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it is necessary for the cell multiplication and cartilage maturation which results in the growth of long bones .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 24, 43 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 90, 96 ] }
[ multiplication of the different varieties of cells of the mouse pubic symphysis during growth and early gestation : radioautographic study with the use of tritiated thymidine ] .
process_initiates_biological_process
{ "id": "C0596290", "name": "multiplication", "pos": [ 2, 16 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 89, 95 ] }
[ multiplication of mycobacterium lepraemurium in cell-free liquid medium . 8. growth of m. lepraemurium in culture media which were preserved before inoculation ( author 's transl ) ] .
process_initiates_biological_process
{ "id": "C0596290", "name": "multiplication", "pos": [ 2, 16 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 79, 85 ] }
[ multiplication of mycobacterium lepraemurium in cell-free liquid medium . 9. effect of transfer of the smeared slide on the growth of m. lepraemurium ( author 's transl ) ] .
process_initiates_biological_process
{ "id": "C0596290", "name": "multiplication", "pos": [ 2, 16 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 126, 132 ] }
the data obtained are in agreement with the hypothesist hat membrane-stabilizing drugs improve cell metabolism in pathological conditions related to deterioration of cytomembrane structure components .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological conditions", "pos": [ 114, 137 ] }
{ "id": "C0868945", "name": "related", "pos": [ 138, 145 ] }
the results suggest that steroidogenesis , through the adenylate cyclase-cyclic adenosine 3':5'-monophosphate system , in human oocytes may play some important role in oocyte maturation , fertilization , and early embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 188, 201 ] }
{ "id": "C0013936", "name": "embryonic", "pos": [ 214, 223 ] }
elucidation of the different effects of polyamines and other naturally-occurring inhibitors of cell proliferation ( chalones ) on t-lymphocyte and granulocyte colony growth in vitro .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 95, 113 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 166, 172 ] }
the changes in rate of oxygen consumption at fertilization by the different species of eggs , differing both in direction and magnitude , appear to be such as to bring the rate , when development is initiated , to about the same rate , which is also the rate of other comparable normally growing cells .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 45, 58 ] }
{ "id": "C0678723", "name": "development", "pos": [ 184, 195 ] }
this thesis , that the rate of oxygen consumption is not necessarily nor ordinarily the limiting factor in the inhibition of the unfertilized egg , and conversely that increase in the rate of oxygen consumption is not usually the essential feature of fertilization , is quite in agreement with the general relations between the rate of oxygen consumption on the one hand and anesthesia , growth , and development on the other in fertilized eggs and other organisms .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 251, 264 ] }
{ "id": "C0678723", "name": "development", "pos": [ 401, 412 ] }
thus , fertilization results in increases in tyrosine-specific protein kinase ( s ) activity which continues to increase during early embryonic development ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 7, 20 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 134, 155 ] }
the significance of these results is discussed in terms of the preparation of the immature oocyte for fertilization and the mechanisms of modification of ion channel properties during development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 102, 115 ] }
{ "id": "C0678723", "name": "development", "pos": [ 184, 195 ] }
in nonparous females , reproductive failure was attributed equally to fertilization failure and embryonic mortality , which had occurred or was occurring by d 8 of gestation .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 70, 83 ] }
{ "id": "C0032961", "name": "gestation", "pos": [ 164, 173 ] }
it was concluded that ranitidine hydrochloride has no harmful effect on mating , fertilization , implantation , or embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 81, 94 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 115, 136 ] }
a possibility of using swiss 3t3 cells , adapted to the growth in the eagle basal medium and bovine serum , in studies of cell proliferation and quiescent state was shown on the basis of their growth characteristics .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 122, 140 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 193, 199 ] }
this initial stimulation was followed by an inhibitory effect of calcitonin upon cell proliferation , which occurred during the log phase of growth , was dose dependent , and resulted in prolongation of doubling time from 36 to 90 hr .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 81, 99 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 141, 147 ] }
some biological limitations include a lack of understanding of the interaction of semen quality and quantity on fertility , the effect of the female reproductive tract on selective sperm transport and sperm retention and the influence of spermatozoal traits on fertilization of the ovum and sustenance of embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 261, 274 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 305, 326 ] }
these two mutants provide further evidence for the hypothesis that many genes expressed prior to fertilization also perform a critical function during growth and development of the sporophyte .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 97, 110 ] }
{ "id": "C0678723", "name": "development", "pos": [ 162, 173 ] }
dfmo was also found to suppress cell proliferation in , and the growth of , the transplantable colon cancers .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 32, 50 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 64, 70 ] }
the insulin-like growth factors i and ii ( igf-i and -ii ) are proteins which stimulate cell proliferation and are important in normal human growth and development .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 88, 106 ] }
{ "id": "C0018270", "name": "normal", "pos": [ 128, 134 ] }
a preliminary trial comparing amniotic fluid with t6 + maternal serum in human ivf showed no significant difference in fertilization rate and embryo development during 42 to 48 hours in vitro .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 119, 132 ] }
{ "id": "C0013936", "name": "embryo", "pos": [ 142, 148 ] }
the effect of toxicants on gamete fertilizing capacity in mammals can be measured by direct assessment of fertilization and embryo development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 106, 119 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 124, 142 ] }
on the basis of literature data concerning the interaction between stroma and epithelia under physiological and pathological conditions it is hypothesized that the interaction of collagen type i trimer fibrils with tumour cells is instrumental in augmenting tumour cell progression and that the trimer may provide contact guidance for invasive growth .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological conditions", "pos": [ 112, 135 ] }
{ "id": "C0178874", "name": "tumour", "pos": [ 258, 264 ] }
thus , we conclude that the reduced expression of these mrnas is due to a translational deficiency .
process_initiates_biological_process
{ "id": "C1515670", "name": "expression", "pos": [ 36, 46 ] }
{ "id": "C1519614", "name": "translational", "pos": [ 74, 87 ] }
analysis of the earlier obtained data on the effect of hydroxyurea on megakaryocytopoiesis by a simulation model has shown that differentiation of proliferating precursors of the megakaryocytes depends on their amount in bone marrow ;
process_initiates_biological_process
{ "id": "C0522310", "name": "megakaryocytopoiesis", "pos": [ 70, 90 ] }
{ "id": "C1159950", "name": "differentiation", "pos": [ 128, 143 ] }
during amphibian limb regeneration , cell proliferation depends upon paracrine release of factors from axons in the limb stump , and the nerve supply can be eliminated or augmented experimentally for study of growth in this system .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 37, 55 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 209, 215 ] }
in the laparoscopy group the oocyte recovery rate was 82.5 % and the fertilization rate 62.5 % , with one twin pregnancy ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 69, 82 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 111, 120 ] }
in the ultrasound group the oocyte recovery rate was 75 % , and the fertilization rate 61.9 % , with a singleton pregnancy .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 68, 81 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 113, 122 ] }
conversely , a definite lower limit of hamster egg penetration to define absolute male infertility could not be established because human oocyte fertilization , cleavage , and even pregnancy occurred in spite of low hamster egg penetration .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 145, 158 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 181, 190 ] }
biogeographic evidence for s. purpuratus indicates that fertilization and development naturally occur below 15 degrees c , hence `` '' spiral asters '' '' in eggs of this species should be regarded as abnormalities induced in the laboratory by unnaturally elevated temperatures .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 56, 69 ] }
{ "id": "C0678723", "name": "development", "pos": [ 74, 85 ] }
accelerated wound repair , cell proliferation , and collagen accumulation are produced by a cartilage-derived growth factor .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 27, 45 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 110, 116 ] }
although this cell line showed estrogen-induced enhancement of cell proliferation in vitro , a moderately high concentration ( 10 ( -8 ) m ) of estradiol was required to stimulate maximum growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 63, 81 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 188, 194 ] }
cell proliferation , maturation , and differentiation were modulated by egf and ct : cultures maintained on egf showed optimal growth but cells typically displayed only limited differentiation .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 0, 18 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 127, 133 ] }
influence of microsurgical reanastomosis of the fallopian tube on luminal ph and po2 and on the fertilization rate and embryo development in the rabbit oviduct .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 96, 109 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 119, 137 ] }
these data suggest that elevated serum prl concentrations may have no effect on fertilization of oocytes in vitro or embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 80, 93 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 117, 138 ] }
a normal radionuclide bone image can facilitate distinction between a bone island and significant pathologic processes , especially an osteoblastic metastasis .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathologic processes", "pos": [ 98, 118 ] }
{ "id": "C0027627", "name": "metastasis", "pos": [ 148, 158 ] }
fertilization in chlamydomonas reinhardi , with special reference to the structure , development , and fate of the choanoid body .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 0, 13 ] }
{ "id": "C0678723", "name": "development", "pos": [ 85, 96 ] }
direct intercellular communication mediated by membrane junctions is known to occur between a variety of cells and may play an important role in the control of cell growth and differentiation .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular", "pos": [ 7, 20 ] }
{ "id": "C0007589", "name": "differentiation", "pos": [ 176, 191 ] }
testosterone increased cell proliferation , and the anti-androgen cyproterone acetate ( 100 nm ) completely inhibited this growth stimulation .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 23, 41 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 123, 129 ] }
[ research on the influence of the quality of spermatozoon on the quality of the product of fecundation and in disorders of embryogenesis : dissociation of two essential functions of the spermatozoon ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fecundation", "pos": [ 92, 103 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 124, 137 ] }
that such replications occur at a critical stage ( e.g . gametogenesis , fertilisation , very early embryogenesis ) in the course of reproduction ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilisation", "pos": [ 73, 86 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 100, 113 ] }
ms 204 and ms 207 were also found to inhibit the fertilization of mouse oocytes in vivo and embryo development in vitro , when superovulated mice were injected intraperitoneally with given doses of antibodies prior to the mating .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 49, 62 ] }
{ "id": "C0013936", "name": "embryo", "pos": [ 92, 98 ] }
the best follicular fluid indicator of oocyte fertilization in vitro was the a/e ratio , which was less than 1 when the oocyte was fertilized in vitro and led to a pregnancy .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 46, 59 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 164, 173 ] }
similar increases in zpp and fpp were detected in patients with inflammatory processes , suggesting a common effector of erythropoiesis in these pathological conditions and in metastatic diseases .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological conditions", "pos": [ 145, 168 ] }
{ "id": "C0027627", "name": "metastatic diseases", "pos": [ 176, 195 ] }
it is concluded that cell multiplication is practically arrested at this period of life , and growth of the ventricular mass is due to polyploidization of virtually all cycling cells , while their number remains unchanged .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 21, 40 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 94, 100 ] }
some examples serve to illustrate pathologic conditions , such as inflammation and benign and malignant primary and secondary neoplasia .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathologic conditions", "pos": [ 34, 55 ] }
{ "id": "C0027627", "name": "secondary neoplasia", "pos": [ 116, 135 ] }
e2 had a more rapid effect on cell proliferation than 5 alpha-dht , the latter requiring at least 5 to 6 days to exert significant growth inhibition .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 30, 34 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 131, 137 ] }
during the progressive pathological process , as a result of the gradual deterioration of the interterritorial substance of the uncovered hyaline cartilage , spaces , fissures and deep pits were formed in the upper , then the lower , articular layers .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological process", "pos": [ 23, 43 ] }
{ "id": "C0868945", "name": "uncovered", "pos": [ 128, 137 ] }
a randomized control trial involving the fertilization and culture of human embryos in culture medium ( t6 ) containing either 10 % maternal serum or no protein or amino acid supplement was carried out to assess the effect of deletion from culture of all fixed nitrogen on fertilization , embryo development , and embryo viability .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 41, 54 ] }
{ "id": "C0013936", "name": "embryo", "pos": [ 314, 320 ] }
there was no difference in fertilization rates ( 68 vs 69 % ) , development of apparently normal embryos ( 96 vs 97 % ) , pregnancy rate ( 18 vs 14 % ) , or birth rate ( 13 vs 11 % ) between protein-containing and protein-free media .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 27, 40 ] }
{ "id": "C0013936", "name": "development", "pos": [ 64, 75 ] }
us also plays an increasingly important role in monitoring ovulation induction and alternative methods of fertilization and has improved pregnancy rates by distinguishing between the presence of one or more mature follicles as opposed to a cohort of immature follicles , suggesting the possibility of multiple ovulation with the risks of hyperstimulation or poor pregnancy outcome from multiple gestation , indicating optimum timing of human chorionic gonadotropin administration , allowing detection and confirmation of normal follicular rupture and ovulation , indicating optimum timing of oocyte retrieval in programs of in vitro fertilization with embryo transfer ( ivf-et ) or insemination programs , and assessing pathologic pelvic conditions and ovarian accessibility in ivf-et programs .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 106, 119 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 363, 372 ] }
the observations presented here suggest that the haftl-1 cell line represents the early stage of b-cell differentiation at which immunoglobulin gene rearrangement is initiated .
process_initiates_biological_process
{ "id": "C0007589", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C1512666", "name": "immunoglobulin", "pos": [ 129, 143 ] }
in earlier studies , the free beta-subunit of hcg was demonstrated in the serum of women with natural fertilization pregnancy , 2-6 weeks post ovulation .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 102, 115 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 116, 125 ] }
since the findings as a whole are consistent with the assumption that bone growth in length is largely a matter of increase in cell number , while bone growth in weight is largely a matter of increase in cell size and density , the generalization is made that , in the bones at least , growth by increase in cell number is more stable than growth by increase in cell size and density .
process_initiates_biological_process
{ "id": "C0596290", "name": "growth", "pos": [ 75, 81 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 340, 346 ] }
the restraining power of adult serum on cell multiplication may be due to the antagonistic action of growth-promoting and growth-inhibiting substances , the growth-promoting substance being as unstable as alexin and certain tissue juices which have the property of increasing the rate of cell proliferation .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 40, 59 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 157, 163 ] }
these studies provide the conceptual basis and the operational approach for the use of t beta gene rearrangements as markers of t-cell lineage , clonality , and differentiation , analogous to immunoglobulin gene rearrangements in b cells .
process_initiates_biological_process
{ "id": "C0007589", "name": "differentiation", "pos": [ 161, 176 ] }
{ "id": "C1512666", "name": "immunoglobulin gene rearrangements", "pos": [ 192, 226 ] }
disadvantages include the inability to determine if fertilization has occurred in the absence of pregnancy , the theoretical risk of increased ectopic gestation and tubal infection , and perhaps an increase in multiple gestations .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 52, 65 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 97, 106 ] }
in patients with pathological stage d1 disease bilateral orchiectomy significantly reduced disease progression ( p less than 0.0001 ) .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological", "pos": [ 17, 29 ] }
{ "id": "C0242656", "name": "progression", "pos": [ 99, 110 ] }
such a passive immunization of females given after fertilization had no effect on embryonic development or the sex ratio of fetuses .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 51, 64 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 82, 103 ] }
many endocrinological factors control cellular growth of different tissues ( cell multiplication and cell volume ) and skeletal growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 38, 42 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 128, 134 ] }
alteration of the normal events of fertilization and/or embryonic development following transfer of in vitro fertilized embryos into surrogate dams can serve as end point ( s ) in applying this means for toxicity testing .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 35, 48 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 56, 77 ] }
bulbosum ( 2n = 14 ) crosses result after fertilization from the subsequent elimination of bulbosum chromosomes during early embryo development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 42, 55 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 125, 143 ] }
the following pathologic conditions were reported in 29 patients with focal lesions ( excepted systemic diseases ) : 6 plain cysts , 1 cystic lymphangioma , 3 echinococcus cysts , 3 abscesses , 7 hematomas and 9 metastases .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathologic conditions", "pos": [ 14, 35 ] }
{ "id": "C0027627", "name": "metastases", "pos": [ 212, 222 ] }
exposure to low ph before fertilisation caused a drastic reduction of the development of mouse embryos .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilisation", "pos": [ 26, 39 ] }
{ "id": "C0013936", "name": "development", "pos": [ 74, 85 ] }
the changes in the neuron-capillary relationship arising in ah can be one of the possible pathogenetic factors in the pathologic process progression .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathologic process", "pos": [ 118, 136 ] }
{ "id": "C0242656", "name": "progression", "pos": [ 137, 148 ] }
similarly , when pb from patient 8 was studied in liquid culture without using added growth factor , cell proliferation declined identical to controls , whereas pb from the other three patients showed exuberant growth of monocyte-macrophage elements .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 101, 119 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 211, 217 ] }
cell proliferation is increased in both cases , showing that mammary growth can occur during established lactation .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 0, 18 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 69, 75 ] }
autoradiography after [ 3h ] thymidine pulse-labeling showed reduced cell proliferation on days 19 and 20 mainly due to lower fibroblast growth with a smaller reduction in epithelial labeling .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 69, 87 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 137, 143 ] }
protein kinase c is probably important in cell proliferation , as activation of this enzyme by phorbol esters promotes growth in many systems .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 42, 46 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 119, 125 ] }
there have been numerous reports of pathological conditions in the hominid fossils , but these have only involved trauma or age-related deterioration in the health of otherwise normal individuals .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological conditions", "pos": [ 36, 59 ] }
{ "id": "C0868945", "name": "health", "pos": [ 157, 163 ] }
studies were made to determine whether fertilization and pregnancy were possible by mating at the time of induced estrus .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 39, 52 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 57, 66 ] }
whereas coii mrna expression is in step with the known modifications of brown-fat mitochondria content during the breeding cycle of the rat , ucp mrna expression appears to be diminished much earlier than the mitochondrial proton-conductance-pathway activity .
process_initiates_biological_process
{ "id": "C1515670", "name": "mrna expression", "pos": [ 13, 28 ] }
{ "id": "C1171362", "name": "ucp", "pos": [ 142, 145 ] }
we have quantified the expression of hl31 mrna in colorectal tumours and found overexpression in 23 out of 23 cases .
process_initiates_biological_process
{ "id": "C1515670", "name": "expression", "pos": [ 23, 33 ] }
{ "id": "C1514559", "name": "overexpression", "pos": [ 79, 93 ] }
in fact , cu , zn-superoxide dismutase activity is present at an approximately constant level until late embryonic development , while its mrna disappears soon after fertilization to be accumulated again only during the last part of embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 166, 179 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 233, 246 ] }
bovine follicular oocytes ( n = 454 ) , obtained after laparoscopy , were used to study in vitro capacitation , fertilization , and embryo development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 112, 125 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 132, 150 ] }
maturation , fertilization , and development studies were carried out in brackett 's defined medium or in ham 's f-10 .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 13, 26 ] }
{ "id": "C0678723", "name": "development", "pos": [ 33, 44 ] }
fertilization and concomitant establishment of pregnancy were reduced significantly , in a dose-dependent manner , only in those animals immunized with m29 igm ( e.g. , 4 mg m29 igm : 12.6 % of 304 eggs fertilized ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 0, 13 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 47, 56 ] }
the data support the hypothesis that unregulated amplification is a pathological process , occurring readily in neoplastic but rarely in normal cells , that together with other chromosomal disturbances contributes to the rapid evolution and progression of cancer .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological process", "pos": [ 68, 88 ] }
{ "id": "C0178874", "name": "progression", "pos": [ 241, 252 ] }
intercellular communication is a fundamental process in multicellular organisms developed to orchestrate homeostatic control of mitotic and differentiation processes in pre- and postmitotic cells .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 0, 27 ] }
{ "id": "C0007589", "name": "differentiation", "pos": [ 140, 155 ] }
fertilization and pregnancy correlated with prog production , in that granulosa-luteal cells associated with oocytes that were fertilized produced significantly ( p less than 0.001 ) less prog than those associated with nonfertilized oocytes .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 0, 13 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 18, 27 ] }
in 14 aspirates , after a similar pattern of growth , cell proliferation began again after about 6 weeks , with a rapid appearance and growth of cell clumps from the feeder layer -- a type of growth typical of spontaneous lymphoblastoid cell lines .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 54, 72 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 192, 198 ] }
increased dox retention could be observed even after brief exposure to cebs and washout and correlates with a decrease in cell proliferation over a 3-day growth assay .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 122, 140 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 154, 160 ] }
the similar des-like inhibitory effect on the growth of the prostate was achieved by keeping animals from fertilization throughout the pregnancy until weaning on diet containing soy , rich in environmental estrogens .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 106, 119 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 135, 144 ] }
this article concerns the following points : impregnation , formation of the human embryo , eve 's creation , indirect fecundation and spermatic pollution , bi-sexuality of the first man , libido , signs of virginity , female infertility , incest , multiparity , post-menopausal conception , the fructifying powers of amulets , plants and seeds , the course of pregnancy and antenatal care , normal and difficult labour , premature birth ( was moses premature ? ) , perineal tears , the first birth without pain , twin pregnancy , procidentias , breech delivery , maternal deaths , midwives and pharaoh , nursing , swaddling , breast-feeding and weaning of the baby .
process_initiates_biological_process
{ "id": "C0015914", "name": "fecundation", "pos": [ 119, 130 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 519, 528 ] }
gap junctional intercellular communication appears to be important in the regulation of cellular homeostasis , differentiated cell functions , and growth control in adult tissues .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 15, 42 ] }
{ "id": "C0007589", "name": "differentiated", "pos": [ 111, 125 ] }
u3 snrnps and nucleolar development during oocyte maturation , fertilization and early embryogenesis in the mouse : u3 snrna and snrnps are not regulated coordinate with other snrnas and snrnps .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 63, 76 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 87, 100 ] }
u3 small nuclear ribonucleic acids ( snrna ) and u3 small nuclear ribonucleoprotein ( snrnp ) , which are thought to be responsible for ribosomal rna processing , are quantitated and localized during oocyte maturation , fertilization , and early embryogenesis in the mouse .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 220, 233 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 246, 259 ] }
these changes in the redox balance of both low-molecular-weight thiols and protein-bound thiols correlate with cell proliferation and mostly precede the major growth phase .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 111, 129 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 159, 165 ] }
we concluded that subclinical lead administration exerts its effect by slowing cell proliferation in the very early growth phase of the brain .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 79, 97 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 116, 122 ] }
nhps are synthesized de novo in the chromosomes after fertilization providing genetic function of the chromosomes in the development and differentiation of cell systems in new generation of organisms .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 54, 67 ] }
{ "id": "C0678723", "name": "development", "pos": [ 121, 132 ] }
the concentrations of immunoreactive hcg , fsh , and prl were correlated with the degree of maturation of the oocyte-corona-cumulus complex mass ( occc ) , fertilization , rate of cleavage , and the incidence of pregnancy after embryo transfer .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 156, 169 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 212, 221 ] }
these discrepancies are interpreted as an indication that prenatal selection associated with abo incompatibility may operate at various stages from fertilization through pregnancy , and that different incompatible combinations may be subject to selection at different stages .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 148, 161 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 170, 179 ] }
however , there was no obvious association between fertilization and cleavage of human oocytes and the quality of the medium ascertained by the mouse embryo development test .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 51, 64 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 150, 168 ] }
fats are synthetized in oleaginous seeds according to the following diagram : lipid synthesis , very slow immediately after fecundation , becomes very intensive between the second and the fifth weeks after florescence and is reduced to zero at the end of maturation .
process_initiates_biological_process
{ "id": "C0015914", "name": "fecundation", "pos": [ 124, 135 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 255, 265 ] }
the results at four steps in the procedure can be analysed : the rate of oocyte collection is 85 to 90 per cent , the rate of fertilization , 80 to 90 per cent , the rate of embryo development , 50 to 70 per cent , and the pregnancy rate per laparoscopy , 4 to 13 per cent .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 126, 139 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 174, 192 ] }
a potassium concentration of 115 mm was used in experiments with synchronized cells since at that level cell proliferation is almost completely halted , recovery of growth is rapid and complete , and the membrane potential is reduced to a level well below that normally found in cells in the g1 phase .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 104, 122 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 165, 171 ] }
ultrastructural investigations have been carried out on parthenogenetic rabbit eggs in an effort to elucidate events occurring during artificial activation and their similarity to processes of fertilization and embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 193, 206 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 211, 224 ] }
cell multiplication occurred during 38 % of the growth cycle in populations synchronized in this manner .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 0, 19 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 48, 54 ] }
after an initial delay in the increase in the cell numbers during the period of rapid growth the total number of cells shows a dose dependent decrease at the plateau stage of the ascites growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "in", "pos": [ 9, 11 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 187, 193 ] }
s17 supports myelopoiesis and the differentiation of early b cell precursors into b lymphocytes while s10 supports myeloid cell differentiation and not b lymphopoiesis .
process_initiates_biological_process
{ "id": "C0525006", "name": "myelopoiesis", "pos": [ 13, 25 ] }
{ "id": "C1622499", "name": "myeloid cell", "pos": [ 115, 127 ] }
the irradiated cell proliferation expressed as the percentage of the non-irradiated control growth on the third and seventh days , respectively , after beta irradiation was : 97 % and 96 % after 30 rads ;
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 15, 33 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 92, 98 ] }