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these results suggest that ( i ) only one dna-binding site is sufficient for the reca protein to promote the processive unwinding ( the ability of the protein to form spontaneous filaments is closely related to this process ) and that ( ii ) two dna-binding sites on each of the reca polypeptides or those composed of a dimer ( or oligomer ) of the polypeptide are required for the reca protein to promote both the conjunction of parental dna molecules and the homologous pairing ( the ability to form the spontaneous filaments is not essential to this process ) . | process_involves_gene | {
"id": "C1148673",
"name": "dna-binding",
"pos": [
42,
53
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
382,
386
]
} |
glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene . | process_involves_gene | {
"id": "C0007621",
"name": "neoplastic transformation",
"pos": [
24,
49
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
122,
134
]
} |
host response using this model can be predictive of clinical response in atopic diseases such as allergic rhinitis and urticaria . | process_involves_gene | {
"id": "C0301872",
"name": "host response",
"pos": [
0,
13
]
} | {
"id": "C1334103",
"name": "allergic rhinitis",
"pos": [
97,
114
]
} |
and ( iv ) pts protein-hpr interactions influence the conformation of hpr , thereby retarding or stimulating the rate of kinase-catalyzed seryl-46 phosphorylation . | process_involves_gene | {
"id": "C0872079",
"name": "protein",
"pos": [
15,
22
]
} | {
"id": "C1337105",
"name": "hpr",
"pos": [
70,
73
]
} |
the study of the sos-response in the cells which are deficient in genes for repair and recombination has shown that induction is significantly suppressed in the mutants reca , lexa and recf ; | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
87,
100
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
169,
173
]
} |
for any particular induced type of microsomes the substrate with the fastest metabolism was not necessarily the substrate whose metabolism was induced the most , so that in order to characterize each of the 5 different inducers ( pb , mc/bnf , aro , iso , skf ) it was necessary to compare both the degrees of induction and the specific activities of the reactions . | process_involves_gene | {
"id": "C0025519",
"name": "metabolism",
"pos": [
77,
87
]
} | {
"id": "C1366496",
"name": "aro",
"pos": [
244,
247
]
} |
cholinesterases are primarily involved in drug hydrolysis in the plasma , arylesterases in the plasma and red blood cells , and carboxylesterases in the liver , gut and other tissues . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
47,
57
]
} | {
"id": "C1413347",
"name": "carboxylesterases",
"pos": [
128,
145
]
} |
using temperature sensitive prp19.6 replication , hfr strains have been obtained by integration of the plasmid into the chromosome of e. coli rec+ and reca- cells and their properties were studied . | process_involves_gene | {
"id": "C0598312",
"name": "replication",
"pos": [
36,
47
]
} | {
"id": "C1424025",
"name": "rec",
"pos": [
151,
154
]
} |
our results indicate that a biological activity , neurite extension , which is critical for the development of the nervous system , is associated with a disulfide form of s100 beta . | process_involves_gene | {
"id": "C0598282",
"name": "development",
"pos": [
96,
107
]
} | {
"id": "C1419790",
"name": "s100 beta",
"pos": [
171,
180
]
} |
here we demonstrate that although the rat and human gh genes alone do not restore growth in transgenic mutants , a metallothionein-rat growth hormone fusion gene ( mt-rgh ) does . | process_involves_gene | {
"id": "C0018270",
"name": "growth",
"pos": [
82,
88
]
} | {
"id": "C1333673",
"name": "growth hormone",
"pos": [
135,
149
]
} |
the analyses also suggest that the gene 44-62 translational unit harbors a stable rna structure that obligates translational coupling of these two genes . | process_involves_gene | {
"id": "C1519614",
"name": "translational",
"pos": [
46,
59
]
} | {
"id": "C1336806",
"name": "translational",
"pos": [
111,
124
]
} |
rf , a high molecular weight cell supernatant factor , reverses protein synthesis inhibition in heme-deficient reticulocyte lysates and also reverses hri inhibition of ternary complex formation . | process_involves_gene | {
"id": "C1519619",
"name": "protein synthesis inhibition",
"pos": [
64,
92
]
} | {
"id": "C1539340",
"name": "hri",
"pos": [
150,
153
]
} |
results of two-factor crosses in reca genetic background and structural analysis of recombination products suggest that strand exchange occurs in the absence of a functional reca gene . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
84,
97
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
174,
178
]
} |
this segment also promotes site-specific recombination : when cloned in pbr322 it promotes multimer formation in a reca- strain . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
41,
54
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
115,
119
]
} |
the influence of bile salts was thus similar to that which has earlier been described for the hydrolysis of phosphatidylcholine ( pc ) with pig pancreatic phospholipase a2 . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
94,
104
]
} | {
"id": "C1418617",
"name": "pancreatic phospholipase a2",
"pos": [
144,
171
]
} |
these results suggest that the novel vitamin d3 derivatives , 26-homo-delta 22-1 alpha,25 ( s ) - ( oh ) 2d3 and 26-homo-delta 22-1 alpha,25 ( r ) - ( oh ) 2d3 , have preferential activity in inducing phenotypic differentiation and in inducing cell proliferation related c-myc mrna activity . | process_involves_gene | {
"id": "C0596290",
"name": "cell proliferation",
"pos": [
244,
262
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
271,
276
]
} |
a model depicting possible relationships between ligand binding sites on brain hexokinase , and how their interactions might lead to observed regulatory properties , is developed based on these and previous studies of ligand binding as well as evidence that mammalian hexokinases ( mr 100,000 ) have evolved by duplication and fusion of a gene coding for an ancestral hexokinase with mr 50,000 and which , like the mammalian enzyme , was sensitive to inhibition by glc-6-p . | process_involves_gene | {
"id": "C1517880",
"name": "ligand binding",
"pos": [
49,
63
]
} | {
"id": "C1417249",
"name": "mr",
"pos": [
384,
386
]
} |
multidrug resistance phenotype of human bro melanoma cells transfected with a wild-type human mdr1 complementary dna . | process_involves_gene | {
"id": "C0242640",
"name": "multidrug resistance",
"pos": [
0,
20
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
94,
98
]
} |
since antigen presentation in thyroid autoimmunity is still a matter of debate , we studied the presence of antigen-presenting dendritic cells in the thyroid of the bb/o rat during the development of the disease in relation to the presence of other leucocytes and the aberrant expression of class ii mhc determinants by thyrocytes . | process_involves_gene | {
"id": "C0206431",
"name": "antigen presentation",
"pos": [
6,
26
]
} | {
"id": "C0017349",
"name": "class ii mhc",
"pos": [
291,
303
]
} |
to determine if the complex undergoes internalization , its susceptibility to hydrolysis by trypsin at 2 c was measured . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
78,
88
]
} | {
"id": "C1418970",
"name": "trypsin",
"pos": [
92,
99
]
} |
preincubation of normal pmn with iga from the patient 's serum ( 0.5 mg/ml ) inhibited chemotaxis to c5a and to the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) by 80 % , while iga or igg from pooled human serum and igg from the patient were without effect . | process_involves_gene | {
"id": "C0008018",
"name": "chemotaxis",
"pos": [
87,
97
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
101,
104
]
} |
the ability of cam-oct plasmid to suppress the recombination deficiency in reca mutants was tested by assaying for bacteriophage f116l-generalized transduction of a tn7 insertion in the alkane utilization genes of cam-oct . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
47,
60
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
75,
79
]
} |
neither dtt nor h2o2 treatment of cells could induce significant reca transcription in the absence of uv-radiation , implying that both agents modify reca activity primarily by interfering with repair of reca-inducing dna lesions . | process_involves_gene | {
"id": "C0012899",
"name": "repair",
"pos": [
194,
200
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
204,
208
]
} |
these results suggest that the ras protein is an upstream effector of plc activity in phosphoinositide-specific signal transduction and that plc-gamma activity is necessary for ras-mediated induction of dna synthesis . | process_involves_gene | {
"id": "C0037083",
"name": "signal transduction",
"pos": [
112,
131
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
177,
180
]
} |
while ghf-1 transcripts were detected within 24 hr of the first observable events in anterior pituitary differentiation , no ghf-1 protein could be detected until about 3 days later . | process_involves_gene | {
"id": "C0007589",
"name": "differentiation",
"pos": [
104,
119
]
} | {
"id": "C1418759",
"name": "ghf-1",
"pos": [
125,
130
]
} |
to analyze the fibre differentiation response of lens epithelial cells in later life , we compared the fibre differentiation responses of lens epithelia from 3- , 10- and 21-day- 14-week- , and 6-month-old rats to basic fibroblast growth factor ( bfgf ) . | process_involves_gene | {
"id": "C0007589",
"name": "differentiation",
"pos": [
21,
36
]
} | {
"id": "C0812296",
"name": "6",
"pos": [
194,
195
]
} |
dna and rna from 11 established nsclc cell lines ( 4 adenocarcinoma cell lines , 3 squamous cell carcinoma cell lines , 3 large-cell carcinoma cell lines and 1 mesothelioma cell line ) were isolated and analysed using the southern , dot blot and northern hybridization technique . c-myc rna expression was found in all nsclc cell line , l-myc expression only in 1 adenocarcinoma cell line , n-myc and c-myb expression in none of the 11 cell lines examined . | process_involves_gene | {
"id": "C0040649",
"name": "rna expression",
"pos": [
287,
301
]
} | {
"id": "C0812287",
"name": "n-myc",
"pos": [
391,
396
]
} |
the protein displayed a nuclear location and could still bind to dna , indicating that the n-terminal region retained dna-binding activity but was insufficient to produce characteristic v-erba changes in erythroblasts . | process_involves_gene | {
"id": "C1148673",
"name": "dna-binding",
"pos": [
118,
129
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
188,
192
]
} |
the results demonstrate that the mutated hormone-binding domain , in addition to the dna-binding region , is critical for v-erba biological and transcriptional control functions . | process_involves_gene | {
"id": "C1148673",
"name": "dna-binding",
"pos": [
85,
96
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
124,
128
]
} |
id is missing the basic region adjacent to the hlh domain that is essential for specific dna binding in another hlh protein , myod . | process_involves_gene | {
"id": "C1148673",
"name": "dna binding",
"pos": [
89,
100
]
} | {
"id": "C1417574",
"name": "myod",
"pos": [
126,
130
]
} |
with this method , hydrolytic ge activity was found to be increased in bronchoalveolar lavage fluid from patients with ards or pneumonia , synovial fluid from patients with rheumatoid arthritis , and blister fluid from burn patients . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolytic",
"pos": [
19,
29
]
} | {
"id": "C3538705",
"name": "ge",
"pos": [
91,
93
]
} |
comparison of initial ( early-phase ) and terminal ( late-phase ) sequence activation of complement by agarose beads and endotoxin was evaluated in an enzyme immunoassay ( eia ) of serum levels of c3c and c9 neoepitopes , respectively . | process_involves_gene | {
"id": "C0009528",
"name": "activation",
"pos": [
75,
85
]
} | {
"id": "C1332656",
"name": "c3c",
"pos": [
197,
200
]
} |
exposure of neutrophils to granulocyte macrophage-csf ( gm-csf ) increases chemotaxis , phagocytosis and cytotoxicity and primes the cells for enhanced oxidative metabolism in response to stimuli , such as formylated oligopeptides derived from bacteria ( f-met-leu-phe ) and endogenous activated complement components ( c5a ) . | process_involves_gene | {
"id": "C0008018",
"name": "chemotaxis",
"pos": [
75,
85
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
320,
323
]
} |
rabbit thrombomodulin ( tm ) influences blood coagulation by serving as a cofactor for thrombin-induced protein c activation ( activity a ) , by directly affecting the procoagulant activity of thrombin ( activity b ) and by accelerating the inhibition of thrombin by antithrombin iii ( at iii ) ( activity c ) . | process_involves_gene | {
"id": "C0005778",
"name": "blood coagulation",
"pos": [
40,
57
]
} | {
"id": "C1414509",
"name": "cofactor",
"pos": [
74,
82
]
} |
the dna-binding , annealing and recombinational activities of purified reca-dna complexes stabilized by atp gamma s ( a slowly hydrolysable analog of atp ) are described . | process_involves_gene | {
"id": "C0034865",
"name": "recombinational",
"pos": [
32,
47
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
71,
75
]
} |
our experiments indicate that both dna binding sites within reca helical filaments can be occupied by either single- or double-stranded dna . | process_involves_gene | {
"id": "C1148673",
"name": "dna binding",
"pos": [
35,
46
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
60,
64
]
} |
measurement of plasma c3d provides a useful means of detecting in vivo complement activation , which may be involved in the pathogenesis of rheumatoid arthritis , but neither c3d levels nor any of the other variables correlated as closely with disease activity as did the serum crp concentration . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
71,
92
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
175,
178
]
} |
further studies have shown that bovine brain fibroblast growth factor is composed of three fragments derived by limited proteolysis from myelin basic protein ( westall , f. c. , lennon , v. a. , and gospodarowicz , d. ( 1978 ) proc . natl . acad . sci . u. s. a . 75 , 4675-4678 ) . | process_involves_gene | {
"id": "C0597304",
"name": "proteolysis",
"pos": [
120,
131
]
} | {
"id": "C1418943",
"name": "proc",
"pos": [
227,
231
]
} |
although the changes in the ratio of h chain forms , h and l synthesis , and cell viability take several days to occur , bmf will program significant later responses after only 1 or a few hr of interaction with target b cells . | process_involves_gene | {
"id": "C0007620",
"name": "cell",
"pos": [
77,
81
]
} | {
"id": "C1420809",
"name": "bmf",
"pos": [
121,
124
]
} |
phenytoin did not provoke leakage from neutrophils of the cytoplasmic enzyme , lactate dehydrogenase , and did not inhibit directed migration ( chemotaxis ) of neutrophils toward either fmlp or c5a . | process_involves_gene | {
"id": "C0008018",
"name": "chemotaxis",
"pos": [
144,
154
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
194,
197
]
} |
negative complementation of reca protein by reca1 polypeptide : in vivo recombination requires a multimeric form of reca protein . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
72,
85
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
116,
120
]
} |
recombination in vivo was studied in reca- heterozygous lacz merodiploids by performing beta-galactosidase assays after infection with lambda preca+ . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
0,
13
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
143,
147
]
} |
recombination as measured by beta-galactosidase production was a linear function of lambda peca+ multiplicity of infection ( moi ) when the strain contained a deletion of the chromosomal reca gene . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
0,
13
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
187,
191
]
} |
however , when the strain carried a reca1 missense allele , a higher lambda preca+ moi was required to obtain levels of recombination comparable to the delta ( reca ) strain , and the slope of the dose-response curve increased to approximately two . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
120,
133
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
160,
164
]
} |
it is proposed that negative complementation occurs in mixed tetramers of wild-type and missense reca polypeptides , and that in vivo recombination is a property of a multimeric form of reca protein . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
134,
147
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
186,
190
]
} |
these mutants were recombination deficient , lacked inducible repair , and were phenotypically similar to e. coli reca mutants . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
19,
32
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
114,
118
]
} |
according to this hypothesis , one role for recf in dna repair and recombination is to modulate reca activities to allow reca to participate in these recf-dependent processes . | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
52,
62
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
121,
125
]
} |
according to this hypothesis , one role for recf in dna repair and recombination is to modulate reca activities to allow reca to participate in these recf-dependent processes . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
67,
80
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
121,
125
]
} |
the experimental data can then be fitted satisfactorily assuming pk values of 5.7 and 8.5 for the two residues in the nonphosphorylated enzyme ( changing to 7.7 for one of the two residues , following phosphorylation ) and values of 50.0 and 0.58 for the equilibrium constants of the h2 ( e x hpo4 ) in equilibrium with h ( e-po3 ) + h2o and h ( e x hpo4 ) in equilibrium with e-po3 + h2o reactions , respectively . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
201,
216
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
385,
387
]
} |
cimetidine is shown to inhibit in vivo and in vitro the metabolism by both 3-methylcholanthrene-induced p1-450 and control forms of p-450 ; | process_involves_gene | {
"id": "C0025519",
"name": "metabolism",
"pos": [
56,
66
]
} | {
"id": "C0919425",
"name": "p1-450",
"pos": [
104,
110
]
} |
the chemical reactivity of the beta-lactam ring was estimated either by pseudo-first-order rate constants ( k ) of alkaline hydrolysis measured at ph 9.20 and 35.0 degrees c or by infrared stretching frequencies of the beta-lactam carbonyl measured in dimethyl sulfoxide . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
124,
134
]
} | {
"id": "C1335859",
"name": "ph",
"pos": [
147,
149
]
} |
complement activation was assessed by measurement of c3 conversion using crossed immunoelectrophoresis and by assessment of c5a using a leukocyte aggregation functional assay . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
0,
21
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
124,
127
]
} |
the phosphorylation of this antigen depends on the expression of the v-src gene and contains phosphotyrosine . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
4,
19
]
} | {
"id": "C0038085",
"name": "v-src gene",
"pos": [
69,
79
]
} |
in this paper , we present a detailed description of a third activity , single-stranded dna-dependent nucleoside 5'-triphosphate hydrolysis , and show that this activity is coupled to the unidirectional translocation of the gene 4 protein on single-stranded dna ( tabor , s. , and richardson , c.c . ( 1981 ) proc . natl . acad . sci . u. s. a . 78 , 205-209 ) . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
129,
139
]
} | {
"id": "C1418943",
"name": "proc",
"pos": [
309,
313
]
} |
erythropoietin is the primary regulator of the later stages in erythropoiesis , whereas factors with burst-promoting activity or erythroid-potentiating activity stimulate the growth of the more primitive erythroid cells . | process_involves_gene | {
"id": "C0014819",
"name": "erythropoiesis",
"pos": [
63,
77
]
} | {
"id": "C1367459",
"name": "erythroid-potentiating activity",
"pos": [
129,
160
]
} |
however , the state of phosphorylation of the major putative substrate for the action of the src gene-associated protein kinase , the 34- to 36-kilodalton protein , was not altered . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
23,
38
]
} | {
"id": "C0038085",
"name": "src gene",
"pos": [
93,
101
]
} |
the michaelis constant ( km ) for the hydrolysis of 4-nitrophenyl valerate by nte was found to be 5.55 . 10 ( -5 ) m . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
38,
48
]
} | {
"id": "C1417861",
"name": "nte",
"pos": [
78,
81
]
} |
treatment with trypsin caused a disappearance of the calcium-binding capacity , proving that the active substance in this fraction is a protein ( calcium-binding protein ; cabp ) . | process_involves_gene | {
"id": "C1516144",
"name": "calcium-binding",
"pos": [
53,
68
]
} | {
"id": "C1419788",
"name": "cabp",
"pos": [
172,
176
]
} |
the kinetics of pyruvate phosphorylation by rabbit skeletal muscle pyruvate kinase ( ec 2.7.1.40 ) has been studied with a coupled assay using p-enolpyruvate carboxylase ( ec 4.1.1.31 ) and malate dehydrogenase ( ec 1.1.1.37 ) . | process_involves_gene | {
"id": "C0031715",
"name": "phosphorylation",
"pos": [
25,
40
]
} | {
"id": "C1418610",
"name": "muscle pyruvate",
"pos": [
60,
75
]
} |
comparative analysis of deletion and base-change mutabilities of escherichia coli b strains differing in dna repair capacity ( wild-type , uvra- , pola- , reca- ) by various mutagens . | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
105,
115
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
155,
159
]
} |
dose-response curves were compared for deletions [ colbr ( resistant to colicin b ) mutations being more than 80 % deletions ] and base changes ( reversion of argfam to prototrophy argplus ) induced in the same set of e. coli strains ( wild-type for dna repair , uvra- , pola- and reca- ) by n-methyl-n'-nitro-n-nitrosoguanidine ( ntg ) , ethyl methanesulfonate ( ems ) , hydroxylamine ( ha ) , 4-nitroquinoline i-oxide ( 4nqo ) , mitomycin c ( mtc , uv and x-rays . | process_involves_gene | {
"id": "C0012899",
"name": "dna repair",
"pos": [
250,
260
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
281,
285
]
} |
( i ) the recombination less reca- strain was mutable by only three ( ntg , ems , ha ) of the seven mutagens for either deletions or base changes . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
10,
23
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
29,
33
]
} |
the results also support the idea that the translational regulatory proteins for the l11 and l10 operons are l1 and l10 , respectively , and that the expression of the l12 gene is closely linked to l10 gene expression . | process_involves_gene | {
"id": "C1519614",
"name": "translational",
"pos": [
43,
56
]
} | {
"id": "C1335635",
"name": "l10",
"pos": [
198,
201
]
} |
the less efficient binding of the same ligands to the reverse hybrid ( di ) n. ( dcfl ) n showed that the geometry of the pyrimidine strand is the most critical for the specific interaction . | process_involves_gene | {
"id": "C1517880",
"name": "binding",
"pos": [
19,
26
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
128,
130
]
} |
we have previously shown a marked difference in the inflammatory response to human c5a or c5a des arginine ( arg ) instilled in rabbit lungs . | process_involves_gene | {
"id": "C1155266",
"name": "inflammatory response",
"pos": [
52,
73
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
90,
93
]
} |
with the use of neutral sucrose sedimentation techniques , the size of unirradiated nuclear dna and the repair of double-strand breaks induced in it by ionizing radiation have been determined in both wild-type and homozygous rad52 diploids of the yeast saccharomyces cerevisiae . | process_involves_gene | {
"id": "C1158537",
"name": "repair",
"pos": [
104,
110
]
} | {
"id": "C1419243",
"name": "rad52",
"pos": [
225,
230
]
} |
the activation of human serum complement by incubation with zymosan generates c5a which releases histamine from autologous basophils . | process_involves_gene | {
"id": "C0009528",
"name": "activation",
"pos": [
4,
14
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
78,
81
]
} |
the conditions for inactivation of c1 product include a functional dna recombination system involving the host reca gene . | process_involves_gene | {
"id": "C0034865",
"name": "dna recombination",
"pos": [
67,
84
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
111,
115
]
} |
in 12 anesthetized dogs ( lvh 1 ) the effect of increasing doses of catecholamines on maximum contractility , expressed by ( dp/dt ) max , vpm , t- ( dp/dt ) max was determined in comparison to a control group ( ko 1 ; n = 6 ) . | process_involves_gene | {
"id": "C0026820",
"name": "contractility",
"pos": [
94,
107
]
} | {
"id": "C1416746",
"name": "ko",
"pos": [
212,
214
]
} |
using specific immunofluorescent examinations , the local immune responses were studied in 14 calves prenatally vaccinated ( 10 to 50 days before birth ) with escherichia coli ( o26 : k60 : nm ) antigen or sterile saline solution . | process_involves_gene | {
"id": "C0301872",
"name": "immune responses",
"pos": [
58,
74
]
} | {
"id": "C1366571",
"name": "k60",
"pos": [
184,
187
]
} |
recombination deficient bacteria mutant at the recb or recc loci were protected by r46 , but the r factor had little effect on the survival of a reca strain or a reca recb double mutant . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
0,
13
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
162,
166
]
} |
the role of se in the detoxification of peroxides in foods and the response of gastrointestinal gsh-px to dietary peroxides are discussed . | process_involves_gene | {
"id": "C0025516",
"name": "detoxification",
"pos": [
22,
36
]
} | {
"id": "C1415276",
"name": "gastrointestinal",
"pos": [
79,
95
]
} |
plasma levels of protein c , an important vitamin k-dependent inhibitor of blood coagulation and a profibrinolytic agent , and protein s , a cofactor for protein c , decreased 1 and 2 weeks after initiation of chemotherapy compared with pretreatment values . | process_involves_gene | {
"id": "C0005778",
"name": "blood coagulation",
"pos": [
75,
92
]
} | {
"id": "C1414509",
"name": "cofactor",
"pos": [
141,
149
]
} |
it is suggested that in wilms ' tumorigenesis , imprinting normally renders inactive a transforming gene on the maternally derived chromosome 11 , leaving intact the paternally inherited chromosome 11 and the wilms ' transforming gene that it carries . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
32,
45
]
} | {
"id": "C0029016",
"name": "transforming gene",
"pos": [
217,
234
]
} |
the role of the cd2-lfa-3 interaction in t-cell activation and the potential for other physiologic ligands for cd2 are discussed . | process_involves_gene | {
"id": "C1155065",
"name": "t-cell activation",
"pos": [
41,
58
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
111,
114
]
} |
we constructed genes encoding the dna binding region of the bacterial lexa repressor fused to the v-fos and c-fos oncogene products . | process_involves_gene | {
"id": "C1148673",
"name": "dna binding",
"pos": [
34,
45
]
} | {
"id": "C0087140",
"name": "v-fos",
"pos": [
98,
103
]
} |
crossed immunoelectrophoresis revealed that proteins a and b identified in the proteolytic system of s. cremoris wg2 are both encoded by the proteinase gene . | process_involves_gene | {
"id": "C0597304",
"name": "proteolytic",
"pos": [
79,
90
]
} | {
"id": "C1335528",
"name": "proteinase gene",
"pos": [
141,
156
]
} |
the blood-membrane contact induced complement activation ( rise in c3d ) and transient leukopenia , as described during clinical hemodialysis . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
35,
56
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
67,
70
]
} |
the role of cd2 antigen in t-cell activation was investigated using soluble-phase or cross-linked monoclonal anti-cd2 antibodies . | process_involves_gene | {
"id": "C1155065",
"name": "t-cell activation",
"pos": [
27,
44
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
114,
117
]
} |
sequence analysis of the fragment revealed that from the start to end of transcription , the hmg-17 gene is 3293 base pairs long and is comprised of 6 exons ranging in size from 30 to 890 base pairs . | process_involves_gene | {
"id": "C0040649",
"name": "transcription",
"pos": [
73,
86
]
} | {
"id": "C1333913",
"name": "hmg-17 gene",
"pos": [
93,
104
]
} |
t cell activation through different membrane structures ( t3/ti , t11 , t44 ) and frequency analysis of proliferating and interleukin-2 producer t lymphocyte precursors in aged individuals . | process_involves_gene | {
"id": "C1155065",
"name": "t cell activation",
"pos": [
0,
17
]
} | {
"id": "C1707096",
"name": "t44",
"pos": [
72,
75
]
} |
the hydrolysis of dipalmitoylphosphatidylcholine liposomes by porcine pancreatic phospholipase a2 was studied at 31 degrees c , i.e. , with the substrate in the gel phase . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
4,
14
]
} | {
"id": "C1418617",
"name": "pancreatic",
"pos": [
70,
80
]
} |
changes in white blood cell counts , blood gases ( pao2 and paco2 ) , carbon monoxide diffusing capacity ( dlco ) and complement activation ( c3d and c3a ) were measured pre-treatment and during dialysis . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
118,
139
]
} | {
"id": "C1332656",
"name": "c3d",
"pos": [
142,
145
]
} |
the nh2-terminal leader sequences are believed to function in targeting of the permeases to the membrane , whereas the characteristic cooh-terminal sequences are postulated to mediate interaction with the energy-coupling protein phospho hpr . | process_involves_gene | {
"id": "C0872079",
"name": "interaction",
"pos": [
184,
195
]
} | {
"id": "C1337105",
"name": "hpr",
"pos": [
237,
240
]
} |
recombinant plasmids containing the reca gene from pseudomonas aeruginosa were used in complementation , transcriptional , and translational studies to examine the nature of rec-102 and rec-2 , mutations which confer a reca-like mutant phenotype on p. aeruginosa pao strains . | process_involves_gene | {
"id": "C1519614",
"name": "translational",
"pos": [
127,
140
]
} | {
"id": "C1424025",
"name": "rec",
"pos": [
219,
222
]
} |
sequence requirements for ligand binding and cell surface expression of the tac antigen , a human interleukin-2 receptor . | process_involves_gene | {
"id": "C1517880",
"name": "ligand binding",
"pos": [
26,
40
]
} | {
"id": "C1334114",
"name": "tac",
"pos": [
76,
79
]
} |
this plasmid conferred resistance to methyl methanesulphonate and uv irradiation upon reca mutants of escherichia coli and enhanced recombination proficiency , as measured by hfr-mediated conjugation , in reca mutants of e. coli . | process_involves_gene | {
"id": "C0034865",
"name": "recombination",
"pos": [
132,
145
]
} | {
"id": "C1419240",
"name": "reca",
"pos": [
205,
209
]
} |
the role of ras oncogenes in cellular signalling pathways involving phospholipid breakdown was studied in untransfected and proto-h-ras and mutated h- , k- and n-ras transfected nih/3t3 cells . | process_involves_gene | {
"id": "C0037083",
"name": "cellular signalling",
"pos": [
29,
48
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
130,
135
]
} |
the role of ras oncogenes in cellular signalling pathways involving phospholipid breakdown was studied in untransfected and proto-h-ras and mutated h- , k- and n-ras transfected nih/3t3 cells . | process_involves_gene | {
"id": "C0037083",
"name": "cellular signalling",
"pos": [
29,
48
]
} | {
"id": "C0809246",
"name": "n-ras",
"pos": [
160,
165
]
} |
a chinese hamster cell line ( lz ) , selected for multidrug resistance ( mdr ) , exhibits a 3,000-fold resistance to doxorubicin , compared to parental v-79 cells . | process_involves_gene | {
"id": "C0242640",
"name": "multidrug resistance",
"pos": [
50,
70
]
} | {
"id": "C0376622",
"name": "resistance",
"pos": [
103,
113
]
} |
t cell activation by pha-p , but not by the other polyclonal t-cell activators studied thus seems to be mechanistically similar to 'alternative pathway ' activation induced by anti-cd2 mab in that the costimulatory effect of lfa-3 is independent of its prescence on an accessory cell membrane . | process_involves_gene | {
"id": "C1155065",
"name": "t cell activation",
"pos": [
0,
17
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
181,
184
]
} |
moreover , a minority of e mu-myc b lymphomas exhibit ras mutation , and the tumorigenesis can be reconstructed by crossing e mu-myc and e mu-ras mice , or by retroviral delivery of v-ras or v-raf , either in vitro or in vivo . | process_involves_gene | {
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
77,
90
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
184,
187
]
} |
however , infected p388d1 cells fixed in 10 % formalin or bouin 's fixative required enzymatic digestion with 1.0 % trypsin for 15 min at 37 c before positive results were evident . | process_involves_gene | {
"id": "C0012238",
"name": "digestion",
"pos": [
95,
104
]
} | {
"id": "C1418965",
"name": "1",
"pos": [
128,
129
]
} |
this conductance has properties consistent with a role in t-cell activation , including activation by pha , lack of voltage-dependent gating , inhibition by ni2+ or cd2+ , and regulation by intracellular ca2+ . | process_involves_gene | {
"id": "C1155065",
"name": "t-cell activation",
"pos": [
58,
75
]
} | {
"id": "C1367475",
"name": "cd2",
"pos": [
165,
168
]
} |
studies with kidney mitochondria pin-pointed the site of action as being involved with the oxidative metabolism of malate but not the inhibition of mitochondrial malate dehydrogenase . | process_involves_gene | {
"id": "C0282636",
"name": "oxidative metabolism",
"pos": [
91,
111
]
} | {
"id": "C1417088",
"name": "mitochondrial malate dehydrogenase",
"pos": [
148,
182
]
} |
biochemical data show that tp90 is distinct and physically independent from the structures already known to be involved in t cell activation , namely t11 , t44 or t3/tcr . | process_involves_gene | {
"id": "C1155065",
"name": "t",
"pos": [
14,
15
]
} | {
"id": "C1707096",
"name": "t44",
"pos": [
156,
159
]
} |
chemotactic activity towards granulocytes and monocytes was also generated by exposure of serum to intermediate filaments , and this activity was dependent on the presence of complement factor c5 and on the classical complement activation cascade , implying that it was due to the c5a peptide . | process_involves_gene | {
"id": "C0009528",
"name": "complement activation",
"pos": [
217,
238
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
281,
284
]
} |
hydrolysis of escherichia coli membrane phospholipids by pancreatic phospholipase a2 was inhibited by lipocortin from human monocytes in a substrate dependent manner . | process_involves_gene | {
"id": "C0020291",
"name": "hydrolysis",
"pos": [
0,
10
]
} | {
"id": "C1418617",
"name": "pancreatic",
"pos": [
57,
67
]
} |
the translational organization we found for trai , together with its identity as the structural gene for dna helicase i , suggests a possible functional link to several other genes from which translational restart polypeptides are expressed . | process_involves_gene | {
"id": "C1519614",
"name": "translational",
"pos": [
4,
17
]
} | {
"id": "C1336806",
"name": "genes",
"pos": [
175,
180
]
} |
the in vitro chemotaxis of peripheral blood neutrophils and monocytes from the patients toward c5a was markedly inhibited after intake of mtx ( p less than 0.01 ) . | process_involves_gene | {
"id": "C0008018",
"name": "chemotaxis",
"pos": [
13,
23
]
} | {
"id": "C1367710",
"name": "c5a",
"pos": [
95,
98
]
} |
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