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parallel to the high expression of h-ras mrna in the transformants we document overexpression of rat alpha-tgf mrna .
process_initiates_biological_process
{ "id": "C1515670", "name": "expression", "pos": [ 21, 31 ] }
{ "id": "C1514559", "name": "overexpression", "pos": [ 79, 93 ] }
the effect of a carbon dioxide ( co2 ) pneumoperitoneum and its duration on rabbit follicular oocytes was assessed by evaluating fertilization and subsequent embryonic development rates .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 129, 142 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 158, 179 ] }
the pf environment is one that hosts the processes of ovulation , gamete transportation , fertilization , and early embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 90, 103 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 116, 137 ] }
thus , c-mos is expressed in both male and female germ cells , suggesting possible roles for this protooncogene in meiosis , germ-cell development , fertilization , and early embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 149, 162 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 175, 188 ] }
ova collected between 7 and 22 h post coitum ( pc ) were examined for evidence of fertilizing sperm , cellular changes accompanying fertilization , and pronuclear development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 132, 145 ] }
{ "id": "C0678723", "name": "development", "pos": [ 163, 174 ] }
such a reduction in ph may affect fertilization and early embryonic development and this study was carried out to study these effects .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 34, 47 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 58, 79 ] }
uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathologic conditions", "pos": [ 87, 108 ] }
{ "id": "C0027627", "name": "tumor metastases", "pos": [ 119, 135 ] }
at and shortly after ovulation , the presence of a probe stimulates , by an unknown mechanism , an increase in the oxygen tension in the oviductal fluid which provides an environment sufficiently well-oxygenated for gamete survival , fertilization , and subsequent further development of the embryo .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 234, 247 ] }
{ "id": "C0013936", "name": "development", "pos": [ 273, 284 ] }
in two cases examined using immunohistochemistry , we were able to correlate the increased expression of the mrna with an increase in protein expression .
process_initiates_biological_process
{ "id": "C1515670", "name": "expression", "pos": [ 91, 101 ] }
{ "id": "C1171362", "name": "protein expression", "pos": [ 134, 152 ] }
the drugs added within 1 min . after the raising of the fertilization layer had stronger effects on cleavage and development ;
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 56, 69 ] }
{ "id": "C0678723", "name": "development", "pos": [ 113, 124 ] }
cell proliferation may , however , be associated with an episodic growth of lesions , and growth factor-mediated responses could , therefore , be important for the eventual clinical outcome in the individual patient .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 0, 18 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 90, 96 ] }
there is no difference in the basic pathological process of sclerotic or lytic metastases , the radiographic appearance purely indicating the net balance between the different types of bone formation and the simultaneous progressive bone destruction .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological process", "pos": [ 36, 56 ] }
{ "id": "C0027627", "name": "metastases", "pos": [ 79, 89 ] }
after fertilization in vitro and transfer into the tube the embryone development occurs in the physiological milieu of the oviduct .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 6, 19 ] }
{ "id": "C0678723", "name": "development", "pos": [ 69, 80 ] }
thiouracil administered after fertilization either prevented embryogenesis , or retarded it , the sporophytes then being deformed and often showing a tendency to produce gametophytic tissue .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 30, 43 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 61, 74 ] }
since melatonin , the major hormone of the pineal gland , has been shown to inhibit the growth of mammary tumors in animal models of human breast cancer , we examined the hypothesis that this indoleamine has the potential to inhibit breast cancer growth by directly inhibiting cell proliferation as exemplified by the growth of the estrogen-responsive human breast cancer cell line mcf-7 in culture .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 277, 295 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 318, 324 ] }
the increase in integrin mrna at a specific point in cell proliferation may be correlated with growth-signal transduction .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 53, 71 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 95, 101 ] }
because the regulation of oogenically accumulated actin is important in various processes of oogenesis , egg formation , fertilization and early embryogenesis , we have purified and characterized the major actin-binding proteins present in oocytes of xenopus laevis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 121, 134 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 145, 158 ] }
it has not been ascertained , however , whether this increase in the fertilization rate is due to extrusion of the first polar body ( meiotic maturation ) during this period , or to some conclusive cytoplasmic maturation subsequent to the polar body extrusion .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 69, 82 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 210, 220 ] }
in order to elucidate the role of this oxygen-dependent anabolic process in the arrest of cell proliferation under anaerobic culture conditions , the effect of the antimetabolite dihydro-5-azaorotic acid on growth , metabolism and cell cycle distribution of ehrlich ascites tumor cells was studied and compared with the effect of oxygen-free culture conditions .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 90, 108 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 207, 213 ] }
the number of oocytes undergoing normal fertilization was increased to about 50 % by ( i ) delaying the addition of su10603 until the last 8 h of the maturation period or ( ii ) adding exogenous steroids to follicles cultured with inhibitor from explantation .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 40, 53 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 150, 160 ] }
observations that ttx does not prevent serum-activated na+ influx , initiation of dna synthesis and cell proliferation suggest that the fast na+ channel which we have identified in fibroblasts is not involved in growth control .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 100, 118 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 212, 218 ] }
to evaluate the possibility that simply increasing the number of gametes at the site of fertilization might account for pregnancies attributed to ivf-et and gift , the authors retrospectively analyzed the outcome of couples undergoing iui during hmg cycles between 1983 and 1986 in women with normal pelvic anatomy .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 88, 101 ] }
{ "id": "C0032961", "name": "pregnancies", "pos": [ 120, 131 ] }
in regards to the follicular fluid constituents , the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 109, 122 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 127, 136 ] }
however , under optimal conditions for cell proliferation , when glucocorticoid inhibited growth is relieved by the exogenous addition of platelet derived growth factor , androgen receptor augmentation is still suppressed .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 39, 57 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 155, 161 ] }
on the other hand , wheat bran , pectin , guar gum , and degraded carageenan all stimulate large bowel cell proliferation , the greatest growth response tending to occur in the cecum or proximal colon .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 103, 121 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 137, 143 ] }
using an immune complex assay , we have measured the level of this c-src related protein kinase during fertilization and early embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 103, 116 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 127, 148 ] }
the highest concentration is seen up to 9 years of age , suggesting that egf promotes cell proliferation during growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 86, 104 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 112, 118 ] }
the mouse oocyte was used to determine whether t-mycoplasma or escherichia coli affects the fertilization and embryonal development of oocytes .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 92, 105 ] }
{ "id": "C0013936", "name": "embryonal development", "pos": [ 110, 131 ] }
[ of the dignity of nascent life . extracorporeal fertilization , heterologous pregnancy and genetic counseling . help from the german protestant church towards formation of ethical decisions ] .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 50, 63 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 79, 88 ] }
the early stages of murine b-cell differentiation are characterized by a series of immunoglobulin gene rearrangements which are required for the assembly of heavy ( h ) and light ( l ) -chain variable regions from germline gene segments .
process_initiates_biological_process
{ "id": "C0007589", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C1512666", "name": "immunoglobulin gene rearrangements", "pos": [ 83, 117 ] }
normotensive controls showed cell proliferation mainly from 21 to 28 days and cellular hypertrophy from 35 to 45 days with an absolute 33 % increase in the number of cells and a 26 % larger volume of the mean smooth muscle cell at 45 days of age . from 21 to 45 days , the above changes in cell size and number provoked an overall 104 % and 67 % growth of the muscle mass in sh and wk rats , respectively .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 29, 47 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 346, 352 ] }
a dose of 56 mg/kg significantly reduced , the fertilization rate 3 and 4 weeks after treatment but did not affect development of 2-cell embryos .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 47, 60 ] }
{ "id": "C0013936", "name": "development", "pos": [ 115, 126 ] }
frequency of fertilization and ability to form male pronuclei after in vitro maturation were found to be independent of both estrual stage and follicular size .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 13, 26 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 77, 87 ] }
the ad12-sv40 cells exhibited rapid cell proliferation to high cell densities and efficient growth in soft agar , but none of 15 transformed melanocyte and nevus cultures formed tumors when injected s.c. or under the renal capsule into athymic nude mice .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 36, 54 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 92, 98 ] }
high ic was observed among jtc-30 cells which showed a differentiated pattern when transplanted into nude mice .
process_initiates_biological_process
{ "id": "C1154413", "name": "ic", "pos": [ 5, 7 ] }
{ "id": "C0007589", "name": "differentiated", "pos": [ 55, 69 ] }
therefore , in this model of normal mouse embryo fibroblasts , while endogenous prostaglandins are not involved in the control of cell proliferation , exogenous pgs have the ability to alter fibroblast growth and pg synthesis .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 130, 148 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 202, 208 ] }
the high incidence of coupling early in development might reflect intercellular communication that contributes to the differentiation and growth of neostriatal neurons .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 66, 93 ] }
{ "id": "C0007589", "name": "differentiation", "pos": [ 118, 133 ] }
in recent years , technical advances have made preimplantational ectogenesis ( in vitro maturation , fertilization and early embryonic development ) more than a theoretical concept .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 101, 114 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 125, 146 ] }
it responded by cell multiplication to an equal extent when either water or dilute nutrients were added , but possibly was able to give a growth response to nutritive amendment when a concentrated nutrient addition was made .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 16, 35 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 138, 144 ] }
ninety-three carbohydrates were examined of which ( a ) 15 supported cell proliferation and ( b ) 42 were toxic or growth inhibitory .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 69, 87 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 115, 121 ] }
the seeds sown during the flight germinated , performed growth processes , formed vegetative and generative organs and , judging by the final result , they succeeded in fecundation , embryogenesis and ripening .
process_initiates_biological_process
{ "id": "C0015914", "name": "fecundation", "pos": [ 169, 180 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 183, 196 ] }
[ the effect of delayed insemination on fertilization in vitro and the development of human embryos ] .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 40, 53 ] }
{ "id": "C0013936", "name": "development", "pos": [ 71, 82 ] }
preincubation of intermediary preovulatory or immature oocytes had no beneficial effect on the fertilization rate and the development of embryos .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 95, 108 ] }
{ "id": "C0013936", "name": "development", "pos": [ 122, 133 ] }
fertilization and subsequent maturation of oospores capable of germination occurred only with the naturally occurring sterols .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 0, 13 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 29, 39 ] }
attention is drawn to the changes in maternal serum osmolality that accompany ovulation , fertilization and early embryogenesis , and the possible significance of those changes is discussed in relation to the sequence of development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 90, 103 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 114, 127 ] }
the proteins which become associated with the paternally derived chromatin during fertilization may be instrumental in its activation and in the dramatic structural metamorphosis of the sperm nucleus during pronuclear development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 82, 95 ] }
{ "id": "C0678723", "name": "development", "pos": [ 218, 229 ] }
an outline is given of the possible effect passive movement has on pathological conditions involving cervical nerve roots in order to cause a resolution of the condition .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological", "pos": [ 67, 79 ] }
{ "id": "C1514893", "name": "resolution", "pos": [ 142, 152 ] }
these observations imply that the initial morphological changes in the sperm nucleus after fertilization may very well be dependent on the state of maturation of eggs at the time of sperm entry .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 91, 104 ] }
{ "id": "C0678723", "name": "maturation", "pos": [ 148, 158 ] }
we conclude that a critical level of nad ( p ) h is essential to nuclear activation and that the increase of nad ( p ) h at fertilization must be included with the increase in calcium and ph as a causal agent in development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 124, 137 ] }
{ "id": "C0678723", "name": "development", "pos": [ 212, 223 ] }
daily incorporations of pulsed [ 3h ] thymidine in whole populations and microscopic observations of individual cell proliferation revealed a complex growth recovery for both survivors and dying cells .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 112, 130 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 150, 156 ] }
in view of the theory of autoregulation of cell multiplication in a growth organ , we attempted to inhibit renal tubular cell hyperplasia in the remaining kidney 48 hours after controlateral nephrectomy .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell multiplication", "pos": [ 43, 62 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 68, 74 ] }
these and other features of mouse oocytes treated with cytochalasin b are of interest in view of the involvement of the oocyte zona pellucida and plasma membrane during meiotic maturation , fertilization , and early embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 190, 203 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 216, 229 ] }
incorporation of [ 3h ] -thymidine and increase in dry weight were used as biochemical parameters for cell proliferation and growth respectively specific alkaline phosphatase activity and uptake of 45ca as the measure for mineralization .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 102, 106 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 125, 131 ] }
most of the maternally expressed genes have very early execution stages indicating translation before fertilization , but some are temperature sensitive late in embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 102, 115 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 161, 174 ] }
while advanced ovulation induced by an injection of the agent on the day of proestrus was followed by pregnancies occurring as frequently as those in spontaneous ovulation group , incidences of mating behavior , fertilization , and pregnancy were considerably reduced in the advanced ovulation group when induced by an injection of synthetic lh-rh during the early period of diestrus 2 .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 212, 225 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 232, 241 ] }
the study included 15 patients with normal spinal cord anatomy and 25 patients whose pathological conditions included canal stenosis , herniated discs , metastatic tumors , primary cord tumor , trauma , chiari malformations , syringomyelia , and developmental disorders .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological conditions", "pos": [ 85, 108 ] }
{ "id": "C0027627", "name": "metastatic tumors", "pos": [ 153, 170 ] }
it was shown that cell hypertrophy not associated with cell proliferation and polyploidy is of great importance for the reparative liver growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 55, 73 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 137, 143 ] }
the first group was characterized by rapid generalization of the pathological process and by the presence of marked symptoms of the involvement of the segmento-nuclear motoneurons and the pyramidal tracts whilst the second group largely manifested impairment of the anterior cornual motor cells and the spinal localization of the process throughout the course of the disease .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological process", "pos": [ 65, 85 ] }
{ "id": "C0242656", "name": "course of", "pos": [ 353, 362 ] }
aminopterin , another folic acid analog , had only a temporary effect on cell multiplication , followed by a return to exponential growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 73, 77 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 131, 137 ] }
these data provide direct evidence in support of the hypothesis that estrogenic follicles are the sole source of ova which undergo fertilisation and subsequently give rise to pregnancy in women .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilisation", "pos": [ 131, 144 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 175, 184 ] }
transferrin is essential for cell proliferation and it was suggested that it may trigger a proliferative response following its interaction with receptors , serving as a growth factor .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 29, 47 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 170, 176 ] }
the dynamics of hypoxic changes of an irreversible character in the brain of the newborn and the existence of chronic hypoxic encephalopathy with pronounced cellular devastation in the late period of asphyxia indicate common genesis of the pathological process in the brain , conditioning its progression .
process_initiates_biological_process
{ "id": "C0030660", "name": "pathological process", "pos": [ 240, 260 ] }
{ "id": "C0242656", "name": "progression", "pos": [ 293, 304 ] }
the results indicate that the rosette inhibition test can be used to detect fertilization , early embryonic death and continued pregnancy in sheep .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 76, 89 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 128, 137 ] }
finally , cell proliferation was not influenced by the growth conditions in the small stanzen areas and proceeded as in normal dishes or larger areas similarly stamped on the bottom of petri dishes .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 10, 28 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 55, 61 ] }
this material could persist after fertilization in the pronuclei until the resumption of transcription at the early stage of embryogenesis .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 34, 47 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 125, 138 ] }
effects of igf-i , rgh , fgf , egf and ncs on dna-synthesis , cell proliferation and morphology of chondrocytes isolated from rat rib growth cartilage .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 62, 80 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 134, 140 ] }
thus , the secretory cells of the baboon oviduct synthesize and secrete a family of estradiol-dependent oviduct-specific glycoproteins that may have potential functional significance during fertilization and embryo development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 190, 203 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 208, 226 ] }
the 33-kda fragment containing only the active-site domain , does not bind to the receptors and does not stimulate cell proliferation , while the 17-kda fragment , containing only the kringle and the growth-factor domains binds to the receptor but does not stimulate growth of the human epidermal cell line .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 115, 133 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 267, 273 ] }
the effect of pneumoperitoneum gases on fertilization , cleavage and pregnancy in human in-vitro fertilization and gamete intra-fallopian transfer .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 40, 53 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 69, 78 ] }
these include novel sequences ( b9 ) , genes previously known to be regulated during myelopoiesis ( c15 ) , as well as sequences not recognized previously as being associated with myeloid differentiation ( c9 ) .
process_initiates_biological_process
{ "id": "C0525006", "name": "myelopoiesis", "pos": [ 85, 97 ] }
{ "id": "C1622499", "name": "myeloid differentiation", "pos": [ 180, 203 ] }
lipoprotein lipase mrna expression in brown adipose tissue : translational and/or posttranslational events are involved in the modulation of enzyme activity .
process_initiates_biological_process
{ "id": "C1515670", "name": "mrna expression", "pos": [ 19, 34 ] }
{ "id": "C1519614", "name": "translational", "pos": [ 86, 99 ] }
this article concerns the following points : impregnation , formation of the human embryo , eve 's creation , indirect fecundation and spermatic pollution , bi-sexuality of the first man , libido , signs of virginity , female infertility , incest , multiparity , post-menopausal conception , the fructifying powers of amulets , plants and seeds , the course of pregnancy and antenatal care , normal and difficult labour , premature birth ( was moses premature ? ) , perineal tears , the first birth without pains , twin pregnancy , procidentias , breech delivery , maternal deaths , midwives and pharaoh , nursing , swaddling , breast-feeding and weaning of the baby .
process_initiates_biological_process
{ "id": "C0015914", "name": "fecundation", "pos": [ 119, 130 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 520, 529 ] }
in the hormone-dependent cancer cell lines ( mcf-7 and t-47d ) this anti-estrogen significantly decreased cell proliferation , but to reduce 50 % of the growth in the mcf-7 cells a very low concentration ( 10 ( -9 ) m ) is necessary .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 106, 124 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 153, 159 ] }
successful pregnancy in the female rat depends upon two sets of physiological events : ( 1 ) transport of gametes ( sperm and egg ) through the reproductive tract so that fertilization can be effected and ( 2 ) establishment of an appropriate hormonal environment ( progestational state ) so that the fertilized egg can implant in the uterus and be maintained during subsequent gestation .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 171, 184 ] }
{ "id": "C0032961", "name": "gestation", "pos": [ 378, 387 ] }
cell proliferation was markedly suppressed in the collagen lattice as compared with that on plastic , with growth being arrested after day 5 .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 0, 18 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 107, 113 ] }
we speculate that a critical level of cytosolic calcium , achieved by increased extracellular calcium or by achievement of intercellular communication established by cell-cell contact , may trigger mechanisms required for initiation of keratinocyte differentiation .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 123, 150 ] }
{ "id": "C1159909", "name": "keratinocyte differentiation", "pos": [ 236, 264 ] }
the guppy is an ovoviviparous teleost with fertilization and gestation occurring intrafollicularly , and ovulation and hatching at around parturition .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 43, 56 ] }
{ "id": "C0032961", "name": "gestation", "pos": [ 61, 70 ] }
f levels decreased significantly during fertilization followed by an increase during gestation and a sharp decline again at periparturition .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 40, 53 ] }
{ "id": "C0032961", "name": "gestation", "pos": [ 85, 94 ] }
attempts at in vitro fertilization-embryo transfer ( ivf-et ) for women with hypergonadotropic hypogonadism and bilateral tubal disease demonstrated a very low fertilization rate and no clinical pregnancies .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 21, 34 ] }
{ "id": "C0032961", "name": "pregnancies", "pos": [ 195, 206 ] }
it is concluded that the serum-free culture medium described and the testing for absence of cytotoxicity in a sensitive bioassay ( hybritest ) have yielded culture conditions capable of sustaining the development in vitro of human preembryos without impairing the fertilization process or the implantation rate , ultimately resulting in a significantly increased rate of deliveries/ongoing pregnancies and an apparently decreased abortion rate .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 264, 277 ] }
{ "id": "C0032961", "name": "pregnancies", "pos": [ 390, 401 ] }
fertilization of the oocytes but no subsequent pregnancy were seen in the other three couples .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 0, 13 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 47, 56 ] }
cell proliferation was measured with a 3h-tdr-incorporation-assay and a tumor-stem cell-assay , the fibroblast-proliferation was measured following growth as monolayer respectively .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell", "pos": [ 0, 4 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 148, 154 ] }
however , there was no obvious association between fertilization and cleavage of human oocytes and the quality of the medium ascertained by the mouse embryo development test .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 51, 64 ] }
{ "id": "C0013936", "name": "embryo", "pos": [ 150, 156 ] }
the pregnancy rates in the first two groups are satisfactory once fertilization has occurred , but there have been no ongoing pregnancies if there are circulating sperm immobilizing antibodies present in either the male or the female .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 66, 79 ] }
{ "id": "C0032961", "name": "pregnancies", "pos": [ 126, 137 ] }
comparative effects of a complete tumor promoter , tpa , and a second-stage tumor promoter , rpa , on intercellular communication , cell differentiation and cell transformation .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 102, 129 ] }
{ "id": "C0007589", "name": "cell differentiation", "pos": [ 132, 152 ] }
the present study was undertaken to define hormonal conditions for in vitro maturation that support subsequent fertilization and embryonic development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 111, 124 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 129, 150 ] }
nevertheless , this model system should facilitate further studies on oocyte maturation , fertilization , and early embryogenesis in primates .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 90, 103 ] }
{ "id": "C0013936", "name": "embryogenesis", "pos": [ 116, 129 ] }
in three estrogen receptor-positive , estrogen-responsive breast cancer cell lines ( mcf-7 , zr75-1 , and t47d ) , type i sr blockade with alpha-ir3 failed to block estrogen-stimulated dna synthesis or cell proliferation , indicating that secreted igf activity is not the sole mediator of the growth effects of estrogen .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 202, 220 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 293, 299 ] }
thirty-two patients undergoing in vitro fertilization ( ivf ) were given bromocriptine either 1 or 12 hours before anesthesia or received no drug to determine what effect suppression of transient , anesthesia-induced hyperprolactinemia would have on peripheral and follicular fluid hormones , fertilization and cleavage rates , and pregnancy .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 40, 53 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 332, 341 ] }
although these changes in hormonal milieu affected neither oocyte fertilization nor pregnancy rate in our ivf patients , they seemed to have a positive influence on embryonic development after ivf .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 66, 79 ] }
{ "id": "C0013936", "name": "embryonic development", "pos": [ 165, 186 ] }
the survival , fertilization , development , and viability in vitro and in vivo of unfertilized mouse eggs frozen by slow cooling to -36 degrees c or -80 degrees c in 1.5 m dimethyl sulphoxide ( dmso ) was examined in a series of experiments which explored some of the problems in freezing the egg .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 15, 28 ] }
{ "id": "C0678723", "name": "development", "pos": [ 31, 42 ] }
the response of these patients to exogenous gonadotropin stimulation , oocyte capture , fertilization , cleavage , and pregnancy was studied .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 88, 101 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 119, 128 ] }
thirty days ' suppression , compared with 15 days ' , resulted in the cancellation of more cycles and a lower fertilization and pregnancy percentage .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 110, 123 ] }
{ "id": "C0032961", "name": "pregnancy", "pos": [ 128, 137 ] }
however , these cells exhibit marked differences in the expression of the cation-independent and -dependent man 6-p receptors , perhaps reflecting differential roles of these receptors in protein trafficking and/or intercellular communication during germ cell differentiation .
process_initiates_biological_process
{ "id": "C1154413", "name": "intercellular communication", "pos": [ 215, 242 ] }
{ "id": "C0007589", "name": "differentiation", "pos": [ 260, 275 ] }
secretory products of the oviduct provide part of the milieu for the critical events of fertilization and embryo development .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 88, 101 ] }
{ "id": "C0013936", "name": "embryo development", "pos": [ 106, 124 ] }
a 2-part study was undertaken to determine the effect of bovine viral diarrhea ( bvd ) virus on fertilization and early development of embryos .
process_initiates_biological_process
{ "id": "C0015914", "name": "fertilization", "pos": [ 96, 109 ] }
{ "id": "C0013936", "name": "development", "pos": [ 120, 131 ] }
the function of afp is unknown , but recent studies suggest the possibility that it may have immunoregulatory properties and/or may influence cell proliferation and growth .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 142, 160 ] }
{ "id": "C0018270", "name": "growth", "pos": [ 165, 171 ] }
the mechanism by which a regenerative stimulus causes hepatocyte proliferation to lose its normal sensitivity to suppression by glucocorticoid , and thereby to exhibit a steroid insensitivity characteristic of other tissues in which cell proliferation reflects cell replenishment rather than normal growth , remains unknown .
process_initiates_biological_process
{ "id": "C0596290", "name": "cell proliferation", "pos": [ 233, 251 ] }
{ "id": "C0018270", "name": "normal growth", "pos": [ 292, 305 ] }
an active host recombination system did not seem to be indispensable for plasmid cotransduction , since reca+ and reca- donors gave similar cotransduction frequencies .
process_involves_gene
{ "id": "C0034865", "name": "recombination", "pos": [ 15, 28 ] }
{ "id": "C1419240", "name": "reca", "pos": [ 114, 118 ] }
the hydrolysis of 5,5'-dithiobis- ( 2-nitrobenzoic acid ) was studied at ph 9.20 and 25 degrees c in presence of tetradecyltrimethylammonium bromide or micellar tetradecyltrimethylammonium bromide .
process_involves_gene
{ "id": "C0020291", "name": "hydrolysis", "pos": [ 4, 14 ] }
{ "id": "C1335859", "name": "ph", "pos": [ 73, 75 ] }