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{
"caption": "Post-operative esophagography.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-0-1749-8090-2-12-5.jpg"
} | 000600 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The size of the aorta appears normal on saggital reconsruction.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-1-1749-8090-2-12-2.jpg"
} | 000601 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Contrast enhanced CT scan showing psedo-aneurysm formation.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-2-1749-8090-2-12-3.jpg"
} | 000602 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Intraoperative colour photograph showing the lesion at the end of the needle holder.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-3-1749-8090-2-12-4.jpg"
} | 000603 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Contrast enhanced CT scan showing aortoesophageal fistula.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-4-1749-8090-2-12-1.jpg"
} | 000604 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Post-operative contrast CT showing complete healing of the lesion.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803784-5-1749-8090-2-12-6.jpg"
} | 000605 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Fatty marrow in post radiotherapy patient.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-0-1477-7819-5-12-6.jpg"
} | 000606 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Tumour invasion in mandible in a broad front (E) characteristic of erosive pattern with no bony remnants within the tumour mass tumour cells are separated from the normal bone by a well demarcated fibrous zone (F).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-1-1477-7819-5-12-1.jpg"
} | 000607 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Tumour invasion in the mandible as irregular cords and islands (I) characteristic of infiltrative pattern, partially lysed bone spicules (B) are present within the tumour mass with no clear cut demarcating tissue between tumour and bone.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-2-1477-7819-5-12-2.jpg"
} | 000608 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Diffuse irregular tumour infiltrating bone, fibrous marrow (FM) and bony remnants (B).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-3-1477-7819-5-12-5.jpg"
} | 000609 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Tumour invasion (T) into the mandible involving the superior portion of the inferior alveolar canal with no invasion of nerve bundles (N).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-4-1477-7819-5-12-4.jpg"
} | 000610 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803788-5-1477-7819-5-12-3.jpg"
} | 000611 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Dose distributions of the summed plan (overall treatment) for Patient 1 and Patient 2.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803794-0-1748-717X-2-7-1.jpg"
} | 000612 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Dose distributions of the summed plan (overall treatment) for Patient 3 and Patient 4.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1803794-3-1748-717X-2-7-2.jpg"
} | 000613 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Cytochrome oxidase blobs. (a) The distribution of a metabolic activity index from the RFs generated by the model shows a clustering of cells with broad selectivity generating a blob-like pattern. (b) Regions of high metabolic activity (putative location of the CO blobs), as expected, tend to align with regions of low spatial frequency preference. (c) An example of an orientation map along with regions of high (white contours) and low (dark contours) metabolic activity. There appears to be no obvious relationship between the two. (d) A closer examination by plotting the metabolic activity index versus the orientation map structure index shows that regions of rapid orientation change (pinwheels/fractures) tend to align with regions of low metabolic activity, consistent with the experimental finding of Shoham et al (1997).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804100-7-ponep0000251pg008.jpg"
} | 000614 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "BP-induced cell-cycle arrest and apoptosis in GBM cells. DBTRG-05MG and RG2 cells underwent apoptotic cell death after a 48 h treatment with 75 µg/mL BP (a and b), as determined by TUNEL assay for DNA fragmentation (iii and vii) and PI counterstaining for genomic DNA (iv and viii). Control cells were trypsinized and stained in parallel with BP-treated cells (i, ii, v and vi). (c and d) DBTRG-05MG and RG2 cells were arrested in the G0/G1 phase with 75 µg/mL BP. Flow cytometric analysis of DNA contents in the BP-treated (open bars) and control cells (black bars) revealed the proportions of cells at different cell-cycle stages after BP treatment for 6, 12 and 24 h. Each column represents the mean ± SD (*p < 0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804119-3-jnc0099-1251-f1_cow.jpg"
} | 000615 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "BP reduction in tumor volume in a syngenic rat GBM tumor in situ model. RG2 cells (5 × 104) were implanted i.c. (striatum) in F344 rats. (a) Tumor volume shown by MRI imaging of serial sections (1.5 μm thick): C1–C6 were from the vehicle control rat; BP1–BP6 from a BP-treated rat (tumor mass shown by white arrow). (b) Tumor volume was calculated using echo-planar imaging capability. Each column represents mean ± SEM (*p < 0.05, **p < 0.001). (c) Immunohistochemical staining and TUNEL assay were performed in rat brain tumor tissues (on day 16 after BP treatment). Representative photographs of sections of the control group (i, iii and v) and BP-treated group (ii, iv and vi) GBM tumors immunohistochemically stained for cell proliferation marker with Ki-67 (i and ii), cell apoptosis marker with caspase 3 (active form; iii and iv) and DNA fragmentation of apoptosis cell with TUNEL staining (v and vi). The Ki-67- and caspase 3-positive cells were stained brown and the TUNEL-positive cells were stained green (×400).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804119-5-jnc0099-1251-f4_cow.jpg"
} | 000616 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histological features of abdominal skin obtained from perinatal autopsy cases with and without histological chorioamnionitis. Epidermis and dermis do not show significant changes in a fetus without histological chorioamnionitis (A,C). An inflammatory infiltrate is evident in the epidermis and dermis of a fetus with histological chorioamnionitis (B,D). The dermoepidermal junction is studded with CD15+ neutrophils.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804207-0-his0049-0506-f1.jpg"
} | 000617 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Expression profiles of TLR-2 and TLR-4 in the fetal skin with and without histological chorioamnionitis. In cases without histological chorioamnionitis, faint TLR-2 immunoreactivity (A) is found only in the superficial layer of the epidermis, while TLR-4 immunoreactivity (C) is found throughout the whole layer of the epidermis. However, both TLR-2 (B) and TLR-4 (D) are expressed throughout the whole epidermis in cases with histological chorioamnionitis. The increase in TLR-4 immunoreactivity is not as prominent as that of TLR-2. Insets show immunofluorescence staining results with corresponding antibodies.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804207-1-his0049-0506-f2.jpg"
} | 000618 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Expression of proinflammatory cytokines [interleukin (IL)-1α, tumour necrosis factor (TNF)-α] and chemokine (IL-8) in the fetal skin. Expression of IL-1α, TNF-α and IL-8 is markedly increased in the fetal epidermis of a case with histological chorioamnionitis, compared with that of a case without this condition.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804207-2-his0049-0506-f3.jpg"
} | 000619 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Mitral regurgitation.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804269-0-1749-8090-2-14-1.jpg"
} | 000620 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Left Ventricular Apical Ballooning (LVAB).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804269-1-1749-8090-2-14-2.jpg"
} | 000621 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Systolic motion of the anterior leaflet of the mitral valve (SAM).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804269-4-1749-8090-2-14-3.jpg"
} | 000622 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Cellular model of hepatic fibrosis. (A) Morphological changes of M1-4HSCs treated with TGF-β1 either for 72 hours or for long-term (myofibroblastoid M-HT) as analyzed by phase contrast microscopy. (B) Nuclear translocation of Smad2/3 as visualized by confocal immunofluorescence analysis. (C) Confocal immunofluorescence images after staining of cells with anti-desmin antibody.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804283-4-1476-5926-6-1-1.jpg"
} | 000623 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Functional Analysis of Synergids and Central Cells in lis-1/LIS Plants(A–C) GUS staining in synergids after fertilization of wild-type and lis-1/LIS plants with pollen from the ET434G pollen-tube marker line. (A) Ovule with GUS-stained synergids. The arrowhead points at pollen tube. (B) Ovule in which no GUS staining was detected in synergids. (C) Frequencies of GUS negative synergids. Dark bars represent wild-type, light bars represent lis-1/LIS plants. The y-axis shows the percentage of the scored phenotype (lis-1/LIS: 50.8%, n = 789; wild-type: 21.5%, n = 287).(D–F) Endosperm development after fertilization of wild-type and lis-1/LIS plants with wild-type pollen. (D) Ovule with developing embryo (star) and endosperm (arrowhead). (E) Ovule with a developing embryo (star), but no endosperm. The undeveloped central cell nucleus is visible (arrowhead). (F) Frequencies of ovules with a developing embryo, but no endosperm. Dark bars represent wild-type, light bars represent lis-1/LIS plants. The y-axis shows the percentage of the scored phenotype (lis-1/LIS: 11.2%, n = 267; wild type: 0.5%, n = 191).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804285-1-pbiop0050047pg003.jpg"
} | 000624 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "LIS Is Strongly Expressed in Gametic Cells(A) RT-PCR analysis of LIS expression in leaves (1), roots (2), flower buds (3), open flowers (4), inflorescences (5), siliques (6), and stem (7) (upper panel). ACTIN 2 was used as control (lower panel).(B–E), Expression of pLIS::NLS_GUS in wild-type ovules during female gametophyte development. (B) Arrowhead points at the functional megaspore in which GUS expression is detected in the nucleus. (C) Two-nucleate embryo sac showing GUS expression in both nuclei (arrowheads). (D) Young eight-nucleate gametophyte. Antipodal nuclei are not visible. Inset shows area with GUS-positive nuclei at higher magnification. White arrowheads point to the synergid nuclei; star points to the egg cell nucleus; and black arrowheads point to the unfused polar nuclei. (E) Mature gametophyte showing strong GUS signal in both the egg cell (star) and fused central cell nucleus (arrowhead). Expression in synergid cells is hardly detectable.(F) Proposed model for LIS function. Expression of LIS in gametic cells (egg cell [ec] and central cell [cc]) is necessary for the generation of a lateral inhibition signal that prevents the adjacent accessory cells (synergids [s] and antipodal cells [a]) from adopting gametic cell fate.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804285-4-pbiop0050047pg006.jpg"
} | 000625 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Accessory Cells in lis-1 Gametophytes Morphologically Resemble Gametic Cells(A–D) Schematic representation of wild-type female gametophyte development. Sporophytic structures are shown in grey; gametophytic structures are colored. (A) After meiosis, the haploid functional megaspore is formed. (B) A series of three mitotic divisions results in the formation of an eight-nucleate syncytium. (C) After nuclear migration and cellularization, a seven-celled gametophyte is formed containing two synergids at the micropylar end (dark green), one egg cell (red), one central cell (orange) with two polar nuclei, and three antipodal cells at the chalazal pole (light green). (D) Prior to fertilization, the two polar nuclei fuse to form one large central cell nucleus, and the antipodal cells degenerate.(E) Wild-type silique showing full seed set.(F) Silique of lis-1/LIS plants containing aborted ovules (arrowheads).(G–I) Mature wild-type gametophyte. (G) At the micropylar end, the two small synergid nuclei are detected (stars). The larger egg cell nucleus (arrowhead) is oriented towards the adjacent central cell. (H) A large central cell nucleus (arrowhead) resulting from the fusion of the two polar nuclei can be detected. (I) The antipodal cells at the chalazal end degenerate (star).(J–N) lis-1 gametophytes. (J) The synergid nuclei are enlarged and mis-polarized (star). As a consequence, synergid and egg cell become indistinguishable when lying in a similar position (arrowheads). (K) Polar nuclei are unfused (arrowheads) and occasionally ectopically cellularized (arrowheads in M). (L and M) Antipodal cells do not degenerate, but enlarge and protrude towards the center (stars). (N) Disintegration of antipodal cells and fused antipodal nuclei (star).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804285-5-pbiop0050047pg001.jpg"
} | 000626 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "(a) Fluorescent microscopic view of the nonlesional\nskin biopsy material of psoriatic patient. There is no fluorescent\nstaining. (b) Fluorescent microscopic view of the psoriatic skin\nbiopsy material of the same patient. There is positive\nfluorescent staining which is the accumulation areas of oxidized\nlow-density lipoprotein (X100).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804297-0-MI2007-78454p001.jpg"
} | 000627 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Normal histological structure of rat gastric mucosa.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804299-0-MI2007-65873p001.jpg"
} | 000628 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Histological appearance of the gastric ulcers 1 hour after ethanol treatment. Severe erosion with necrosis of gastric mucosa, detachment of necrotic gastric mucosa (arrow) H&E magnification, X 250.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804299-1-MI2007-65873p002.jpg"
} | 000629 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Rat pretreated with OSO, slight erosion of\nthe gastric mucosa is observed. Arrow: H&E; magnification, X 100.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1804299-2-MI2007-65873p003.jpg"
} | 000630 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Detailed views of the internal structure of female organs. a. A female organ with a broken envelope and its exposed central unit. Note the sheathing envelope (P), central unit (O), and longitudinal ribs with dark coaly residues on them. The central unit is attached to the receptacle by a wide base (arrow). Specimen number 8604a. Bar = 1 mm. b. A view of the envelope apex of the female organ in Fig. 3d with the SEM. Note the elongated cells on the smooth epidermis and slightly elongated cells in the tissue of the envelope (arrows). Specimen number 8604b. Bar = 0.1 mm. c. A view of an envelope fragment with the SEM. Note the smooth surfaces and the border between different parts of the envelope (arrow). Specimen number 8604a. Bar = 50 μm. d. A view of a female organ with the envelope (P) and the central unit (O) with the SEM. The texture and the central unit outline (white arrow) could be traced to the envelope apex (black arrow). On the right, there is another female organ with its apex plunging into the sediment matrix (black rectangle). Specimen number 8604b. Bar = 0.5 mm. e. A detailed view of the rectangular region in Fig. 3d with the SEM. Note the spatial relationship between the envelope (P) and the central unit (O), and the longitudinal ribs (arrow) on the internal walls of the central unit. Specimen number 8604b. Bar = 0.1 mm. f. A detailed view of the apex of the central unit in Fig. 3e (rectangle) with the SEM. Note the septum (arrow) across the central unit (O) apex. The black dot beside the bar is about 20 μm in diameter, the size of an average pollen grain. An entry point for a pollen grain of similar size, if present, would be hard to ignore in this image. Therefore, at least the tip of the upper locule (carpel), which is not eclipsed by the septum vestige or in its shadow, is closed. Specimen number 8604b. Bar = 0.1 mm. g. A cross section of two female organs embedded in the sediment. Note the pale sediment (upper half), dark resin (lower half), and darker stripes of two fused female organs (a and b, outlined by black and white lines, respectively). Specimen number 8604a. Bar = 0.5 mm. h. A detailed view of the female organ in Fig. 3g. Note the septum (arrow) and its smooth connection to the side walls of the central unit. Specimen number 8604a. Bar = 0.1 mm. i. A thin section across the apex of the central unit in Fig. 3f. Note the septum (arrow) separating two locules and its smooth connection to the side walls. Light microscope. Specimen number 8604b. Bar = 0.1 mm. j. A view of the internal surface of an envelope apex with the SEM. Note the converging longitudinal ribs. Specimen number 8604a. Bar = 0.5 mm. k. A detailed view of the rectangular region in Fig. 3j. Note the pollen grain (arrow) adherent to one of the longitudinal ribs on the internal surface of the envelope. Specimen number 8604a. Bar = 50 μm. l. A detailed view of the pollen grain in Fig. 3k. Specimen number 8604a. Bar = 10 μm. m. The rugulate sculpture on the pollen grain in Fig. 3l. Specimen number 8604a. Bar = 2 μm. n. Another pollen grain adherent to the internal surface of the envelope apex. Specimen number 8604a. Bar = 5 μm. o. The rugulate sculpture on the pollen grain in Fig. 3n. Specimen number 8604a. Bar = 2 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805421-1-1471-2148-7-14-3.jpg"
} | 000631 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The morphology and structures of the female organs. a. Several female organs attached to the axis of the female structure (A). Note the longitudinal ribs on the sheathing envelope and the central unit (O), the short peduncle (arrow), the extended envelope apex, and dark coaly residues. Specimen number 8604a. Bar = 3 mm. b. Several female organs attached to the axis of the female structure (A). Note the envelope (P) and central unit (O), the fused bases of the female organ pair (white arrow), the mark on the central unit left by the fallen envelope (black arrow), and the extended envelope apex. Specimen number 8604a. Bar = 3 mm. c. An isolated female organ pair in the proximal portion of specimen A. Only one of the pair is evident (white arrow); the other one (black arrow) is obscure due to preservation. Note the longitudinal ribs on the axis of the female structure (A) and the less-extended envelope apex. Specimen number 8604a. Bar = 1 mm. d. The top female organ pair in specimen B. Note the longitudinal ribs on the sheathing envelope, the relic of the missing female organ of the pair (arrow), and the less-extended envelope apex. Specimen number 8604b. Bar = 1 mm. e. A female organ pair in the proximal portion of specimen A. Note the axis of the female structure (A), central units (O), sheathing envelope (P), fused female organ bases (arrow), their spatial relationship (the axis of the female structure is in the foreground), and the extended envelope apices. Colored from an original greyscale picture. Refer to Fig. 4a. Specimen number 8604a. Bar = 2 mm. f. Female organs attached to the axis of the female structure. Note the longitudinal ribs on the axis of the female structure (A), female organs of various sizes and orientations, longitudinal ribs on the envelope, and the extended envelope apex. Specimen number 8604a. Bar = 2 mm. g. A detailed view of the rectangular region in Fig. 2f. Note the exposed internal details of the central unit, smooth wall in the lower part, rough wall in the upper part, large locule, and dark coaly residue. Because the septum and part of the central unit are raised above the level of the side wall, they cast a dark shadow on the latter (arrow) and the shadow extends from the base to the upper parts of the central unit. Refer to Fig. 4b. Specimen number 8604a. Bar = 1 mm. h. A view of a female organ with the exposed interior details of the central unit with the SEM. Note the central unit margin (black arrow) and papillate septum (white arrow and upper left inset) distinct from the interior wall with longitudinal ribs. Specimen number 8604a. Inset bar = 20 μm, Bar = 0.5 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805421-2-1471-2148-7-14-2.jpg"
} | 000632 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Comparison Chêneau/Chêneau light. Dorsal and ventral aspect of two patients with comparable curve patterns. The left patient wears a Rigo-System Chêneau (RSC) brace and the patient on the right a Chêneau light brace. The material necessary for the Chêneau light brace is clearly less.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805423-0-1748-7161-2-2-1.jpg"
} | 000633 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Example of a double major scoliosis treated with a Chêneau light brace. Nearly 13 year old girl with a 29/29° Double major AIS in the ScoliOlogiC „Chêneau light\" corrected to 11/9° Cobb.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805423-1-1748-7161-2-2-2.jpg"
} | 000634 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Example of a patient with an overcorrection in a Chêneau light brace. Overcorrection of a thoracic curve from 38° to -14° in a T2 „Chêneau light\" model in an 11-year old premenstrual girl with Tanner II. For the measurement of the corrected curve the neutral vertebra of this X-ray was used. If we would have taken the neutral vertebrae of the previous X-ray the correction effect would have been less important.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805423-3-1748-7161-2-2-3.jpg"
} | 000635 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "End-diastolic (left) and end-systolic (right) MR images in a mid-ventricular slice from a control (top) and diabetic (bottom) mouse. The LV diameters for the control and diabetic mouse were similar at end diastole (ED), but apparently increased at end systole (ES) for the diabetic mouse heart compared with control. The wall thickness at both end diastole and end systole in the diabetic mouse heart was decreased compared with control.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805425-3-1475-2840-6-6-2.jpg"
} | 000636 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical staining of human brain tissue using a PGRN-specific polyclonal antibody. In a neurologically normal individual, PGRN immunoreactivity is present in hippocampal pyramidal neurons, but particularly high in CA1 (A), dentate fascia (B) and endplate/CA4 (C). In AD, neurons and activated microglia (arrows) in the endplate are labeled (D), along with PGRN immunoreactivity associated with dystrophic neurites in senile plaques (inset).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805428-1-1742-2094-4-7-2.jpg"
} | 000637 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Neuropathology of FTLD-U with PGRN mutations. Gross cortical atrophy is visible in frontal and superior temporal lobes (A). In coronal sections (B), the lateral ventricle is dilated and the caudate nucleus is flat (arrow). Laminar spongiosis in the layer II of the cortical ribbon (C) is associated with TDP-43-positive neuronal cytoplasmic (D, arrows) and \"lentiform\" intranuclear inclusions (inset). Severe neuronal loss (D) in these regions is associated with microgliosis (E) and astrogliosis (F), shown by a microglial marker [ionized calcium-binding adapter molecule 1 (Iba-1)) and glial fibrillary acidic protein (GFAP) specific immunohistochemistry, respectively.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805428-3-1742-2094-4-7-4.jpg"
} | 000638 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Apoptosis in BEAS-2B bronchial epithelial cells following up-regulation of pirin levels by infection with AdPirin. BEAS-2B cells were infected with AdPirin, AdNull, or control (naive) and TdT-mediated dUTP nick end labeling (TUNEL) was used to assess apoptosis after 24 hr. A. control (naive); B. AdNull (104 particle units); and C. AdPirin (104 particle units). D. Quantitative assessment of apoptosis in BEAS-2B bronchial epithelial cells exposed to AdPirin, AdNull or control by TUNEL assay. The percentage of apoptotic cells per 10× field were manually counted in 10 fields per slide, with three replicates.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_103-PMC1805431-3-1465-9921-8-10-4.jpg"
} | 000639 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Computed tomography of the brain conducted at 5 weeks of age showing an intra cerebral hemorrhage.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805439-0-1471-2431-7-8-1.jpg"
} | 000640 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "siNS1 decreases CD4+ T cell infiltration of lung tissue. Rats (n = 6) were given siNS1 or control vector followed by RSV 24 h later. After 5 days, the lungs were removed, sectioned and stained for CD4 and CD8. Experiments were repeated twice and representative fluorescent micrographs are shown.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805440-0-1479-0556-5-4-4.jpg"
} | 000641 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Microview of resected specimen H&E stain, ×20. Tumor cells (1) and tuberculosis changes (2) are seen.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805441-0-1477-7819-5-22-4.jpg"
} | 000642 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Postoperative specimen. Tumor occludes lumen of bronchus (1) and tuberculosis(2).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805441-1-1477-7819-5-22-3.jpg"
} | 000643 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Chest CT. There is pulmonary bulla in the right S1 segment, and focus of mottled opacity 7,5 × 2,5 cm with infiltration around it.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805441-2-1477-7819-5-22-2.jpg"
} | 000644 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "X-ray of the thorax. Infiltrative changes are observed in the left upper lobe.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805441-3-1477-7819-5-22-1.jpg"
} | 000645 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemistry of SIV/SHIV-infected pre-pubertal macaque testis (A-C) and normal adult human testis (D-F). Human testis tissue was used as positive control for antibodies targeting immune cells present in the testis. Formalin-fixed, paraffin-embedded testis tissue was stained with isotype matched control (IgG1, data not shown), a macrophage and dendritic cell marker (DC-SIGN, panel A and D), a myeloid cell marker (CD68, panel B and E) and a dendritic cell marker (Fascin/p55, panels C and F). DAB-positive cells indicated by arrows in sections conterstained with haematoxylin.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805449-0-1742-4690-4-7-2.jpg"
} | 000646 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Identification of SIV and SHIV target cells in the testis and epididymis of infected macaques. (i) Gp41 SIV positive cells in the interstitium of the testis (panels A and B, phase-contrast micrograph of section under bright-field versus immunofluorescence micrograph of same area, respectively). P24 Gag (HIV) or SIV/SHIV capsid positive cells in the testis interstitium (arrow heads) and seminiferous tubules of a pre-pubertal animal (long arrow) (panels C and D). Strong p24 positive staining of spermatogonia in SHIV infected macaque (panels E and F). The frequency of infected cells in SIV infected animals (counted 5 high magnification fields/section, bright field versus stained nr of cells) is from 1–5 positive cells/tubule (out of 16–20 total number of cells) and up to 50 % of total germ cells infected in some of the SHIV infected macaques (6 cells infected in one tubule in the example shown). (ii) Individual staining and merged images of a αβTCR+/p24+ double positive cell in the testicular interstitium of a pubertal macaque (panels A, B and C). CD68+/p24+ double positive cell in the testicular interstitium of a pre-pubertal macaque (panel D, E and F). A representative image of two DC-SIGN+/p24+ double positive cells in the testicular interstitium of a pre-pubertal macaque (panels G, H and I). (iii) CD68+/p24+ double positive cell in the epididymis of a pubertal macaque (panels A, B and C).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805449-1-1742-4690-4-7-5.jpg"
} | 000647 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Electron microscopy analysis of the epididymis of infected macaques (x100). Premature sloughing of immature germ cells (spermatocytes and spermatids, arrows) into the epididymal lumen of some pre-pubertal SIV and SHIV infected macaques (panel B), a pattern that was distinct from that of the epididymal lumen of other mature macaques (panel A). ES: elongated spermatids; IGCs: immature germ cells.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805449-2-1742-4690-4-7-4.jpg"
} | 000648 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Light microscopy of the macaque testis and epididymis (PAS staining). A. Testis of an immature monkey: only seminiferous cords containing Sertoli cells and basally situated spermatogonia (long arrow) are present. B. Epididymis of immature monkey: note absence of germ cells in the epididymal lumen (block arrow). C. Spermatogenesis occuring in the testis of a more mature monkey (block arrow indicates elongated spermatids). D. Sperm present in the epididymal lumen of a mature monkey (block arrow). E. Epididymides of some infected monkeys were characterized by the presence of large mononuclear cell infiltrates (arrows). Macrophages are present in the testicular and epididymal tissues (short arrows, panels A – D). Indicated macrophages and T cells are also shown in higher magnifications (panels A, D and E).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805449-4-1742-4690-4-7-1.jpg"
} | 000649 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "H&E and reticulin stained sections from rats fed standard diet (A), coconut diet (B), butter diet (C) for 14 weeks or MCD diet (D) for 6 weeks (magnification × 10), lipid vesicles are shown by a black arrow and inflammation point by a white arrow. (E) Liver triacylglycerol content (mg/g liver) in standard diet (std), coconut diet (Coco), butter diet (Butter) or MCD diet (MCDD). Results are means ± SEM, P < 0.05 vs standard.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805500-4-1743-7075-4-4-4.jpg"
} | 000650 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Diameter and volume of isolated adipocytes from the retroperitoneal white adipose tissue of rats fed standard diet or coconut diet. Measures were realised in triplicate on 3 rats per group; values are means ± SEM, P < 0.001 vs standard diet.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805500-5-1743-7075-4-4-3.jpg"
} | 000651 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "a) A carcinoid tumor proliferating submucosa b) A carcinoid tumor: uniform small round, polygonal prominent round nuclei.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805501-0-1477-7819-5-19-2.jpg"
} | 000652 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "a) A section of the mucosa and submucosa showing extensive ganglioneuromatosis b) A ganglion cell (arrow) is surrounded by spindle cells.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805501-1-1477-7819-5-19-3.jpg"
} | 000653 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "a) Macroscopic findings of the resected rectum demonstrating multiple submucosal tumors. 1.b) A schematic drawing of the resected rectum showing the location of submucasal tumors (●).1.c) A schematic drawing of the resected rectum showing the location of carcinoid tumors ().",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805501-2-1477-7819-5-19-1.jpg"
} | 000654 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "A subpopulation of cells in developing mouse sympathetic ganglia expresses TrkB. (A) Transverse sections of E13.5 mouse embryos were cut and stained for TH (red) and Hu C/D (green) to locate developing ganglia. The ganglion shown in the box is shown at higher magnification in the inset. Different subsets of cells express TH, Hu C/D, or both markers. Sections taken from another ganglion stained with (B) TH (green), (C) TrkB (red), (D) Hoechst dye, and the overlay of all three photos. Arrow points to a cell that co-expresses TH and TrkB.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805739-0-1471-213X-7-10-4.jpg"
} | 000655 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "TrkB-expressing neural crest cells migrate with sympathetic neurons at stage 27, or late E5. (A) Transverse section of St. 27 (late E5) chick embryo spinal column region. At this stage, a stream of Hu C/D-positive cells (white) and TrkB-positive cells (green) are found in the region surrounding the dorsal aorta (DA) and ventral to the neural tube (NT), dorsal root ganglion (DRG), and notochord (NC). (B, C, D) St. 27 sections stained for TrkB (green) and a marker of neural crest cells, HNK-1 (red). In migrating clusters of TrkB-positive cells, HNK-1 is co-expressed. (E, F, G) St. 27 sections stained for Hu C/D (green) and tyrosine hydroxylase (red). All of the migrating neurons and some of the surrounding cells express tyrosine hydroxylase. (H) TrkB (green) is only expressed in cells adjacent to Hu C/D-positive cells (red), (I, J) TrkA and TrkC (both green) are expressed in both Hu C/D-positive (red) migrating cells and in surrounding cells. The box in (A) indicates the region where we obtained high power images. Calibration bars: Low power image: 200 μ; high power images: 20 μ.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805739-2-1471-213X-7-10-2.jpg"
} | 000656 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The majority of TrkB-positive cells in St. 29 sympathetic ganglia do not proliferate under basal conditions in vivo. St. 27 embryos were injected with 25 μg BrdU and embryos were harvested at St. 29. Transverse sections of sympathetic ganglia prepared to determine whether TrkB-positive cells (red) in sympathetic ganglia positively-labeled for BrdU. The majority of TrkB-positive cells do not proliferate under basal conditions in vivo. Arrows indicate proliferating cells. Calibration bars = 20 μ.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805739-4-1471-213X-7-10-10.jpg"
} | 000657 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "TrkB-expressing cells surround neurons during sympathetic gangliogenesis. Chicken embryos at St. 25, 26, 27, and 28/29 were sectioned through the trunk and the patterns of Hu C/D-(white or red) and TrkB-(green) immunoreactivity were determined. (A) Low and (B) high power images demonstrating that at St. 25 (early E5) very few Hu C/D-positive cells are found in the region where sympathetic ganglia form, ventral to the spinal cord (SC) and dorsal root ganglion (DRG) and lateral to the dorsal aorta (DA). (C) At St. 26, migrating Hu C/D-positive cells are present, but TrkB is still not expressed. (D) At St. 27, TrkB-positive cells \"cluster\" around Hu C/D-expressing cells, although TrkB is not expressed in the neuronal cells. (E) Sympathetic ganglia coalesce at St. 28/29, and TrkB-expressing cells remain adjacent to Hu C/D expressing cells. The box in (A) indicates the region where we obtained high power images. Calibration bars: Low power image: 200 μ; high power images: 20 μ.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805739-7-1471-213X-7-10-1.jpg"
} | 000658 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The protein encoded by the novel Leishmania-specific gene localises to the endoplasmic reticulum. Images of an L. major 'Friedlin' promastigote expressing a recombinant GFP-fused version of the protein encoded by the novel CDS. (A) Phase contrast microscopy; scale bar : 10 microns. (B) DAPI-staining of the nucleus (arrowhead) and the single mitochondrial DNA or kinetoplast (arrow). (C) Localisation of the GFP-fused protein viewed in fluorescence. (D) Colour combination of GFP (green) and DAPI (blue) fluorescence. (E) Mitochondrion labeled with Mitotracker™. (F) Merged picture: blue = DNA; red = Mitotracker™; green = GFP-fused protein. The protein localised to a subpellicular, cytoplasmic and perinuclear network that is clearly different from the mitochondrion and closely resembles the endoplasmic reticulum; the latter being identified by expression of the plasmid construct GFP-MDDL that acts as an endoplasmic reticulum retention signal in trypanosomatids [31] [see Additional File 2].",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805754-3-1471-2164-8-57-3.jpg"
} | 000659 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Map of BF cholinergic cells with GABAAR labeling across conditions. ChAT+ cells plotted in single sections (of triple-immunostained series, Fig. 1A) through the middle level of the MCPO (~A8.2) from representative brains of SC (A), SD (B) and SR (C) groups. Presumed to reflect a threshold for immunohistochemical detection, GABAAR labeling was judged to be negative (open circles) or positive (filled circles) in each ChAT+ cell within the section. Note the ChAT+/GABAAR+ cells are most prevalent in the SD brain. Abbreviations: f, fornix; LPO, lateral preoptic area; MCPO, magnocellular preoptic area; MPO, medial preoptic area; SI, substantia innominata.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805759-1-1471-2202-8-15-2.jpg"
} | 000660 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "C-Fos expression and GABAAR labeling in BF cholinergic cells across conditions. A. From triple-immunostained sections, a BF cell triple-labeled for c-Fos (with DAB-Ni in gray, A1), ChAT (with Cy2 in green) and β2–3 GABAAR (with Cy3 in red, A2) from an SD brain. Note prominent GABAAR labeling over the plasma membrane of the cell. B. From dual-immunostained sections, a BF cell double-labeled for ChAT (with Cy2, B1) and β2–3 GABAAR (with Cy3, B2) from an SD brain and showing the prominent labeling along the membrane of the soma and proximal dendrites along with the boxes (in yellow) that were used for luminance measurements of the GABAAR labeling over the plasma membrane (on two sides) and the nucleus. The luminance of the nucleus, which was considered to represent and thus control for nonspecific, background fluorescence, was subtracted from the mean luminance of the membrane of each cell as a measure of intensity membrane GABAAR (Fig. 3). C-E. BF cells dual-immunostained for ChAT (Cy2, C1, D1, E1) and β2–3 GABAAR (Cy3, C2, D2, E2) from representative brains (selected according to mean values of membrane intensity per condition) of SC, SD and SR groups (Fig. 3). Scale bar, 20 μm. Abbreviations: SC, sleep control; SD, sleep deprived; SR, sleep recovery.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805759-2-1471-2202-8-15-1.jpg"
} | 000661 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "JunB and HBZ bZIP are involved in the formation of HBZ-NBs. COS cells were cotransfected with pcDNA-JunB and pEGFP-HBZ bZIP in the absence (b) or in the presence of pcDNA-HBZ-SP1-Myc (c-e). Analysis of the green (a, b, c, and f), red (d and g), and merged (e and h) fluorescent signals was performed by fluorescence microscopy. The HBZ-SP1 protein was detected using the anti-Myc antibody and the goat anti-mouse IgG antibody coupled to Texas Red. COS cells transfected with pEGFP-HBZ bZIP (but without JunB) in the absence (a) or in the presence of pcDNA-HBZ-SP1-Myc (f-h) were also analyzed through the same approach. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-1-1742-4690-4-14-5.jpg"
} | 000662 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Stimulation of HBZ-NBs formation by JunB. COS cells were transiently transfected with EGFP (a), HBZ bZIP fused to EGFP (b), or JunB (c), cultivated on glass slides, fixed, and then were analyzed by fluorescence microscopy. JunB was detected using a mouse anti-JunB antibody and goat anti-mouse IgG antibody coupled to Texas Red. JunB was also cotransfected into COS cells with either EGFP-HBZ bZIP (d-f), or EGFP-HBZ-SP1 (g-i), or EGFP (j-l). Analysis of the green (a, b, d, g, and j), red (c, e, h, and k) and merged (f, i, and l) fluorescent signals was performed by fluorescence microscopy. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-2-1742-4690-4-14-4.jpg"
} | 000663 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Targeting of endogenous JunB to HBZ-NBs in HeLa cells transfected with pEGFP-HBZ-SP1. (A) Nuclear localization of endogenous JunB in HeLa cells transfected with different mutants of the HBZ-SP1 protein. HeLa cells were transfected with pNLS-EGFP, pEGFP-HBZ-SP1, pEGFP-HBZΔAD. HeLa cells were arrested using a double thymidine block and restimulated with 10% FCS for the indicated times and the subnuclear localization of endogenous JunB was analyzed by immunofluorescence microscopy. JunB was detected using a mouse anti-JunB antibody and goat anti-mouse IgG antibody coupled to Texas Red. (B) Colocalization of endogenous JunB with EGFP-HBZ-SP1 and EGFP-HBZΔAD in transfected HeLa cells arrested in the cell cycle. The shown data correspond to t = 0 of Fig. 9A and are representative of the experiments obtained at different times. Analysis of the green, red, and merged fluorescent signals was performed by fluorescence microscopy. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-4-1742-4690-4-14-9.jpg"
} | 000664 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The HBZ-NBs do not colocalize with endogenous RNA polymerase II. COS cells cotransfected with pcDNA-JunB and pEGFP-HBZ bZIP were labelled with a mouse anti-RNA polymerase II antibody and detected using goat anti-mouse IgG antibody coupled to Texas Red. Analysis of the green, red, and merged fluorescent signals was performed by fluorescence microscopy. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-6-1742-4690-4-14-6.jpg"
} | 000665 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Subcellular localization of HBZ-SP1. (A) Subnuclear localization of the HBZ-SP1 protein in transfected COS cells. The original HBZ (a) and HBZ-SP1 (b and c) isoforms fused to the Myc epitope were transiently transfected into COS cells. Cells were cultivated on glass slides, fixed and treated with Vectashield containing DAPI for direct observation by fluorescence microscopy. For immunofluorescence analysis, the anti-Myc antibody was detected with goat anti-mouse IgG antibody coupled to FITC. (B) HBZ-SP1 does not colocalize with endogenous SC35. COS cells transfected with pEGFP-HBZ-SP1 were labelled with a mouse anti-SC35 antibody and detected using goat anti-mouse IgG antibody coupled to Texas Red. Analysis of the green, red, and merged fluorescent signals was performed by fluorescence microscopy. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-7-1742-4690-4-14-1.jpg"
} | 000666 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunofluorescence microscopy analysis of the colocalization of JunD and the HBZ-SP1 protein in vivo. COS cells cotransfected with pCMV-JunD-Flag and pEGFP-HBZ-SP1 were labelled with a mouse anti-Flag antibody and detected using goat anti-mouse IgG antibody coupled to Texas Red. Analysis of the green, red, and merged fluorescent signals was performed by fluorescence microscopy. The white bars correspond to a scale of 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805765-9-1742-4690-4-14-10.jpg"
} | 000667 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Principal sensory trigeminal nucleus and olfactory bulb.a, Cresyl Violet stained coronal section through the pons of a kiwi showing the large sensory trigeminal nucleus (PrV) that receives tactile input from the beak; b, Cresyl Violet stained sagittal section of a kiwi brain showing the olfactory bulb, which in the adult is a cortical-like sheet surrounding the frontal pole of the brain (bracketed by dashed line, and see Fig. 4). Scale bar: 5 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805817-1-ponep0000198pg006.jpg"
} | 000668 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Organisation of the forebrain of the Kiwi. Series of coronal sections through the forebrain of the Kiwi (top rostral, bottom caudal). Left hemisections show the regional demarcation that results from CR-LI. APH: Parahippocampal area; Bas: Nucleus basorostralis; CA: Anterior commissure; E: Entopallium; HA: Hyperpallium apicale; M: Mesopallium; MSt; Medial Striatum; N: Nidopallium; OB: olfactory ‘bulb’; St: Striatum; H: Hippocampus; Ov: Nucleus ovoidalis; SRt: Nucleus subrotundus; v: ventricle. Scale bar: 2 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805817-3-ponep0000198pg004.jpg"
} | 000669 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "A: Maximum intensity projection of a representative confocal image stack with Chromosome territories 7 (Red, Spectrum orange) and 19 (Green, Rhodamine Green) from DLD-1+19 B: A 3D reconstruction of the nucleus and chromosome territories from the image shown in A (X-Y orientation). C: A scheme adopted for 3D distance measurements of chromosome territories in Red (R1 and R2) and Green (G1, G2, and G3) from the geometric center of the nucleus (Nc), to the nuclear periphery (NP). Points on the nuclear periphery (eg. NpR1) are extensions from the nuclear center through the geometric center of the chromosome territory. D: 3D reconstruction in B shown in X-Z orientation.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805818-0-ponep0000199pg003.jpg"
} | 000670 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Representative maximum intensity projection of confocal image stacks from DLD-1 parental and derived nuclei. A–C: Parental DLD-1 nuclei. D: DLD-1+7 nuclei. E: DLD-1+18 nuclei. F: DLD-1+19 nuclei. DAPI: DNA counterstain; CT-7: Chromosome 7; CT-18: Chromosome 18; CT-19: Chromosome 19; Merge: merged image of DAPI and chromosome territories.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1805818-3-ponep0000199pg002.jpg"
} | 000671 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Snapshots Averaged over the Last 10 ns from the End of Each SimulationThe deuterium order parameters, S\nCD\n, of selected carbons (C5–C7) of POPC and PSM chains were binned in the xy-plane (column 1, from left). The in-plane electron densities, σ, have been plotted separately for CHOL (column 2) and the selected chain carbons (column 3). The average bilayer thickness, d, was obtained from the grid of the undulation analysis (column 4). Systems SA to SC are represented on rows from top to bottom, respectively. Only the bottom leaflet has been used for columns 1–3, whereas both leaflets were used for column 4. The equivalent plots for the top leaflet have been presented in Figure S2.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808021-2-pcbip0030034pg002.jpg"
} | 000672 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "New World Monkey skull with landmarks. Craniofacial landmarks recorded from Cebinae skulls using three-dimensional digitizer. See Tables 9 and 10 for landmarks and measurements details.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808050-0-1471-2148-7-20-9.jpg"
} | 000673 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Von Kossa staining on tendon-derived fibroblasts cultured for 21 days in osteogenic (A) or control medium (B). Calcium deposition was seen in osteogenic medium (A), not in control medium (B) or in adipogenic or chondrogenic media (figures not shown).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808058-0-1471-2474-8-16-6.jpg"
} | 000674 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Ki-67, D7-FIB, and α-SMA staining on tendon explants (day 6 of explantation period) and on tendon-derived fibroblasts (TDF) in monolayer culture. Ki-67 positive (proliferating) cells in the explants were located in the tendinous tissue (A, black arrow), in the endotenon (A, white arrow), and in the vascular walls (A, circle). Cells in the tendon tissue and in the endotenon stained positive for fibroblastmarker D7-FIB (B). Cells in the vascular walls remained negative for D7-FIB (B) and instead stained positive for α-SMA, a marker for pericytes and smooth muscle cells (C). All TDFs in monolayer culture stained positive for D7-FIB from passage one (D) to passage four (E) and remained negative for α-SMA from passage one (F) to passage four (G).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808058-1-1471-2474-8-16-1.jpg"
} | 000675 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical staining for collagen type 2 on tendon-derived fibroblasts. 5% of the cells cultured for 21 days in alginate beads in chondrogenic medium stained positive (A). Cells cultured in monolayer in control medium remained negative (B) as did cells in adipogenic or osteogenic media (figures not shown).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808058-3-1471-2474-8-16-4.jpg"
} | 000676 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical staining of β-catenin in normal and cancer tissues of the esophagus. In this cancer tissues, β-catenin was expressed in the nuclei, and was hardly detectable at the plasma membrane (a). In normal esophageal epithelium, β-catenin was expressed at the cell membrane (b).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808060-0-1477-7819-5-21-1.jpg"
} | 000677 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical staining of cyclin D1 expression in normal and cancer tissues of the esophagus. In all normal esophageal mucosa, cyclin D1 staining was negative (a). In some cancer tissues, cyclin D1 was expressed at the nuclei (b).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808060-1-1477-7819-5-21-2.jpg"
} | 000678 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "MRI Studies of the Patient's Pituitary GlandMRI of the pituitary gland showing a non-enhancing lesion occupying the bulk of the pituitary fossa (yellow arrow). The remaining normal pituitary is pushed to the left, as is the pituitary stalk. The optic chiasm can be seen just superior to the pituitary gland (white arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808067-0-pmedp0040029pg002.jpg"
} | 000679 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Oocyst Morphology of wt and Δpblap ParasitesDifferential interference contrast images of wt day 21 p.i. (A), Δpblap2 day 13 p.i. (B), Δpblap4 day 18 p.i. (C), and Δpblap6 day 21 p.i. oocysts (D) in An. stephensi. Most wt oocysts have undergone sporulation (open arrow). No sporozoite formation is observed in Δpblap infections, and oocysts appear either immature/enlarged (open arrowhead) or degenerate/vacuolated (closed arrowhead). Some Δpblap4 oocysts are melanized (closed arrow). Scale bar = 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808070-0-ppatp0030030pg002.jpg"
} | 000680 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Transmission Electron Micrographs of wt and Δpblap OocystsAll images taken on day 13 p.i. unless otherwise indicated. Scale bar = 1 μm (A, B, F) or 5 μm (C–E). ep, midgut epithelium.(A) wt oocyst showing normal morphology of the endoplasmic reticulum (er).(B) Δpblap2 oocyst showing extensive expansion of the endoplasmic reticulum (er).(C) Δpblap1 oocyst (day 27 p.i.) showing extensive expansion of the endoplasmic reticulum (er) and some budding sporozoites (s).(D) wt oocyst showing normal morphology following cytokinesis to produce hundreds of daughter sporozoites (s).(E) Δpblap2 oocyst showing extensive degeneration and few nuclei (some of which are labelled n).(F) Degenerate Δpblap4 oocyst showing prominent melanization (m) of the extracellular oocyst wall (cw) which appears to spread into the mosquito basal lamina (bl).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808070-3-ppatp0030030pg003.jpg"
} | 000681 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "In the Absence of TBK1, Bacteria Enter the Host Cytosol(A) Tbk1+/+ and tbk1−/− MEFs were infected with Salmonella-GFP (green). Infected cells were fixed at 2 h p.i., stained with anti-LAMP-1 antibody followed by a TRITC-labeled secondary antibody (red), and analyzed by confocal immunofluorescence microscopy. Percent colocalization was determined by counting the number of bacteria out of 150 bacteria per experiment that colocalized with LAMP-1. The experiment shown is representative of three independent experiments.(B) MEFs were infected for 1 h with the Salmonella-GFP (green), fixed at 4 h p.i., and stained with an anti-ubiquitin monoclonal antibody followed by a TRITC-labeled secondary antibody (red). The percent of ubiquitin-associated bacteria was determined by counting the number of bacteria out of 150 bacteria per experiment that colocalized with ubiquitin as observed by confocal microscopy. The experiment shown is representative of three independent experiments.(C) Transmission electron microscopy was performed on MEFs infected for 1 h with Salmonella, and images acquired at 64,000× magnification. White arrowheads point to bacterial membranes, black arrowheads point to host vacuolar membranes, and arrows point to bacteria no longer completely surrounded by vacuolar membranes.(D) MEFs were incubated with 125I-EGF and the rate of endocytic uptake (cell associated), degradation (TCA soluble), and accumulation of undegraded product (TCA insoluble) was determined at 0.5, 1, 2, and 3 h after endocytosis. The data represent the mean of four independent experiments.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808071-1-ppatp0030029pg002.jpg"
} | 000682 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Cryptococcosis of the Lung in a Patient with AIDSHistopathology of lung shows widened alveolar septa containing a few inflammatory cells and numerous yeasts of the fungal pathogen C. neoformans. The inner layer of the yeast capsule stains red. Cryptococcosis is transmitted through inhalation of airborne yeast cells and/or biospores. At risk are the immunocompromised, especially those with HIV infection. Photo: CDC/Dr. Edwin P. Ewing, Jr.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808087-0-pmedp0040047pg001.jpg"
} | 000683 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Hookworms (Ancylostoma caninum) Attached to the Intestinal MucosaBarely visible larvae penetrate the skin (often through bare feet), are carried to the lungs, migrate through the respiratory tract to the mouth, are swallowed, and eventually reach the small intestine. This journey takes about a week. (Photo: Centers for Disease Control)",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808099-0-pmedp0040072pg001.jpg"
} | 000684 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Arkadia Facilitates All Major Nodal-Dependent Developmental Events(A–F) In situ hybridization on 6.5 dpc embryos (mid- to late-streak stage) shown as lateral views with anterior to the left and posterior to the right, with probes (A–C), Hex and Brachyury; (D–F), Cer-l. In (C), Akd−/− Nodal+/− embryo showing lack of elongation and proximal positioning of the Brachyury–expressing primitive streak, as well as loss of Hex expression indicating absence of AVE. (E) An Akd−/− embryo with normal Cer-l expression in the AVE but no Cer-l expressing ADE. (F) An Akd−/−, Nodal+/− embryo showing a distal Cer-l-expressing domain indicating lack of AVE migration (three other embryos do not express Cer-l, not shown). Red arrowheads point to a constriction between extraembryonic and embryonic regions indicating incomplete anterior-posterior axis specification.(G–I) Nkx2.5 probe on four-somite stage, 8.5 dpc embryo showing expression in the cardiac precursor tissue in the wild-type (G) and Akd−/− (H), but not in the Akd−/−, Nodal+/− embryo (I).(J–L) Shh probe on 12-somite stage embryos 9.5 dpc viewed from the ventral side with anterior toward the top. In the Akd−/− Nodal+/−embryo (L), note the reduction of Shh expression, the increased severity of the anterior truncation, and the absence of a morphologically distinguishable heart tube. PS, primitive streak; T, Brachyury; CP, cardiac precursors; HF, head folds; NC, notochord; GE, gut endoderm. Bars, 0.1 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808117-0-pbiop0050067pg001.jpg"
} | 000685 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Arkadia Regulates Nodal Target Gene Expression and Phenocopies Smad2 in DevelopmentIn situ hybridization with Nodal probe on 6.5 dpc (A and B) and 8.5 dpc (C–H) embryos; (C–H) embryos are shown as ventral views with anterior to the top and left toward the right; (A, C, and G) wild-type (+/+); (B, E, and F) Arkadia−/− (−/−); and (D and H) tetraploid chimeras (TC). Compare (A) and (B) to see reduced Nodal expression in the mutant embryo. The TC shows normal expression of Nodal around the node (D) and reduced expression in the left-LPM (H), while the −/− embryo has no node or Nodal expression (E and F). Lefty2 probe on 8.5 dpc embryos (I and J) showing loss of expression in the left-LPM in the TC; Pitx2 (K and L) on 9.5 dpc embryos showing reduction of expression in the TC; and Hex (M and N) on 8.5 dpc showing loss of expression in the foregut pocket of the TC. Heart-level sections from 9.5 dpc (O) and 8.5 dpc (P) mosaic embryos (chimeras) stained for β-galactosidase activity (blue). Note selective contribution of wild-type cells in the foregut. Black arrowheads point at the visceral endoderm; black arrow, points at the node; red dots indicate the left-LPM; red arrows point at the head folds; red arrowheads indicate the definitive endoderm at the level of the foregut. Bars, 0.1 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808117-2-pbiop0050067pg007.jpg"
} | 000686 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "In the Absence of Arkadia, P-Smad2 Is More Stable and Correctly Localized in the Nucleus(A) Western blot of 8.5 dpc wild-type and Akd−/− embryo extracts. Each lane contains total protein extracts from three embryos. Note that P-Smad2 levels are at least 2-fold higher in mutants than in wild-type.(B and C) Western blot of extracts from Akd−/− and wild-type ES cells cultured with Activin for different intervals (in minutes (') and hours (h). Note that P-Smad2 is more stable in mutant than in wild-type cells. Loading control: PCNA, proliferation cell nuclear antigen.(D) Densitometry analysis of the bands on the blots in (C) showing the trend in P-Smad2 levels normalized against Smad2 where Akd−/−ES cells treated with Activin for 45 min is taken as 100%.(E) Western blot analysis showing P-Smad2 and Smad2 levels in ES cells stimulated with Activin for 1 h (1 h Act) and subsequently treated for different time points with H7 inhibitor as indicated.(F) Densitometry analysis of the blots in (E) showing the trend in P-Smad2 levels normalized against Smad2 where Akd−/− and wild-type ES cells treated with Activin for 1 h are represented as 100%.(G) Western blot showing P-Smad2 and Smad4 protein distribution in cytoplasmic and nuclear fractions of three different wild-type and Akd−/−ES cell lines as indicated. 30 μg of each protein sample was loaded for analysis. Histone H3, a nuclear protein, was used as a control for fractionation. C, cytoplasmic; N, nuclear.(H) Immunofluorescence with anti-P-Smad2 and anti-Smad2/3 (red) antibody on Akd −/− and wild-type ES cells treated with Activin A for 1.5 h prior to fixation, indicating no difference in the localization of P-Smad2 in the absence of Arkadia. Note the nuclear accumulation of P-Smad2, Smad2/3, and Smad4 in Akd−/− cells. White bar, 12 μm. WT, wild-type.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808117-6-pbiop0050067pg002.jpg"
} | 000687 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Ectopic expression of mili in BM cells promotes cell proliferation.A. Schematic construct of Lenti-GFP-Mili viral vector. B, The effect of ectopic expression of mili on marrow cell proliferation: BM cells from B6 mice were transduced with Lenti-GFP-Mili or Lenti-GFP viruses in 24-well plates (n = 4 well/group), as described in Methods. The number of GFP+ colonies were counted at indicated times. **, p<0.01, compared to Lenti-GFP group. C, Representative eGFP+ EB-like colonies at day 10 post transduction (arrow). The micrographs were taken under the inverted fluorescent microscope (Nikon, TE2000-U, Japan), using original magnification: ×200.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808425-3-ponep0000293pg007.jpg"
} | 000688 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "pCSCs developed into various type of tumors in immunodeficient mice.A, Tumor incidence from 3 experiments. Equal numbers of sex matched SCID mice were injected s.c. or i.p. with 5×106 pCSCs. No significant difference in incidence was observed between s.c. and i.p. injected mice. As a control, C57BL/6 mice injected s.c. (n = 10) or i.p. (n = 10) with 2C4 cells did not develop tumors within 5 months of observation (data not shown) “*” indicates that a mouse developed ascites, “**” indicates that the 3B6C cells infiltrated in the liver and spleen (see E). B, Kinetics of tumor growth: the data shown are from experiments 1 & 2 in A. Each color in B corresponds to a specific cell line. C, Comparison of tumorigenesis between pCSCs (2C4) and differentiated cancer cells (3B11); (n = 10/group, each group includes 5 males and 5 females). D, A representative of gross tumors from a mouse injected i.p. with 3B5C clone. E, A histological representative of pCSC-derived tumors from the mice injected i.p. with 2C4 or 3B5C clones. F, A histological representative from the spleen of mice injected i.p. or s.c. with 3B6C clone. Note that megakaryocytes in the spleen of normal SCID mice were replaced by atypical neutrophils or eosinophils. G, Benign differentiation of pCSCs in the liver with metastatic cancers: (a) H & E staining of a liver section with metastatic cancers from a mouse injected i.p. with 2C4 cells (original magnification: ×200). (b) Immunohistochemical staining of the liver section from the same mouse with antibody to neomycin, showing neomycin+ cancer cells (original magnification: ×400). (c) Immunohistochemical staining of pCSC-derived hepatoid cells in the regenerative area of the liver sections from the same mouse (original magnification: ×200). (d) The enlarged micrographs of hepatoid cells demonstrated in (c).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808425-4-ponep0000293pg004.jpg"
} | 000689 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Protocol for the generation of oligodendrocytes from NS cells.NS cells propagated in NS-A medium plus N2 in the presence of EGF and FGF2 (A) were cultured in DMEM/F12 plus N2 in the presence of FGF2, PDGF and forskolin for 4 days on polyornithine/laminin coated plastic (B) before they were induced to differentiate by growth factor withdrawal in the presence of 3,3,5-tri-iodothyronine hormone (T3) and ascorbic acid (AA) (C,D). After four days, immunostaining for the O4 antigen revealed differentiation into oligodendrocytes (C). The differentiated cultures also contained GFAP-positive astrocytes and ß-III tubulin/TUJ1-positive neurons (C,D), demonstrating the tripotential differentiation capacity of these cells.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808430-0-ponep0000298pg001.jpg"
} | 000690 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Tripotential differentiation of NS cells in vitro and generation of myelinating oligodendrocytes in vivo.(A–E) Quantitative marker expression and representative immunofluorescence images. The specific culture conditions used to differentiate NS cells resulted in the generation of oligodendrocytes (∼20%) positive for O4 (B), Rip (D) and PLP (E), GFAP-expressing astrocytes (∼40%; C–D) and neurons positive for ß-III tubulin/TUJ1 (∼10%; C). (F–H) NS cells cultured in N2 medium and proliferated for 4 days in the presence of FGF2, PDGF and forskolin were transplanted into the brain of 2- to 3-day-old myelin-deficient rats. Two weeks after transplantation, the engrafted cells had formed PLP-positive myelin internodes. Shown are representative pictures from septum (F) and corpus callosum (G–H). Scale bars B–D, 100 µm; F–H, 20 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808430-1-ponep0000298pg002.jpg"
} | 000691 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Neoplastic cells are strongly positive for Ki-67. (B-SA, anti-Ki-67, original magnification × 200).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-0-1746-1596-2-7-6.jpg"
} | 000692 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Axial CT scan showing a destructive lesion of the left mandible with invasion of the surrounding musculature.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-1-1746-1596-2-7-1.jpg"
} | 000693 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Numerous lysosomes are seen in neoplastic cell cytoplasm. (electron microscopy, original magnification × 8000).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-2-1746-1596-2-7-7.jpg"
} | 000694 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Neoplastic round and spindle cells are strongly positive for CD163. (B-SA, anti-CD163, original magnification × 400).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-3-1746-1596-2-7-4.jpg"
} | 000695 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Note prominent spindle cell differentiation. (hematoxylin-eosin, original magnification × 200).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-4-1746-1596-2-7-3.jpg"
} | 000696 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Diffuse proliferation of large round to oval cells with pleomorphic vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm. A mitosis is seen. (hematoxylin-eosin, original magnification × 400).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-5-1746-1596-2-7-2.jpg"
} | 000697 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histiocytic sarcoma. Residual follicular dendritic cells are strongly positive for CD21. (B-SA, anti-CD21, original magnification × 200).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808440-6-1746-1596-2-7-5.jpg"
} | 000698 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Lateral plain radiograph Turner syndrome scoliosis with hypokyphosis.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_104-PMC1808441-0-1748-7161-2-3-3.jpg"
} | 000699 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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