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in the present study , both glucose and fructose were found to stimulate the gene expression at the transcriptional level in liver . | process_includes_biological_process | {
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} | {
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in contrast , insulin release was not required for fructose to trigger the gene transcription , nor did the high cyclic amp levels in fasted rat liver prevent rna synthesis by fructose . | process_includes_biological_process | {
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"name": "gene transcription",
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} | {
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"name": "rna synthesis",
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these sequences can stimulate the expression of heterologous genes in a manner largely independent of position and orientation , arguing that they possess a transcriptional enhancing activity that regulates the c-ha-ras1 promoter . | process_includes_biological_process | {
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it had no effect on the enhancement of gene expression by the hiv transcription unit tatiii . | process_includes_biological_process | {
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} | {
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he also exhibited pulmonary tuberculosis and impaired immunity with skin anergy , poor lymphocyte mitogens stimulation test , and low serum immunoglobulin . | process_includes_biological_process | {
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"name": "immunity",
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} | {
"id": "C0206120",
"name": "anergy",
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aluminum-exposed rabbits developed learning and memory deficits which were strongly correlated with the degree of whole brain neurofibrillary degeneration ( nfd ) , but not with motor , sensory or motivational factors . | process_includes_biological_process | {
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} | {
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"name": "motivational",
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my conclusion remains that , in general , sporadically occurring goldenhar variants , as distinct from familial cases , should be considered to be just casualities in the broad 'continuum of reproductive wastage ' seen in high risk conceptions , one of which is ivf . | process_includes_biological_process | {
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} | {
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it appears possible that peripheral hypersecretion of sexual steroids may cause a rise of gonadotropins secondarily followed by true pp in older children provided such longstanding hypersecretion leads to a generalized maturation of the body including skeletal maturation . | process_includes_biological_process | {
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} | {
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although adolescent patients in one recent study ( denholm , 1986 ) did not show evidence of negative behavior following discharge , this should not minimize the reported reactions , thoughts , and behaviors of adolescents which may occur during the hospitalization . | process_includes_biological_process | {
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} | {
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"name": "thoughts",
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the partial overlapping of the translation termination and initiation sites in the formed operon must provide translational coupling of appropriate gene product synthesis . | process_includes_biological_process | {
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} | {
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decreasing the distance between the tata sequence and the initiation site did not alter gene expression , but the site of transcription was shifted 3'-ward . | process_includes_biological_process | {
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} | {
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addition of the purified factor to the extract from hela cells increased several fold the efficiency of transcription and corrected the initiation of transcription . | process_includes_biological_process | {
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} | {
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sequence elements within the mouse beta maj-globin transcription unit required for efficient termination of transcription by rna polymerase ii have been delineated . | process_includes_biological_process | {
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} | {
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reproductive capacity of both males ( first ejaculation ) and females ( first conception ) appears to be reached around the 4th birthday . | process_includes_biological_process | {
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} | {
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"name": "conception",
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coronal angulated 10-second images were obtained during suspended respiration ( inspiratory apnea ) and showed excellent anatomic detail . | process_includes_biological_process | {
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} | {
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although immunity regularly developed and lasted for many weeks when the proper conditions of vaccination were used , the immune response was never sufficient to protect the animals against ultimate death from infection with virulent tubercle bacilli . | process_includes_biological_process | {
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} | {
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} |
from the results may be suggested that regulatory interactions between general behavioural activation originating from the brain stem , motivational processes and the analyzer systems are disrupted . | process_includes_biological_process | {
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} | {
"id": "C0026605",
"name": "motivational",
"pos": [
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} |
significant differences were not present among specimens with columnar epithelium but they differed from cell proliferation in adjacent squamous epithelium where s phase was similar but labeling and mitotic indexes were lower and generation time increased to 105 +/- 6 hr . | process_includes_biological_process | {
"id": "C0596290",
"name": "cell proliferation",
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} | {
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"name": "s phase",
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} |
throughout this discussion it has been emphasized that the therapist who uses any of these drugs , needs to be aware of the possible changes in mood , behavior and physiological signs that are thought to occur in animals . | process_includes_biological_process | {
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} | {
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the transcription and polyadenylation reaction could be separated temporally and a portion ( 10 % ) of the polyadenylated rna was released into the extra nuclear fraction . | process_includes_biological_process | {
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} | {
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the sex of the twins appeared to have little influence on subsequent reproduction , in spite of the fact that for singleton-containing fraternities a further pregnancy was more likely if the first two children were of the same sex than if they were of opposite sexes . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproduction",
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} | {
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"name": "pregnancy",
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} |
under conditions of the glucose deficiency accompanying tumor growth the atp deficit proves to be greater in cells of the second half of the mitotic cycle than in cells of the beginning of mitosis , thus resulting in redistribution of cells with stages of the mitotic cycle . | process_includes_biological_process | {
"id": "C1155839",
"name": "cells",
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} | {
"id": "C0026255",
"name": "mitotic cycle",
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unlabelled : the influence of a first gravida 's legal abortion to the later reproduction was researched on 406 patients in the age between 13 up to 18 years -- result : the rate of abortion and premature birth is significantly increased at subsequent pregnancies when there took place an interruption of the first gravidity. -- about 70 % of the coming gravidities following an interruption of the first gravidity deliver in the time between 37 . | process_includes_biological_process | {
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} | {
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a short reproductive life , and a pregnancy prior to the age of 30 years , both reduce the risk of breast cancer ( doll , 1975 ) . | process_includes_biological_process | {
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} | {
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} |
cv-1 cells are able to repair , at least partially , the induced transcription-terminating lesions and progressively recover rna synthesis with a reversion of the initially observed modifications . | process_includes_biological_process | {
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} | {
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from the electron-microscope study no definite conclusion can be drawn as regards the histogenesis of this tumor . we feel , as do others , that many of the principal mononuclear tumor cells are poorly differentiated mesenchymal cells . | process_includes_biological_process | {
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} | {
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} |
during control breathing and with nip the acceleration of heart rate during inspiration was associated with rising pba and rising net filling pressures of both ventricles . | process_includes_biological_process | {
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} | {
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} |
ventilatory responses to co2 and hypoxia were measured in four normal volunteers breathing 30-50 per cent n2o with and without added inspiratory resistance . | process_includes_biological_process | {
"id": "C0035203",
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} | {
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just to maintain the admittedly inadequate level of research in reproduction and contraceptive development attained in 1974 would require an investment of $ 143 million this year -- a level that has not been reached . | process_includes_biological_process | {
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} | {
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} |
utilization of temperature-sensitive mutants of tetrahymena pyriformis affected in cell division or developmental pathway selection has permitted elucidation of causal dependencies interrelating micronuclear and macronuclear replication and division , oral development , and cytokinesis . | process_includes_biological_process | {
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"name": "cell division",
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} | {
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"name": "cytokinesis",
"pos": [
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286
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} |
in addition analysis of transcription in vitro has indicated that the nucleotide sequence u6 purine may be part of a transcription termination signal in prokaryotes . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
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} | {
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it appears that the chemotherapy for ovarian carcinoma may not be significantly immunosuppressive against established levels of cell-mediated immunity and may in certain instances have effects potentially beneficial to the host as evaluated by lymphocyte-mediated cytotoxicity and blocking factor studies . | process_includes_biological_process | {
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} | {
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} |
after stabilization of the blood pao2 values with the animal breathing different mixtures of oxygen and nitrous oxide , the inspired mixture was abruptly changed to normal air . | process_includes_biological_process | {
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} | {
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} |
the immune response of anesthetists exposed to halothane was investigated using pha-induced lymphocyte stimulation ( normal in males , elevated in females ) and lymphocyte transformation to halothane and its metabolites ( no evidence of allergy was observed ) . | process_includes_biological_process | {
"id": "C0301872",
"name": "immune response",
"pos": [
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} | {
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186
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} |
the ultraviolet-induced alterations of transcription disappear progressively with time after irradiation : the rates of total rna and of 45 s rna synthesis increase whereas the synthesis of unusual rnas decreases ; | process_includes_biological_process | {
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} | {
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} |
proceedings : evidence for translational control of protein synthesis as part of the mechanism of aldosterone action in toad bladder . | process_includes_biological_process | {
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} | {
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} |
the results indicated that three behavioural techniques ( listening to tv/radio/stereo , sleeping , talking about pain ) and one cognitive technique ( thinking about something else ) were rated as effective by the majority of subjects for average levels of pain . | process_includes_biological_process | {
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} | {
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} |
in addition , in adenovirus-infected cells , transcription initiated from upstream promoters on the adenovirus chromosome terminates within the same mlp promoter-proximal region , both establishing the physiological relevance of the observed ccaat-box dependent termination , and also suggesting a possible function for transcription termination in adenovirus infection . | process_includes_biological_process | {
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58
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} | {
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320,
333
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} |
these results indicate a deficiency in the repair of uv-induced dna damage associated with human tumorigenesis and the transformation of human cells by sv40 but not the transformation of human cells by adenovirus . | process_includes_biological_process | {
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} | {
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} |
in vivo and in vitro expression of u7 snrna genes : cis- and trans-acting elements required for rna polymerase ii-directed transcription . | process_includes_biological_process | {
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} | {
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} |
in contrast , under conditions similar to those of humans , in whom underlying immunity to c. albicans is usually present , suppression of host responses to c. albicans was not observed in immunized mice in response to treatment with rmuifn-gamma . | process_includes_biological_process | {
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} | {
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} |
more recently , it has become apparent that transcription of this sequence occurs ( 9 ) and that it may also be involved in some aspect of termination of 35 s rrna transcription . | process_includes_biological_process | {
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"pos": [
44,
57
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} | {
"id": "C0597600",
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} |
at the transcriptional level , pretreatment of mo with pge2 attenuated the ability of new pge2 to inhibit lps-dependent tnf mrna expression . | process_includes_biological_process | {
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"name": "transcriptional",
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} | {
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} |
these results indicate that the hbv trans-acting moiety suppresses the expression of the human beta interferon gene at the transcriptional level by interacting with the regulatory dna sequences 5 ' to the coding sequences for beta interferon . | process_includes_biological_process | {
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} | {
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} |
thus , stypoldione uncouples cytokinesis from mitosis at the lowest effective concentrations and , although it can disrupt microtubules at relatively higher concentrations , it inhibits cell division at the lowest effective concentrations by a selective action on cytokinesis through a mechanism that does not appear to involve disassembly of microtubules . | process_includes_biological_process | {
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} | {
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} |
this report shows that in the absence of their cognate promoter , two bacteriophage rna polymerases are capable of performing unusual transcription reactions : ( i ) the dna template serves also as a primer for rna synthesis and this leads to hybrid dna/rna molecules , ( ii ) if the dna template forms a hairpin structure , the linear dna can be transcribed via the 'rolling circle ' mechanism . | process_includes_biological_process | {
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147
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} | {
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"name": "rna synthesis",
"pos": [
211,
224
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} |
the difference between fibroblasts and keratinocytes in the time course of muscle gene expression is likely to reflect mechanisms of gene activation at the transcriptional level , since the kinetics of muscle protein accumulation paralleled that of muscle transcripts . | process_includes_biological_process | {
"id": "C0017262",
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"pos": [
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} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
156,
171
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} |
to obtain an understanding of the sex steroid hormonal milieu during early gestation , the concentrations of estradiol-17 beta and progesterone were measured in endometria and reproductive tract luminal fluids collected during the post-ovulatory period ( days 2 to 6 ) of conception , and of non-mated menstrual cycles of the rhesus monkey ( macaca mulatta ) . | process_includes_biological_process | {
"id": "C0035150",
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} | {
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} |
to obtain an understanding of the sex steroid hormonal milieu during early gestation , the concentrations of estradiol-17 beta and progesterone were measured in endometria and reproductive tract luminal fluids collected during the post-ovulatory period ( days 2 to 6 ) of conception , and of non-mated menstrual cycles of the rhesus monkey ( macaca mulatta ) . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
176,
188
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} | {
"id": "C0025329",
"name": "menstrual cycles",
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302,
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} |
successful resolvers were also found to report employing significantly more behavioral strategies and less self-blame and wishful thinking than unsuccessful resolvers . | process_includes_biological_process | {
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} | {
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} |
multidrug-resistance is frequently characterized by enhanced drug efflux resulting from a membrane glycoprotein of 170,000 daltons ( p-glycoprotein ) . | process_includes_biological_process | {
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} | {
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} |
despite probable adequate acyclovir levels in the spinal fluid , a second episode or progression of herpetic encephalitis occurred , suggesting impairment of host defenses , particularly cellular immunity . | process_includes_biological_process | {
"id": "C0520990",
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"pos": [
158,
171
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} | {
"id": "C0020966",
"name": "cellular immunity",
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187,
204
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} |
such effects support the hypothesis that nab affects the expression of many proteins by modification of gene expression , probably at the transcriptional level . | process_includes_biological_process | {
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104,
108
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} | {
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"name": "transcriptional",
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138,
153
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} |
three approaches were investigated for improvement of in vitro maturation ( ivm ) , in vitro fertilization ( ivf ) , and early embryonic development in cattle . | process_includes_biological_process | {
"id": "C0678723",
"name": "maturation",
"pos": [
63,
73
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} | {
"id": "C0013936",
"name": "embryonic development",
"pos": [
127,
148
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} |
in 14 spontaneously breathing anesthetized rabbits , we used cyanoacrylate to glue a hollow capsule , at end expiration or at end inspiration , to the peritoneal surface of the tendinous portion of the diaphragm . | process_includes_biological_process | {
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"name": "breathing",
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29
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} | {
"id": "C0004048",
"name": "inspiration",
"pos": [
130,
141
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} |
1 ) in animals breathing spontaneously , we used infinite inspiratory ( ri ) or expiratory ( re ) resistive load and intravenous injections of carbachol , histamine , or phenyl diguanide ( pdg ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
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15,
24
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} | {
"id": "C0004048",
"name": "inspiratory",
"pos": [
58,
69
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} |
1 ) in animals breathing spontaneously , we used infinite inspiratory ( ri ) or expiratory ( re ) resistive load and intravenous injections of carbachol , histamine , or phenyl diguanide ( pdg ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
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15,
24
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} | {
"id": "C0231800",
"name": "expiratory",
"pos": [
80,
90
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} |
we have identified and partially purified an activity from hela cells that causes the transcription complex to read through this block to transcription elongation . | process_includes_biological_process | {
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"name": "transcription",
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86,
99
]
} | {
"id": "C1519591",
"name": "transcription",
"pos": [
138,
151
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} |
in the work reported in this paper , the effects of various analogues of s-adenosylmethionine ( s-ado-met ) and atp on polyadenylation in an in vitro transcription system were examined to determine whether s-ado-hcy exerted its effect on polyadenylation due to its relationship to s-ado-met or to atp . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
150,
163
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
238,
253
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} |
in addition , c-myc amplification was not selected during tumourigenesis , indicating that this event is not required for a-mulv transformed swiss 3t3 cells to display a full tumourigenic phenotype . | process_includes_biological_process | {
"id": "C0007621",
"name": "tumourigenesis",
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58,
72
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} | {
"id": "C1510411",
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} |
these mutations were : a -2 g/c -- -- a/t change ( -2a ) promoting transcription at position +11 , a +1 a/t -- -- t/a change ( +1t ) promoting transcription initiation at position +13 , and a +10 c/g -- -- a/t change ( +10a ) promoting transcription initiation at a complex series of positions . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
67,
80
]
} | {
"id": "C1158830",
"name": "transcription initiation",
"pos": [
236,
260
]
} |
in spontaneously breathing , anesthetized cats , the airway was occluded at end-expiration at both control functional residual capacity ( frc ) and an end-expiratory lung volume elevated with an expiratory threshold load ( etl ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
17,
26
]
} | {
"id": "C0231800",
"name": "expiratory",
"pos": [
195,
205
]
} |
the direction of respiration during spoon contact was consistent for each individual and the pharyngeal stage of swallowing was almost always followed by a large expiration . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
17,
28
]
} | {
"id": "C0231800",
"name": "expiration",
"pos": [
162,
172
]
} |
the protective effect of ionol on the energy metabolism in hypoxia was shown to occur mainly at the level of glycolysis . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy",
"pos": [
38,
44
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
109,
119
]
} |
impaired humoral immunity is manifested in polyclonal b-cell activation and in impaired antibody responses to soluble antigens in vivo and in vitro . | process_includes_biological_process | {
"id": "C0020967",
"name": "humoral immunity",
"pos": [
9,
25
]
} | {
"id": "C1155003",
"name": "b-cell activation",
"pos": [
54,
71
]
} |
the reductions in serum igf-i and igf-i mrna during protein restriction of neonatal rats suggest that these responses are mediated by decreased igf-i gene expression at the level of transcription or rna stabilization . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
150,
165
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
182,
195
]
} |
examination of the fate of p. aeruginosa and escherichia coli injected into parasitized larvae suggested that the cellular antibacterial defenses of the host , nodule formation , and phagocytosis , were impaired . | process_includes_biological_process | {
"id": "C0520990",
"name": "defenses",
"pos": [
137,
145
]
} | {
"id": "C0031308",
"name": "phagocytosis",
"pos": [
183,
195
]
} |
in order to determine whether the expression of ribosomal protein genes is coordinately regulated , we measured the effect of dexamethasone on their transcription . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
34,
44
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
149,
162
]
} |
also , the 66q cells continued to proliferate slowly with about 85 per cent in the g1 phase and 10 per cent in the s phase , while the 67 q cells displayed a more complete g1 arrest ( 92-95 per cent ) . | process_includes_biological_process | {
"id": "C0079395",
"name": "g1 phase",
"pos": [
83,
91
]
} | {
"id": "C1517342",
"name": "g1 arrest",
"pos": [
172,
181
]
} |
thus , the effects of camp on alpha and cg beta gene expression are predominantly transcriptional , but camp also increases mrna levels via a posttranscriptional mechanism . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
48,
63
]
} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
146,
161
]
} |
it is assumed that the contrary effect of immunization with serotonin-protein conjugate on the alcoholic behavior of animals with a different initial level of alcoholic motivation is linked with the difference in their neurochemical organization . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
105,
113
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
169,
179
]
} |
since there is increasing evidence for a network of immuno-modulating cytokines playing a crucial role in the regulation of immunity and inflammation , in the present study we investigated whether an altered production of these mediators is one of the pathomechanisms responsible for the altered immune response in ad . | process_includes_biological_process | {
"id": "C0020964",
"name": "immunity",
"pos": [
124,
132
]
} | {
"id": "C0301872",
"name": "immune response",
"pos": [
296,
311
]
} |
after 4 weeks of combine therapy , patients receiving adjunctive amitriptyline or desipramine , as compared with those receiving adjunctive placebo , tended to score higher on the brief psychiatric rating scale hallucinatory behavior item and on the thinking disturbance factor than patients receiving placebo . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
225,
233
]
} | {
"id": "C0039869",
"name": "thinking",
"pos": [
250,
258
]
} |
once the immune response has been initiated , however , cytokines and other factors , released by activated cells at the inflammatory site , stimulate a variety of changes in various cell types that alter their capacity to function as antigen-presenting cells and facilitate antigen-induced t-cell activation . | process_includes_biological_process | {
"id": "C0301872",
"name": "immune response",
"pos": [
9,
24
]
} | {
"id": "C1155065",
"name": "t-cell activation",
"pos": [
291,
308
]
} |
effects of kinetin on cell division , with special reference to initiation and duration of mitosis . | process_includes_biological_process | {
"id": "C0007590",
"name": "cell division",
"pos": [
22,
35
]
} | {
"id": "C0026255",
"name": "mitosis",
"pos": [
91,
98
]
} |
synthesis of t-antigen is also time limited and precedes the first sv40-induced cellular dna replication and mitosis . | process_includes_biological_process | {
"id": "C0007590",
"name": "cellular",
"pos": [
80,
88
]
} | {
"id": "C0026255",
"name": "mitosis",
"pos": [
109,
116
]
} |
the ability of the ctnt distal promoter region to confer skeletal muscle-specific activity upon a heterologous promoter is abolished when it is displaced 60 nucleotides upstream , indicating that its ability to direct skeletal muscle-specific transcription probably requires proximity to other components of the transcription initiation region . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
243,
256
]
} | {
"id": "C1158830",
"name": "transcription initiation",
"pos": [
312,
336
]
} |
this allows individual steps along the transcription reaction pathway to be tested directly , thus providing a basis for understanding basic transcription initiation mechanisms as well as the regulatory processes that act on them . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
39,
52
]
} | {
"id": "C1158830",
"name": "transcription initiation",
"pos": [
141,
165
]
} |
the failure of attempts to separate these two cell types by repeated recloning procedures indicates their close histogenetic relationship and suggests that differentiation in this tumor proceeds in a similar manner to that in normal striated muscle where postmitotic myotubes arise from mononuclear myoblasts by fusion . | process_includes_biological_process | {
"id": "C0178679",
"name": "histogenetic",
"pos": [
112,
124
]
} | {
"id": "C0007589",
"name": "differentiation",
"pos": [
156,
171
]
} |
the differentiation of mild and moderate from severe mitral stenosis by pulse doppler echocardiography of mitral valve circulation , analyzed by histogram of the time intervals , is achieved with satisfactory precision by determination of the speed of the circulation fall in the early 1/3 of the diastole . | process_includes_biological_process | {
"id": "C0005775",
"name": "circulation",
"pos": [
119,
130
]
} | {
"id": "C0012000",
"name": "diastole",
"pos": [
297,
305
]
} |
for this reason , the expression of the pt genes in plasmid prh121 proved the existence of a transcription terminator between the lac promoter and the pt operon in plasmid prh119 . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
22,
32
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
93,
106
]
} |
reparative processes and cell proliferation in lymphocyte tissue resulted in a slow decrease in sce rate after the 4th day . | process_includes_biological_process | {
"id": "C0596290",
"name": "cell",
"pos": [
25,
29
]
} | {
"id": "C0037211",
"name": "sce",
"pos": [
96,
99
]
} |
implications of these findings with respect to problems of regulatory control of cytokeratin synthesis in tissue development and differentiation , and the possible functional meaning of the occurrence of trichocytic cytokeratins in such histologically diverse tissues , are discussed . | process_includes_biological_process | {
"id": "C0178679",
"name": "tissue development",
"pos": [
106,
124
]
} | {
"id": "C0007589",
"name": "differentiation",
"pos": [
129,
144
]
} |
to characterize the mechanisms by which interferon gamma ( ifn-gamma ) upregulates major histocompatibility complex class ii mrna levels in mouse macrophages , we studied the effect of ifn-gamma on the transcription rate of class ii genes and investigated the requirement for ongoing protein synthesis for the induction of class ii mrna expression . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
202,
215
]
} | {
"id": "C1515670",
"name": "mrna expression",
"pos": [
332,
347
]
} |
the observations that long hybrid formation is prevented as long as the polymerases are present , and the maintenance of the constant length of the transcription bubble during transcription elongation , suggest that during elongation the enzyme that actively unwinds the template allows the synchronous displacement of the nascent transcript and rewinding of the template . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
148,
161
]
} | {
"id": "C1519591",
"name": "transcription elongation",
"pos": [
176,
200
]
} |
our studies indicate that , whereas 1,25- ( oh ) 2d3 does not regulate 28-kda cabp mrna levels in the brain , the hormone modulates 28-kda cabp gene expression in intestine and kidney in a tissue-specific manner , by acting through both transcriptional and post-transcriptional mechanisms . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
144,
159
]
} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
262,
277
]
} |
energy metabolism ( oxygen consumption and glycolysis ) and electrophysiological function ( determined by electroretinogram ) of the in vitro retina were monitored , and their responses to a series of agents that may reduce energy requirements were determined . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy metabolism",
"pos": [
0,
17
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
43,
53
]
} |
the relative steady-state amounts of the slow and fast skeletal tnc mrnas in various adult and embryonic striated muscles are similar to the expected amounts of the corresponding protein , suggesting that the expression of tnc genes is controlled predominantly by the production or accumulation of mrna rather than by translational or post-translational mechanisms . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
209,
219
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
340,
353
]
} |
at +30 degrees flow varied minimally with the cardiac cycle and was primarily respiration dependent , stopping at peak inspiration . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
78,
89
]
} | {
"id": "C0004048",
"name": "inspiration",
"pos": [
119,
130
]
} |
this compound also stimulates cellular immunity , as shown by the increase observed in proliferative responses in vitro , cell-mediated lymphocytotoxicity and natural killer cell-dependent cytotoxicity . | process_includes_biological_process | {
"id": "C0020966",
"name": "cellular immunity",
"pos": [
30,
47
]
} | {
"id": "C0301896",
"name": "lymphocytotoxicity",
"pos": [
136,
154
]
} |
this decrease in anf gene expression resulted from a decrease in activity of the same major transcription start site employed in the adult atria and ventricle . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
21,
36
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
92,
105
]
} |
in higher eukaryotes there can be as many as four distinct cycles , with growth , dna synthesis , cell division , and nuclear division each possessing its own functional sequence of events . | process_includes_biological_process | {
"id": "C0007590",
"name": "cell",
"pos": [
98,
102
]
} | {
"id": "C1155789",
"name": "nuclear division",
"pos": [
118,
134
]
} |
two cases of mixed depression and dementia showed behavioural and mood improvement after treatment with ect , but without improvement in cognition . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioural",
"pos": [
50,
61
]
} | {
"id": "C0009240",
"name": "cognition",
"pos": [
137,
146
]
} |
we have performed a detailed transcriptional analysis in vivo and have found that the his mrna in this polar mutant is reduced in size as a result of premature termination of transcription at a cryptic rho-dependent site within the proximal region of the hisc cistron . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
29,
44
]
} | {
"id": "C0597600",
"name": "termination",
"pos": [
160,
171
]
} |
subjects attained maximal mouth pressure ( pm ) while breathing at either 1.25 or 1 l/s , utilizing a fixed breathing pattern ( duty cycle 0.43 ) with an inspiratory time of 1.5 s . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
54,
63
]
} | {
"id": "C0004048",
"name": "inspiratory",
"pos": [
154,
165
]
} |
these observations also suggest that transcription from ribosomal protein promoters may be special , perhaps able to overcome transcription termination signals . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
37,
50
]
} | {
"id": "C0597600",
"name": "transcription termination",
"pos": [
126,
151
]
} |
expression of the gene encoding the 17-kilodalton antigen from rickettsia rickettsii : transcription and posttranslational modification . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
0,
10
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
87,
100
]
} |
the transcriptional behavior of the mutated leader regions in vitro and the extent of transcription termination observed with each in vivo were virtually identical to that of the wild type leader region . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
4,
19
]
} | {
"id": "C0597600",
"name": "transcription termination",
"pos": [
86,
111
]
} |
therefore the control of gene expression , leading to a balanced synthesis of alpha and beta subunits , is likely to occur at the translational level . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
25,
40
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
130,
143
]
} |
434 mhz appears to deliver energy to the anaerobic cancer metabolism by causing a resonance phenomenon amongst one or more of the substrates which comprise the first few stages of glycolysis . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy",
"pos": [
27,
33
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
180,
190
]
} |
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