text
stringlengths 10
10.1k
| source
stringclasses 1
value |
|---|---|
understanding the highrisk adolescents perception of risk taking is essential for health professionals to determine appropriate interventions the purpose of this T0 was to examine the psychometric properties of the revised adolescent risktaking SF-36 arti designed to measure the highrisk adolescents perception of risk taking this T0 also examined the variables that are most predictive of social adaptation and risk taking an ex post facto design was used to standardize data collection and to assess the psychometric properties of the revised arti the nonprobability sample consisted of adolescents attending school in an urban healthunderserved area exploratory factor analysis supported construct validity and chronbachs coefficient alpha supported internal consistency reliability the reliability coefficient for the risk taking and social adaptation constructs were and respectively current perspectives on adolescent risk taking and implications for the use of the arti in clinical practice are addressed
|
MEDAL
|
neonatal HFE is a disorder which affects foetuses and newborns it is characterized by HCC insufficiency often appearing on the first day of life in the form of coagulopathy hypoalbuminemia hypoglycemia and jaundice while spontaneous REC has been reported most of these infants die and the diagnosis was previously often made during autopsy with the help of mri and SSG biopsies plus increasing awareness of this disorder the diagnosis is now often made quite early and successful liver transplantations have been reported recently there have also been encouraging preliminary reports of successful intervention with antioxidant and chelation pharmacotherapy using a combination of Se VE nacetylcysteine deferoxamine and prostaglandin e we describe two patients with neonatal haemochromatosis who were both treated with this new cocktail one of whom died at five days of age while the other survived but needed a liver transplant at months of age the pathology of this condition is characterized by hepatic cirrhosis with giant cell transformation and by siderosis of extrahepatic tissues the prognosis is poor and our experience with antioxidant treatment has been disappointing liver transplantation is a therapeutic option but its use is limited by the scarcity of donor organs and the small size of many of the patients
|
MEDAL
|
here we have systematically characterized the CS- response properties of mechanosensitive sensory fibers in the mouse saphenous nerve we tested mechanoreceptors and nociceptors with defined displacement stimuli of varying amplitude and velocity for each sensory afferent investigated we measured the mechanical RL which is the delay between the onset of a ramp displacement and the first evoked spike QTc for conduction delay mechanical RL plotted as a CF of CS- strength was very characteristic for each receptor type and was very short for RA mechanoreceptors ms but very long in myelinated and unmyelinated nociceptors ms increasing the stimulus speed decreased mechanical RL in all receptor types with the notable exception of cfiber nociceptors in which mean mechanical RL was not reduced less similar ms even with very fast ramp stimuli microms we examined stimulus response functions and mechanical latency at two different temperatures and degrees c and found that CS- response properties of almost alril improved OP and hypertension whereas treatment with LOS an angiotensin receptor blockers specific for at resulted in exacerbation of the low BMC phenotype thus blocking the synthesis of angii may be an effective treatment of OP and hypertension especially for those afflicted with both conditions
|
MEDAL
|
this report examines the mechanisms involved in the downregulation of the immune response in acute viral infection and documents the presence of apoptotic lymphocytes in situ in the spleens of mice during the resolution of the immune response to acute lymphocytic choriomeningitis virus infection apoptotic cells were detected by an in situ nucleotidyl GOT CA both t and b lymphocytes were shown to be dying in vivo the latter in clusters a biphasic occurrence of apoptosis during the course of the acute infection was observed with elevated C2 occurring at day after infection and a second more pronounced peak at day T3 infection coincident with the decline of the cytotoxic t lymphocyte response and with the decrease in total splenic leukocyte number apoptosis in vivo was detected in lpr mice suggesting that fas expression is not imperative for lymphocyte apoptosis in the context of an acute viral infection apoptosis in situ and the decline of the t lymphocyte response to acute lymphocytic choriomeningitis virus infection was unaffected by the enforced lymphocytedirected expression of bcl a protein that blocks growth factor deprivationinduced apoptosis of lymphocytes in vitro these results argue that the silencing of the t cell response to acute infection may not be a result simply of growth factor deprivation the susceptibility of activated TA to apoptotic death which has previously been associated with virusinduced immune deficiency may therefore also explain the en masse elimination of the expanded lymphocyte pool subsequent to an acute viral infection
|
MEDAL
|
aging is known to impair the formation of EM a process dependent upon the integrity of the hippocampal region to investigate this issue hippocampal place cells were recorded from MA and old f male rats while running on a figure track the top and bottom arcs of the track were removed converting it into a plus maze and the animals were required to conduct a WM task following this change in task the arcs were replaced and the animals again ran the figure task analysis of place fields across the recording session demonstrated that both middleaged and old rats had reliable representations of the figure task a comparison of place fields between different behavioral tasks figure and plus maze demonstrated a NC in the hippocampal representation of the environment in both age CG despite the fact that the animals remained on the maze throughout the recording session notably place cells in old animals were less affected by the NC in task than those in middleaged animals the results suggest that hippocampal SN reflect significant behavioral events within a given environment furthermore the data indicate that agerelated EM deficits may result from decreased sensitivity of the hippocampal network to respond to meaningful changes in the environment
|
MEDAL
|
enterohemorrhagic escherichia coli is a causative agent of gastrointestinal and diarrheal diseases pathogenesis associated with enterohemorrhagic e coli involves direct delivery of VFs from the bacteria into epithelial cell cytosol via a syringelike organelle known as the TTS system the TTS system protein espd is a critical factor required for formation of a translocation pore on the host CM here we show that recombinant espd spontaneously integrates into C1 unilamellar vesicle luv lipid bilayers however pore formation required incorporation of anionic phospholipids such as phosphatidylserine and an acidic ph leakage assays performed with FL dextrans confirmed that espd formed a structure with an inner diameter of â¼ nm protease mapping indicated that the two transmembrane helical hairpin of espd penetrated the lipid SL positioning the n and CT domains on the extralumenal surface of luvs finally a combination of glutaraldehyde crosslinking and rate zonal centrifugation suggested that espd in luv CM forms an â¼kda oligomeric structure consisting of â¼ subunits
|
MEDAL
|
animal models of OA are used to T0 the pathogenesis of cartilage degeneration and to evaluate potential antiarthritic drugs for clinical use animal models of naturally occurring osteoarthritis oa occur in knee joints of guinea pigs mice and other laboratory animal species transgenic models have been developed in mice commonly utilized surgical instability models include medial meniscal tear in guinea pigs and rats medial or lateral partial meniscectomy in rabbits medial partial or total meniscectomy or ACL transection in dogs additional models of cartilage degeneration can be induced by intraarticular iodoacetate i.t. or by administration of oral or parenteral quinolone antibiotics none of these models have a proven track record of predicting efficacy in human disease since there are no agents that have been proven to provide anything other than symptomatic relief in human oa however agents that are active in these models are currently in PCTs methodologies gross and histopathologic features and comparisons to human disease will be discussed for the various models
|
MEDAL
|
EPEC escherichia coli epec are a leading cause of diarrheal illness among infants in developing countries e coli isolates classified as typical epec are identified by the presence of the locus of enterocyte effacement lee and the bundleforming pilus bfp and absence of the shigatoxin genes while the atypical epec also encode lee but do not encode bfp or shigatoxin comparative genomic analyses have demonstrated that epec isolates belong to diverse evolutionary lineages and possess lineage and isolatespecific genomic content to investigate whether this genomic diversity results in significant differences in global mRNA we used an rna sequencing rnaseq approach to characterize the global transcriptomes of the prototype typical epec isolates e b c and the prototype atypical epec isolate e the global transcriptomes were characterized during laboratory growth in two different media and three different growth phases as well as during adherence of the epec isolates to human cells using in vitro TC assays comparison of the global transcriptomes during these conditions was used to identify isolate and growth phasespecific differences in epec mRNA these analyses resulted in the ID of genes that encode proteins involved in survival and metabolism that were coordinately expressed with virulence factors these findings demonstrate there are isolate and growth phasespecific differences in the global transcriptomes of epec prototype isolates and highlight the utility of comparative transcriptomics for identifying additional factors that are directly or indirectly involved in epec pathogenesis
|
MEDAL
|
the secretion of cytokines such as TN factor alpha tnfalpha and interleukin il during immune activation induces sickness behavior we have previously demonstrated that administration of either lipopolysaccharide lps or il suppresses sexual SMB in female but not in male rats in the present T0 we sought to determine some of the mechanisms that are involved in mediating the alterations of female sexual SMB during immune activation we report that sexual motivation of estrous females was reduced by intracerebroventricular administration of either recombinant rat rrtnfalpha micrograt or rrilbeta ngrat whereas sexuang people covered by our prepaid healthcare institution clinic physician and nurse and home nurse blood pressure measurements were performed times each with semiautomatic electronic equipment selfmeasurements were performed by the subjects manually activating the ambulatory device we analyzed individuals who were not receiving antihypertensive therapy from participants selfmeasurement was available in a subgroup of participants younger than the whole sample normal ambulatory blood pressure limits were estimated as those that best correlated with mm hg at clinic estimated values were mm hg for hour ambulatory range to and to mm hg and mm hg for daytime ambulatory range to and to blood pressure depending on gender and age ambulatory and clinic BPs increased with age the agedependent increase in abp was similar in women and men average blood pressure at clinic was mm hg by physician and mm hg by nurse nurse measurement at home was mm hg daytime ambulatory was mm hg and hour ambulatory was mm hg the values of the subgroup with selfmeasurement were physician mm hg nurse at clinic mm hg nurse at home mm hg selfmeasured mm hg daytime ambulatory mm hg and hour ambulatory mm hg this study shows that a hour abp average value of mm hg and a daytime abp average value of mm hg are suitable upper limits for normality higher limits would yield an artificially higher prevalence of white coat hypertension most subjects showed higher blood pressure C2 when measurements were performed by healthcare personnel at a clinic or at home than when selfmeasured at home
|
MEDAL
|
we report three cases of and yearold patients presenting annular lesions with centrifugal migratory extension they occur exclusively on sunexposed Az in two cases the lesions were multiple in the third case the lesion was single and mimicked an EAC the past PH ranged from months to years microscopic examination of the CE part showed a disappearance of elastic fibers in upper Rt dermis examination of the ring showed in upper reticular dermis an histiocytic granulomatous infiltration with many giant cells lymphocytes and patterns of elastic fibers phagocytosis similar features were found by electronmicroscopy these three cases illustrate the typical features of obriens actinic granuloma relationship between this actinic granuloma and granuloma annulare occurring on sunexposed Az on one side and necrobiosis lipoidica mieschers granuloma and granuloma multiforme on the other side are discussed on the basis of some clinical and histological patterns the autonomy of obriens actinic granuloma appears to be established
|
MEDAL
|
translationally inactive histone mrna is stored in frog oocytes and translation is activated at oocyte maturation the replicationdependent histone mrnas are not polyadenylated and end in a conserved stemloop structure there are two proteins slbps which bind the end of histone mrna in frog oocytes slbp participates in premrna processing in the nucleus slbp is oocyte specific is present in the cytoplasm and does not support premrna processing in vivo or in vitro the stored histone mrna is bound to slbp as oocytes mature slbp is degraded and a larger fraction of the histone mrna is bound to slbp the mechanism of activation of translation of histone mrnas may involve exchange of slbps associated with the end of histone mrna
|
MEDAL
|
phosphatidylserine ps is normally intracellular but becomes exposed on the luminal surface of vascular EC cells in PT it also becomes exposed on PT cells responding to therapy in the present T0 we optically imaged exposed ps in vivo using pgn a novel monoclonal antibody that binds ps the fab fragment of pgn was labeled with the IR nir dye irdyecw in vivo dynamic nir imaging was performed after injection of cwpgn into mice bearing radiationtreated or UT u glioma xenografts growing subcutaneously or orthotopically nir optical imaging revealed a clear RT contrast in nonirradiated subcutaneous u gliomas T3 injection of cwpgn the RT contrast was visible as early as hours later and was maximal hours later tumortonormal tissue ratio tnr ± irradiation enhanced the RT contrast at hours tnr ± similar results were observed for orthotopic gliomas localization of cwpgn to tumors was antigen specific because cwaurexis a control probe of irrelevant specificity did not localize to the tumors and preadministration of unlabeled pgn blocked the uptake of cwpgn fluorescence microscopy confirmed that cwpgn was binding to pspositive vascular endothelial cells in nonirradiated gliomas irradiation of the gliomas increased ps exposure on both RT VE cells and tumor cells and gave rise to an increase in RT contrast with cwpgn that was predictive of the reduction in RT growth cwpgn may be a useful new imaging trated the vp shunt to be IN but displaced inferiorly with the VVI catheter in the extracranial soft tissue of the neck and the peritoneal catheter passing into the abdomen bladder and out through the urethra shunt removal was achieved through a multidisciplinary RPA involving both neurosurgery and urology teams the authors discuss other reported cases of perforation by a vp shunt potential mechanisms and considerations for management of this rare complication
|
MEDAL
|
sublytic complement attack can elicit protective cellular responses without precipitating cell death our investigation examined the effects of nonlethal complement activation in isolated hearts new zealand white rb hearts were subjected to min of ischemia followed by h of reperfusion prior to ischemia NF were perfused for min with normal human plasma nhp NF treated with nhp developed significantly p smaller infarcts compared with controls expressed as percent of area at risk aar vs respectively heatinactivation soluble CR1 scr nm and antica antibody reversed the protective effect of nhp and aar respectively NF treated with nm ca exhibited infarct sizes similar to those exposed to nhp aar scr CT did not affect infarct size aar the results suggest that nonlethal complement activation attenuates RI through formation of ca
|
MEDAL
|
the mitochondrial atpdependent k channel mitokatp has been shown to play a role in cellular protection against apoptosis or programmed cell death this channel has been identified and characterized in a number of cell and tissue types but to date the possible existence of mitokatp in OB cells has not been investigated the aim of this investigation was to establish whether the mitochondria of human osteosarcomaderived OBs saos cells contain the putative mitokatp subunits kir and kir ultrathin sections of saos cells were prepared for transmission electron microscopy using an adaptation of the tokuyasu method and immunolabelled using goat antikir or antikir antisera as the primary label and a nm colloidal goldconjugated donkey antigoat AA antibody the suitability of the antisera and the IS protocol were confirmed by using a sample of rat cardiac muscle as a PC ultrastructural analysis revealed that saos cells contain kir but not kir and that kir is present in the mitochondria but in extremely low abundance these findings suggest that hOB cells might contain mitokatp channels in which kir is the poreforming subunit although it appears that these channels are likely to be present in extremely low abundance
|
MEDAL
|
acute gastroenteritis age is a common illness treated in the emergency department delays in initiating rehydration for children with mild or moderate dehydration from age can lead to prolonged ed visits and increased resource utilization that do not provide prognostic value or support FCC the purpose of this SQ improvement project was to promote early oral rehydration therapy ort for persons with age in an attempt to reduce unnecessary resource utilization and length of stay los
|
MEDAL
|
chronic stretch of the chicken EDL patagialis muscle increases the rate of growth and percentage of fasttwitch oxidative SF we have analyzed the effects of stretch on the expression of two previously identified embryonic MHC chain mhc mrnas p and p both mhc mrnas were expressed in the PAT at their highest C2 in the embryo and wk after hatching during posthatch OD wk the p mrna was expressed in only trace quantities while the p mrna was not detectable T3 wk of stretch of the patagialis in or wkold birds the p mrna was increased to C2 similar to that found in PAT of newly hatched chicks whereas expression of the p transcript was not affected the existence of two other mhc mrnas homologous to the p mrna was suggested by the s mapping analysis one of which was expressed at dramatically reduced levels in the stretched PAT it is concluded that stretch can cause selective alterations in the expression of developmentally regulated mhc isoforms in chicken EDL muscle
|
MEDAL
|
in patients in whom VP fusion according to cloward was performed because of traumatic or degenerative discopathy the presurgery finding of discography was compared with the finding established during the operation it was found that preoperative discography enables to diagnose damage of the NP and anulus fibrosus as well as tearing of the posterior and ALL it is emphasized that in degenerative damage escape of the contrast medium in ventral direction merely represents backflow of the contrast medium along the puncture channel and rarely represents rupture of the anterior longitudinal ligament side localisation is possible by means of the semioblique xray in case of a traumatic damage at least two disc spaces should be diagnosed
|
MEDAL
|
we describe a simple experimental approach for delivering selfassembled monolayers sams of octadecylphosphonic acid opa on many oxide surfaces using a nonpolar medium with a dielectric constant around eg trichloroethylene this approach readily results in the formation of fullcoverage opa sams on a wide variety of oxide surfaces including cleaved mica si wafer quartz and aluminum especially the availability of delivering fullcoverage opa sam on a si wafer is unique as no opa sams at all could be formed on a si wafer when using a polar opa solution the reason a nonpolar solvent is superior lies in the very fact that the hydrophilic opa headgroup tends to escape from the nonpolar solution and is thus EC at the mediumair interface it is these opa headgroups seeking a hydrophilic surface that make possible the wellcontrolled opa ML on an oxide surface
|
MEDAL
|
calculations based on an exact theory have been made of the scattering properties of spherical particles possessing arbitrarily placed spherical inhomogeneities the inclusions are homogeneous but of otherwise arbitrary composition and are limited in size only by that of the host it has been found that a single inclusion though having a volume of only that of the host can produce C1 fluctuations in light scattered by the system as the inclusion passes through regions of high local intensity the resonance spectrum of a glycerol droplet with inclusions centered in a hot spot reveals that the inclix reversal penalty was determined which is related to the intermolecular hydrogen bonds that are present in all studied derivatives for asymmetrically substituted bta derivatives an oddeven effect was found in the degree of chiral amplification when changing the position of the stereogenic center with respect to the NH functionality it was found that the mismatch penalty could be directly related to the number of stereocenters present in the molecules increasing this number from one to three resulted in an increase in this SE penalty while leaving the helix reversal penalty unaffected for the majorityrules principle this implies that a single stereocenter present in the molecule contains sufficient chiral information at the molecular level to result in a chirally amplified state at the supramolecular level further evidence that the mismatch penalty is directly related to the number of stereocenters was obtained from mixed majorityrules experiments where two bta derivatives with different numbers of stereocenters with opposite stereoconfiguration were studied in a majorityrules experiment finally the ultimate limits of chiral amplification for the majorityrules principle were investigated revealing that given a certain helix reversal penalty there is an optimum to which the mismatch penalty can be reduced while also enhancing the degree of chiral amplification temperaturedependent majorityrules experiments could indeed confirm these simulations these findings show the relevance of both energy penalties when trying to enhance the degree of chiral amplification for the majorityrules principle in a onedimensional helical supramolecular polymer
|
MEDAL
|
in the years in the department of neurosurgery military medical academy patients were treated surgically for cervical spondylosis the author describes the methods of surgical treatment calling particular attention to the necessity of wide decompression of the nervous structures and vessels of the vertebral canal and good stabilization of the cervical spine using osseous grafts in severe cervical myelopathy it is necessary to decompress the spinal cord and its vessels both anterior and posterior this is achieved in a twostage operation the T0 from anterior approach is always done in the first stage of the treatment the results of surgical treatment of cervical spondylosis are reported good and very good results were obtained in of cases improvement in no improvement in worsening of the neurological status was never observed
|
MEDAL
|
nitric oxide no has been implicated in the secondwindow of ICM preconditioning pc however the identity of the end effector T3 initiation of preconditioning by no is not known it is likely that no is involved in opening of mitochondrial atpsensitive potassium mitokatp channels we hypothesized that no is an important trigger for the opening of mitokatp channels in the late phase of preconditioning and iNOS synthase inos upregulation via nf kappa b plays a critical role in diazoxideinduced cardioprotection to examine this diazoxide mgkg was po to wildtype wt mice and mice lacking the gene hours before minutes of global ischemia NF were perfused in a langendorff mode and effects of activation of mitokatp channel and other interventions on functional PSA and pathological changes in ICM hearts were assessed in hearts from wt mice treated DZ leftventriculardeveloped pressure EDV pressure and CF were significantly improved T3 ischemiareperfusion ir lactate dehydrogenase ldh release was also significantly decreased while atp contents were significantly higher administration of hd a TPS blocker of mitokatp channel or l name an inhibitor of inos before ir during diazoxidepretreatment CR blocked the late cardioprotection against ischemia late cardioprotection was also blocked by inhibition of either pkc delta by rottlerin or nf kappa b by ddtc before DZ i.c.v. diazoxide pretreatment significantly increased nuclear translocation of p which was blocked by protein kinase c pkc or nitric oxide synthase nos inhibition DZ was totally inefffective in inos KO these results suggest that DZ activates nf kappa b via pkc signaling pathway and that leads to inos upregulation after hours no which is generated upon ICM stress triggers the opening of mitokatpchannel as an end effector of cardioprotection during late pc
|
MEDAL
|
glycyrrhetinic acid ga inhibits betahydroxysteroid dehydrogenase and increases the C2 and thus the action of endogenous glucocorticoid we considered that ga could be used effectively for treatment of AD that have been treated by synthetic glucocorticoids in this report we demonstrated that ga delayed the OD of autoimmune disease in spontaneously autoimmune CS mrl lprlpr referred to as lpr mice ga was administered via drinking water at approximately mgkgday for days an increase of urine protein levels in the mice treated with ga was delayed as compared to the control mice after ga treatment began urinary protein levels in the gatreated mice were found to be significantly lower than vehicletreated mice p between days to at weeks of ga treatment serum igg C2 were lowered significantly in comparison with the control mice p in this circumstance betahsd MICs in CL and kidney were significantly inhibited by ga treatment p p respectively concentration of corticosterone and dehydrocorticosterone in liver significantly increased after weeks of ga treatment p p respectively in contrast to the local tissue levels of CSs the SS concentration of dehydrocorticosterone significantly decreased with ga treatment p these data suggest that ga could modify the local and SVR homeostasis of steroid metabolism in lpr mice we concluded that the continuous treatment of ga is able to retard the development of autoimmune disease by suppressing urinary protein excretion and serum igg C2 in lpr mice modulation of local tissue C2 as well as serum levels of corticosteroid by ga may thus be implicated in the therapeutic efficacy of ga
|
MEDAL
|
a twoway selective experiment for CH50 activity ch was carried out in a colony of new zealand WG rabbits for the purpose of developing hereditary deficiency of espectively in milk from quarters infected with s aureus somatic cell counts were elevated p less than with x cellsml for s aureusinfected quarters as compared with x cellsml for uninfected quarters somatic cell counts were negatively correlated with d calf weaning weights staphylococcus aureusinfected cows weaned calves weighing kg less p less than than uninfected cows at a present market value of kg economic losses were placed at calf from cows INF with s aureus in one or more quarters
|
MEDAL
|
the role of intestinal bacteria in induction and repression of ulcer formation in the ileum of rats treated with one of the nonsteroidal antiinflammatory drugs nsaids bromofluorophenylmethylsulfonylphenyl thiophene bfmet was examined in this study bfmet was po by intragastric gavage once at doses of mgkg of body weight to wistar rats treated with and without antibiotics BC neomycin streptomycin GF rats and gnotobiotic rats and hr later their gastrointestinal tracts were examined for ulcer formation a single oral administration of bfmet induced ileal ulcers in specific pathogenfree rats however the rats given antibiotics to reduce the intestinal bacteria had no ulcers bfmettreated germfree rats and GN rats monoassociated with bifidobacterium adolescentis or lactobacillus acidophilus also had no intestinal ulcers however the drug induced ileal ulcers in gnotobiotic rats monoassociated with eubacterium limosum or escherichia coli an overnight SC of b adolescentis or l acidophilus or yogurt containing bifidobacterium breve and streptococcus thermophilus when given as drinking water inhibited ulcer formation in the ileum of rats treated with bfmet gram staining of the ileal contents of normal rats revealed that of the stained microorganisms were GP rods and only were gramnegative rods in the group of rats with ulcers induced by bfmet the grampositive rods decreased by and the GN rods including escherichia coli klebsiella proteus and bacteroides increased by however in the group of rats po the bifidobacterium culture the lactobacillus SC or yogurt the percentages of the GN rods were decreased although lactobacillus was a L1 bacterium in the ileum of normal rats the GN facultatively anaerobic rods ecoli klebsiella and proteus were increased in the ulcerated ileum of rats treated with bfmet suggesting that these bacteria are associated with ulcer formation in rats treated with nsaids and that lactobacillus and bifidobacterium inhibit it by repressing the growth of ulcerinducing bacteria
|
MEDAL
|
podocyte injury contributes to the OD of focal segmental glomerulosclerosis fsgs endocapillary hypercellularity which is one of the pathological characteristics of fsgs suggests that glomerular EC injury may also be involved in the pathogenesis of fsgs in EM of patients with fsgs n we conducted morphometric measurements of foot process width fpw and podocyte detachment pd as markers of podocyte injury and subendothelial widening sw of the glomerular basement membrane as a marker of endothelial injury and compared them to those in patients with minimal NC nephrotic syndrome mcns n and control kidney donors n associations between ultrastructural and clinical parameters were analyzed according to the fsgs variants defined by the columbia classification fpw was significantly higher in the fsgs group than that in the mcns and control groups particularly in the collapsing tip and cellular SCV of fsgs percentage of glomerular basement membrane gbm length showing pd and sw was significantly increased in the fsgs group especially in the collapsing cellular and NOS SCV in fsgs fpw was inversely correlated with disease duration but not with PU finally the percentage of gbm length with sw significantly correlated with clinical parameters indicativtional mode conversion over and above that seen for an uncoated pipe when an incident wave is scattered by a defect accordingly it is shown that when studying coated pipes one need account only for the attenuation imparted by the coating so that one may normally neglect the effect of coating on modal dispersion and scattering
|
MEDAL
|
this paper discusses natal and postnatal care services in saudi arabia as revealed by the national maternal child health survey of the latter was based on a national random sample of clusters with households from urban and rural Az of five geographic regions the target of evermarried saudi women years old included currently married women of whom reported a pregnancy data on maternal care were analysed including where and why natal care was attended and for both natal and postnatal care how much and by whom by respondents age urbanrural residence geographical location and education of wife and husband about threequarters of the respondents had one or more births within the years preceding the survey with a total of children under six institutional deliveries reached per cent and about per cent of deliveries were attended by physicians or nurses with a ratio of PN care attendance amounted to per cent mainly by physicians than nurses with a ratio of in GA the above results describe relatively high coverage with natal and postnatal care services which can still be improved through HE and community support particularly of the women judging by the high level of institutional care and physician involvement good quality of care is implied but needs to be further confirmed by defining morbidity and mortality patterns
|
MEDAL
|
a water soluble ca plus mgactivated aptase has been extracted with mm edta and mm atp from human erythrocyte membranes the TPS activity of the extracted protein is increased to fold in comparison with untreated ghosts sodium dodecyl sulfatepolyacrylamide gel PACE of gammapatplabeled erythrocyte membranes shows that the ca plus mgactivated atpase is located in the Sp region mr the radioactivity of these high molecular peptide bands is decreased markedly after the SE of the atpase at LIS
|
MEDAL
|
polyaminohydroxynaphthalene sulfonic acidmodified GC electrode polyahnsagce was prepared for simultaneous determination of caffeine and PAR using squarewave voltammetry the method was used to study the effects of ph and scan rate on the voltammetric response of caffeine and PAR linear calibration curves in the range of μm were obtained for both caffeine and paracetamol in acetate buffer solution of ph with a correlation coefficient of and respectively the calculated detection limits sn were μm for caffeine and μm for PAR the effects of some interfering substances in the determination of caffeine and PAR were also studied and their interferences were found to be negligible which proved the selectivity of the modified electrode the method was successfully applied for the quantitative determination of caffeine and paracetamol in cocacola pepsicola and tea samples
|
MEDAL
|
CA cells must detach from the primary focus to initiate the process of metastasis previously we demonstrated that intracellular ca levels are increased in EC cells in the presence of cancer cells and that atp derived from these cells causes this increase the present T0 clarifies the mechanism of atp release from CA cells by investigating the effects of cl channel inhibitors and other drugs on atp PR from HT-1080 cells ht cells levels of extracellular atp and its metabolites were measured using highperformance liquid chromatography hplc with FL detection significantly more extracellular atp was released by suspended than by Ad ht cells the cl channel inhibitors nitrophenylpropylamino benzoic acid micromoll gadolinium micromoll and nations were designed and traditional preparation procedures were used in vitro drug PR was studied and the similarity between the conditions of orifice only on the side of the drug SL and orifices of the same diameter on both sides was evaluated it was found that the drug release from ppop could be influenced by formulation and core hardness while it could hardly be influenced by orifice size no significant difference was observed between the dissolution profiles of orifice only on the side of the drug SL and orifices of the same diameter on both sides mechanism of drug PR was discussed the conclusion was that the disadvantage of side ID in ppop manufacturing process could be overcome by drilling orifices on both sides
|
MEDAL
|
helper cells with specificity for the haptens hydroxynitrophenylacetyl np or hydroxyiodonitrophenylacetyl nip were raised in bbr mice by in vivo priming and in vitro longterm enrichment with haptenderivatized syngeneic SP cells upon coculture with the homologous antigen np or nip self selected helper cells specifically responded by proliferation and by inducing large numbers of B1 to clonal expansion and immunoglobulin secretion crisscross experiments demonstrated the nonheteroclitic nature of antigen recognition by helper cells as the proliferative and helper cell MICs were in every case one order of magnitude higher when confronted with the rat hapten used for immunization
|
MEDAL
|
cardiovascular implantable electronic devices cieds are frequently utilized for management of cardiac dysrhythmias in patients with chronic kidney disease or endstage renal disease receiving hemodialysis the survival benefit from use of implantable cardioverter defibrillators in patients with ckd or esrd is not as clear as in the GA population particularly when used for primary prevention of sudden cardiac death transvenous cied leads are associated with CE vein stenosis resulting in significant adverse consequences for existing or future arteriovenous access A-V hypertension from cied leadrelated central vein stenosis is a challenging clinical problem and may require repeated percutaneous interventions replacement of the cied or creation of alternative arteriovenous access infections associated with transvenous cied leads are more frequent and associated with worse outcomes in patients with renal disease epicardial cied leads or other nontransvenous devices may reduce complications of both CE A-V stenosis and endovascular infection in these vulnerable patients consensus recommendations are offered for avoidance and management of complications arising from the use of cieds and arteriovenous hemodialysis access
|
MEDAL
|
claudins are tightjunction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells in the kidney claudins determine the permeability and selectivity of different nephron segments along the renal tubule in the proximal tubule claudins have a role in the bulk reabsorption of salt and water in the thick ascending limb claudins are important for the reabsorption of calcium and magnesium and are tightly regulated by the calciumsensing receptor in the distal nephron claudins need to form cation barriers and chloride pores to facilitate electrogenic sodium reabsorption and potassium and acid secretion aldosterone and the withnolysine wnk proteins likely regulate claudins to finetune distal nephron salt transport genetic mutations in claudin and cause familial hypomagnesemic hypercalciuria with nephrocalcinosis whereas polymorphisms in claudin are associated with kidney stone risk it is likely that additional roles for claudins in the pathogenesis of other types of kidney diseases have yet to be uncovered
|
MEDAL
|
a synthetic peptide corresponding to amino acids of the E2 of the human alpha aadrenergic receptor was used to raise antibodies in rabbits affinitypurified antibodies specifically recognized main bands with a molecular weight of about and kd on the electrotransferred membrane proteins of rat ventricle CM the incubation of these antibodies with rat myocardial CM resulted in a decrease in the number of binding sites for the specific radiolabelled alpha antagonist prazosin these antibodies were also able to mimic the effects of agonist stimulation as demonstrated by a positive chronotropic effect on cultured cardiomyocytes these results constitute the first immunochemical evidence of the presence of both the a and b subtypes of the alpha adrenergic receptor in the HR they also confirm that the second extracellular loop of the alpha adrenergic receptors is an immunologically and functionally important domain
|
MEDAL
|
we examined the efficacy of several betaadrenergic agents commonly used to treat asthma and evaluated the optimum route of administration two hundred and sixtynine persons aged to years who came to the emergency ward while suffering from acute asthma were treated with either inhalation isoetharine hydrochloride or subcutaneous EN or terbutaline sulfate patients were evaluated using clinical scores and pulmonary function tests and were monitored for adverse side effects regardless of mode of therapy the acute attack was either treated successfully terminated in hospital admission or required further therapy within hours in a comparable number of patients adverse side effects were more common with terbutaline sulfate than with either EN or isoetharine in the doses used thus inhalation of betaadrenergic agents is as effective as subcutaneous administration in the treatment of acute asthma in childhood
|
MEDAL
|
the clinical and urodynamic findings in consecutive women referred for investigation of UI and other urinary symptoms were reviewed impaired bladder emptying was defined as a repeated MFR below mlsecond or a PVR of ml or more one hundred and sixtyfive women were diagnosed as having voiding dysfunction fiftysix of the women had a residual UV of ml or more voiding dysfunction was the only abnormal urodynamic finding in women and was associated with genuine SI detrusor instability or bladder hypersensitivity in a further patients overflow incontinence was diagnosed in women symptoms of impaired bladder emptying were significantly more common in women with proven voiding dysfunction but were absent in a third of these patients one in women with normal micturition had PS of voiding difficulty neurological disease pelvic surgery and psychological AF were important causes of voiding dysfunction voiding disorders are a common cause of lower urinary tract dysfunction and should be an important consideration in future patient management
|
MEDAL
|
patients with MB are often asymptomatic but this anomaly may be associated with exertional angina acute coronary syndromes cardiac arrhythmias syncope or even sudden cardiac death this review presents our understanding of the pathophysiology of myocardial bridging and describes prevailing diagnostic modalities and therapeutic options for this challenging clinical entity
|
MEDAL
|
to evaluate the effects of spironolactone on cardiac SNA csna and left VVI lv remodelling in patients with stsegment elevation myocardial infarction stemi
|
MEDAL
|
a threedimensional d FEM fe model of human ear with accurate structural geometry of the external ear canal Tty membrane tm ossicles ME suspensory ligaments and middle ear cavity has been recently reported by our group in present T0 this d fe model was modified to include acousticstructural interfaces for coupled analysis from the ear canal through the tm to ME cavity pressure distributions in the canal and middle ear cavity at different frequencies were computed under input sound pressure applied at different locations in the canal the spectral distributions of MEP at the oval window round window and medial site of the umbo were calculated and the results demonstrated that there was no significant difference of pressures between those locations at frequency below khz finally the influence of tm perforation on pressure distributions in the canal and middle ear cavity was investigated for perforations in the inferiorposterior and inferior sites of the tm in the fe MM and human temporal bones the results show that R2 of MEP is related to the perforation type and location and is sensitive to frequency
|
MEDAL
|
drug combination in cancer therapy aims to achieve synergistic therapeutic effect reduced drug dosage reduced drug toxicity and minimizes or delays the induction of DR in the present T0 we investigated the anticancer effects of the combination of two metabolic modulators dichloroacetate dca and bacillus caldovelox arginase bca or pegyated human arginase ha
|
MEDAL
|
recent studies had demonstrated that serum and mesangial immunoglobulin a iga in patients with iga nephropathy igan were polymeric and deglycosylated the current T0 was to investigate the binding characteristics of monomeric and polymeric normal human iga on mesangial cells and the influence of in vitro deglycosylation of iga molecules the normal human iga was desialylated and degalactosylated with specific enzymes respectively the monomeric iga miga and polymeric iga piga were separated by sephacryl s chromatography the IB capacities of the miga and piga to primary human mesangial cells hmc were evaluated by CP radioligand CA both the native miga and piga could bind to hmc in a dosedependent and saturable manner the MBC of the native piga were significantly higher than that of the native miga p however the affinity of the native miga was almost times higher than that of the native piga T3 deglycosylation binding of the two deglycosylated miga to hmc could not be detected however the maximal binding capacities of the two deglycosylated piga to hmc were increased significantly compared with that of native piga the affinity of the two deglycosylated piga was similar to that of native piga p the current T0 suggests differential binding characteristics of native monomeric and polymeric iga on mesangial cells glycosylation of iga molecules could significantly affect the IB of iga on hmc
|
MEDAL
|
the harmonic scalpel has been used in tonsil surgery for several years the comparison of harmonic scalpel tonsillectomy with other tonsillectomy techniques has been the subject of many studies the research results proved to be contradictory particularly concerning postoperative complications and complaints most authors observed reduced intraoperative one during harmonic scalpel tonsillectomy
|
MEDAL
|
the hyperperfusion syndrome is a recognized complication of CE reports of cerebral hyperperfusion injury following internal carotid artery angioplasty and stenting are few we report a case of yearold hypertensive man who was admitted to our hospital for assessment years T3 experiencing an ICM stroke of right hemisphere angiography confirmed stenosis of left IC ica percutaneous transluminal stenting of left ICA i.a. was performed without any immediate complications two hours T3 the procedure the patient suddenly deteriorated computed tomography ct of the BB revealed extensive intracerebral hemorrhage and he died days later there was precipitating migranous HA and his blood pressure was moderately elevated at the time of deterioration sentinel headache could solely indicate the early sign of hyperperfusion injury T3 CS especially in the presence of arterial hypertension patients with sentinel headache T3 angioplasty should be recognized early and they deserve intensive study for other features of cerebral hyperperfusion injury and prompt early management
|
MEDAL
|
prenatal diagnosis of conotroncal disease has developed by examination of the great arteries during morphological foetal US scanning in the second term of pregnancy this study reports the results of a series of of these malformations diagnosed in the foetus over five and a half years their incidence with respect to all foetal cardiac malformations is tetralogy of fallot and pulmonary atresia with VVI septal defect make up of these cases vascular malposition coarctation with or without interruption of the aortic arch truncus arteriosus and agenesis of the pulmonary valves a karyotypic anomaly was found in cases and in the foetus with a normal standard karyotype deletion of chromosome q was identified in out of cases there was an associated polymalformative syndrome in cases the training of obstetricians has increased the number of antenatal diagnoses of conotroncal abnormalities prenatal counselling should be given by a pluridisciplinary team because the association of these malformations with chromosomal CA or with syndromes difficult to diagnose is common
|
MEDAL
|
PLB is an important diagnostic tool for the management of patients following CL transplantation however it may be associated with severe complications to evaluate the incidence and type of complications after LB we retrospectively analyzed patients who underwent orthotopic liver transplantation olt from september to may a total biopsies were performed with ultrasound guidance and use of the menghini needle mm diameter the biopsies were performed according to the protocol on the th postoperative day and one three five years T3 olt or when clinically indicated patients with severe coagulopathy thrombocytes nl and quick were excluded from this protocol biopsy was complicated by bleeding in of patients the incidence of procedure related complications was of five patients showed intrahepatic hematoma four patients developed a hematothorax three patients had IA one and one patient suffered from hemobilia seven of patients required surgical MI LAP four thoracotomy two retransplantation one graft dysfunction T3 CL transplantation requires rapid assessment and TPS treatment to achieve good results percutaneous liver biopsy is an important procedure in the evaluation and identification of graft dysfunction such as AR SH reinfection or toxic alterations from our data we conclude that percutaneous LB is a safe procedure and advocate is liberal use
|
MEDAL
|
the influence of overweight as a precursor to obesity was analyzed on the elastic properties of the ts based on body mass index bmi children years ± mo were classified as control con n bmi sdz scoresd or overweight ow n bmi sdz scoresd with regard to REF data from the world health organization musculotendinous mt stiffness of the series elastic component sec was determined using quickrelease tests to obtain the mt stiffness index from the slope of either linear stiffnesstorque simttorque or stiffnessemg simtemg relationships and passive stiffness from the intercept point with the ordinate finally the sec AS α and passive fractions cpassive were separated as described by morgan am j physiol using alphatorque αtorque cpassivetorque or alphaemg αemg cpassiveemg relationships no significant differences in simttorque or αtorque were observed between ow and con simtemg or αemg values were significantly different between ow and con which indicate an increase in mt stiffness in all cases passive stiffness kp cpassivetorque cpassiveemg was significantly greater in ow but independent of the activation capacities these results indicate that a weightrelated additional loading of the mt structures in ow children caused the mt system to response accordingly to the PET demand ie higher stiffness of the mt structures due to a concomitant increase in the stiffness of the sec passive and AS fraction this study also reveals that possible differences in the activation capacities influence the determination of mt stiffness of the sec active fraction
|
MEDAL
|
highdose interleukin il results in objective clinical regression in up to of patients with metastatic melanoma and renal cell carcinoma with about half of these patients experiencing a complete regression of all lesions gastrointestinal gi perforation is a rare but potentially serious complication of il administration a retrospective review of all patients treated with il in the surgery CB of the national cancer institute nci between nov and may was performed in addition a review of the published english literature on gi perforation in conjunction with il therapy was performed among the patients treated at the nci there were eight cases of gi perforation seven of the eight patients were treated with highdose iukg every hours intravenous il and one was treated with subcutaneous il these patients developed various signs and symptoms of gi perforation six patients developed ABD pain yet only two of the eight patients had a fever all six patients who underwent radiographic evaluation prior to diagnosis had free intraperitoneal air seen on the study the location of the perforation included the stomach SB appendix and colon all underwent surgical treatment successfully and four patients received further il therapy T3 recovering from the perforation with the patients presented in this article there have now been cases reported in the english literature two of the patients at the nci had a ruptured appendix which has not been previously reported in the literature the key to early diagnosis of gi perforation during il therapy is radiographic DUE patients with gi perforation can be safely retreated with il if they are given adequate time to recover from their surgical intervention and if careful assessment is performed to rule out residual infection
|
MEDAL
|
anticadm antibody anticadm also referred to as antimelanoma differentiationassociated gene mda antibody is a myositisspecific antibody identified in the sera of patients with clinically amyopathic dermatomyositis cadm and is associated with a worse prognosis in dermatomyositis progression to severe cav in LT followup
|
MEDAL
|
the olfactory bulb ob kindling is a model of limbic secondary generalized epilepsy ten days after the completion of ob kindling we have studied the long term effects of both electrode IS and kindling on the IB of hdiazepam to crude mitochondrial fractions on the one hand we have shown that electrode implantation in shamoperated controls induced an obvious increase in benzodiazepine bzd receptor density bmax only at the site of the electrode in comparison to shamunoperated rats these results might indicate an additional mechanism extending earlier observations reported by others who have shown that prolonged electrode implantation induced changes in shamoperated and kindled rats on the other hand the long lasting effect of ob kindling on the IB parameters of hdiazepam was examined in the focus and in the hippocampus the results indicate a bilateral increase of bzd receptors in the ob and an ipsilateral increase in the hippocampus these changes might be a regulation phenomenon in response to a hyperexcitability state and to focal stimulations
|
MEDAL
|
the opossum monodelphis domestica possesses a welldeveloped vomeronasal system uptake of chemical stimuli into the VN organ vno involves a stereotypical nuzzling behavior in the present study ten animals were examined by CS and electron microscopy the peripheral oronasal structures that apparently enhance access of solutes into the vno include two lateral grooves of the ventral rhinarium and a network of channels leading into them dental gap adjacent to the grooves butterflyshaped incisive papilla and unique bristlecupshaped filiform papillae on the tongue the longitudinal axis of the VN complex is composed of the vno proper at its rostral end and an extensive compound serous gland at its caudal end with a distinct transition zone in between the transition zone is characterized by the following features merging of the main excretory duct of the C1 VN gland with the vno lumen and drainage of auxiliary glandular clusters into the lumen irregularities in the sensory epithelium rosette appearance and the ending of the cartilaginous support surrounding the vno multiple elongated bundles of smooth muscle are positioned between the sensory epithelium and the cartilaginous capsule and more caudally are intertwined with the glandular parenchyma these bundles become more numerous at the transition zone contraction and extension of these muscles may function to enhance the flow of solutes and glandular secretion within the lumen two extensive venous sinuses are associated with the opossum vno complex the internal vein bordering the sensory epithelium at its rostral end and the external vein alongside the nonsensory epithelium this arrangement suggests a unique dual pumping mechanism
|
MEDAL
|
xlinked hyperimmunoglobulin m xhim syndrome is a rare genetic immunodeficiency syndrome caused by mutations in the gene encoding cd ligand cdl cd allogeneic hematopoietic SC transplantation hsct offers the prospect of immune reconstitution in xhim syndrome standard hsct using highdose chemoradiotherapy can be followed by serious hepatic problems including venoocclusive disease graftversushost disease andor druginduced hepatotoxicity in patients whose LF is compromised before hsct such as in xhim syndrome caused by cholangiopathy and SH related to opportunistic infections there is a higher likelihood of hepatotoxicity we explored nonmyeloablative hsct in patients with xhim syndrome nonmyeloablative hsct without CL SPK for xhim syndrome to our knowledge has not been described previously
|
MEDAL
|
studies were conducted to determine the nutritional value of LAL for rats and chicks and the nutritional value of lanthionine for chicks for each experiment purified crystalline amino acid diets and crystalline LAL and lanthionine were employed results indicated that the lysine moiety of lysinoalanine is completely unavailable to the rat and only partially available to the chick of rats fed lysinoalanine seven developed nephrocytomegaly the lanthionine studies indicated that the cysteine moiety of lanthionine is available when fed as the racemic mixture and available when fed as the ldlisomeric mixture thus it appears that LAL formation in alkalitreated proteins results in a corresponding decrease in nutritionally available lysine however the lanthionine formed under similar conditions results in loss of only onehalf of the corresponding level of nutritionally available cysteine
|
MEDAL
|
ifosfamide CE ice are associated with grade iiiiv doselimiting thrombocytopenia the childrens oncology group conducted a phase i dose escalation pharmacokinetic and biological study of recombinant human thrombopoietin rhtpo after ice in children with recurrentrefractory solid PT ccg to assess the toxicity and maximum tolerated dose of rhtpo po at or microgkg per dose
|
MEDAL
|
delirium is the most common mental disorder at older age in hospitals after acute admission the pathogenesis of delirium is largely unknown hyperactivity of the hypothalamicpituitaryadrenal axis leading to increased cortisol levels has been suggested to play a role in the development of delirium the effects of cortisol the most important glucocorticoid gc in humans are mainly mediated by the gc receptor gr several polymorphisms in the gr gene that alter the gc sensitivity are known the aim of this study was to study the role of these gr polymorphisms in delirium in elderly patients patients aged years and older admitted to the medical department or scheduled for hip surgery were included delirium was diagnosed using the confusion assessment method five single nucleotide polymorphisms in the gc receptor gene were genotyped and haplotypes were constructed delirium was associated with impaired cognitive p and functional CF p as well as with older age p homozygous carriers of haplotype characterized by the presence of the bcli and tthiiii minor alleles had a decreased risk of developing delirium p independent of age cognitive and functional state homozygous carriage of the bclitthiiii haplotype of the gr gene is related to a reduced risk of developing delirium this suggests that altered gc signaling may be involved in the pathogenesis and development of delirium in the elderly
|
MEDAL
|
SA is an idiopathic multisystem disorder with several clinical and roentgenographic features suggestive of respiratory infection in the absence of infection it is characterized by the microscopic presence of noncaseating epithelioid granuloma in affected tissues when present constitutional PS fever coughing and exertional dyspnea usually develop insidiously although occasionally lofgrens syndromethe triad of bilateral hilar adenopathy erythema nodosum and polyarticular arthritismay herald the ON of acute disease pulmonary involvement is the roentgenographic hallmark of sarcoidosis BL hilar adenopathy is the most common manifestation however parenchymal infiltrates and pleural effusion may occur although numerous bacterial and fungal organisms may mimic the clinical and roentgenographic features of sarcoidosis tuberculosis and fungal infections associated with granulomatous inflammation are the infectious processes most apt to cause diagnostic confusion several diagnostic clues are available to the clinician confronted with the consideration of SA roentgenographic staging of the disorder stage normal radiograph stage i isolated BL hilar adenopathy stage ii hilar adenopathy and PC involvement stage iii isolated PC involvement and stage iv PC fibrosis provides a FR on which a differential diagnosis of likely infectious agents may be constructed and a history of travel to regions of endemic fungal infection may further narrow the differential diagnosis an unexplained exudative lymphocytic pleural effusion or cd LP in bronchoalveolar lavage bal fluid may also suggest a diagnosis of sarcoidosis however the definitive diagnosis of sarcoidosis is dependent upon the histological demonstration of noncaseating granuloma and the exclusion of infection in the appropriate clinical and roentgenographic setting
|
MEDAL
|
an acute arthritis may accompany the onset of CA a case of metastatic adenocarcinoma of the synovium presenting as an acute ICA is described the diagnostic importance of a careful synovial fluid analysis and the use of closed synovial biopsy are emphasized
|
MEDAL
|
peroxisome proliferator activated TRG ppargamma is a ligandactivated transcription factor activation of ppargamma has recently been demonstrated to inhibit various tumor cells growth progression and metastasis ecadherinmediated cell adhesion system is now considered to be an invasion suppressor system in CA tissues matrix metalloproteinases mmp is a prerequisite for metastasizing tumor cells however their rho is still unknown in gastric carcinoma the aim of this T0 was to assess the expression of ppargamma EC mmp and their correlation in gastric carcinoma and metastases
|
MEDAL
|
the paradigm that chronic rejection causes all progressive late allograft failure has been replaced by a hypothesis of cumulative damage where a series of timedependent immune and nonimmune mechanisms injure the kidney and lead to chronic IF and tubular atrophy representing a final common pathway of injury and its consequent fibrotic healing response allograft damage is common progressive timedependent clinically important and modified by IS early Tx TI damage is predominantly related to ischemia RI ATN acute and subclinical rejection andor calcineurin inhibitor nephrotoxicity superimposed on preexisting donor disease later cellular inflammation lessens and is replaced by microvascular and glomerular injury from calcineurin inhibitor nephrotoxicity hypertension immunemediated fibrointimal V1 PH SPK glomerulopathy and capillary injury polyoma virus andor recurrent glomerulonephritis additional mechanisms of injury include internal architectural disruption of the kidney cortical ischemia persistent chronic inflammation replicative senescence cytokine excess and fibrosis induced by epithelialtomesenchymal transition current understanding of the etiology pathophysiology and evolution of pathological changes are detailed an RPA to histological assessment of the individual failing VG are presented and a series of postulates are defined for future studies of chronic allograft nephropathy
|
MEDAL
|
this paper presents shear bond strength data and SEM photo micrographs of six dentinal adhesives allbond etched and unetched syntac prisma universal bond scotchbond multipurpose tenure solution and adhesive by choice the methods used in tooth treatment and SEM microscopic observation were MZ to those used in previous studies this permitted comparisons among a total of dentinal adhesives seven from previous studies all treated under the same experimental conditions and all currently available to the practitioner scanning electron micrographs showed the types of failures that occurred when the composite resin was fractured from the dentin most of the fractures were adhesive with the exception of scotchbond multipurpose which had many cohesive failures in the dentin or the composite resin there was no significant difference among any of the shear bond strength values with the exception of scotchbond multipurpose which was significantly stronger than the other five adhesives studied
|
MEDAL
|
this study evaluated the prevalence of human cytomegalovirus hcmv and epsteinbarr virus ebv in periimplantitis and mucositis sites and the correlation between HHV-8 and clinical parameters fiftysix dental implants mean time of loading ± years were evaluated periimplantitis mucositis healthy periimplant sites the clinical parameters assessed were visible plaque index pi one on probing bop suppuration sup probing depth pd a polymerase chain reaction assay identified hcmv and ebv in subgingival PI samples the percent of CS with PI and bop was significantly higher around mucositis and periimplantitis compared with healthy implants p the mean pd around the implants was significantly higher in periimplantitis followed by mucositis and healthy implants p hcmv was detected in and ebv in of the periimplantitis sites hcmv was found in of the healthy periodontal CS and ebv in a statistically significant correlation was found between presence of hcmv and ebv subgingivally and clinical parameters of periimplantitis and healthy sites these results confirm the high prevalence of hcmv and ebv in subgingival plaque of periimplantitis CS and suggest the viruses have a possible active pathogenic role in periimplantitis
|
MEDAL
|
we conducted a study to evaluate the followup characteristics of patients with trigeminal neuralgia tn and to evaluate the AF affecting longterm outcome of microvascular decompression mvd in tn between and patients with tn treated with mvd by neurosurgeons at university medical centre groningenthe netherlands were evaluated baseline data from operative outcome were evaluated using univariate and MVA the group consisted of patients with tn females and males with a median followup period of years the average age of initial PS was years the average duration of symptoms was months postoperative patients had a facial hyperpathia or hyperesthesia postoperatively patients had immediate relief postoperatively year patients still had a good outcome of the T0 twentyseven patients with good immediate postoperative results had recurrent pain from the group of patients with typical tn had good LT results after operation patients with typical tn and immediate postoperative remission in univariate analysis had significantly more often an excellentgood postoperative outcome immediate postoperative remission is an independent predictive factor for a good LT outcome the longterm results of mvd in majority of patients were good with no mortalities and no L1 morbidities patients with typical tn had better longterm outcomes and less recurrence
|
MEDAL
|
we have developed a measure of subjective health status quality of life for patients with inflammatory bowel disease ibd ninetyseven patients with ibd described problems they had experienced as a result of the disease the most frequent and improns in area distributed axon collaterals to all fields of si as well as projecting a main axon to motor cortex in GA the axon collaterals of area b pyramidal cells outside layer iii remained confined to area b most of the nonpyramidal SN labeled were basket cells in layers iii and vi these SN formed dense axonal fields around their cell bodies and none of their axons could be followed into the underlying VWM the results of the present T0 demonstrate that area b somatosensory cortical neurons and their axons are vertically organized in a manner similar to that reported for other sensory cortical areas they also show that widespread horizontal connections are formed by pyramidal SN of layer iii and that these horizontal axons can travel for great distances in the cortical grey matter
|
MEDAL
|
the aim of this study was to evaluate the pathological significance of antibodies against cornea and inner ear tissue in the OD of audiovestibular and ocular symptoms in patients with cogans syndrome cs we analysed the serum of cs patients for IB of igm and igg to fresh cryosections of rat labyrinth semicircular canals ampulla utricle saccule and cornea by indirect immunofluorescence if the predominant pattern of anticorneal igm was IF of the SF cell layer of the nonkeratinizing squamous epithelium igm against cornea was found in patients all of whom had bilateral inflammatory eye signs at the start of the disease however igm was also detected in the chronic stage of the disease when no clinical signs of eye involvement were apparent the T0 includes the first followup examination of anticorneal igm and EA during a complete episode of active cs during the first episode of cs in patient anticorneal igm became detectable week after the onset of interstitial keratitis and weeks after the onset of audiovestibular symptoms it increased over several weeks and then fell to very low levels however at no time was anticorneal igg found in the course of followup examinations the SS of patients intermittently contained low titre igg antibodies against inner ear labyrinthine tissue but without any clear rho with the AS stages of cs in addition highta estradiol androstenedione alphadihydrotestosterone levonorgestrel and cholestenbeta diol hydroxycholesterol resulted in stimulation of progesterone synthesis hydroxycholesterol augmented progesterone synthesis stimulated by estradiol alphadihydrotestosterone levonorgestrel and bromoadenosine cyclic monophosphate brcamp this increase in progesterone synthesis was additive with estradiol alphadihydrotestosterone and levonorgestrel and synergistic with brcamp cholera toxin progesterone levonorgestrel and androstenedione increased pscc mrna C2 whereas estradiol had no effect cholera toxin progesterone and levonorgestrel increased betahsd mrna C2 but estradiol and androstenedione had no effect the results were interpreted to mean that estrogens androgens and progestins regulate progesterone synthesis in the jc cells the effect of androgens appears to be mediated by stimulation of pscc mRNA while progestins stimulate both pscc and betahsd gene expression our results support the concept that progesterone is an autocrine regulator of its own synthesis in granulosa cells
|
MEDAL
|
beet black scorch virus bbsv encodes three movement proteins pa pb and p that facilitate its celltocell movement an argininerich motif of pa nterminus was found to determine nuclear and nucleolar localization amino acids substitution or deletion of the rrich motif interfered with pa nuclear and nucleolar localization bimolecular fluorescence complementation bifc assays revealed that pa protein interacted with nicotiana benthamiana nuclear import factor importin α suggesting that pa is translocated into the nucleus by the classical importin αβdependent pathway moreover pa also interacted with the nucleolar protein fibrillarin mutations in the rrich motif of pa diminished pa interactions with importin α and fibrillarin influenced viral replication in nicotiana benthamiana protoplasts and altered the symptom phenotype and viral rna accumulation in chenopodium amaranticolor plants these results demonstrate that the rrich motif of pa is correlated with nuclear and nucleolar localization viral replication and virus infection
|
MEDAL
|
astrocytes of mouse cerebellum were grown in chemically DM for days subcultivated and grown in serumcontaining medium for up to days T3 days in defined medium the cells showed fatty degeneration from which they recovered histologically and chemically T3 one week in serumsupplemented medium at this point of the cells were GFA proteinpositive and synthesized phosphatidylinositol phosphatidylserine and bismonoacylglycerophosphate besides other phospholipids
|
MEDAL
|
sdz pco and cromakalim are BK opening drugs which relax airway smooth muscle and reverse airway one due to i.v. of airway spasmogens reduction of airway one by these drugs may be attributed to actions upon airway reactivity as well as airway smooth muscle spasmolysis for at concentrations which do not induce overt EC50 of airway smooth muscle both sdz pco and cromakalim suppressed OD of airway hyperreactivity due to administration of immune complexes paf or isoprenaline and reversed act with several lps components including one of about kda which contains the probable site of sialylation by cmpnana the reactions with the mab were not affected by growing the strains with cmpnana nor by neuraminidase treatment of the sialylated lps the mab also goldlabelled the surface of both strains before and T3 treatment with cmpnana these data indicate that sialylation by cmpnana and staining with ruthenium red renders more visible the surface lps which sometimes in the past has been seen as a capsule
|
MEDAL
|
neurologic disturbances are common following the intensive chemotherapy and radiotherapy of bone marrow transplantation bmt conditioning regimens the somnolence syndrome which occurs in most children treated for leukemia with prophylactic cranial irradiation has previously not been reported following bmt this syndrome consists of transient lethargy irritability headaches low grade fevers gastrointestinal disturbances and depression we report the case of a yearold female with acute nonlymphocytic leukemia who developed symptoms typical of the somnolence syndrome weeks following cgy total body irradiation and cyclophosphamide conditioning encephalographic findings were consistent with the syndrome and no additional infectious or metabolic disorders could be identified as predicted by the pediatric experience the symptoms were transient resolving following steroid and antidepressant therapy among patients undergoing radiation based conditioning regimens especially those not receiving concurrent steroid therapy the appearance of posttransplantation somnolence may be an expression of this syndrome
|
MEDAL
|
fortythree patients with limiteddisease inoperable nonsmall cell lung CA received two intravenous courses of cyclophosphamide adriamycin and cisplatin cap chemotherapy over a week period this was followed by weeks of combined chemoradiotherapy ccrt consisting of low weekly doses of cap for weeks plus gy continuous x ray therapy xrt to the primary RT site chemotherapy was continued until disease progression occurred or until the TD of adriamycin reached mgm whichever came first ccrt improved the response rate CR response cr plus partial responses pr from T3 two courses of cap alone to after ccrt previous response to two courses of cap influences response subsequent to cap plus xrt a pretherapy WL of or greater had a significant adverse effect on both response and survival time the median survival time for all patients was weeks patients whose disease responded to treatment survived significantly longer than patients with nonresponding disease the median time until PD was weeks twentyseven patients relapsed the first CS of relapse were local in of the patients distant in of them and both local and distant in severe esophagitis occurred in of the patients and was doselimiting the administration of ccrt resulted in an improved response rate compared with the rates reported in previous studies of chemotherapy or radiotherapy alone further improvement of the ccrt program is needed to increase LT survival time and to decrease esophageal toxicity
|
MEDAL
|
the vestibular cerebellar and Rt systems are CE in importance in MS and habituation to the effects of motion NM single photon emission computed tomography spect studies of cerebral blood flow and power spectral electroencephalographic recordings during motion sickness were used to determine alterations in the CNS system the rotating chair with and without visual stimulation was used to study the rate of habituation and the effect of antimotion sickness medications on this rate an increase of theta waves over the FC cortex indicated a decreased activation of the higher centers during MS motion sickness also produces an increase of blood flow in the CE cerebellum that has connections to the reticular system this increase in cerebellar activity is relayed to the Rt system whereby neural recruitment builds up to trigger the vomiting center producing motion sickness habituation may be a CS compensatory activation of the Rt neurons that prevents this disruption of normal activation the rate of habituation when motion sickness was prevented by scopolamine was slowed indicating that if the CNS system is not challenged by disruption of normal activation it does not produce the compensatory reactions that result in habituation
|
MEDAL
|
tuberous sclerosis tsc gene is the target of a germline IS in the eker rat MM of inherited cancer susceptibility this tumor suppressor gene when mutated gives rise to a spectrum of epithelial and nonepithelial neoplasms in the rat as well as multisystem involvement of hamartomas in the human in this T0 we characterized the rat tsc cdna and found that it is highly homologous with the human gene including a conserved rapgap catalytic domain sequence analysis of independent rat clones from a kidney cdna library revealed distinct but related variants of the tsc transcripts stemming from alternative splicing involving two noncontiguous exons within the translated region the first of these located at amino acids to gives rise to isoforms with or without the bp exon there exists another variant related to the use of a cryptic splice acceptor site in the downstream exon that results in an inframe bp deletion a separate bp exon encoding a novel serinerich CAA CS to was also alternatively spliced together we have found a minimum of four and potentially eight tsc isoforms that are differentially expressed in a tissuespecific manner these splice variants are highly conserved in the human gene suggesting a possible functional role of these tsc isoforms in various cell regulatory and developmental processes
|
MEDAL
|
atrial fibrillation af is the most common sustained arrhythmia it is associated with increased risks of death and stroke most strokes in af patients are thought to arise from thrombi in the LAA surgical ablation of af includes excision of the left atrial appendage and is an ERP means of treating this arrhythmia with the classic maze procedure curing af in of patients and virtually eliminating the risk of late stroke a complex but safe operation the maze procedure has been applied by relatively few surgeons however recent advances in the understanding of the pathogenesis of af and development of new ablation technologies enable surgeons to perform BPV ablation create linear left atrial lesions and remove the LAA rapidly and safely lesions are created under direct vision minimizing the risk of damage to the pulmonary veins and adjacent mediastinal structures the majority of surgical ablation procedures have been performed in conjunction with mitral valve surgery with the combination of MVR and cure of af enabling patients to avoid lifelong AC recently developed surgical instrumentation now enables thoracoscopic and keyhole approaches facilitating extension of epicardial af ablation and excision of the left atrial appendage to patients with isolated af and no other indication for CS in addition novel devices designed specifically for minimally invasive Epi exclusion of the LAA will broaden the range of treatment options for patients with af possibly eliminating the need for AC in selected patients
|
MEDAL
|
with the prevalence of wireless radio frequency rf devices interest is growing to more fully understand the effect of rf on biological tissue this research explores how dna interacts with rf SE by sweeping a radio frequency range from ghz to ghz we hope to observe if specific frequencies show significantly elevated rf energydna interaction eg either absorbed andor reflected our procedure is as folnts the SL hairpin dna capture probe hp which was labeled by thiolated methylene blue mb at the protruding termini and ferrocene fc in the middle of the loop first selfassembled on the gold electrode surface via a aus bond in the presence of tdna the tdna hybridized with hp which triggered the exo iii cleavage process and accompanied the PR of tdna as a result the mb tags were away from and the fc tags close to the gold electrode surface leading to the decrease of the oxidation peak current of mb imb and the increase of that of fc ifc the value of δifcδimb δifc and δimb are the change values of the oxidation peak currents of fc and mb respectively is linear with the concentration of tdna from pm to pm the detection limit fm of the developed method is much lower than that of the most reported electrochemical dna biosensors this strategy provides a simple and sensitive RPA for the detection of tdna and has promising applications in bioanalysis disease diagnostics and clinical biomedicine
|
MEDAL
|
between and infants with transposition of the great arteries tga have been repaired within their first six months of life from the simple tga forming the study group underwent intraatrial repair according to mustard and brom group i and received the arterial switch procedure group ii we compared the observed rhythm disorders T3 both surgical methods there were no deaths in group i and deaths in group ii GI cases had early postoperative arrhythmias patients received transient therapy there were cases of SVT ART svt cases of frequent supraventricular premature beats svpb infant with temporary av junctional rhythm and with temporary total av block both needed external pacemaker support for maximal two days group ii cases prs and peers did not agree on their selections of socially rejected children but had good PA concerning the ID of children with externalizingtype SMB problems finally teacher and peer classifications of aggressivedisruptive children were highly SD throughout the preschool year these findings indicate that peerrejected children can be identified at very young ages and that preschoolers can be reliable informants about the social maladjustment of peers
|
MEDAL
|
the intracellular ph phi of live MF from the anterior tibialis of the frog rana temporaria was measured at degrees c using phsensitive microelectrodes in ringer solutions containing a fixed bicarbonate concentration mm and varying pco concentrations of as extracellular ph was changed from to mean phi changed from to similar results were obtained at degrees c in parallel experiments force and rate of HP in s ISO tetani at degrees c were measured and compared to control observations co phi as the fibres became more acid to phi force and heat rate were progressively reduced to and of the control values respectively as the fibres became more ALP to phi force increased slightly by a maximum of of the control value but heat rate did not increase when the dependence on ph of the molar enthalpy NC for phosphocreatine splitting is taken into account these results indicate that the FTI per crossbridge cycle increases with phi over this range
|
MEDAL
|
the measurement of heart rate during exercise in the horse has been recommended as a means of prescribing work effort monitoring the changes in aerobic capacity during training and as part of the clinical examination of the performance horse the accuracy of four heart rate meters peh pu hr and hrm was assessed by comparison with heart rate determined by simultaneous telemetry electrocardiography ecg using a rapid incremental exercise test on a treadmill heart rate displayed by all four meters showed significant correlations with the ecg HR rate but only two meters peh and hrm had correlation coefficients of or greater
|
MEDAL
|
checkpoint blockade has revolutionized the treatment of melanoma however it benefits only the minority of patients several agents have been combined with immunotherapy to improve tcell activation and persistence including growth factor chemotherapy and radiation preclinical data suggest that temozolomide which metabolizes to the same AS compound as dacarbazine selectively depletes RII TA this potential immunomodulatory effect of temozolomide provides rationale for combination with ipilimumab we performed an openlabel singlearm phase ii T0 of ipilimumab plus temozolomide in the frontline setting for patients with M1 melanoma and ldh â¤Ã upper limit of normal ipilimumab was given at mgkg on day and TMZ mgm
|
MEDAL
|
fiftyone patients with relapsed or refractory intermediate or highgrade nonhodgkins lymphoma were referred for ABMT transplantation abmt the primary criterion for eligibility was sensitivity to conventionaldose salvage chemotherapy of patients who received salvage chemotherapy demonstrated chemotherapysensitive disease six eligible patients did not undergo abmt for various reasons a total of patients underwent abmt with etoposide MEL ± total body irradiation as the IT regimen there was one early treatmentrelated death and three nonresponders of the remaining patients relapsed while remain in continuous complete remission cr at a median followup of months T3 SPK range months two patients with chemosensitive disease and bone marrow involvement underwent allogeneic bmt with marrow from hlaidentical siblings both are in CCR at and months followup of the patients who did not undergo abmt all have died median survival months the results indicate that approximately onehalf of relapsed or refractory aggressive histology lymphoma patients referred for abmt eventually undergo transplantation if chemotherapysensitive relapse is the L1 criterion for eligibility approximately of the referred patients may become longterm diseasefree survivors with this RPA reports of marrow SPK series should include all patients referred for abmt as the denominator for calculating diseasefree survival in order to reduce the bias of patient selection
|
MEDAL
|
the human monocytic leukemia cell line thp produces an immunosuppressive factor that inhibits interleukin ildependent proliferation of mouse thymocytes as well as the mitogenic effects of concanavalin a con a and phytohemagglutinin pha on human IP blood MNC cells the mechanism of action of this factor includes interference with both the production of interleukin il and its effects on target cells thus the suppressor abrogates the proliferation of an ildependent Tc cell L1 ctll but not of il independent cells like the l fibroblasts or the el t lymphoma and u histiocytic lymphoma lines it also suppresses il production by human IP blood EC t cells and mouse splenocytes the mediator has a molecular weight of dalton as determined by gel filtration chromatography is heat labile and is CS to TR chymotrypsin and protease
|
MEDAL
|
hydroxytryptamine serotonin or ht stimulated the incorporation of pi into phosphatidylinositol pi but not into PPIs in c glioma cells with an ec of x m the phosphoinositide response was blocked by the ht antagonists ketanserin and spiperone but inhibited only partly by methysergide and mianserin atropine prazosin and yohimbine did not block the response whereas FLU and haloperidol did so partially but also inhibited basal incorporation by approximately the hta 8-OH-DPAT did not cause stimulation incubation with ht microm for h increased the incorporation of hmyoinositol into all PIs but not into Ins phosphates ips li CT at mm increased labeling in inositol bisphosphate ip and trisphosphate ip whereas labeling in ip and PIs remained unaltered addition of ht had no effect on this increase mn at mm enhanced labeling in pi piphosphate lysopi glycerophosphoinositol and ip but the presence of ht again did not cause further stimulation ht also stimulated the PR of ips in cells prelabeled with hmyoinositol incubated with licl mm and inositol mm and then exposed to ht microm radioactivity in ip and ip was very low was stimulated approximately as early as s and remained elevated for at least min radioactivity in ip was at least times as high as in ip but was increased only from min on with a peak at min when the elevation was approximately times that in ipabstract truncated at words
|
MEDAL
|
a years old female presented with fever RD and a rapidly enlarging soft left postauricular lump for last two months she was found anaemic had a RA supraclavicular nontender lymph node of about cm diameter and mild hepatosplenomegaly she had a positive mantoux test and normal chest xray ultrasonography of abdomen showed multiple preand paraaortic enlarged CL NO mild pericardial effusion was detected on echocardiography fine NAC from the RA supraclavicular lymph node showed epithelioid cell granuloma excision and biopsy of the dermoid were carried out the content was pus which was smearnegative but culturepositive for acidfast bacilli the patient responded to antituberculous chemotherapy satisfactorily
|
MEDAL
|
clinical features laboratory findings and complications of typhoid fever were correlated with sex through a retrospective case note review of hospitalized culturepositive patients in durban SA intestinal perforation p occult blood losses in stools p and a mild reticulocytosis in the absence of hemolysis p occurred more frequently in males than in females a sinquin in the supernatant slices obtained from pwm treated animals had a tenfold increase in quin accumulation in spleen no changes in lung and a decrease in liver suggesting that the SP contributes to the increased quin levels found in the blood and brain of immunestimulated mice C1 doses of KYN hydroxylase inhibitors increased kyn and kyna but unexpectedly did not decrease quin content in control blood and BB when tested in organ slices obtained from either controls or immunestimulated animals mnba microm and ro microm strongly reduced quin neoformation suggesting that in vitro kynurenine hydroxylase activity is required for quin neosynthesis indeed after repeated doses of mnba or ro quin content in blood and brain of immunestimulated animals significantly decreased our results suggest that under basal conditions sufficient quin synthesis may occur through kynurenine hydroxylaseindependent pathways in immunestimulated animals however KYN hydroxylase inhibitors significantly reduce blood and BB accumulation of quin
|
MEDAL
|
changes in vascular volume caused by a pharmacologic agent are frequently inferred rather than directly measured we investigated the effects of nitroprusside in dogs divided into groups control and splenectomized we anesthetized the dogs using pentobarbital and surgically prepared a venoright atrial bypass preparation whose controlled cardiac output and external reservoir allowed measurement of both changes in V1 resistance and changes in vascular volume in both groups blood pressure mean sd decreased at each successive level of nitroprusside mmhg base L1 mmhg microgrammin mmhg microgrammin mmhg microgrammin mmhg microgrammin nitroprusside caused a large and similar decrease in vascular resistance in both CG in the control group vascular volume increased above base line and mlkg at each successive level of nitroprusside infusion whereas in the splenectomized group VV increased above base L1 and mlkg at each successive level of nitroprusside infusion but increased significantly less than the control group we concluded that nitroprusside decreases V1 resistance and increases vascular volume and that the spleen is the L1 site of changes in VV caused by nitroprusside
|
MEDAL
|
the patient was the fourth of affected male siblings cortisol micrograms per cent cortisone and corticosterone sulfate concentrations were low in cord blood the larger amount of cortisone may have originated from maternal cortisol aldosterone was undetectable in cord blood indicating lack of fetal secretion or maternofetal transfer unexpectedly normal concentrations of deoxycorticosterone doc sulfate in cord serum could represent maternal transfer of doc with subsequent fetal sulfurylation low estrone and estradiol concentrationlithotomy position were evaluated retrospectively during the postoperative neurological evaluation those patients who developed neuropraxic complications were reviewed in detail to identify those with LE sensory and motor deficiencies the electromyographic emg results of the patients with neurological deficiencies were evaluated the patients were studied with respect to age length of operation type of T0 and mode of anaesthesia fischers exact probability test was used for the statistical analyses postoperative neurapraxia complications developed in of the patients of these cases two had irreversible neurological deficiencies all other patients recovered without any treatment during the first postoperative month no correlation was discovered between the type of anaesthesia used and neurapraxia p however it was found that age type of operation and T0 time contributed to neurapraxia developing p old age older than prolonged operation time more than min and an inappropriate lithotomy position were seen as the main risk factors in developing postoperative neurapraxia mistakes in the positioning of the operating staff might be an additional contributing factor
|
MEDAL
|
positron emission tomography pet appears to be an innovative method for imaging the proliferative activity of malignant tissue in particular by means of flabelled fluorodeoxyglucose fdg the potential role of pet scanning was investigated in a satellite centre as an adjunct to conventional methods for estimating the likelihood of pulmonary malignancy therefore the sensitivity of detection of LC in candidates was determined prior to exploratory or therapeutic thoracotomy by fdg pet imaging the study involved patients with abnormal chest roentgenogram and suspected lung cancer who were due for thoracotomy the pet scans were evaluated qualitatively and semiquantitatively pulmonary malignancy was found in patients and had a focal increase in fdg pulmonary uptake benign pulmonary lesions were found in patients three of whom had a negative pet scan the sensitivity of PCD of LC by fdg pet was therefore bayesian T0 shows that fdg pet could be the most useful method in a population with a low prevalence of lung CA as illustrated by our T0 a simple fdg pet scanning protocol in a satellite pet centre could provide adequate clinical information and help in deciding subsequent patient management
|
MEDAL
|
in glucocorticoidremediable aldosteronism gra a chimeric gene has been described with the activity of CYP11B2 but the promoter of betahydroxylase leading to ectopic expression of aldosterone synthase activity in the zona fasciculata similar to gra in aldosteroneproducing adenomas apa the primary regulation of aldosterone production is acth and there is increased production of the oxygenated cortisol compounds oxocortisol and hydroxycortisol because of these hormonal similarities we tested whether a chimeric gralike gene was present in apa from patients a gralike chimeric gene was not found in the dna from these tumors and therefore is not the mechanism responsible for hyperaldosteronism in apa
|
MEDAL
|
sibutramine hydrochloride bts has been evaluated in a range of behavioural and PSA models predictive of potential antidepressant activity bts exhibited potent activity in acute behavioural tests for detecting potential ADs bts rapidly and potently downregulated rat cortical betaadrenoceptors being effective after only three days of p.o. bts showed very little activity in a range of experiments predictive of sideeffect potential bts possesses a pharmacological profile which suggests that it may be a potent antidepressant with a rapid onset of action and with a low potential for causing sideeffects
|
MEDAL
|
in the process of studying charge holding capability and delay time for breakdown in liquids under nanosecond ns time scales a tesla based IPG has been developed PP generator is a combination of tesla transformer pulse forming line a fast closing switch and test chamber use of tesla transformer over conventional marx generators makes the IPG very compact cost ERP and requires less maintenance the system has been designed and developed to deliver maximum SO voltage of kv and rise time of the order of tens of nanoseconds the paper deals with the system design parameters breakdown test procedure and various exp results to validate the pulse generator performance experimental results have been compared with pspice simulation software and are in good agreement with simulation results
|
MEDAL
|
we report a case of retrovesical fibrosarcoma with severe hypoglycemia a yearold man was admitted to our hospital with second recurrence of the retrovesical RT with hypoglycemia the episodes of hypoglycemia were accompanied by the advance of RT size complete tumor resection with total cystectomy was performed on december and the tumor was diagnosed histopathologically as fibrosarcoma soon T3 removal of the RT hypoglycemia disappeared and the patient has been well without local recurrence or distant metastasis for more than months
|
MEDAL
|
wt and pax are transcription factors involved in kidney development and phenotypic regulation of glomerular epithelial cells in primary focal segmental glomerulosclerosis fsgs the alteration of the podocyte is important for the development of the cellular lesion cl and glomerular scar formation to investigate the contribution of wt and pax to the development of the cl in primary fsgs immunohistological studies were performed using renal biopsy specimens on the expression of wt pax and cytokeratin ck which is an epithelial marker but never found in normal podocytes the expression of wt was decreased in the cl compared with unaffected podocytes but pax and ck were expressed significantly in the cl and also in the cells morphologically recognized as podocytes in cases with cl our results suggest that reexpression of pax resulting in phenotypic change of podocytes to a different epithelial form is important for the development of the cl in primary fsgs normal podocytes resemble mesenchymal cells since they express both vimentin and wt in contrast epithelial cells including parietal epithelial cells of the bowmans capsule express both pax and ck therefore the mechanism of phenotypic change of podocytes in the cl in primary fsgs might be mesenchymalepithelial transformation and a developmental paradigm
|
MEDAL
|
the original definition of aerobic dive limit adl was the dive duration after which there is an increase in postdive concentration of lactate in the blood of weddell seals freely diving in the field the only other species in which such measurements have been made is the emperor penguin for all other species aerobic dive limit has been calculated cadl by dividing usable oxygen stores with an estimation of the rate of oxygen consumption during diving unfortunately cadl is often referred to as the ADL implying that it is equivalent to that determined from the measurement of postdive blood lactate concentration however this is not so as at cadl all of the usable oxygen would have been consumed whereas weddell seals and emperor penguins can dive for at least times longer than their adl thus at adl there is still some usable oxygen remaining in the stores it is suggested that to avoid continued confusion between these two terms the former is called diving lactate threshold dlt as it is somewhat analogous to the LT in exercising terrestrial vertebrates possible explanations of how some species routinely dive beyond their cadl are also discussed
|
MEDAL
|
to evaluate the effect of regularly scheduled administration of analgesic medication on SMB emotional wellbeing and use of asneeded psychotropic medications in nursing home residents with moderatetosevere dementia
|
MEDAL
|
gliomas are routinely graded according to histopathological criteria established by the world health organization although this classification can be used to understand some of the variance in the clinical outcome of patients there is still substantial heterogeneity within and between lesions of the same grade this study evaluated imageguided tissue samples acquired from a large cohort of patients presenting with either new or recurrent gliomas of grades iiiv using ex vivo proton highresolution magic angle spinning spectroscopy the quantification of metabolite C2 revealed severale iufd is a complication of UV varix however recent studies are more reassuring when foetal intraabdominal UV varix is isolated there is no reason to change the management of the pregnancy foetal US followup is recommended focusing on an increase in the size of the varix and the appearance of a clot a particular clinical form connecting the umbilicus to the extrahepatic portal vein should be known because of a high risk of thrombosis on the basis of this finding PN monitoring by ultrasound is necessary
|
MEDAL
|
infections of the foot in the person with diabetes are the result of a complex myriad of pathophysiologic alterations neuropathy vascular disease and host immune alterations all interact to present a fertile ground for significant microbiologic invasion when infection occurs it is commonly due to a mixed flora of aerobic and anaerobic organisms although pure aerobic or anaerobic infections are sometimes seen treatment of these infections requires a broad RPA including surgery local care and antibiotics most often treatment against aerobic and anaerobic pathogens will be necessary these infections can be divided into two categories based on clinical appearance severe life or limbthreatening infections can present with massive cellulitis of the foot and leg high fever significantly elevated white blood count septicemia and tissue gas AGA antibiotics in this setting include either combination or singleagent therapy imipenemcilastatin offers coverage of all usual pathogens along with potentially lower toxicity and lower cost than combinations combinations containing CLI and aztreonam or ciprofloxacin may be useful for patients allergic to betalactam antibiotics less severe infections can usually be treated with a singleagent antibiotic such as ticarcillinclavulanic acid or ampicillinsulbactam cephalosporins with anaerobic activity including cefoxitin cefotaxime and ceftizoxime can be used in Az where enterococci are not a major problem
|
MEDAL
|
alopecia can be divided into disorders in which the hair F2 is normal but the cycling of hair growth is abnormal and disorders in which the hair F2 is damaged androgenetic alopecia is the most common cause of hair loss in women other disorders include AA telogen effluvium cicatricial alopecia and traumatic alopecias the diagnosis is usually based on a thorough history and a focused PE in some patients selected laboratory tests or punch biopsy may be necessary topically administered minoxidil is labeled for the treatment of AGA in women CSs and other agents are typically used in women with AA telogen effluvium is often a selflimited disorder because alopecia can be devastating to women management should include an assessment for psychologic effects
|
MEDAL
|
leftsided pulmonary artery agenesis is a rare malformation that commonly requires childhood MI secondary to associated congenital cardiovascular anomalies we present an uncommon case of leftsided agenesis with an associated rightsided aortic arch and significant hypoplasia of the ipsilateral lung additionally there is radiographic evidence of emphysema and pulmonary artery hypertension pulmonary artery agenesis is not a common entity but should be considered in AD patients presenting with recurrent pneumonias and radiographic evidence suggestive of PH a prompt diagnosis is beneficial for affected individuals who may be candidates for a revascularization procedure or embolization of collaterals earlier diagnosis also allows for proper management and followup care considering pulmonary artery hypertension is a severe complication of pulmonary artery agenesis
|
MEDAL
|
we prepared a dodecasaccharide TPS for the oantigenic polysaccharide chain of salmonella typhimurium oantigens and by the partial hydrolysis of the opolysaccharide chain utilizing bacteriophage b endoalphalrhamnosidase the dodecasaccharide was shown by chemical and spectroscopical analyses to be totally devoid of lipid a and OS by coupling this dodecasaccharide to human serum Al a glycoconjugate dodecaitchsa was prepared and found to be i nonpyrogenic ii unable to gelate a limulus amoebocyte lysate and iii unable to induce earlyphase pyrogenic tolerance to endotoxin rabbits immunized either intravenously with the glycoconjugate suspended in saline or intrapopliteally with the glycoconjugate suspended in freund CR adjuvant developed a significant although modest pyrogenic tolerance against challenge with the oantigenic rat s typhimurium lipopolysaccharide p less than and p less than for immunized and control rabbits respectively the evoked tolerance was oantigen TPS since no pyrogenic tolerance against challenge with lipopolysaccharide from s thompson possessing MZ lipid a and core oligosaccharide structures but differing in the oantigen polysaccharide chain could be seen p greater than these results demonstrate that a nonpyrogenic oantigenic polysaccharide hapten when coupled to an immunogenic carrier protein evokes immune responses which mediate significant although modest latephase tolerance and is capable of partly reducing the pyrogenic activity of the oantigenic homologous lipopolysaccharide
|
MEDAL
|
the direct oral anticoagulants doacs have been compared with parenteral anticoagulants and vitamin k antagonists vkas for the treatment of A-V TE vte in several robust studies doacs have shown similar efficacy in preventing recurrent vte and significant reductions in critical site intracranial bleeding fatal one major and nonmajor bleeding warfarin and other vkas are not dead as treatment modalities for vte a better way to describe the current situation is to use a boxing expression down but not out vkas and parenteral anticoagulants still have a role to play in the management of vte in several clinical settings in indications where doacs can be used vkas should not as the safety profile of vkas is considerably worse than doacs hence guidelines are now recommending doacs in preference to vkas in this article we consider where doacs are indicated where there is growing evidence for use where we have little evidence for use and finally wade of agricultural commodities eg animal feed requires monitoring for fungal toxins also little is known about masked and emerging toxins and metabolites samples from countries were analysed for toxins and metabolites of EDC detected up to metabolites were found in a single sample a subset of finished feed maize and maize silage samples containing compounds from to from countries was investigated using liquid chromatography and mass spectrometry deoxynivalenol don zearalenone zen and fumonisins showed C1 increases of annual medians in europe within a region distinct trends were observed suggesting importance of local meteorology and cultivars in median don concentrations increased to μ g·kg in austria but were SD in germany at μ g·kg in enniatins occurred at median concentrations of μ g·kg in europe at levels similar to don and zen the latter were frequently correlated with donglucoside and zensulfate cooccurrence of regulated toxins was frequent with eg enniatins and MON correlation was observed between don and donglucoside and with beauvericin results indicate that considerably more than of agricultural commodities could be contaminated with mycotoxins as suggested by fao although this is at least partly due to the lower limits of PCD in the current survey observed contamination percentages ranged from to for b trichothecenes and for zen
|
MEDAL
|
we investigate the possibility of the existence of the exotic torus configuration in the highspin excited states of ca we here consider the spin alignments about the symmetry axis to this end we use a threedimensional cranked skyrme hartreefock method and search for stable singleparticle configurations we find one SD state with the torus configuration at the total angular momentum j ħ and an excitation energy of about mev in all calculations using various skyrme interactions the total angular momentum j ħ consists of aligned nucleons with the orbital angular momenta λ and for spinup or down neutrons and protons the obtained results strongly suggest that a macroscopic amount of circulating current breaking the timereversal symmetry emerges in the HS excited state of ca
|
MEDAL
|
two variants of the methylotrophic bacterium wa designated was slimy and wans nonslimy were compared with respect to their ability to grow in batch culture on the c substrates methylamine methanol and TMA substrate utilization cell density ph cellular and soluble polysaccharide production and concentrations of the enzymes MA dehydrogenase TMA dehydrogenase and methanol dehydrogenase produced were measured as a CF of growth the ability of the two bacterial variants to excrete the redox cofactor pyrroloquinoline quinone into the growth medium was also investigated the two SCV were similar with respect to all properties measured except that was produced significantly more capsular polysaccharides than variant wans pyrroloquinoline quinone was excreted when either variant was grown on any of the c substrates investigated but was maximally produced when the methylamine concentration was wtvol this cofactor is excreted only as bacterial growth enters the stationary phase a time when the C2 of trimethylamine dehydrogenase and the quinoproteins methanol dehydrogenase and methylamine dehydrogenase begin to decline it is not known whether the pyrroloquinoline quinone found in the medium is made de novo for excretion derived from the quinoprotein pool or both pyrroloquinoline quinone excretion has been observed with other methylotrophs but this is the first instance where the excretion was observed with substrates other than methanol
|
MEDAL
|
townesbrocks syndrome tbs is an autosomal dominantly inherited malformation syndrome characterized by anal renal limb and ear anomalies recently we showed that mutations in the putative zinc finger transcription factor gene sall cause tbs to determine the spectrum of sall mutations and to investigate the genotypephenotype correlations in tbs we examined additional families with tbs or similar phenotypes for sall mutations in of these families mutations were identified none of the mutations has previously been described two of these mutations are nonsense mutations one of which occurred in three unrelated families five of the mutations are short deletions all of the mutations are located of the first double zinc finger dzf encoding region and are therefore predicted to result in putative prematurely terminated proteins lacking all dzf domains this suggests that only sall mutations that remove the dzf domains result in tbs we also present evidence that in rare cases sall mutations can lead to phenotypes similar to goldenhar syndrome however phenotypic differences in tbs do not seem to depend on the site of mutation
|
MEDAL
|
the prevalence of college students tobacco use is widely recognized but successful cessation and relapseprevention programs for these smokers have drawn little attention the authors who explored the feasibility of training peers to lead cessation and relapseprevention programs for undergraduates found a quit rate of suggesting that peers were ERP facilitators relapseprevention interventions which began immediately after participants quit smoking included monthly group programs and individual meetings each session provided education and training in SM nutrition and exercise habits managing environmental smoking triggers and coping in social situations T3 participating in the relapseprevention programs of the initial quitters remained smoke free another indication that peers were ERP facilitators the success of the program combined with the dearth of populationspecific cessation and relapseprevention tools suggests that college administrators and health educators should develop integrated tobacco management strategies on college campuses
|
MEDAL
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.