).
| null | null |
brainsci6010008_perova
| 0 |
We have addressed each concern below and made changes in the manuscript accordingly.
| null | null |
This manuscript describes a cohort randomized crossover design comparing cutaneous heat pain ratings and brain activity during heat stimuli after conditions of quiet rest and cycling in patients with a physician-confirmed diagnosis of Fibromyalgia (FM) and age and sex matched controls.
| null | null |
brainsci6010008_perova
| 0 |
Author Response We would like to thank the reviewer for their positive and critical review of our work.
| null | null |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
brainsci6010008_perova
| 0 |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
In paralell pain sensitivity to heat was decreased by exercise.
| null | null |
brainsci6010008_perova
| 0 |
Our responses to the reviewer’s specific concerns follow each point and are indented and in red font.
| null | null |
We have addressed each concern below and made changes in the manuscript accordingly.
| null | null |
brainsci6010008_perova
| 0 |
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