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Author Response We thank the reviewers for their guidance on this manuscript.
| null | null |
All comments have been addressed below, and all changes in the revised manuscript have been performed using track changes.
| null | null |
life12060901_perova
| 0 |
However, I see several issues with the ending of this paper.I liked the ideas and the methodological setting (i.e., online survey) of this study and I think the reported data have potential.
| null | null |
I would suggest another factor - frustration with not getting well.
| null | null |
life12060901_perova
| 0 |
However, what I disliked was the interpretation and discussion of the empirical results.
| null | null |
R3: Besides these two major issues, I detected some smaller errors and miss-spellings (note, this list in not complete).
| null | null |
life12060901_perova
| 0 |
They analyzed the collected data descriptively and with logistic regression models and multivariate analyses of variances (MANOVAs).
| null | null |
For example, see Table 4 (page 7, line 269): Column Fatgigue, why is ES not printed in bold?
| null | null |
life12060901_perova
| 0 |
COVID-patients with long COVID felt higher psychological distress, higer fatigue, and higer perceived stress than COVID-patients without long COVID.
| null | null |
2) Table 1 (page 3, line 137): I detected an error in the third column (“COVID-19 infection”).
| null | null |
life12060901_perova
| 0 |
4) Table 3, Table 4, and Table 5: The authors use a very inconsistent style of bold.
| null | null |
However, the authors wrote “While participants with long COVID generally perceived more psychological distress, fatigue, and stress than those without long COVID, differences were larger for men than for women” page 9, line 303), Authors’ response: Thank you for pointing this out, we have revised the sentence (see section 4.1).
| null | null |
life12060901_perova
| 0 |
However, this table is still wrong, it must be 310 and not 303.
| null | null |
Hence, I urge the authors to re-calculate percentages in Table 1.
| null | null |
life12060901_perova
| 0 |
Frankly speaking, the authors are overselling their results.
| null | null |
I liked the ideas and the methodological setting (i.e., online survey) of this study and I think the reported data have potential.
| null | null |
life12060901_perova
| 0 |
I know, there were 7 missing values within the 310.
| null | null |
I found two major issues in the discussion of this paper: Authors response: Please see our comments to each of the listed issues below.
| null | null |
life12060901_perova
| 0 |
The percentage of 87 long COVID (28.7%) then refers to 303 (87/303=28.7%).
| null | null |
Authors’ response: We have revised the sentence; see section 5.
| null | null |
life12060901_perova
| 0 |
The introduction guides the reader smoothly into this topic, all necessary background information (i.e., citing appropriate literature) is given.
| null | null |
Frankly speaking, the authors are overselling their results.
| null | null |
life12060901_perova
| 0 |
They also make quantitative measurements to describe the behaviour of the model trichomes.
| null | null |
Their suggested bending modulus value implies a very high persistence length of 0.5 metres.
| null | null |
life4030433_makarova
| 0 |
Qualitative comparisons are made to the fossil record and modern experiments.
| null | null |
While the authors might be able to find a similar phenomenological agreement with more reasonable parameters, it will change all of their results and amounts to a substantial revision.
| null | null |
life4030433_makarova
| 0 |
The trichomes were completely flaccid and would collapse into a heap as soon as one collided with another trichome, unlike the smooth sinuous shape filamentous cyanobacteria often display.
| null | null |
The paper can be published once the authors more clearly confront their disagreement with the results of Boal and Ng.
| null | null |
life4030433_makarova
| 0 |
Round 2: Author Response to Reviewer 1 We have addressed the reviwer’s requests: (1)
| null | null |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
life4030433_makarova
| 0 |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
The paper can be published once the authors more clearly confront their disagreement with the results of Boal and Ng.
| null | null |
life4030433_makarova
| 0 |
While the authors might be able to find a similar phenomenological agreement with more reasonable parameters, it will change all of their results and amounts to a substantial revision.
| null | null |
I have a few comments, suggestions, and questions.
| null | null |
life4030433_makarova
| 0 |
They also make quantitative measurements to describe the behaviour of the model trichomes.
| null | null |
In their response, the authors mention that with the lower value from Boal and Ng the trichomes collapse into a heap, and so a larger bending modulus was necessary.
| null | null |
life4030433_makarova
| 0 |
The paper can be published once the authors more clearly confront their disagreement with the results of Boal and Ng.
| null | null |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
life4030433_makarova
| 0 |
Second Round of Evaluation Round 2: With the exception of their response to one key point, the authors' responses are satisfactory.
| null | null |
The paper can be published once the authors more clearly confront their disagreement with the results of Boal and Ng.
| null | null |
life4030433_makarova
| 0 |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
In response to the reviewers’ comments: (1) We initially attempted to use the bending modulus implied from Boal and Ng’s study, however we found that during simulations this value seemed to be too low.
| null | null |
life4030433_makarova
| 0 |
While the authors might be able to find a similar phenomenological agreement with more reasonable parameters, it will change all of their results and amounts to a substantial revision.
| null | null |
Qualitative comparisons are made to the fossil record and modern experiments.
| null | null |
life4030433_makarova
| 0 |
Round 2: Author Response to Reviewer 1 We have addressed the reviwer’s requests: (1)
| null | null |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
life4030433_makarova
| 0 |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
The paper can be published once the authors more clearly confront their disagreement with the results of Boal and Ng.
| null | null |
life4030433_makarova
| 0 |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
I have a few comments, suggestions, and questions.
| null | null |
life4030433_makarova
| 0 |
Second Round of Evaluation Round 2: With the exception of their response to one key point, the authors' responses are satisfactory.
| null | null |
Their suggested bending modulus value implies a very high persistence length of 0.5 metres.
| null | null |
life4030433_makarova
| 0 |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
In their response, the authors mention that with the lower value from Boal and Ng the trichomes collapse into a heap, and so a larger bending modulus was necessary.
| null | null |
life4030433_makarova
| 0 |
I have a few comments, suggestions, and questions.
| null | null |
The trichomes were completely flaccid and would collapse into a heap as soon as one collided with another trichome, unlike the smooth sinuous shape filamentous cyanobacteria often display.
| null | null |
life4030433_makarova
| 0 |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
Second Round of Evaluation Round 2: With the exception of their response to one key point, the authors' responses are satisfactory.
| null | null |
life4030433_makarova
| 0 |
Simulations using the model address the observation of reticulate patterns in experiments with filamentous cyanobacteria.
| null | null |
Round 1: Author Response to Reviewer 2 We would like to thank the reviewer for his/her thorough review of our manuscript and thoughtful comments.
| null | null |
life4030433_makarova
| 0 |
The authors find that for a certain parameter regime, they observe in their simulations patterns with characteristics similar to the characteristics of the experimental patterns.
| null | null |
They also explore behaviour in much of the available parameter space.
| null | null |
life4030433_makarova
| 0 |
I have a few comments, suggestions, and questions.
| null | null |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
life4030433_makarova
| 0 |
Simulations using the model address the observation of reticulate patterns in experiments with filamentous cyanobacteria.
| null | null |
The trichomes were completely flaccid and would collapse into a heap as soon as one collided with another trichome, unlike the smooth sinuous shape filamentous cyanobacteria often display.
| null | null |
life4030433_makarova
| 0 |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
life4030433_makarova
| 0 |
Simulations using the model address the observation of reticulate patterns in experiments with filamentous cyanobacteria.
| null | null |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
life4030433_makarova
| 0 |
As a result, I do not recommend that this paper should be published in its current form.
| null | null |
They also explore behaviour in much of the available parameter space.
| null | null |
life4030433_perova
| 0 |
Simulations using the model address the observation of reticulate patterns in experiments with filamentous cyanobacteria.
| null | null |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
life4030433_perova
| 0 |
As a result, I do not recommend that this paper should be published in its current form.
| null | null |
Thus, the length of a filament is not a model parameter.
| null | null |
life4030433_perova
| 0 |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
As I recall, these cyanobacteria reproduce (with doubling time τ ) by adding cells to the filament and that filaments periodically break (rate k+).
| null | null |
life4030433_perova
| 0 |
They also explore behaviour in much of the available parameter space.
| null | null |
However, their parameterization of the bending modulus is not acceptable because it leads to an unreasonably large (0.5 metre) persistence length for a bacterial trichome.
| null | null |
life4030433_perova
| 0 |
Qualitative comparisons are made to the fossil record and modern experiments.
| null | null |
Rather, length is determined dynamically as ~ N k τ + (10)
| null | null |
life4030433_perova
| 0 |
Thus, the length of a filament is not a model parameter.
| null | null |
In their response, the authors mention that with the lower value from Boal and Ng the trichomes collapse into a heap, and so a larger bending modulus was necessary.
| null | null |
life4030433_perova
| 0 |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
Round 1: Author Response to Reviewer 2 We would like to thank the reviewer for his/her thorough review of our manuscript and thoughtful comments.
| null | null |
life4030433_perova
| 0 |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
Second Round of Evaluation Round 2: With the exception of their response to one key point, the authors' responses are satisfactory.
| null | null |
life4030433_perova
| 0 |
As I recall, these cyanobacteria reproduce (with doubling time τ ) by adding cells to the filament and that filaments periodically break (rate k+).
| null | null |
While the authors might be able to find a similar phenomenological agreement with more reasonable parameters, it will change all of their results and amounts to a substantial revision.
| null | null |
life4030433_perova
| 0 |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
Second Round of Evaluation Round 2: With the exception of their response to one key point, the authors' responses are satisfactory.
| null | null |
life4030433_perova
| 0 |
In their response, the authors mention that with the lower value from Boal and Ng the trichomes collapse into a heap, and so a larger bending modulus was necessary.
| null | null |
Rather, length is determined dynamically as ~ N k τ + (10)
| null | null |
life4030433_perova
| 0 |
They also argue that a very large persistence length implies that the cyanobacteria are stiff enough to largely be unaffected by thermal fluctuations.
| null | null |
I do not feel that any of these points demand major changes to the manuscript, which is generally fine in the present form.
| null | null |
life4030433_perova
| 0 |
Thus, the length of a filament is not a model parameter.
| null | null |
However, their parameterization of the bending modulus is not acceptable because it leads to an unreasonably large (0.5 metre) persistence length for a bacterial trichome.
| null | null |
life4030433_perova
| 0 |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
Thus, the length of a filament is not a model parameter.
| null | null |
life4030433_perova
| 0 |
In their response, the authors mention that with the lower value from Boal and Ng the trichomes collapse into a heap, and so a larger bending modulus was necessary.
| null | null |
The model is successful in producing local alignment of filaments and some sharp bends—both characteristics of the experimental system.
| null | null |
life4030433_perova
| 0 |
As I recall, these cyanobacteria reproduce (with doubling time τ ) by adding cells to the filament and that filaments periodically break (rate k+).
| null | null |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
life4030433_perova
| 0 |
They also argue that a very large persistence length implies that the cyanobacteria are stiff enough to largely be unaffected by thermal fluctuations.
| null | null |
Their suggested bending modulus value implies a very high persistence length of 0.5 metres.
| null | null |
life4030433_perova
| 0 |
Qualitative comparisons are made to the fossil record and modern experiments.
| null | null |
The authors find that for a certain parameter regime, they observe in their simulations patterns with characteristics similar to the characteristics of the experimental patterns.
| null | null |
life4030433_perova
| 0 |
They also make quantitative measurements to describe the behaviour of the model trichomes.
| null | null |
They also explore behaviour in much of the available parameter space.
| null | null |
life4030433_perova
| 0 |
As I recall, these cyanobacteria reproduce (with doubling time τ ) by adding cells to the filament and that filaments periodically break (rate k+).
| null | null |
Thus, the length of a filament is not a model parameter.
| null | null |
life4030433_perova
| 0 |
Thus, the length of a filament is not a model parameter.
| null | null |
Round 1: Author Response to Reviewer 2 We would like to thank the reviewer for his/her thorough review of our manuscript and thoughtful comments.
| null | null |
life4030433_perova
| 0 |
Round 1: Author Response to Reviewer 1 We would like to thank the reviewer for taking the time to do a thorough review of our paper.
| null | null |
As a result, I do not recommend that this paper should be published in its current form.
| null | null |
life4030433_perova
| 0 |
Notably, the introduction of reproduction does not introduce another parameter.
| null | null |
Round 1: The authors develop and analyze a model for the dynamics of filamentous bacteria gliding in two dimensions.
| null | null |
life4030433_perova
| 0 |
Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
| null | null |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
life4040819_makarova
| 0 |
Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
| null | null |
presents characterization of the growth dynamics and motility of a newly isolated Phormodium strain.
| null | null |
life4040819_makarova
| 0 |
R3 Minor comments The addition of a time stamp to the supplemental movies would be useful
| null | null |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
life4040819_makarova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
By characterizing motility of colonies, as well as single-filament motility of short filaments, the authors find that increasing the agar concentration of the media results in smaller colonies, and slower individual filament movement.
| null | null |
life4040819_makarova
| 0 |
A few major comments can be found below concerning R2 the possible presence of type IV pili in their EM images, some confusion regarding descriptions of motility analysis and others.
| null | null |
In addition, Figure 3A was replaced by a figure of better contrast.
| null | null |
life4040819_makarova
| 0 |
Using TEM, the authors observed junctional pore complexes arrayed at septa, and extending through the cell envelope to the exterior of the cell, and potentially identified basal body complexes at the cytoplasmic face of the inner membrane.
| null | null |
presents characterization of the growth dynamics and motility of a newly isolated Phormodium strain.
| null | null |
life4040819_makarova
| 0 |
R3 Minor comments The addition of a time stamp to the supplemental movies would be useful
| null | null |
Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
| null | null |
life4040819_makarova
| 0 |
However, a number of shortcomings need to be addressed before the manuscript could be accepted for publication.
| null | null |
The observations and models are consistent with previously published work on motility of various cyanobacteria and provide new insights into the mechanics of motility of cyanobacteria that are interesting.
| null | null |
life4040819_makarova
| 0 |
By characterizing motility of colonies, as well as single-filament motility of short filaments, the authors find that increasing the agar concentration of the media results in smaller colonies, and slower individual filament movement.
| null | null |
Response: We thank the reviewers for giving us helpful comments.
| null | null |
life4040819_makarova
| 0 |
A few major comments can be found below concerning R2 the possible presence of type IV pili in their EM images, some confusion regarding descriptions of motility analysis and others.
| null | null |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
life4040819_makarova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
The authors demonstrate the presence of putative junctional pores by electron microscopy and other ultrastructural data that would appear to support polysaccharide secretion as the driving force for motility in this organism.
| null | null |
life4040819_makarova
| 0 |
R3 Minor comments The addition of a time stamp to the supplemental movies would be useful
| null | null |
A model is presented to describe how the rotation of the filament causes left-handed sliding for the portion of the filament not encased in a slime sheath, which leads to formation of counter-clockwise spirals, the predominant macroscopic feature of colonies noted.
| null | null |
life4040819_makarova
| 0 |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
In addition, Figure 3A was replaced by a figure of better contrast.
| null | null |
life4040819_makarova
| 0 |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
R4 Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
| null | null |
life4040819_makarova
| 0 |
The contribution of motility to the formation of supracellular structure is generally an area of research regarding cyanobacteria that has been overlooked.
| null | null |
The authors’ conclusions are generally well supported and the electron microscopy provides some of the clearest images to date of the junctional pores.
| null | null |
life4040819_makarova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
life4040819_makarova
| 0 |
By characterizing motility of colonies, as well as single-filament motility of short filaments, the authors find that increasing the agar concentration of the media results in smaller colonies, and slower individual filament movement.
| null | null |
The authors demonstrate the presence of putative junctional pores by electron microscopy and other ultrastructural data that would appear to support polysaccharide secretion as the driving force for motility in this organism.
| null | null |
life4040819_makarova
| 0 |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
Within the text, corrected words are highlighted.
| null | null |
life4040819_makarova
| 0 |
Response: We thank the reviewers for giving us helpful comments.
| null | null |
The text was revised according to the comments.
| null | null |
life4040819_makarova
| 0 |
A few major comments can be found below concerning R2 the possible presence of type IV pili in their EM images, some confusion regarding descriptions of motility analysis and others.
| null | null |
ISSN 2075-1729 www.mdpi.com/journal/life Peer-Review Record: Cellular Dynamics Drives Emergence of Supracellular Structure in the Cyanobacterium Phormidium sp.
| null | null |
life4040819_makarova
| 0 |
The authors demonstrate the presence of putative junctional pores by electron microscopy and other ultrastructural data that would appear to support polysaccharide secretion as the driving force for motility in this organism.
| null | null |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
life4040819_makarova
| 0 |
By characterizing motility of colonies, as well as single-filament motility of short filaments, the authors find that increasing the agar concentration of the media results in smaller colonies, and slower individual filament movement.
| null | null |
ISSN 2075-1729 www.mdpi.com/journal/life Peer-Review Record: Cellular Dynamics Drives Emergence of Supracellular Structure in the Cyanobacterium Phormidium sp.
| null | null |
life4040819_makarova
| 0 |
The authors demonstrate the presence of putative junctional pores by electron microscopy and other ultrastructural data that would appear to support polysaccharide secretion as the driving force for motility in this organism.
| null | null |
Response: We thank the reviewers for giving us helpful comments.
| null | null |
life4040819_perova
| 0 |
In particular, the appearance of bulges in the extracellular sheath adjacent to the site of the junctional pores appears to be consistent with this mode of motility.
| null | null |
Finally, the authors performed a detailed characterization of the motility of individual filaments of the organism by time lapse microscopy providing additional evidence that would appear to support polysaccharide secretion as the driving force for motility, and provide a model for how this motility drives the formation of supercellular structures; in this case, spirals.
| null | null |
life4040819_perova
| 0 |
presents characterization of the growth dynamics and motility of a newly isolated Phormodium strain.
| null | null |
Round 1: and Author Response The manuscript “Cellular dynamics drives emergence of supracellular structure in the cyanobacterium Phormidium sp.
| null | null |
life4040819_perova
| 0 |
Additionally, the authors sequenced the genome of this organism and identified homologs to genes conserved among filamentous cyanobacteria that have been demonstrated to be essential for motility in Nostoc punctiforme and may encode for the junctional pore proteins (hps locus) or a chemotaxis system (hmp locus).
| null | null |
A model is presented to describe how the rotation of the filament causes left-handed sliding for the portion of the filament not encased in a slime sheath, which leads to formation of counter-clockwise spirals, the predominant macroscopic feature of colonies noted.
| null | null |
life4040819_perova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
Additionally, individual filaments were found to undergo polarity reversals, and the maximum velocity was observed immediately following the reversal.
| null | null |
life4040819_perova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
ISSN 2075-1729 www.mdpi.com/journal/life Peer-Review Record: Cellular Dynamics Drives Emergence of Supracellular Structure in the Cyanobacterium Phormidium sp.
| null | null |
life4040819_perova
| 0 |
In particular, the appearance of bulges in the extracellular sheath adjacent to the site of the junctional pores appears to be consistent with this mode of motility.
| null | null |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
life4040819_perova
| 0 |
By characterizing motility of colonies, as well as single-filament motility of short filaments, the authors find that increasing the agar concentration of the media results in smaller colonies, and slower individual filament movement.
| null | null |
R4 Because the EM figures are difficult to view within the Word document, we provide a high-quality figure as a supplement.
| null | null |
life4040819_perova
| 0 |
Round 1: and Author Response The manuscript “Cellular dynamics drives emergence of supracellular structure in the cyanobacterium Phormidium sp.
| null | null |
Additionally, individual filaments were found to undergo polarity reversals, and the maximum velocity was observed immediately following the reversal.
| null | null |
life4040819_perova
| 0 |
Additionally, individual filaments were found to undergo polarity reversals, and the maximum velocity was observed immediately following the reversal.
| null | null |
In particular, the appearance of bulges in the extracellular sheath adjacent to the site of the junctional pores appears to be consistent with this mode of motility.
| null | null |
life4040819_perova
| 0 |
Within the text, corrected words are highlighted.
| null | null |
The text was revised according to the comments.
| null | null |
life4040819_perova
| 0 |
Response: We thank the reviewers for giving us helpful comments.
| null | null |
Using TEM, the authors observed junctional pore complexes arrayed at septa, and extending through the cell envelope to the exterior of the cell, and potentially identified basal body complexes at the cytoplasmic face of the inner membrane.
| null | null |
life4040819_perova
| 0 |
This study is our new exploration into a new field, and the comments from different fields help us to revise our manuscript.
| null | null |
In addition, Figure 3A was replaced by a figure of better contrast.
| null | null |
life4040819_perova
| 0 |
Additionally, the authors sequenced the genome of this organism and identified homologs to genes conserved among filamentous cyanobacteria that have been demonstrated to be essential for motility in Nostoc punctiforme and may encode for the junctional pore proteins (hps locus) or a chemotaxis system (hmp locus).
| null | null |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
life4040819_perova
| 0 |
R3 Minor comments The addition of a time stamp to the supplemental movies would be useful
| null | null |
In addition, Figure 3A was replaced by a figure of better contrast.
| null | null |
life4040819_perova
| 0 |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
The authors demonstrate the presence of putative junctional pores by electron microscopy and other ultrastructural data that would appear to support polysaccharide secretion as the driving force for motility in this organism.
| null | null |
life4040819_perova
| 0 |
The authors’ conclusions are generally well supported and the electron microscopy provides some of the clearest images to date of the junctional pores.
| null | null |
Additionally, individual filaments were found to undergo polarity reversals, and the maximum velocity was observed immediately following the reversal.
| null | null |
life4040819_perova
| 0 |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
Additionally, individual filaments were found to undergo polarity reversals, and the maximum velocity was observed immediately following the reversal.
| null | null |
life4040819_perova
| 0 |
Overall, this study presents observations related to slime-mediated motility on multiple scales (molecular, single-filament and colony), and integrates these findings into a coherent model for the relationship between the cellular organization and the behavior of the colony.
| null | null |
R3 Minor comments The addition of a time stamp to the supplemental movies would be useful
| null | null |
life4040819_perova
| 0 |
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