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We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.
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PATIENTS AND METHODS: Three patients with Parkinson's disease undergoing bilateral micro-recording guided surgery of the subthalamic nucleus (STN) are described; deep brain stimulation (DBS) was used in one case, and subthalamotomy in the other two.
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Leucopenia and thrombocytopenia developed but were resolved by hydroxocobalamin infusion during administration.
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Most breaches are not considered harmful.
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Treatment has mainly been empirical.
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METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.
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She was stabilized with prednisone, azathioprine, and tacrolimus.
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The patient was ultimately treated with a nasal septal button with good symptom relief.
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There were no immediate reactions on prick and intracutaneous testing with the commercial product used by the patient.
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Although botulinum therapy effectively reduced the patient's refractory myofascial pain, signs and symptoms of SIS developed in association with the upper trapezii weakness after the third set of injections.
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Long-term survival was studied in a group of 123 patients with malignant ventricular arrhythmia treated with antiarrhythmic drugs chosen primarily with noninvasive testing methods.
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It is becoming increasingly evident the population at highest risk for sustaining a complication related to anticoagulation is that group presenting with traumatic brain injury.
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A 27-year-old woman was admitted because of breathlessness, orthopnea, and hemoptysis.
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The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.
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At least three other studies do not support these observations, but the tightly controlled conditions in these studies may not have simulated actual clinical practice.
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Physicians and pharmacists should be aware of this possibility and must educate patients about the potentially serious adverse effects of such use.
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Vancomycin-induced vasculitis.
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The reflex was interrupted by blocking bilaterally the third division of trigeminal nerve.
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The use of epidural local anaesthetics immediately after surgery delays the diagnosis of a postoperative neurological deficit.
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These patients had robust responses to pramipexole augmentation of their treatment regimen.
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We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.
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This review is an in-depth report of the efficacy and safety of 1% lindane compared with the agents that have been preferred as alternative.
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After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.
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During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.
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Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.
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Aorto-oesophageal fistula complicating carcinoma of the oesophagus.
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DISCUSSION: Two other case reports of nephrotic syndrome have been reported in the literature.
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CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.
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Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".
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The hope is that these cases will increase awareness of the potential use of capsaicin cream as an adjuvant analgesic in patients with residual limb pain.
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Although psoralens are useful components of the psoralen ultraviolet A-range therapy that is mainly used for the treatment of vitiligo, psoriasis, and hypopigmented scars, they have a narrow margin of safety.
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She had had her tongue painted with silver nitrate repeatedly 6 years ago for the treatment of oral ulcers.
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OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.
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METHODS: A 55-year-old man had diabetes with unilateral rubeosis and macular edema.
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This resulted in a comatose state with depression of some brainstem reflexes.
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The metabolic acidosis associated with the seizures may have caused hypotension by direct cardiotoxicity, an increase in bioavailability of tricyclic antidepressant because of changes in protein binding, an alteration of the effects of tricyclic antidepressant on cardiac membrane sodium channels, or a combination of these mechanisms.
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The cutaneous manifestations of infection can include papules, plaques, nodules, vesicles, ulcers, ecchymosis, and, rarely, cellulitis.
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We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.
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These cases were all fatal, and it is suggested that the use of clindamycin in leukaemic patients should be reserved for specific indications.
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It must be distinguished from bilateral occipital lobe ischemia caused by vertebrobasilar system disease.
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This eruption appears to be a distinct cutaneous toxicity of PLD.
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We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.
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Development of persistent late onset asthma following treatment with captopril.
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METHODS: Four cases of essential hypertension patients (1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations.
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Cardiopulmonary arrest following intravenous phenytoin loading.
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They are proof of a disturbed GABA metabolism in pyridoxine dependent seizures.
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We report a case of CMV ventriculoencephalitis after unrelated double cord blood SCT with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.
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However, she developed new pulmonary symptoms and an enlarged cavitary lesion associated with the rapid formation of a fungal, ball-shaped shadow that was serially observed by radiological analysis.
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Nineteen months after diagnosis, her mother gave birth to an HLA-compatible sibling, whose cord blood was cryopreserved.
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Antimalarial psychosis revisited.
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Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.
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Bisphosphonates (eg, alendronate) are also indicated in the treatment of osteoporosis.
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All patients were maintained on prophylactic topical ofloxacin 0.3% or polymyxin-B/trimethoprim, as well as prednisolone acetate 1% (in 2 cases, medroxyprogesterone 1%), at least twice daily.
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The severity of this frequently irreversible and disabling condition warrants careful consideration in the use of long-term antipsychotic drug treatment in the young psychiatric outpatient population.
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We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.
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These findings suggest that disturbed serine-glycine metabolism may have a key role in certain schizophreniform psychotic syndromes.
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Treatment with tacrine reversed the delirium, and a history of repeated benztropine use was obtained.
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We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.
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Toxoplasma gondii retinochoroiditis after cardiac transplantation.
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Pathophysiology of this disease is manifold and has been discussed as a posthemorrhagic complication as well as a neurological complication after operations with cardiopulmonary bypass.
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Fatal cold medication intoxication in an infant.
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All patients improved within 2 months after the drug was stopped.
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DATA SOURCES: All relevant articles from January 1985 through February 1993 were identified, primarily through MEDLINE search and review of pertinent articles' bibliographies.
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Treatment of pemphigus commonly entails both corticosteroids and steroid-sparing agents.
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Intravenously administered itraconazole and rectally administered aminoglutethimide were used to suppress endogenous glucocorticoid synthesis.
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The major adverse reactions of antithyroid drugs are hematologic; aplastic anemia (AA) is one of the rarest and most severe complications.
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At this time, changing to another ACE inhibitor or additive therapy with nonsteroidal antiinflammatory drugs is not recommended.
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The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.
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We present a case of accidental injection of tranexamic acid instead of bupivacaine during spinal anesthesia.
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Lymphomatoid granulomatosis after immunosuppression for pemphigus.
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Plasma levels of alprazolam, a substrate for the 3A4 isozyme, fell rapidly when nefazodone was discontinued, presumably because of renewed 3A4 isoenzyme activity.
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The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma.
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A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.
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We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.
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Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.
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Although there is no rigorous evidence to support this management, private hyperbaric centers have been established throughout the United States and Canada.
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Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy.
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Cholesterol embolization treated with corticosteroids--two case reports.
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One with stable chronic renal failure due to reflux nephropathy underwent a rapid deterioration of renal function which proved fatal.
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The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.
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METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.
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Mucin secretion was measured using an enzyme-linked lectin assay, and lung water was measured by wet/dry weight ratios.
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The patients immune system and lung function slowly recovered during the same time period.
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OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.
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About 45% of the total body amount can be extracted through a 3-h course of hemodialysis with resultant improvement in symptoms.
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The diagnosis was confirmed by arteriography.
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Crumley).
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Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
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In addition, one must also question the effects that misplaced corticosteroids could have on the surrounding tissues.
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Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis.
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A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.
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Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies.
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A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.
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CONCLUSION: Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.
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The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis.
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We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.
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We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.
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Both the long-term affects of residual catheter within the central venous system and the need to remove the foreign body have yet to be addressed.
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During the two weeks following the commencement of this treatment she occasionally complained of shortness of breath.
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Four of 5 chronic hemo- or peritoneal dialysis patients also received multiple antibiotics.
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