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stringlengths 57
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dict |
|---|---|---|---|
specific phosphorylation pattern differences for wild-type and mutant proteins probably represented deletions of specific phosphate acceptor sites in the abl region . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
9,
24
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
154,
157
]
} |
repair of interstrand cross-links in dna of saccharomyces cerevisiae requires two systems for dna repair : the rad3 system and the rad51 system . | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
94,
104
]
} | {
"id": "C1419240",
"name": "rad51",
"pos": [
131,
136
]
} |
the recombination-repair system , represented by the rad51 mutation , is necessary for double-strand break repair following cross-link removal , but it has no role in the repair of monoadducts . | process_involves_gene | {
"id": "C1158512",
"name": "recombination-repair",
"pos": [
4,
24
]
} | {
"id": "C1419240",
"name": "rad51",
"pos": [
53,
58
]
} |
these data demonstrate that the representation of the t15 idiotype in the anti-pc immune response is determined by genes outside both the mhc and igh genetic loci . | process_involves_gene | {
"id": "C0301872",
"name": "immune response",
"pos": [
82,
97
]
} | {
"id": "C0017351",
"name": "igh",
"pos": [
146,
149
]
} |
these results indicate that neither pmns nor circulating complement determine the ovp following intravitreous lps , and that the chemotactic activity present in aqueous humor at the height of the inflammatory response is not primarily c5a . | process_involves_gene | {
"id": "C1155266",
"name": "inflammatory response",
"pos": [
196,
217
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
235,
238
]
} |
evidence for multiple steps in neoplastic transformation of normal and preneoplastic syrian hamster embryo cells following transfection with harvey murine sarcoma virus oncogene ( v-ha-ras ) . | process_involves_gene | {
"id": "C0007621",
"name": "neoplastic transformation",
"pos": [
31,
56
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
185,
188
]
} |
complement activation as reflected by c3 , c4 , and c3d levels was studied in 56 patients following myocardial infarction , 13 with the postmyocardial infarction syndrome ( pmis ) ; | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
0,
21
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
52,
55
]
} |
removal of an ammonium sulfate fraction from reticulocyte lysates produces a proteolytic system markedly different from the whole lysate [ speiser , s. & etlinger , j. d. ( 1983 ) proc . natl acad . sci . usa 80 , 3577-3580 ] . | process_involves_gene | {
"id": "C0597304",
"name": "proteolytic",
"pos": [
77,
88
]
} | {
"id": "C1418943",
"name": "proc",
"pos": [
180,
184
]
} |
replication of the incfii plasmid nr1 is controlled by regulating the amount of synthesis of the repa1 initiator protein at both the transcriptional and translational levels . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
0,
11
]
} | {
"id": "C1419618",
"name": "repa1",
"pos": [
97,
102
]
} |
the genes which encode each of the individual wild-type or mutant regulatory components from the replication control region of nr1 have been cloned independently into pbr322 vectors , and their effects in trans , either individually or in various combinations , on plasmid incompatibility , stability , copy number , and repa1 gene expression have been defined . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
97,
108
]
} | {
"id": "C1419618",
"name": "repa1",
"pos": [
321,
326
]
} |
regulation of transcription of the repa1 gene in the replication control region of incfii plasmid nr1 by gene dosage of the repa2 transcription repressor protein . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
53,
64
]
} | {
"id": "C1419619",
"name": "repa2",
"pos": [
124,
129
]
} |
this results in transcriptional deregulation of the translocated c-myc oncogene , which is transcribed constitutively at elevated levels , while the normal c-myc oncogene on the uninvolved chromosome 8 is either silent or expressed at very low levels ( a.ar-r. and c.m.c. , unpublished results ) . | process_involves_gene | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
16,
31
]
} | {
"id": "C0086661",
"name": "myc",
"pos": [
158,
161
]
} |
one antiserum was made against a polypeptide overlapping the in vivo tyrosine phosphorylation site of murine p120gag-abl and what is believed to be a homologous tyrosine phosphorylation site of the predicted normal human c-abl gene product ( v-abl 263-280 ) . | process_involves_gene | {
"id": "C1519726",
"name": "tyrosine",
"pos": [
69,
77
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
244,
247
]
} |
immune complex kinase assays using conditions that allow the tyrosine phosphorylation of p120gag-abl showed that in vitro phosphorylation of p190 and p240 occurs primarily at tyrosine residues . | process_involves_gene | {
"id": "C1519726",
"name": "tyrosine phosphorylation",
"pos": [
61,
85
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
97,
100
]
} |
as a consequence of acyl lipids hydrolysis , destruction of some chlorophyll a-protein complexes ( cp1a , cp1 , cpa ) or monomerization of the oligomeric of light harvesting chlorophyll a/b protein complex ( lhcp ) was observed . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
32,
42
]
} | {
"id": "C1413662",
"name": "cpa",
"pos": [
112,
115
]
} |
hydrolysis of phosphatidylcholine by phospholipase a2 of synaptic membranes i n tris-chl buffer was stimulated by cyclic amp , cyclic gmp , cyclic cmp , cyclic ump and adenosine ( 0.1 mm ) . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
0,
10
]
} | {
"id": "C1416943",
"name": "phospholipase a2",
"pos": [
37,
53
]
} |
to clarify the role of gene products for genetic recombination which might be concerned in excision repair , the repair of dna lesions induced by ultraviolet ( uv ) irradiation was examined under non-growing conditions with a variety of recombination deficient ( rec- ) mutants of bacillus subtilis . | process_involves_gene | {
"id": "C0012899",
"name": "repair",
"pos": [
100,
106
]
} | {
"id": "C1424025",
"name": "rec",
"pos": [
263,
266
]
} |
the content of 5'-mononucleotides released during hydrolysis does not correspond to the calculated one based on the 3'-terminal nucleotide sequence of ms2 rna . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
50,
60
]
} | {
"id": "C1412206",
"name": "ms2",
"pos": [
151,
154
]
} |
these data suggest that intravascular complement activation leads to activation of neutrophils and their intrapulmonary capillary sequestration , and subsequent acute lung injury , which is associated with production and release of oxygen-derived free radicals by c5a-activated blood neutrophils . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
38,
59
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
264,
267
]
} |
the accumulation in normal oogenesis of mrnas for only three of the seven heat shock proteins indicates the existence of differential , possibly multiple controls of heat shock gene expression , and suggests that heat shock proteins hsp83 , hsp28 and hsp26 function in the oocyte or early embryo . | process_involves_gene | {
"id": "C0282498",
"name": "heat shock",
"pos": [
74,
84
]
} | {
"id": "C1333928",
"name": "hsp28",
"pos": [
241,
246
]
} |
functional human x mouse somatic cell hybrid clones secreting hprl were isolated in order to study hprl gene expression and regulation . | process_involves_gene | {
"id": "C1327616",
"name": "secreting",
"pos": [
52,
61
]
} | {
"id": "C1418938",
"name": "hprl gene",
"pos": [
99,
108
]
} |
human chromosome 6 was identified in hybrid cells secreting hprl , and the cells expressed human malic enzyme , a marker for this chromosome , thus confirming the chromosome assignment of the hprl gene . | process_involves_gene | {
"id": "C1327616",
"name": "secreting",
"pos": [
50,
59
]
} | {
"id": "C1418938",
"name": "hprl gene",
"pos": [
192,
201
]
} |
with phage mutants affected in their methylation potential , we show that phage-coded methyltransferase genes are interchangeable among the phages studied . | process_involves_gene | {
"id": "C0025723",
"name": "methylation",
"pos": [
37,
48
]
} | {
"id": "C1334751",
"name": "methyltransferase genes",
"pos": [
86,
109
]
} |
however , phosphorylation of the binary complex by hri prevents its dissociation by rf and , as a consequence , ternary complex formation is inhibited . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
10,
25
]
} | {
"id": "C1539340",
"name": "hri",
"pos": [
51,
54
]
} |
analysis of the proteins from chondrocytes infected with rous-associated virus 1 , a virus unable to induce cell transformation in vitro , indicated that the altered expression of the differentiated proteins in rous sarcoma virus-infected chondrocytes depended upon the action of src gene product . | process_involves_gene | {
"id": "C0007589",
"name": "differentiated",
"pos": [
184,
198
]
} | {
"id": "C0038085",
"name": "src gene",
"pos": [
280,
288
]
} |
seven mutants of haemophilus influenzae strain rd ( mmsa- ) have been isolated that are more sensitive to methyl methane sulfonate ( mms ) than recombination-deficient ( reca- ) mutants . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
144,
157
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
170,
174
]
} |
the hyper-recombination effect is abolished by an additional mutation in lexa that limits synthesis of reca protein and other gene products regulated by lexa repressor , and is not restored when increased synthesis of reca protein is facilitated by a recaoc mutation . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
10,
23
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
251,
255
]
} |
the repair of gamma-ray induced dna single and double-strand breaks was looked at in wild type and rad18-2 strains of the yeast saccharomyces cerevisiae using sucrose gradient centrifugation . | process_involves_gene | {
"id": "C0012899",
"name": "repair",
"pos": [
4,
10
]
} | {
"id": "C1425416",
"name": "rad18",
"pos": [
99,
104
]
} |
these results suggest a direct role for ssb in recombinational repair apart from and in addition to its role in facilitating induction of the reca-lexa regulon . | process_involves_gene | {
"id": "C1158512",
"name": "recombinational repair",
"pos": [
47,
69
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
142,
146
]
} |
these findings are consistent with an insertional mutagenesis model for tumorigenesis by mmtv , in which the integration of a provirus in a particular region of cellular dna may activate a neighboring oncogene . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
72,
85
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
201,
209
]
} |
recombination between the is50 sequences that flank tn5 has been found to occur readily after the transformation of e. coli reca strains with a plasmid that contains direct repeats of these sequences . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
0,
13
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
124,
128
]
} |
the r. meliloti reca protein can function in recombination and in response to dna damage when expressed in an e. coli reca host , and hybridization studies have shown that dna sequence homology exists between the reca gene of e. coli and that of r. meliloti . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
45,
58
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
213,
217
]
} |
we tested the hypothesis that pf4 , which is bound to the platelet surface after platelet activation and secretion , could promote the binding of viii : vwf and subsequent platelet agglutination . | process_involves_gene | {
"id": "C0032173",
"name": "platelet activation",
"pos": [
81,
100
]
} | {
"id": "C1336938",
"name": "vwf",
"pos": [
153,
156
]
} |
a microcomputer interface for computer-assisted monolayer experiments was developed , tested , and used for analysis of the enzymatic hydrolysis by pancreatic phospholipases a2 ( ec 3.1.1.4 ) of 1,2-didodecanoyl-sn-glycero-3-sulfate monitored under constant surface pressure . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
134,
144
]
} | {
"id": "C1418617",
"name": "pancreatic phospholipases a2",
"pos": [
148,
176
]
} |
a pair of derivatives of e. coli k-12 strain 343/113 was constructed which differed vastly in dna repair capacity ( uvr+/rec+ vs uvrb/reca ) , as a means of assessing dna damaging effects ; | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
94,
104
]
} | {
"id": "C1424025",
"name": "rec",
"pos": [
134,
137
]
} |
a pair of derivatives of e. coli k-12 strain 343/113 was constructed which differed vastly in dna repair capacity ( uvr+/rec+ vs uvrb/reca ) , as a means of assessing dna damaging effects ; | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
94,
104
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
134,
138
]
} |
a molecular model for conjugational recombination based on this idea is presented in terms of the known activities of reca and recbc products . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
36,
49
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
118,
122
]
} |
tranexamic acid did not reduce complement activation , measured by plasma concentrations of the complement c3 split product c3d . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
31,
52
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
124,
127
]
} |
glucagon ( 2.9 x 10 ( -7 ) m ) stimulated the phosphorylation of 15 polypeptides ( by approximately 20-50 % ) with major phosphorylation of proteins with mol wts of 138,000 , 93,000 , 53,000 , 49,000 , 35,000 , 27,000 and 15,000 in intact rat islets and also stimulated insulin release by 202 % . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
46,
61
]
} | {
"id": "C1705714",
"name": "wts",
"pos": [
158,
161
]
} |
the presence of intact rsf103 replication determinants between direct tn1deltaap repeats appears to accelerate this precise tnpr- and rec-independent breakdown . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
30,
41
]
} | {
"id": "C1424025",
"name": "rec",
"pos": [
134,
137
]
} |
the knowledge that the activation of complement and the generation of c5a is followed `` '' in vitro '' '' and possibly `` '' in vivo '' '' by a rapid granulocyte aggregation suggested to study the levamisole-dependent changes of granulocyte aggregation `` '' in vitro '' '' . | process_involves_gene | {
"id": "C0009528",
"name": "activation",
"pos": [
23,
33
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
70,
73
]
} |
however , the increased rate of metabolism can not be completely accounted for by the activity of the purified phenobarbital-inducible cytochrome p-450 isozyme 2 , even in the presence of cytochrome b5 . | process_involves_gene | {
"id": "C0025519",
"name": "metabolism",
"pos": [
32,
42
]
} | {
"id": "C1382176",
"name": "phenobarbital-inducible cytochrome p-450",
"pos": [
111,
151
]
} |
the gtp binding regions of p21 ras and a c-terminal cysteine involved in membrane anchoring are also present in ral ; | process_involves_gene | {
"id": "C1149035",
"name": "gtp binding",
"pos": [
4,
15
]
} | {
"id": "C0812284",
"name": "ral",
"pos": [
112,
115
]
} |
the transcript appears late in this differentiation process and is most abundant at a time when the f9 cells begin to express tissue-specific markers and the expression of another murine homeo box gene , m6 , has decreased . | process_involves_gene | {
"id": "C0007589",
"name": "differentiation",
"pos": [
36,
51
]
} | {
"id": "C0017347",
"name": "homeo box gene",
"pos": [
187,
201
]
} |
unlike the t cell activation induced by antibodies directed to the t3-t cell receptor ( ti ) complex or to t44 molecules , the anti-t11 mab-induced cell activation was not accompanied by surface modulation of the t11 antigen . | process_involves_gene | {
"id": "C1155065",
"name": "t cell activation",
"pos": [
11,
28
]
} | {
"id": "C1707096",
"name": "t44",
"pos": [
107,
110
]
} |
properties of spontaneous mitotic recombination occurring in the presence of the rad52-1 mutation of saccharomyces cerevisiae . | process_involves_gene | {
"id": "C1158501",
"name": "mitotic recombination",
"pos": [
26,
47
]
} | {
"id": "C1419243",
"name": "rad52",
"pos": [
81,
86
]
} |
however , about 70 % of the ljp patients suffer from a defect in chemotaxis , with their neutrophils responding poorly to bacterial chemotactic factors , synthetic chemotactic peptides , and complement fragments ( c5a ) . | process_involves_gene | {
"id": "C0008018",
"name": "chemotaxis",
"pos": [
65,
75
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
214,
217
]
} |
the data suggest that the activation of protein kinase c and/or coordinate elevation of intracellular calcium may provide at least one mechanism of signal transduction for the regulation of ifn-gamma gene transcription . | process_involves_gene | {
"id": "C0037083",
"name": "signal transduction",
"pos": [
148,
167
]
} | {
"id": "C1334085",
"name": "ifn-gamma gene",
"pos": [
190,
204
]
} |
the first mode was found in six tumors in which a moloney murine leukemia virus component had inserted in the same transcriptional orientation upstream of the 5'-most exon with v-myb homology ( ve1 ) . | process_involves_gene | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
115,
130
]
} | {
"id": "C0026900",
"name": "v-myb",
"pos": [
177,
182
]
} |
the results suggest that in pc12 cells c-fos transcription is activated by a protein-synthesis-independent mechanism , whereas c-myc stimulation requires new protein synthesis . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
45,
58
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
127,
132
]
} |
in the uninduced state , k562 cells show little or no class i gene expression but actively express the erythroid-specific gamma-globin gene as well as genes associated with cell proliferation , including the transferrin receptor , c-myc , and alpha-actin genes at both the surface protein and mrna levels , ifn-gamma induces class i and beta 2-microglobulin gene expression , but does not alter the expression of the gamma-globin , transferrin receptor , c-myc , or alpha-actin genes . | process_involves_gene | {
"id": "C0596290",
"name": "cell proliferation",
"pos": [
173,
191
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
455,
460
]
} |
enhanced tyrosine phosphorylation of cellular proteins is thus a feature shared by cells transformed by v-abl and cells expressing a rearranged bcr-abl gene . | process_involves_gene | {
"id": "C1519726",
"name": "tyrosine phosphorylation",
"pos": [
9,
33
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
148,
151
]
} |
oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
30,
43
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
117,
130
]
} |
in order to demonstrate a suspected complement activation in bronchial asthma , we measured the c3d ( split product of c3 ) and the c3d/c3 ratio in 73 adults . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
36,
57
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
132,
135
]
} |
the existence of a real complement activation in the joints of the three different patient groups was further proved by the elevated levels of c3 breakdown products ( c3d ) . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
24,
45
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
167,
170
]
} |
knowledge of these properties is critically important for understanding the clinical sequelae exhibited by patients undergoing extracorporeal circulation since we now know that both hemodialysis and cardiopulmonary bypass [ 28-30 ] procedures promote intravascular complement activation and c5a formation . | process_involves_gene | {
"id": "C0009528",
"name": "complement",
"pos": [
265,
275
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
291,
294
]
} |
plasma markers of platelet activation ( beta-thromboglobulin , btg ) and of endothelium activity ( factor viii/von willebrand factor , fviii/vwf ) and plasma renin activity ( pra ) were determined in 17 healthy normotensive volunteers and in 21 hypertensives without target-organ damage before and after mental stress ( a colour-word conflict test ) . | process_involves_gene | {
"id": "C0032173",
"name": "platelet activation",
"pos": [
18,
37
]
} | {
"id": "C1336938",
"name": "vwf",
"pos": [
141,
144
]
} |
anti-sense transcription within the c-myc locus was found to be constitutive under all these physiological states , thereby demonstrating that c-myc transcriptional control is strand specific . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
11,
24
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
143,
148
]
} |
we have recently demonstrated that human serum cohn fraction iv ( alpha-globulin enriched ) inhibits ligand binding at putative dopamine and serotonin2 receptors labeled by [ 3h ] spiroperidol in human brain ( andorn , pappolla , fox , klemens , and martello : proc . | process_involves_gene | {
"id": "C1517880",
"name": "ligand",
"pos": [
101,
107
]
} | {
"id": "C1418943",
"name": "proc",
"pos": [
261,
265
]
} |
an alternative , but not mutually exclusive , explanation would be that the insertional translocation prevents synthesis of a niia niad dicistronic transcript so that only that component of niia expression which is due to a monocistronic niia messenger can be induced by nitrate ( and nitrite ) in nis-5 strains . | process_involves_gene | {
"id": "C0220781",
"name": "synthesis",
"pos": [
111,
120
]
} | {
"id": "C1420204",
"name": "nis",
"pos": [
298,
301
]
} |
kinetic parameters for the hydrolysis of a number of physiologically important phosphoesters by purified human liver alkaline phosphatase have been determined . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
27,
37
]
} | {
"id": "C1412364",
"name": "liver alkaline phosphatase",
"pos": [
111,
137
]
} |
evidence is presented that the decreased opsonization of the k+ strains in normal serum is caused by a low rate of complement activation of the strains , with subsequent absence of c3b fixation or c3d fixation or both to the cell wall of the bacteria . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
115,
136
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
197,
200
]
} |
genes coding for proteins involved in signal transduction may be activated by point mutations in certain , important domains ( example : the ras-family ) . | process_involves_gene | {
"id": "C0037083",
"name": "signal",
"pos": [
38,
44
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
141,
144
]
} |
in this study , however , it was demonstrated that differentiation of strains with mic 's less than 0.5-1.56 micrograms/ml was possible when discs containing 1-10 micrograms of czon were used . | process_involves_gene | {
"id": "C0007589",
"name": "differentiation",
"pos": [
51,
66
]
} | {
"id": "C1335222",
"name": "mic 's",
"pos": [
83,
89
]
} |
by contrast , in msb-1 cells , which lack any c-myc rearrangements , transcription begins at the normal promoter in exon 1 and c-myc rna has a half-life of approximately 15 minutes . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
69,
82
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
127,
132
]
} |
to investigate further the role of individual dna polymerases in replication , we have isolated the polb gene on multicopy plasmids . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
65,
76
]
} | {
"id": "C1335230",
"name": "polb gene",
"pos": [
100,
109
]
} |
thus , in this system , tgf beta selectively reduced expression of certain genes associated with cell proliferation ( c-myc and kc ) , and at least part of the tgf beta effect was at a posttranscriptional level . | process_involves_gene | {
"id": "C0596290",
"name": "cell proliferation",
"pos": [
97,
115
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
118,
123
]
} |
transcription elongation factor sii interacts with a domain of the large subunit of human rna polymerase ii . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
0,
13
]
} | {
"id": "C1335231",
"name": "large subunit",
"pos": [
67,
80
]
} |
a radioimmunoassay for chick intestinal calcium-binding protein ( calbindin-d28k , cabp-28k ) has been developed in our laboratory with a detection limit of 0.3 ng/ml . | process_involves_gene | {
"id": "C1516144",
"name": "calcium-binding",
"pos": [
40,
55
]
} | {
"id": "C1419788",
"name": "cabp",
"pos": [
83,
87
]
} |
the smaller ligand-binding subunit generated by exposing cytosol to 0.5 m kcl sedimented at 4.9 +/- 0.62 s , had a stokes radius of 5.0 +/- 0.14 nm , and an apparent mr 104,000 +/- 12,000 . | process_involves_gene | {
"id": "C1517880",
"name": "ligand-binding",
"pos": [
12,
26
]
} | {
"id": "C1417249",
"name": "mr",
"pos": [
166,
168
]
} |
although most of these additives inhibited the cell growth , cytotoxic agents such as adriamycin , vincristine and ara-c did not affect the level of p210bcr/abl protein . | process_involves_gene | {
"id": "C0007595",
"name": "cell growth",
"pos": [
47,
58
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
157,
160
]
} |
the region required for induction of putp and puta expression by proline was located at the hpai site 182 bp upstream of the translational starting site of puta , suggesting that a sequence of dyad symmetry located 1 bp to the left of the hpai site is a candidate for the binding site of the puta gene product . | process_involves_gene | {
"id": "C1519614",
"name": "translational",
"pos": [
125,
138
]
} | {
"id": "C2984182",
"name": "1 bp",
"pos": [
215,
219
]
} |
tumorigenic transformation of rat fr3t3 fibroblasts carrying an activated myc oncogene requires subsequent mutational events . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenic transformation",
"pos": [
0,
26
]
} | {
"id": "C0086661",
"name": "myc",
"pos": [
74,
77
]
} |
a comprehensive peptide map of the oat phytochrome subunit is presented , which incorporates the results of these proteolytic studies with the recent , yet unpublished sequence analyses of avena phytochrome cdna clones which show the n-terminal localization of the chromophore binding site ( hershey , h. p. , colbert , j. t. , lissemore , j. l. , barker , r. f. , and quail , p. h. ( 1984 ) proc . natl . acad . sci . u.s.a. 81 , 2332-2336 ) . | process_involves_gene | {
"id": "C0597304",
"name": "proteolytic",
"pos": [
114,
125
]
} | {
"id": "C1418943",
"name": "proc",
"pos": [
392,
396
]
} |
the activity responsible for the phosphorylation of the major phosphoproteins ( mol . wts . 120 000 , 115 000 and 72 000 ) of virions was found to be similar in its properties to the host enzyme casein kinase ii . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
33,
48
]
} | {
"id": "C1705714",
"name": "wts",
"pos": [
86,
89
]
} |
competition experiments indicate a substrate specificity of specific 3h-ro 5-4864 binding similar to the properties already demonstrated for the specific binding of this ligand to peripheral benzodiazepine binding sites in many other tissues . | process_involves_gene | {
"id": "C1517880",
"name": "binding",
"pos": [
82,
89
]
} | {
"id": "C1823521",
"name": "peripheral benzodiazepine binding sites",
"pos": [
180,
219
]
} |
hydrolytic activities of human pancreatic phospholipase a2 and endotoxin-stimulated endogenous phospholipase a2 toward membrane phospholipids of erythrocytes . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolytic",
"pos": [
0,
10
]
} | {
"id": "C1418617",
"name": "pancreatic phospholipase a2",
"pos": [
31,
58
]
} |
the remarkable similarities of these two proteins with respect to cis-acting autophosphorylation , trans-acting phosphorylation of exogenous substrates , and kinase inhibition , using site-directed abl-specific antisera , suggested that c-abl p210 could function similarly to v-abl in vivo . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
81,
96
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
278,
281
]
} |
arrhenius plots of hydrolysis of pyrenephospholipids by porcine pancreatic phospholipase a2 revealed no discontinuities , thus indicating the absence of phase transition for these lipids in the temperature range 15-45 degrees c . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
19,
29
]
} | {
"id": "C1418617",
"name": "pancreatic phospholipase a2",
"pos": [
64,
91
]
} |
nuclear run-on assays showed that e1 transcription , as well as transcription of c-fos , c-myc , and beta-actin was stimulated in 293 cells within 30 min of tpa exposure and returned to basal levels by 60 min . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
37,
50
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
89,
94
]
} |
we suggest that modulation of cellular enhancer activity could play a key role in tumorigenesis by oncogenes . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
82,
95
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
99,
108
]
} |
dimethylsulfoxide at concentrations used in the 2-aminofluorene acetylation assay in earlier studies , inhibited the a/j liver n-acetyltransferase to a greater extent than the c57bl/6j enzyme , which may have contributed to the larger difference in liver nat activity with 2-aminofluorene reported previously . | process_involves_gene | {
"id": "C0001038",
"name": "acetylation",
"pos": [
64,
75
]
} | {
"id": "C0796518",
"name": "nat",
"pos": [
255,
258
]
} |
this was observed neither in cells which expressed one of the oncogenes responsible for the terminal stages of tumorigenic transformation ( polyoma virus pmt ( middle t protein ) , mutated ras genes ) , nor in cell lines carrying oncogenes of both types . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenic transformation",
"pos": [
111,
137
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
230,
239
]
} |
the activation of complement , as indicated by the release of anaphylatoxins ( c3a and c5a ) , reduced activity of whole complement , and decreased levels of c3 , c4 , and c5 in plasma , was evaluated . | process_involves_gene | {
"id": "C0009528",
"name": "activation",
"pos": [
4,
14
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
87,
90
]
} |
since covalent attachment of pk 14105 totally precludes the binding of other ligands to this binding site , it is suggested that , during ultraviolet irradiation , this compound inserts covalently into the binding domain of the peripheral-type benzodiazepine-binding site . | process_involves_gene | {
"id": "C1517880",
"name": "binding",
"pos": [
60,
67
]
} | {
"id": "C1823521",
"name": "binding",
"pos": [
259,
266
]
} |
a strong correlation was shown between levels of aggregated igg bearing c3d and complement activation , as judged by c3d levels . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
80,
101
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
117,
120
]
} |
egf per 1 microgram of protein and stimulated protein phosphorylation of the 170 kd protein in nrk cell membranes . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
54,
69
]
} | {
"id": "C1538486",
"name": "nrk",
"pos": [
95,
98
]
} |
phosphorylation of p210bcr-abl in an immune complex kinase assay using an anti-v-abl peptide serum was observed in blast cells from four philadelphia chromosome ( ph1 ) -positive cml patients in blast crisis . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
0,
15
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
81,
84
]
} |
in addition to the previously reported p210 and p190 abl-related proteins , a novel mr 53,000 protein was found to undergo phosphorylation at serine and tyrosine in immune complex kinase assays of two blast crisis cml cell lines ( k562 and em2 ) and in samples from blast crisis patients in which p210bcr-abl was detected . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
123,
138
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
305,
308
]
} |
a degree of transcription elevation varies among the tested genes : c-src , c-ha-ras and c-sis , c-myc . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
12,
25
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
97,
102
]
} |
unlike transcriptional regulation , periodic posttranscriptional regulation appears to operate on a clock which is independent of events in the mitotic dna cycle . | process_involves_gene | {
"id": "C1158770",
"name": "transcriptional regulation",
"pos": [
7,
33
]
} | {
"id": "C1413503",
"name": "clock",
"pos": [
100,
105
]
} |
dna-repair-proficient and various dna-repair-deficient ( uvrb , uvrd , recb and reca ) strains of escherichia coli were transformed by the damaged plasmids and the ratios of the transformation frequencies of cells by damaged plasmids relative to those by untreated plasmids were determined . | process_involves_gene | {
"id": "C0012899",
"name": "dna-repair",
"pos": [
0,
10
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
80,
84
]
} |
this 'alternative pathway ' of t-cell activation was observed in vitro in response to combinations of anti-cd2 monoclonal antibodies ( mabs ) that bind to distinct epitopes of cd2 , such as mabs against t11 ( 2 ) plus t11 ( 3 ) . | process_involves_gene | {
"id": "C1155065",
"name": "t-cell",
"pos": [
31,
37
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
176,
179
]
} |
thus , one of the signals required for t-cell activation through the alternative pathway is provided by the interaction of cd2 with a naturally occurring complementary cell-surface molecule . | process_involves_gene | {
"id": "C1155065",
"name": "t-cell activation",
"pos": [
39,
56
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
123,
126
]
} |
prevention of tumorigenesis of oncogene-transformed rat fibroblasts with dna site inhibitors of poly ( adp ribose ) polymerase . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
14,
27
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
31,
39
]
} |
the kinetics and pharmacological properties of the binding of this ligand are similar to peripheral-type benzodiazepine binding sites elsewhere . | process_involves_gene | {
"id": "C1517880",
"name": "binding",
"pos": [
51,
58
]
} | {
"id": "C1823521",
"name": "peripheral",
"pos": [
89,
99
]
} |
this prospective study demonstrated complement activation in vivo in all burned patients , measured by c3d/c3 ratio index which was not related to the extent of the burned surface . | process_involves_gene | {
"id": "C0009528",
"name": "complement",
"pos": [
36,
46
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
103,
106
]
} |
thermodynamics and kinetics of the hydrolysis of the reactive-site peptide bond in pancreatic trypsin inhibitor ( kunitz ) by dermasterias imbricata trypsin 1 . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
35,
45
]
} | {
"id": "C1418965",
"name": "trypsin 1",
"pos": [
149,
158
]
} |
thus , the regulation of transcription and translation of threonine and isoleucine-valine operons depends upon the allelic state of the rela gene . | process_involves_gene | {
"id": "C1158770",
"name": "regulation",
"pos": [
11,
21
]
} | {
"id": "C1335610",
"name": "rela gene",
"pos": [
136,
145
]
} |
it has been suggested that plasmid r1 replication is under negative control by an r1-mediated repressor protein . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
38,
49
]
} | {
"id": "C1335648",
"name": "r1",
"pos": [
82,
84
]
} |
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