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in this review we address the main cutaneous manifestations and diseases associated with deficiencies in components of the complement system the first part is devoted to hereditary angioedema in which acute sometimes lifethreatening recurrent attacks of acute swelling usually associated with gastrointestinal symptoms occur it is related to a structural or functional deficiency of c esterase inhibitor patients usually have lowered c levels and diagnosis relies on determination of antigenic andor functional c inhibitor level the second part focuses on lupus erythematosus as deficiencies in early components of the complement system such as cq cr cs c or c are the strongest known disease susceptibility genes for the development of human systemic LE severe infections early in life atory cytokines and il and glycemia in the ow group a positive correlation was found between il and triglycerides adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents this suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents the positive correlation between il and TNF and il suggests an attempt to inhibit the production of these cytokines by il
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scanning electron microscopy sem and transmission electron microscopy tem were used to study the ultrastructure of human respiratory cilia in patients with chronic or recurrent respiratory infections and control patients specimens of pathological mucosa were taken from maxillary sinuses and middle turbinates control tissues were taken from middle turbinates or from sphenoid sinuses during transsphenoidal pituitary surgery findings in control tissues or specimens with minimal amounts of pathological findings showed that tem and sem findings correlated well tem revealed axoneme structure better while much larger populations of cilia could be studied 3D with sem sem also was the better study when cilia orientations or lengths were evaluated optimal examination of ciliary ultrastructure required both tem and sem studies
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the bacteriophage mu com protein is a small zinc fingerlike protein that binds a specific site in commom operon mrna and activates translation of the mom openreadingframe com contains six cysteine and five histidine residues that have the potential to form several alternative zincfingerlike motifs we have used oligonucleotide SDM to individually alter each of these amino acids cys to ser and his to asn or gln and tested the various forms of com for their ability to function in vivo we observed that mutation of any one of the four NT cysteine residues cys or resulted in loss of com activity the com protein requires zinc in order to fold into its functional tertiary structure as demonstrated by characteristic h nuclear magnetic resonance nmr delta h chemical shifts revert to random coil values in the presence of the metal chelator edta the metalbinding specificity and thermal stability of com also has been investigated using h nmr we report the use of cd nmr hcd hn spinecho difference spectroscopy hsed and zn extended xray absorption fine structure spectroscopy exafs to determine the zincprotein stoichiometry as and the ligand environment as tetrathiolate comparative nmr spectra of com mutants cs and cs suggest position is involved in zinc coordination while position is not metalliganded these studies indicate that the metal coordination site of com is a fourcysteine complex involving residues and
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in the food and agriculture organization undertook to revitalise its MICs in the control of transboundary animal disease by establishing a new special programme known as the emergency prevention system empres against transboundary animal and plant pests and diseases the emphasis of the empres livestock component is placed on preempting outbreaks and losses experienced by agriculture through the enhancement of local capacity to detect and react rapidly to plague events empres concentrates on the coordination of the global rinderpest eradication programmea timebound eradication programmewhilst addressing the progressive control of the most serious epidemic diseases within a broad FR of emergency preparedness programme activities are discussed in relation to early S1 early reaction facilitating research and coordination in addition to RP particular attention has been paid to contagious bovine pleuropneumonia a reemerging disease in africa targeted for strategic attention and foot and mouth disease for which coordinated regional control in latin america and SE asia has been initiated tactical responses to other disease emergencies such as african swine fever CP swine fever hog cholera rift valley fever peste des petits ruminants and LSD are described
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the organization of actin filaments into large ordered structures is a tightly controlled feature of many cellular processes however the mechanisms by which actin filament polymerization is initiated from the available pool of profilinbound actin monomers remain unknown in plants because the spontaneous polymerization of actin monomers bound to profilin is inhibited the MI of an actin promoting factor is required for efficient actin polymerization two such factors have been characterized from yeasts and metazoans the arp complex a complex of seven highly conserved subunits including two actinrelated proteins arp and arp and the formin family of proteins the recent finding that arabidopsis thaliana plants lacking a PET arp complex exhibit rather modest morphological defects leads us to consider whether the large formin family plays a central role in the regulation of actin polymerization here we have characterized the mechanism of action of arabidopsis formin afh overexpression of afh in pollen tubes has been shown previously to induce abnormal actin cable formation we demonstrate that afh has a unique SMB when compared with nonplant formins the activity of the formin homology domain fh containing the actin IB activity is modulated by the FH domain fh indeed the presence of the fh domain switches the fh domain from a tight capper kd approximately nm able to nucleate actin filaments that grow only in the pointedend direction to a leaky capper that allows barbedend elongation and efficient nucleation of AFs from actin monomers bound to profilin another exciting feature of afh is its ability to bind to the side and bundle AFs we have identified an actin nucleator that is able to organize AFs directly into unbranched actin filament bundles we suggest that afh plays a CE role in the initiation and organization of actin cables from the pool of actin monomers bound to profilin
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lowering of the coâ concentration in the environment induces OD of a pyrenoidal ST sheath as well as that of pyrenoid and coâconcentrating mechanisms in many microalgae in the green algae chlamydomonas and chlorella activity of granulebound starch synthase gbss concomitantly increases under these conditions in this study effects of the gbssdefective mutation sta on the development of pyrenoidal ST were investigated in chlamydomonas stroma starch and pyrenoid starchenriched samples were obtained from logphase cells grown with air containing coâ highcoâ conditions favouring stromal starch synthesis and from those transferred to lowcoâ conditions air level coâ favouring pyrenoidal starch synthesis for h respectively in the wild type total ST content per SC volume did not increase during the lowcoâ conditions in spite of the OD of pyrenoidal ST suggesting that degradation of some part of stroma ST and synthesis of pyrenoid starch simultaneously occur under these conditions even in the gbssdeficient mutants pyrenoid and pyrenoid ST enlarged T3 lowering of the coâ concentration however the morphology of the pyrenoid starch was thinner andement method dem is used to computationally model the motion and orientation of several novel pharmaceutical tablet shapes in a film coating pan in order to predict coating uniformity the MM predictions are first confirmed with exp data obtained from an equivalent film coating pan using a machine vision system the MM is then applied to predict coating uniformity for various tablet shapes pan speeds and pan loadings the relative effects of these parameters on both inter and intratablet film coating uniformity are assessed the dem results show intratablet coating uniformity is strongly influenced by tablet shape and the extent of this can be predicted by a measure of the tablet shape the tablet shape is shown to have little effect on the mixing of tablets and thus the intertablet coating uniformity the pan rotation speed and pan loading are shown to have a small effect on intratablet coating uniformity but a more significant impact on intertablet uniformity these results demonstrate the usefulness of modeling in guiding drug product OD decisions such as selection of tablet shape and process operating conditions
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increase in endurance swimming capacity caused by capsaicin cap a pungent component of red pepper induced increase of fat metabolism in mice was investigated using an adjustablecurrent water pool the mice administered cap via a stomach tube showed longer swimming time until exhaustion than the control group of mice in a dosedependent manner the maximal effect was observed at a dose of mgkg while more than mgkg had no effect the increase of endurance was observed only when cap was po two hours before swimming after the administration of cap the serum glucose concentration rapidly increased and then decreased within min while the concentration of SF fatty acids gradually increased through hours the residual glycogen concentration of the GM after min of swimming was significantly higher in the capadministered mice than in control mice suggesting that use of the SS free fatty acids spared muscle glycogen consumption the SS adrenaline concentration significantly increased with twin peaks at min and two hours after administration of cap an experiment using adrenalectomized mice was done to confirm that the effect of cap is due to increased SE metabolism through the secretion of adrenaline from the adrenal gland the swimming endurance capacity of the adrenalectomized mice was not increased by cap administration although adrenaline injection induced a increase in the Tlim these results suggest that the increase of swimming endurance induced by cap in mice is caused by an increase in fatty acid utilization due to capinduced adrenal catecholamine secretion
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in an estimated million people died from mycobacterium tuberculosis mtb moreover people developed multidrugresistant tb mdrtb
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the consultative study is one model of academic involvement in public MH services however the effects of consultation and how it acts as a catalyst for change have been poorly documented the authors describe a consultative study in which a team from a academic training center examined the system of MH and related human services for children and adolescents in a semirural county in western PA they also present results of a sixyear followup survey assessing the studys effects improvement in the system of care during the followup period included creation and maintenance of a childrens unit and a partial hospital program for adolescents at the countrys community mental health center the consultative T0 and the followup survey were instrumental in establishing a comprehensive range of services including intensive case management for severely disturbed youngsters and a homebased MH services program
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we investigated the effect of cilnidipine on cardiovascular and neuroendocrine responses to acute cold AS in conscious and unrestrained or moderately restrained spontaneously hypertensive rats shrs acute CS significantly increased mean blood pressure without marked change in heart rate the acute cold stressinduced elevation in blood pressure was almost abolished by mgkg po of prazosin the cold AS also elevated plasma norepinephrine and EN C2 cilnidipine at mgkg po significantly inhibited the pressor response to acute CS although mgkg po of nifedipine nicardipine or manidipine lowered mean blood pressure to a similar extent as cilnidipine none of these three drugs affected the pressor response cilnidipine also reduced the cold stressinduced increment in plasma norepinephrine but not the epinephrine level these findings suggest that acute cold AS may induce the elevation in blood pressure due to an enhanced activation of the sympathoadrenal system in shrs and that cilnidipine may suppress the pressor response by inhibiting the sympathetic nerve activity
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the use of betablockers to enhance performance in some sports is forbidden based on this regulation there is a demand for dynamic analytical procedures for analyzing these EDC quickly and without manual sample preparation therefore the use of a molecularly imprinted CP mip in a multidimensional LC system coupled to a mass spectrometer provides a good alternative for improving the selectivity and practicality of the betablocker analyses as described in this paper a watercompatible mip for oxprenolol was synthesized by the precipitation method using methacrylic acid as a PET monomer and hydroxyethyl methacrylate and glycerol dimethacrylate as hydrophilic monomers a column filled with mip was coupled to an lcmsms SF-36 under the multidimensional configuration with mmol l ammonium formate buffer ph as the loading and reconditioning mobile phase and a formic acid aqueous solutionmethanol v v as the elution mobile phase the system was used for online SE and quantization of oxprenolol from to μg l atenolol propranolol nadolol pindolol labetalol and metoprolol all from to μg l simultaneously from urine samples the rho coefficient was higher than for all the analytes suitable precision and accuracy were obtained
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immunohistochemical markers to assist in the diagnosis and classification of hyperplastic endometrial epithelial proliferations would be of diagnostic use to examine the possible use of pax as a marker of hyperplastic endometrium cases of normal endometrium simple and complex hyperplasia without atypia AH and international federation of gynecology and obstetrics figo grade endometrioid carcinomas were stained for pax two hundred and six endometrial samples were available for interpretation of pax staining the percentage of cases with CR pax loss of cells staining increased with increasing severity of hyperplasia of normal proliferative and secretory endometrium n of simple PH n of complex hyperplasia n of atypical hyperplasia n and of figo grade endometrioid cancers n partial loss of pax expression did occur in normal endometrium but in smaller proportions of tissue and was less frequent than in SH with partial loss complex hyperplasia AH and figo grade carcinomas uniform pax expression was rare in complex and atypical PH and carcinoma when evaluating loss of pax in histologically normal endometrium adjacent to lesional endometrium in a given case statistically significant differences in staining were observed for SH p complex PH p atypical hyperplasia p and figo grade endometrioid CA p in summary pax loss seems to occur early in the development of endometrial precancers and may prove useful in some settings as a diagnostic marker in determining normal endometrium from complex and AH and lowgrade carcinomas however it is not useful in distinguishing between these diagnostic categories
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a total of clinical isolates of flavobacteria including isolates of flavobacterium meningosepticum of flavobacterium indologenes and of flavobacterium odoratum were collected from january to december from patients in taiwan the in vitro activities of antimicrobial agents were determined concomitantly by the standard agar dilution and DD methods more than of the flavobacterial isolates were resistant to cephalothin CTX ceftriaxone moxalactam aztreonam imipenem aminoglycosides erythromycin and glycopeptides the majority of f meningosepticum isolates were susceptible to piperacillin and to minocycline but resistant to ceftazidime with mics at which of the isolates are inhibited being and microgml respectively approximately half of the f indologenes isolates were susceptible to piperacillin cefoperazone ceftazidime and minocycline with mics at which of the isolates are inhibited being and microgml respectively the majority of f odoratum isolates were resistant to all the antimicrobial agents tested except minocycline to which five of six isolates were susceptible with leastsquares SRA and error ratebounded analysis methods the following resistant and susceptible zone diameter breakpoints were established or and or mm respectively for piperacillin against f meningosepticum and f indologenes or and or mm respectively for ceftazidime against f meningosepticum and f indologenes or and or mm respectively for ofloxacin against f indologenes or and or mm respectively for ciprofloxacin against f meningosepticum valid breakpoints for the DD method could not be established for cefoperazone and ofloxacin against f meningosepticum and for minocycline against f meningosepticum and f indologenes due to a poor correlation coefficient for the regression L1 or for CPZ and ciprofloxacin against f indologenes due to the presence of remarkable error rates
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our ICC investigation of the magnocellular NE cells in the cat hypothalamus reveals a mixture of vasopressin vp and oxytocin otcontaining neurons in the supraoptic nso the paraventricular npv and in five AN nac we describe the lateral hypothalamic nucleus nlh a new accessory nucleus lying at the junction of the internal capsule and pallidum and possibly involved in drinking SMB previously characterized incompletely in mammals the four other accessory nuclei consist of the circularis nc anterior fornical naf posterior fornical npf and retrochiasmatic nrc the two peptidergic cell types vp and ot are equally mixed in the npv and the nac but in the nso vp SN predominate the perikarya of these vp and ot neurons do not show distinct morphological differences at the level of CS microscopy the organization of MC neuroscretory SN in the cat hypothalamus closely resembles that described in other mammals with the exception of the unique presence of the lateral hypothalamic accessory nucleus
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human factor viii circulates as a series of AS heterodimers composed of a CS chain kda linked by divalent metal ions to a VL sized heavy chain kda purified factor viii subunits were modified with sulfhydrylspecific fluorophores probe selection was based upon the limited number of free cysteine residues in each S1 C2 of probe incorporation suggested the presence of a single reactive cysteine residue per S1 aminoterminal sequence analysis of fluorescent tryptic MMP derived from the modified subunits indicated fluorophore attachment sites at cys of the heavy chain a domain and cys of the CS chain a domain S1 reassociation was measured by fluorescence SE transfer using light chain modified with npyrenyl maleimide fluorescence donor and heavy chain modified with diethylaminomaleimidophenylmethylcoumarin fluorescence acceptor donor fluorescence quenching paralleled the formation of factor viii clotting activity and both effects were saturable with respect to added heavy chain based upon the degree of donor quenching a distance of a was calculated separating the two fluorophores these results indicate a close spatial relationship between the a domain of onfined to the anterior periventricular and medial parvicellular subdivisions of the nucleus the galanincontaining projection from the locus coeruleus was most circumscribed with the vast majority of doubly labeled varicosities confined to the periventricular and adjoining aspects of the anterior and medial parvicellular subdivisionsabstract truncated at words
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transitional cell carcinoma of the ovary tcco is a less common type of malignant surface epithelialstromal RT of the ovary still with uncertain incidence histologically tcco resembles UC of the urinary system and by definition does not contain a brenner RT component tcco may not be a bona fide urothelial neoplasm however but rather a lesion of the müllerian type derived from the ovarian surface epithelium this notion is supported by the existence of mixed tumors consisting of tcco and other histological types of ovarian carcinoma as well as the observation that tcco has a müllerian type but not a urotheliallike immunohistochemical profile besides M1 UC of the urinary tract the other types of ovarian carcinoma as well as sex cordstromal PT such as AD granulosa cell tumors have to be considered in the differential diagnosis of tcco a recent analysis of a C1 series of T3 ovarian carcinomas treated by RS and postoperative chemotherapy confirms studies that had suggested that tcco has a better prognosis with current treatment than that of the other histological types of ovarian carcinoma further studies applying standardized histopathological criteria are needed to clarify the true incidence and behavior of tcco in addition it is important to T0 the biological and molecular BG of this apparently less aggressive phenotype
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this T0 characterized escherichia coli isolates from distinct diseased organs of broiler chickens with clinical symptoms of colibacillosis in the southern brazilian state of rio grande do sul thirtyeight isolates were highly virulent and were virtually avirulent in dayold chicks yet all isolates harbored virulence factors characteristic of avian pathogenic e coli apec including those related to adhesion iron acquisition and SS resistance e coli reference collection phylogenetic typing showed that isolates belonged mostly to group d followed by group a group b and group b phylogenetic analyses using the amplified ribosomal dna restriction analysis and pulsefield gel electrophoresis methods were used to discriminate among isolates displaying the same serotype revealing that five birds were infected with two distinct apec strains among the avian isolates were members of the pandemic e coli ohbst clone
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the purpose of this T0 was to reveal the activation of the frontal lobe in piano performance by the use of nearinfrared spectroscopy participants wereseven healthy volunteer music college students the results of the examination showed a tendency towards an increase in total hemoglobin volume over a wider area in the FC part of the BB during an appropriate piano task compared with an easy piano task or the keio version of the wisconsin card sorting test the results suggest that piano performance is recognized as a frontal lobeactivating task and that performance of an AGA piano task can be expected to elicit wider activation of the FC lobe than an easy one
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cognitive dysfunction in depression has recently been given more attention and legitimacy as a core symptom of the disorder however animal investigations of depressionrelated cognitive deficits have generally focused on emotional or spatial SM processing additionally the relationship between the cognitive and affective disturbances that are present in depression remains obscure interestingly sleep disruption is one aspect of depression that can be related both to cognition and affect and may serve as a link between the two previous studies have correlated sleep disruption with negative mood and impaired cognition the present study investigated whether a long photoperiodinduced depressive phenotype showed cognitive deficits as measured by novel object recognition and displayed a cognitive vulnerability to an acute period of TSD AD male WR were subjected to a LP ld or a normal photoperiod ld condition our results indicate that our LP exposed animals showed behaviors in the FST consistent with a depressive phenotype and showed significant deficits in novel object recognition three hours of TS deprivation however did not significantly change novel object recognition in either group but the trends suggest that the long LD and normal photoperiod groups had different cognitive responses to TSD collectively these results underline the extent of cognitive dysfunction present in depression and suggest that altered sleep plays a role in generating both the affective and cognitive symptoms of depression
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heat shock proteins hsps are a family of highly conserved proteins present in all organisms they mediate a range of cytoprotective functions as molecular chaperones and are recently reported to regulate the immune response using suppression subtractive hybridization we isolated and characterized a cucumber cdna designated cshsp which encodes a putative heat shock protein of kda protein containing three conserved dnaj domains belonging to the type i hsp family realtime quantitative rtpcr analysis revealed that cshsp was significantly induced in cucumber leaves inoculated with downy mildew pseudoperonospora cubensis in this incompatible interaction mRNA was also strongly upregulated by various abiotic stresses cshsp was mainly expressed in flowers with a flowerspecific stamen and pistilpredominant expression DP this suggests that cshsp harbors broadspectrum responses to both biotic and abiotic stresses and may play a role in downy mildew resistance in cucumber
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recent in vitro and in vivo studies suggest that CPs may play an important role in Kd of the glomerular basement membrane gbm by renal glomeruli however little information is available concerning the cysteine proteinases present in glomeruli the distribution of cysteine proteinases in other Az of the kidney or the potential role of endogenous glomerular cysteine proteinases in gbm degradation using well characterized fluorogenic substrates we have documented the presence of the cysteine proteinases cathepsins b h and l in glomeruli and mumg protein mean sem n and other fractions prepared from normal rat kidney the presence of cysteine proteinases in glomeruli was verified by FM for each proteinase the activity was proportional to the amount of tissue protein and time of incubation dependent on the presence of exogenously added dithiothreitol and completely inhibited by the TPS cysteine proteinase inhibitor e the ph optimum for cathepsin b substrate zargarghnmec and l substrate zphearghnmec in the presence of zphephechn was approximately ph for both glomeruli and renal cortex while that for cathepsin h ATP arghnmec was approximately incubation of sonicated glomeruli with hgbm under conditions optimal for CP activity ph mm edta and mm dithiothreitol degrees c resulted in significant gbm Kd as measured by the PR of nonsedimentable x g min radioactivity or hydroxyprolineabstract truncated at words
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twentyfive surgically confirmed softtissue lesions of the hand were examined prospectively by realtime ultrasound use of US enabled a reliable diagnosis of the cystic or solid nature of softtissue lesions an accurate estimation of the volume and precise threedimensional localization of the abnormality sonography also facilitated the location of foreign HB assessment of anatomic relationships of these lesions to tendons and surrounding structures by realtime US during palpation flexion andor extension also aided in the surgical RPA
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the systemic availability of melphalan T3 p.o. is not well known most patients are put on a fixed oral dosage regimen we have studied the disposition of MEL in patients after single oral doses five were also studied T3 receiving the same dose intravenously oral MEL had a mean plasma terminal phase halflife t of min the mean area under the plasma concentrationtime curve cxt was micrograms minml urinary excretion of oral melphalan averaged during the first hr the cxt ratio oralintravenous for the patients studied after both oral and intravenous melphalal mgkg ranged between and and averaged after oral dosing in fasting patients the time at which melphalan first appeared in the plasma varied between min and hr in a myeloma patient who took oral melphalan no MEL was found in plasma or urine up to hr some instances of failure of tumor response to oral MEL may be due to inadequate bioavailability rather than inherent RT resistance
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few studies have focused on the risks of peripheral intravenous catheters pivs as sources for staphylococcus aureus bacteremia sab a lifethreatening complication we identified pivrelated infections in a cohort of patients with sab IP intravenous catheterrelated sab was associated with significantly longer bacteremia duration and thrombophlebitis at old piv sites rather than current pivs
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patients presenting with peyronies disease pd curvature and erectile dysfunction ed can achieve straightening and rigidity through penile prosthesis implantation and manual modeling and if necessary a relaxing tunical incision with or without grafting unfortunately this maneuver will not correct pdinduced shortening in addition incision and grafting after the prosthesis has already been implanted adds to operative time and risk and may indicate mobilization of the neurovascular bundle and possibly a secondary skin incision
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two hundred seventy children of school age of whom were lefthanded and an equivalent number of whom were RH have been examined in the present study using a test battery of nine language ability measures vocabulary similarities comprehension wiscr deductive reasoning inductive reasoning sentence completion comprehension of sentential semantics comprehension of syntax and text processing the data analysis has indicated that onefactor solution applies both to the RA and LH population according to standard error scree method zoski jurs with regard to language ability measures handedness discriminates between righthanders superior and lefthanders VPI in language ability there have been subgroups of LH children who differ in language ability distribution compared with righthanded children according to hierarchical CA extreme versus mild bias to hand preference and hand skill do not differentiate performance subgroups neither within the LH nor within the righthanded main group sex and familial sinistrality do not affect performance the results are discussed in relation to a human balanced polymorphism theory advocated by annett mainly annett a annett manning b potential pathology mainly bishop a coren halpern satz orsini saslow henry and developmental instability yeo gangestad daniel and delay of lefthemisphere maturation in LH individuals geschwind galaburda ab by pointing out the strength and weaknesses of these theoretical approaches in accounting for the present data
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the phase image in RN ventriculography shows the timing of VVI contraction and is valuable in the detection of abnormalities induced by PD disease the image is usually interpreted subjectively and in the present T0 a histogram of left VVI phase values was used to make interpretation more objective the left ventricular ejection fraction and the sigma skewness and kurtosis of the phase histogram were measured at rest during isometric exercise and during the final two stages of maximal dynamic exercise in controls and patients with coronary i.a. disease without previous infarction the ejection fraction and the sigma of the phase had the same predictive accuracy for the presence of disease when measured during the penultimate stage of dynamic exercise as during the final stage but their accuracy was lower during maximal exercise because of motion artefact at high exercise levels skewness and kurtosis of the histogram were of no value for the PCD of disease and IE was of only limited value it is concluded that the phase histogram provides an objective measurement of the synchronicity of left ventricular contraction and can increase sensitivity for the detection of abnormality data should be acquired at all stages of DE and the penultimate stage should be used if there is any doubt about the validity of the final stage
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biological barriers are the main defense systems of the homeostasis of the organism and protected organs the bloodbrain barrier bbb formed by the endothelial cells of BB capillaries not only provides nutrients and protection to the CNS system but also restricts the entry of drugs emphasizing its importance in the treatment of neurological diseases cyclodextrins are increasingly used in human pharmacotherapy due to their favorable profile to form hydrophilic inclusion complexes with poorly soluble active pharmaceutical ingredients they are present as excipients in many marketed drugs application of cyclodextrins is widespread in formulations for oral parenteral nasal pulmonary and skin delivery of drugs exp and clinical data suggest that cyclodextrins can be used not only as excipients for centrally acting marketed drugs like antiepileptics but also as AS pharmaceutical ingredients to treat neurological diseases hydroxypropylβcyclodextrin received orphan drug designation for the treatment of niemannpick type c disease in addition to this rare lysosomal storage disease with neurological PS experimental research revealed the potential therapeutic use of cyclodextrins and cyclodextrin nanoparticles in neurodegenerative diseases stroke neuroinfections and BB tumors in this context the biological effects of cyclodextrins their interaction with PMs and SE of different lipids are highly relevant at the level of the bbb
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a novel class of lipoxygenase lo inhibitors characteriorns is a critical period with possible longterm consequences for human health in this research the OD of the fecal microbiota of a group of exclusively breastfed neonates living in low socioeconomic conditions in the city of são paulo brazil during the first month of life was studied
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the effect of periodontal healing after guided tissue regeneration gtr in association with local application of metronidazole gel was evaluated in this T0 twelve patients with one pair of vertical periodontal bone defects of comparable size and configuration participated in the T0 in a matched paired design the test defects were treated by gtr using expanded polytetrafluoroethylene eptfe CM in combination with local application of metronidazole gel the controls were treated in the same way except for application of metronidazole during the first month of membrane implantation no statistically significant differences between test and control surfaces were noted with respect to inflammation of the marginal gingiva six weeks following insertion the CM were removed six months T3 removal of the membrane the median gain in probing attachment level as a percentage of the initial defect depth was for test defects and for control defects p no statistically significant differences were found between test and control sites regarding PI bleeding on probing reduction in pocket depth gain in bone height or recession of the gingival margin in conclusion the results of the present T0 indicate that local application of metronidazole gel has a beneficial effect on healing of periodontal vertical defects treated by GTR
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based on cases the authors update the low section and subsequent suture technique of the sternocleidomastoid muscle in conservative C2 LA principally for DTC due to the good SE obtained this technique permits functional clearance with excellent visualisation of the structures to be preserved and is associated with very minor PET sequelae a review of the literature confirms the perfect feasability and reproducibility of this technique and justifies its use from a cosmetic viewpoint
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any complaints from a patient about their memory should be examined diagnosis is based on international criteria the basic evaluation consists of the medical history clinical DUE cognitive tests and brain imaging especially using mri when a diagnosis of alzheimers disease ad with cerebrovascular disease or with lewy body disease or dementia associated with FPD or lbd is made evidence based medical therapy is indicated as part of comprehensive care an acetylcholinesterase inhibitor or memantine can be used these drugs are ineffective in the case of frontotemporal degenerations for severe behavioural disorders other psychoactive medications can be applied
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elevated resting heart rate is an independent risk factor for cardiovascular morbidity and mortality in patients with and without coronary artery disease in patients with known coronary artery disease elevated heart rate reduces diastolic filling time and increases cardiac workload resulting in supply demand mismatch with consequent ischemia and angina while lower HR rate is associated with better prognosis it is not known if pharmacological reduction in HR rate is beneficial and if HR rate is merely a marker for increased risk and worse outcomes certainly physiologically lower RHR as attained by exercise improves morbidity and mortality while physiological reduction in HR rate is mainly a manifestation of increased parasympathetic drive pharmacological reduction of HR rate with betablockers is mediated via the sympathetic pathway and associated with mixed outcomes in addition betablockers have other cardiovascular effects lowering blood pressure are metabolically active and it is unknown if the beneficial effects if any are mediated via reduction in heart rate versus other cardiovascular effects ivabradine is a new medication that lowers HR rate selectively by inhibiting the if current without other cardiovascular effects offering for the first time a therapeutic agent that selectively targets HR rate the medication has shown promise in early trials in patients with HR failure but it is unclear if this agent will be beneficial in patients with SD coronary i.a. disease without HR failure
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the aim of this T0 was to determine the prevalence of type diabetes and impaired fasting glucose ifg in a populationbased sample of subjects aged years participating in the french monica population survey from to in three french regions the urban community of lille the basrhin and the hautegaronne
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a yearold woman complained of general malaise she presented with hyponatremia and plasma osmotic pressure was lower than urinary OP in addition SS antidiuretic hormone level was higher than the measurement sensitivity she was diagnosed with the SIADH siadh she fell into a coma despite correction of SS sodium level brain magnetic resonance imaging mri revealed high signal intensities in the CBF SC striatum thalamus hypothalamus midbrain and pons in fluidattenuated inversion REC images spinal mri revealed a longitudinally extending lesion in the cervical cord serum sample was positive for antiaquaporin antibody supporting the diagnosis of neuromye previously this study showed that expression of mitf had little effects on nfatc and nfatc was critical for the induction of mitfe in mitfmimi mice the semidominant mutation in mitf gene leads to arrest of osteoclastogenesis in the early stages however when stimulated by rankl the mitfmimi preosteoclasts responded with a significant induction of nfatc despite that the cells cannot differentiate into functional osteoclasts in the absence of rankl stimulation very high levels of nfatc are required to drive OCL OD our data indicate that mitf functions downstream of nfatc in the rankl pathway and it plays an important role in amplifying nfatcdependent osteoclastogenic signals which contributes to the significant synergy between the two AF during osteoclastogenesis we propose that mitfe functions as a tissuespecific modulator for events downstream of nfatc activation during osteoclastogenesis
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infected arthroplasties reportedly have a lower eradication rate when caused by highly resistant andor polymicrobial isolates and in these patients most authors recommend intravenous antibiotics we asked whether twostage revision with interim oral antibiotics could eradicate these infections we prospectively followed patients mean age years with late hip arthroplasty infections combinations of oral antibiotics were prescribed according to cultures biofilm and intracellular effectiveness the minimum followup was year mean years range years we presumed eradication in the absence of clinical serologic and radiographic signs of infection infection was eradicated in all patients with highly resistant bacteria who completed a twostage protocol with MR staphylococci and in eight of patients treated with only the first stage and six of nine with MRS infection was eradicated in six of six patients with polymicrobial isolates of sensitive andor resistant bacteria who completed a twostage protocol and in five of seven with polymicrobial isolates treated with only the first surgery the harris hip score averaged range in patients who underwent reimplantation and range in patients who underwent resection arthroplasty long cycles of combined oral antibiotics plus a twostage surgical exchange appear a promising alternative for infections by highly resistant bacteria methicillinresistant staphylococci and polymicrobial infections
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polyadenylation is a cotranscriptional process that modifies mrna ends in eukaryotes in yeast cf ia and cpf constitute the core end maturation complex cf ia comprises rnap rnap pcfp and clpp cf ia interacts with the CT domain of rna pol ii largest subunit via pcfp which links premrna end processing to transcription termination here we analysed the role of clpp in processing clpp binds atp and interacts in cf ia with pcfp only SD of clpp abolishes transcription termination moreover we found that association of mutations in the atpbinding domain and in the distant pcfpbinding region impair end processing strikingly these mutations prevent not only clpppcfp interaction but also association of pcfp with rnaprnap chip experiments showed that rnap crosslinking to the end of a proteincoding gene is perturbed by these mutations whereas pcfp is only partially affected our study reveals an essential role of clpp in cf ia organization we postulate that clpp transmits conformational changes to rna pol ii through pcfp to couple transcription termination and end processing these rearrangements likely rely on the correct orientation of atp within clpp
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recently we reported the identification of a novel mitochondrial AI pathway for granzyme b grb the newly identified grbmediated mitochondrial cascade was initiated by the cleavage and subsequent Kd of mcl resulting in the eritoneally and hr T3 partial hepatectomy groups iii and iv respectively for up to hr after partial hepatectomy with ethanol administration starting hr prior to partial hepatectomy animals were killed at and hr T3 partial hepatectomy the rate of LR was evaluated by the mitotic index in hestained sections immunochemical PCD of ki nuclear antigen rate of hthymidine incorporation into hepatic dna and liver thymidine kinase enzymatic activity the biological activity of hss in CG i and ii rats was evaluated using a bioassay ethanol administration arrested LR during the first hr T3 partial hepatectomy and suppressed hss activity throughout the period examined liver regeneration PD after hr despite the low levels of hss activity hss administration at and hr reversed LR arrest induced by ethanol acute ethanol administration induces Tc arrest during the first hr after partial hepatectomy and suppression of hss biological activity seems to contribute to this effect hss administration reversed the inhibitory effect of ethanol on LR and caused synchronized entrance of hepatocytes in the s phase of the Tc hss seems to participate in the network of growth AF controlling the gs cell cycle checkpoint
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according to the resource allocation MM it is logical to think that emotional mood states modulate the allocation of capacity most cognitive tasks require some allocation of capacity and in many instances there is a positive correlation between effort and memory in cognitive science the exp paradigm of LDT is used to investigate visual words recognition and lexical access according to the resource allocation MM we postulated that depressed patients take more time to recognize items from an affective loaded list in order to compare their behavior in lexical decision task in this T0 depressed patients and HCs were studied we hoped to find an interaction between the mood state of subjects and the categories affective or neutral of words this kind of interaction is expected to figure among the cognitive markers of depression two CG of righthanded adults served as subjects in our experiment the subjects were living in the north west region of quebec the G1 consisted of depressed patients mean age sd all of them met the dsm iii criteria for MD and the rdc patients were rated using the item hamilton depression rating scale hdrs all depressed patients were without medications the control group was composed with subjects mean age sd we built a depressive wordlist moodlist and a neutral wordlist neutrallist and used a computer for the lexicaldecision task we noted a significant interaction f p between the subjects group depression vs control and the words category moodlist vs neutrallistabstract truncated at words
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we studied the effect of trifluoroindolebutyric acid tfiba a recently described root growth stimulator and dichloroindoleacetic acid dciaa on growth and microtubule mt organization in roots of lactuca sativa l dciaa and indolebutyric acid iba inhibited root elongation and depolymerized mts in the cortex of the elongation zone inhibited the elongation of stele cells and promoted xylem maturation both auxins caused the plane of cell division to shift from anticlinal to periclinal in contrast tfiba micromolar promoted elongation of primary roots by and stimulated the elongation of lateral roots even in the presence of iba the microtubular inhibitors oryzalin and taxol or the auxin transport inhibitor naphthylphthalamic acid however tfiba inhibited the formation of lateral root primordia IS showed that tfiba stabilized mts orientation perpendicular to the root axis doubled the cortical cell length but delayed xylem maturation the data indicate that the auxininduced inhibition of elongation and swelling of roots results from reoriented phragmoplasts the destabilization of mts in elongating cells and promotion of vessel formation in contrast tfiba induced promotion of root elongation by enhancing cell length prolonging transverse mt orientation delaying cell and xylem maturation
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recurrence of an osteoid osteoma treated by complete excision is thought to be very rare persistence of the lesion and reappearance of clinical and radiological signs have a more frequent occurrence and are due to inadequate resection our case appears to be a true recurrence it required no less than four operations first of these was probably not extensive enough the second consisted of curettage of the osteoid osteoma after it had been exposed by abrasion of its cortical bone covering the third and fourth resections were carried out under BS guidance and were controlled by postoperative radiography and computerised tomography the uncertain aetiology of OO is one factor in the mysteriousness of this serial recurrence of what was apparently an ordinary OO such recurrence might be explained by an unknown persisting pathological environment
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autophagy is a highly conserved intracellular recycling pathway that serves to recycle damaged organellesproteins or superfluous nutrients during times of nutritional AS to provide energy to maintain intracellular homeostasis andd degraded performance to astronauts during reentry and landing of the proposed orion crew VH the purpose of this T0 was to determine if a physiological training procedure autogenicfeedback training exercise afte can mitigate these adverse effects fourteen men and six women were assigned to two CG afte notreatment control matched for MS susceptibility and gender all subjects received a standard rotating chair test to determine MS susceptibility three training sessions on a manual performance task and four exposures in the rotating chair orion tests simulating angular accelerations of the crew VH during reentry afte subjects received h of training before orion tests and motion sickness symptoms task performance and physiological measures were recorded on all subjects results showed that the afte group had significantly lower symptom scores when compared to controls on test p test p and test p although there were no significant group differences on task performance trends showed that afte subjects were less impaired than controls heart rate NC scores rpm minus baseline of afte subjects indicated significantly less CR on test compared to test versus p while controls did not NC significantly across tests results of this T0 indicate that afte may be an effective countermeasure for mitigating SD and motion sickness in astronauts
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the international task force on volunteer cleft missions was set up to provide a report to be presented at the eighth international congress of cleft palate and associated craniofacial anomalies on september in singapore the aim of the report was to provide data from a wide range of different international teams performing volunteer cleft missions and thereafter based on the collected data to identify common goals and aims of such missions thirteen different CG actively participating in volunteer cleft missions worldwide were selected from the international confederation of plastic and reconstructive surgerys list of teams actively participating in volunteer cleft missions because of the time frame within which the EC had to work three CG that did not respond by the stipulated deadline were omitted from the EC the represented members and their respective institutions have undertaken more than volunteer cleft missions to underdeveloped nations worldwide within the last years they have visited over different countries treating more than patients worldwide based on the data collected and by consensus the EC outlined recommendations for future volunteer cleft missions based on mission objectives organization personal health and liability funding trainees in volunteer cleft missions and public relations the task force believed that all volunteer cleft missions should have welldefined objectives preferably with LT plans the task force also decided that it was impossible to achieve a successful mission without good organization and close coordination all efforts should be made and care taken to ensure that there is minimal morbidity and no mortality finally as ambassadors of goodwill and humanitarian aid the participants must make every effort to understand and respect local customs and protocol the main aims are to provide topquality surgical service train local doctors and staff develop and nurture fledgling cleft programs and finally make new friends
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bicuspid aortic valve anatomy is associated with aortic root aneurysm in a relevant proportion of patients these patients require root replacement for prognostic reasons and the valve may be preserved the objective of this analysis is to analyze the early and late outcomes of root remodeling for bicuspid aortic valve
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neurogenic detrusor overactivity ndo often results in decreased bladder capacity UI and vesicoureteral reflux ndo can trigger autonomic dysreflexia and can impair quality of life electrical stimulation of the genital SN gns acutely inhibits reflex bladder contractions and can increase BC quantifying the effect of gns on BC and determining what study AF and subject factors influence BC improvements will inform the design of clinical gns interventions
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a new approach to the data refinement of xray reflection measurements from lipid surface monolayers applied to dmpa on pure water reveals the structural organization of the lipid in unprecedented detail and provides new insights into headgroup conformation and hydration as a function of lateral pressure while conventional box models are incapable of modeling the exp data at high momentum transfer satisfactorily a quasimolecular compositionspace refinement RPA using CSD functions to map the spatial organization of submolecular headgroup fragments yields a much better description and overcomes inherent difficulties of box models upon going from the fluid liquidexpanded le phase to the hexatic liquidcondensed lc phase the orientation of the headgroup is tightly coupled to the ordering of the acyl chains headgroups tilt toward the surface normal to accommodate for the C1 reduction in available area per lipid molecule the spread of the headgroup fragment CSD is considerably larger than the global interface roughness and increases slightly with compression in distinction to earlier work on dmpe using the twobox RPA we find that the phosphate hydration stays essentially constant across the whole isotherm the discrepancy between the results observed with the different models is attributed to intrinsic deficiencies of the box MM
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with the advent of modern therapeutic approaches even patients with T3 HD disease have high cure rates today therefore more attention is gradually being focused upon the late complications of chemotherapy and irradiation appearing long after the patient is in remission and thought to be cured in this report we review the incidence and presentation of some of the cardiovascular and pulmonary complications which may appear later in the course of the disease cardiovascular mishaps reviewed include pericardial manifestations conduction CA cardiomyopathy and premature PD disease pulmonary complications discussed are lung fibrosis SP pulmonary venoocclusive disease and hyperlucent lung three instructive cases from our recent experience are also presented one fatal case was due to cardiac failure because of radiationinduced pericarditis and coronary artery disease another patient with an almost fatal complication required lung transplantation because of severe bilateral radiation fibrosis of the lung and PVOD the third instance was also lifethreatening in nature with radiationinduced arterial changes in the major arteries of the chest and neck resulting in recurrent cerebral and ophthalmic TE disease it is suggested that potentially severe CP complications be considered during the planning of the initial and subsequent management of patients with HD disease particularly in an era employing autologous and allo-BMT as part of therapy in some cases
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this update will focus on new developments which can impact the understanding and management of patients with dlcl the latter disorder is mostly derived from b lymphocytes which can be further subdivided into those that originate from the germinal center versus those that arise from nongerminal center Az in the lymph node the differences between these two types will be discussed the management of several new entities that relate to dlcl such as double hit lymphoma and so called borderline entities will also be featured new entities such as breast implant associated anaplastic large cell lymphoma will be described
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comparative singledose toxicity studies of diethylaminodimethylbutynyl cyclohexylhydroxyphenylacetate monohydrochloride monohydratens a new drug for the treatment of urinary frequency and incontinence were conducted in ddy mice and spraguedawley rats after oralpointraperitonealip and subcutaneoussc administration and in beagle dogs T3 po administration the po ld values of ns were and mgkg for male and female mice and mgkg for male and female rats respectively the ip ld values were and mgkg for male and female mice and and mgkg for male and female rats respectively no death occurred in mice and rats at doses up to sc mgkg minimum lethal dose for dogs could not be determined because of vomiting mydriasis was noted in all three species tested without regard to administration route in addition decreased spontaneous locomotor activity prone or lateral position hypopnea hypothemia ataxic gait twitch and clonic convulsion were observed in mice and rats after po and ip administration in rats salivation was observed T3 po administration and lacrimation was observed after po and ip administration after sc administration scab formation at the site of injection was observed in mice and rats in dogs vomiting hyperemia of both conjunctiva and oral mucosa prone position tremor and clonic convulsion were observed after po administration body weight was decreased or its gain was suppressed in mice and rats without regard to administration route body weight and food consumption were decreased in dogs T3 po administration pathological examination showed congestion of lung in dead mice and rats after po and ip administration distention of small intestine was observed in dead mice and rats T3 po administration and in sacrificed rats after po administration adhesion between the ABD organs was observed in sacrificed mice and rats T3 ip administration thymic atrophy associated with a decrease in its organ weight was observed in dogs T3 po administration
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experimental tuberculosis in rabbits and guinea pigs was favorably influenced by the administration of antuitrins pregnant mare serum and to a lesser extent follutein no retardation of disease was obtained by the use of either anterior pituitary extract or emmenin the results suggest that the gonadotropic hormone may be a factor in the temporary amelioration of PS observed in tuberculous women during pregnancy
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apical control is the inhibition of a lateral branch growth by shoots above it distal shoots if the distal shoots are cut off to remove apical control the lateral CB can grow larger and may bend upwards apical control starts when new lateral buds grow after passing through a period of dormancy buds initially break and produce leaves then apical control is exerted and the lower PT laterals stop growing apical control also inhibits growth of large old branches gravimorphism and restricted water and nutrient transport can inhibit CB growth but they are not primary mechanisms of apical control apical control may reduce branch photosynthesis under apical control allocation of branchproduced assimilate to the stem is relatively high so low assimilates in the branch may limit branch growth even though hormone C2 are adequate for growth hormones appear to be involved in apical control but it is not known how one role of hormones may be to maintain the strength of the stem sink for branchproduced assimilate upward bending of a woody CB after PR from apical control requires both new wood production and production of wood cells that can generate an upward bending moment apical control inhibits radial growth of branches and in some species may regulate the production of wood with an upward bending moment
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transfer rna trna has been demonstrated to be present in axons of both invertebrates and the higher vertebrates but nothing is known of its role in the metabolism of the axon the present experiments were performed to determine whether trna functions in axons as a participant in posttranslational protein modification of endogenous proteins rna was extracted from the axoplasm of squid giant axons and incubated with a variety of hamino acids aminoacyltrna synthetases obtained from squid optic lobe and an appropriate reaction mixture all of the amino acids tested were bound to an rna fraction but this reaction did not occur when samples were incubated in the presence of ribonuclease or in the absence of axoplasmic rna when radioactive rna was chromatographed by polyacrylamide gel PACE the radioactivity comigrated with known trna markers suggesting the presence of haminoacylated trna aminoacylation of rna could also be demonstrated by incubating fresh axoplasm with labeled amino acids and a reaction mixture minus exogenous aminoacyltrna synthetases these findings indicate the presence in axoplasm of a variety of species of aminoacyltrnas as well as their corresponding synthetase enzymes in the latter experiment no radioactivity was found associated with the protein fraction this was also the finding when haminoacylated trna was either injected directly into the axon or incubated with extruded axoplasm thus under the conditions described above there is no evidence of transfer of amino acids from trna to proteins in other experiments axoplasm was pooled to a volume of to microliters homogenized gently and centrifuged at x g for hr some of the high speed supernatant was incubated with labeled amino acids and an appropriate reaction mixture and the remainder was passed through an s sephacryl column before incubation with the same reaction mixture there was no incorporation of amino acids into protein in the HSS fraction however in the s purified fraction hlabeled arg lys tyr leu and asp were all incorporated into proteins in amounts of and times heatinactivated controls the reaction is not inhibited by ca or caactivated PRs but appears to be dependent on the presence of trna the addition of amino acids to protein is not protein synthesis since the reactions occurred in a partially purified fraction of the x g supernatant a fraction devoid of ribosomes and free amino acidsabstract truncated at words
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among pharyngoesophageal diverticula the most frequent type is zenkers diverticulum which originates above the CP muscle and below the thyropharyngeal muscle laimers diverticulum located below the cricopharyngeal muscle is a much rarer type we report a case of a yearold woman with a year history of pharyngeal discomfort that was diagnosed as laimers diverticulum to the best of our knowledge this is only the third such reported case
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in this article we address the role of neuronal activity in the pathways of the brainstemmidbrain circuit in reward and the basis for believing that this circuit provides advantages over previous RL theory several lines of evidence support the rewardbased learning theory proposing that midbrain dopamine da neurons send a teaching signal the reward prediction error signal to control synaptic plasticity of the projection area however the underlying mechanism of where and how the reward PE signal is computed still remains unclear since the pedunculopontine tegmental nucleus pptn in the brainstem is one of the strongest excitatory input sources to da neurons we hypothesized that the pptn may play an important role in activating da SN and reinforcement learning by relaying necessary signals for reward PE computation to da neurons to investigate the involvement of the pptn SN in computation of reward PE we used a visually guided saccade task vgst during recording of neuronal activity in monkeys here we predict that pptn neurons may relay the excitatory component of tonic reward prediction and phasic primary reward signals and derive a new computational theory of the reward PE in da neurons
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the hummeldreyer method in CZE was compared with the corresponding highperformance liquid chromatographic hplc variant in order to study the interaction of racemic carvedilol and its individual enantiomers with isolated human plasma proteins alpha acid glycoprotein agp and human serum albumin hsa the IB parameters characterizing the highaffinity IB site of agp evaluated by using capillary electrophoresis kars lmol kas lmol kar lmol were in good accordance with those obtained by hplc kars lmol kas x lmol kar lmol relatively small quantitative differences have been observed considering the attachment of rcarvedilol to the secondary lowaffinity IB CS on alpha acid glycoprotein by comparing these two methods in general the hummeldreyer method applied to capillary zone electrophoresis conditions was verified to be an efficient and fast technique for reliable description of quantitative IB parameters of hydrophobic drugs
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in postoperative patients one frequently observes respiratory difficulty in excess of what is indicated by physical alterations in respiratory mechanics this would suggest that some patients lack normal compensatory mechanisms which respond to mechanical changes in the lung it is entirely possible that inadequacy of compensatory mechanisms is present before surgery and predisposes patients to RD in the clinical environment elaborate testing is precluded by the PCS status of the patients thus a noninvasive procedure has been designed to apply AS to the respiratory system in order to study the effect of AS at increasing levels of co in this test a subjects QO2 is measured as he rebreathes a mixture of co and o from a closed system on successive trials fixed pressure inspiratory threshold loads are applied in CS with this type of load the increased work required to inspire a given volume depends only on the increased inspiratory pressure in most normal subjects co response was incrementally depressed when threshold loads were introduced patients with BS lesions showed a greater depression at higher loads this may indicate a reduced ability to tolerate increased loads to breathing
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behavioral inhibition is frequently cited as a vulnerability factor for OD of anxiety however few studies have examined the unique relationship between behavioral inhibition and obsessivecompulsive disorder ocd therefore the current study addressed the relationship between BI and ocd in a number of ways in a large unselected student sample frequency of current oc PS was significantly correlated with retrospective selfreports of total levels of childhood BI in addition frequency of current oc symptoms was also significantly correlated with both social and nonsocial components of behavioral inhibition further there was evidence for a unique relationship between behavioral inhibition and oc symptoms beyond the relationship of behavioral inhibition and social anxiety in addition results showed that reports of childhood levels of BI significantly predicted C2 of ocd PS in adulthood finally preliminary evidence suggested that behavioral inhibition may be more strongly associated with some types of oc PS than others and that overprotective parenting may moderate the impact of BI on oc symptoms the current findings suggest the utility of additional research examining the role of BI in the etiology of ocd
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a high sensitive chromium speciation procedure based on spectrophotometric PCD was developed by coupling flow i.t. online preconcentration with a catalytic indicator reaction chromiumvi is retained on a minicolumn packed with PS AE resin strong basic resin which was afterwards eluted with a small volume of nano solution the eluted crvi is then directed to catalyze the decoloration of alizarin cyanine green acg in the presence of bromate as oxidizing reagent and the absorbance NC is proportional to the concentration of crvi with a sampling volume of ml and a loading time of s an enrichment factor of was achieved for the preconcentration the most distinct feature of this procedure is characterized by its overall detection limit ie ngl which is much superior to those achieved by faas and comparable to those obtained by inductively coupled plasma mass spectrometry icpms and electrothermal atomic absorption spectrometry etaas the procedure was validated with a certified REF material it was also applied to the speciation of chromium in a series of surface water samples
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the method of extraction of ciliated epithelium from biopsy samples of human BM with glycerol is suggested permeabilized cilia of glycerolextracted cells can be easily reactivated by exogenous atp this method was used for the study of ciliary dyskinesia in patients with chronic lung diseases it was shown that in patients with kartageners syndrome neither freshlyisolated nor glycerolextracted atptreated cilia were motile on the other hand in some patients with BA atp reactivated glycerolextracted cilia while cilia of freshlyisolated cells remained immotile the study shows that glycerol permeabilization and reactivation by atp can be used for the analysis of cilial contractile apparatus in patients with chronic lung disease
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il and il each act on human endothelial cells ecs to induce expression of V1 cell adhesion molecule on hematopoietic cells il responses may be mediated either through a pathway involving gc the common signaling S1 of the il il il il and IL-2R or through a gcindependent pathway that may be alternatively G1 by il we find that human ecs do not express gc as detected by indirect immunofluorescence and facs analysis or by a reverse transcriptionpcr method like il il activates a protein tyrosine kinase that phosphorylates the ilr binding protein in addition we find that il and il each induce tyrosine phosphorylation of the jak IMT kinase furthermore both il and il induce binding of the stat transcription factor to a consensus CS oligonucleotide we conclude that the il response of human ecs involves the il shared pathway that is independent of gc and uses jakstat signaling
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extramucosal myotomy involving the external longitudinal and internal circular layers of the musculature of the esophagus represent the surgical therapy in patients with dysphagia and regurgitation or with anginalike chest pain AA to functional abnormalities of the musculature of the esophagel body and sphincters surgery has a palliative function because cures PS and complication such a diverticula but not the disease modern surgical techniques also prevent recurrence of symptoms and complications are minimal with better longterm results than conservative therapy myotomy of the lower esophageal sphincter extended to the distal part of the esophageal body hellers T0 is performed as first choice or following insucces of dilatation in patients with primary achalasia of the esophagus using a transabdominal or a transthoracic approach myotomy of the upper esophageal sphincter is indicated in patients with zenkers diverticulum following diverticulectomy or diverticulopessy segmental myotomies are performed T3 diverticulectomy in patients with epiphrenic pulsion diverticula transthoracic long esophageal myotomy performed from the thoracic portion of the LES to the aortic arch is indicated in patients with diffuse esophageal spasm and nutcracker esophagus and sometimes in patients with aspecific CA of the esophageal motor CF associated with diverticula circular miotomies limited to the external longitudinal SL of the esophageal musculature can be performed at the level of anastomosis in order to gain tissue and reduce tissutal tension the recent introduction of the endoscopic surgery allowed some of these operations to be performed through minimally invasive approaches therefore laparoscopic and thoracoscopic hellers myotomy is feasible with clinical and functional results similar to those obtained with traditional open RPA and with less postoperative discomfort and shorter hospital stay this paper deals with the indications and surgical techniques of myotomies of the esophageal body both limited and D2 to the LES
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five carbohydrazides and hydrazones of carboxylic acids of pyrrole were synthesized as new structural analogs of known tuberculostatics such as isoniazid cas and its popular hydrazones the preliminary screening against mycobacterium tuberculosis hrv atcc at microgml in b medium using a BB microdilution CA the microplate alamar blue assay maba registered higher LIA within the hydrazones series up to inhibition compared with that of the carbohydrazides no simple relationship between the activity of a particular hydrazone and that of the parent carbohydrazide or correlations with the structural features introduced by the carbonyl partner could be observed so both most active hydrazones diethyl dimethylhpyrrolylcarbonylhydrazonomethylmethylhpyrroledicarboxylate inhibition and ethyl chlorophenylmethylnitrofurylmethylidenehydrazinooxoethylhpyrrolecarboxylate originated from inactive carbohydrazides and respectively ethyl ethoxyhydroxyphenyl methylidene hydrazinooxoethylmethylnitrophenylhpyrrolecarboxylate showed inhibition although derived from a hydrazide with activity the condensation of six carbohydrazides with the same carbonyl reagent nitrofurfural yielded hydrazones whose activity covered the wide range of inhibition
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cereal consumption is a common dietary SMB that has been associated with positive health outcomes the objective of this T0 was to examine prospective associations between cereal intake in childhood and percent body fat waisttohip ratio lipid levels and PCS activity during late adolescence in this longitudinal investigation data collected data were analyzed for the girls who participated in the year national HR lung and blood institute growth and health study the cumulative percent of days that each girl consumed cereal during childhood based on day food diaries collected during six study visits between ages and years was examined in relation to percent body fat waisttohip ratio lipid C2 and physical activity measured at age years results indicated that nearly all girls reported eating cereal and reported eating cereal on half or more of the days reported in the food diaries girls who ate cereal on a greater percentage of days during childhood had lower percent body fat and total cholesterol and were more likely to exhibit high C2 of PCS activity and less television viewing during study year p values further research should explore lifestyle issues related to cereal consumption
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current researches into the production of biochemicals from lignocellulosic feedstocks are focused on the ID and engineering of individual microbes that utilize complex sugar mixtures microbial consortia represent an alternative approach that has the potential to better exploit individual species capabilities for substrate uptake and biochemical production in this work we construct and experimentally validate a dynamic flux balance model of a saccharomyces cerevisiae and escherichia coli coculture designed for efficient aerobic consumption of glucosexylose mixtures each microbe is a substrate specialist with wildtype s cerevisiae consuming only gl and engineered e coli strain zsc consuming only xylose to avoid diauxic growth commonly observed in individual microbes following exp ID of a common ph and temperature for optimal coculture batch growth we demonstrate that pure SC models developed for optimal growth conditions can be adapted to the suboptimal common growth condition by adjustment of the nongrowth associated atp maintenance of each microbe by comparing pure culture model predictions to coculture exp data the GABA effect of ethanol produced by s cerevisiae on e coli growth was found to be the only interaction necessary to include in the coculture model to generate accurate batch profile predictions coculture MM utility was demonstrated by predicting initial cell concentrations that yield sge fraction of PT fluid reabsorption owes to sglt dapagliflozin acutely reduced proximal reabsorption leading to a increase in ED chloride a saturated tgf response and a L1 reduction in single nephron glomerular filtration rate sngfr acute and chronic effects on jprox were indistinguishable adaptations to days of dapagiflozin included increased reabsorption by henles loop which caused a partial EC50 in the increased tone exerted by tgf that could be explained without desensitization of tgf in summary tgf contributes to LT fluid and salt balance by mediating a persistent decline in sngfr as the kidney adapts to a sustained decrease in jprox
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one challenge in CC crc is identifying novel biomarkers to be introduced in screening programs the present study investigated the promoter methylation status of the sept gene in IP blood samples of subjects positive fecal occult blood test fobt in order to add new insights we investigated the association between sept promoter methylation and micronuclei frequency and polymorphisms in the folaterelated pathway genes sept promoter methylation micronuclei frequency and genotypes were evaluated on individuals fobt positive individuals were subjected to a colonoscopy that provided written IC for T0 participation sept promoter methylation status was significantly lower in the crc group than controls p in contrast the caco cellline analyzed as a tissue specific model of colon adenocarcinoma showed a significantly higher percentage of sept promoter methylation compared to the crc group p linear regression analysis showed an inverse correlation between micronuclei frequency and the decrease in the methylation C2 of sept promoter region among crc patients β p with regard to genotype analysis we showed the involvement of the dhfr polymorphism rs in sept promoter methylation level in crc patients only in particular the presence of at least one bp del S2 significantly correlates with decreased sept promoter methylation compared to the bp insins genotype p while remaining aware of the strengths and limitations of the study this represents the first evidence of a novel RPA for the early PCD of crc using sept promoter methylation micronuclei frequency and genotypes with the potential to improve crc risk assessment
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EN released from the adrenal medulla enhances memory in young rats and mice and apparently does so at least in part by increasing blood glucose C2 like epinephrine administration of glucose enhances cognitive functions in humans and rodents including reversing agerelated impairments in learning and memory EN responses to training are increased in aged rats but the subsequent increase in blood gl levels is severely blunted the absence of increases in blood glucose C2 during training might contribute to agerelated deficits in learning and SM also extracellular gl C2 in the hippocampus are depleted during SA testing to a far greater extent in aged than in young rats importantly SVR i.v. of glucose block the SD in the hippocampus and also enhance performance on the al and km marks was probably due to L1 discharge from fishponds between and km marks levels of ethinylestradiol above ngl a level which can affect fish was seen in of the samples tested the data suggest that hormones in readily measured quantities can be transported considerable distances from the source of pollution
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acromegaly caused by growth hormone gh hypersecretion is characterized by enhanced skeletal growth and soft tissue enlargement insulinlike growth factor igf is the main peripheral mediator of gh action and it has a crucial role in the maintenance of a normal bone mass however in some patients with acromegaly AA osteoporosis is observed despite the strong anabolic effect of gh and igf in bones it is thought to be due to hypogonadism the bone changes are accompanied by increased turnover the aim of this T0 was to assess bone properties by ultrasound and turnover in patients with acromegaly the T0 was carried out in patients men women with AS acromegaly and cured by surgery who had nonactive disease speed of sound sos broadband ultrasound attenuation bua and their combination stiffness index si by QUS qus of the heel hormonal status serum osteocalcin oc concentration and the urinary excretion of pyridinoline collagen crosslinks pyr were all studied controls were age and sexmatched healthy persons we observed statistically significantly lower qus values in patients with AS disease than in those whose disease was cured the differences were more pronounced in men qus values were lower in the entire group of patients compared with the controls however the differences were not statistically significant SS oc concentrations and urinary pyr excretion were higher in AS disease statistically significant inverse correlations between SS gh levels and sos r p bua r p tscore r p and zscore r p were found only in male patients no correlations between igf duration of the disease oc pyr and other data studied were observed in conclusion we have shown decreased qus parameters suggesting impaired bone properties and SQ in terms of density and elasticity in men but not in women with active acromegaly this finding suggests osteoporosis with increased bone turnover the abovementioned changes might be caused by the action of gh on trabecular bone and its metabolism since no hypogonadism in male patients was shown moreover the influence of acromegaly on heel geometry and soft tissue swelling should also be considered
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protein synthesis in the murine hepatitis virus jhminfected cells was temporarily inhibited by hypertonic shock when the cells were returned to isotonic medium the synthesis of six virusspecific polypeptides k k k k k and k was reinitiated simultaneously polyadenylated rna isolated from the cytoplasm or polysomes of INF cells was translated in vitro and the products included polypeptides with molecular weights mol wt of and immunoprecipitation and fingerprinting of smethioninecontaining tryptic peptides showed that the and mol wt products were identical to the k and k polypeptides found in infected cells the mol wt product showed identity with the k intracellular polypeptide and a virusspecific k polypeptide synthesized in tunicamycintreated cells twodimensional polyacrylamide gel electrophoresis strongly suggested that the and mol wt products are equivalent to virusspecific k and k intracellular polypeptides huridinelabelled polyadenylated virus rna was isolated from INF cells and sedimented in SU gradients containing formamide the CSD in the gradient of each of the previously identified virus rnas was determined by gel PACE and gradient fractions enriched for each rna were translated in vitro the and mol wt polypeptides were found to be encoded by mrnas and or respectively these results demonstrate that the virusspecific polypeptides in jhminfected cells are encoded in separate subgenomic mrnas and are translated independently the assignment of coding functions and the known CS relationships of jhm rnas permitted a gene order to be deduced
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the native fluorescence spectra of human cancerous and normal breast tissues were investigated using the selected excitation wavelength of nm to excite key building block molecules such as reduced nicotinamide adenine dinucleotide nadh collagen and flavin the measured emission spectra were analyzed using a nonnegative constraint method namely MCR with alternating leastsquares mcrals the results indicate that the PSA changes of tissue can be exposed by native fluorescence spectra analysis the mcralsextracted components corresponding to the key fluorophores in breast tissue such as collagen nadh and flavin show differences of RCs of fluorophores in cancerous and normal breast tissues this research demonstrates that the native fluorescence spectroscopy measurements are ERP for detecting changes of fluorophores composition in tissues due to the development of cancer native fluorescence spectroscopy analyzed by mcrals may have the potential to be a new armamentarium
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the incidence of harmful algal blooms habs is increasing in the united states and worldwide hab toxins cause a substantial but unquantified amount of human and animal morbidity and mortality from exposures in recreational commercial drinkingsource and potable waters hab biomass and toxins threaten the sustainability of aquatic ecosystems us congressional legislation mandated the establishment of a national research plan for coastal harmful algal blooms but no similar plan exists for freshwater habs fhabs eutrophication and fhabs are conservatively estimated to cost the us economy billion dollars annually a national research plan for FW harmful algal blooms is needed to develop us policy and regulations or guidelines to confront fhab risks this report reviews the state of fhab occurrence risk and risk management assessments in the us research is identified that must be accomplished to characterize occurrence and risks and develop cost ERP strategies for preventing suppressing and mitigating fhabs us congressional legislation is needed to mandate a national research plan for fhabs establish a timeline for developing policy and fund competitive researchgrant programs the research results will provide a sound scientific basis for making policy determinations and implementing RM strategies successfully confronting fhab risks will strengthen the us economy protect human and animal health and help ensure the sustainability oith three particular drugs phenytoin cyclosporin a and nifedipine a case report of gingival overgrowth induced by nifedipine in an elderly patient treated with nonsurgical periodontal therapy is described a yearold male with generalised GO reported the problem of oral malodour and significant gingival one the medical history revealed a controlled hypertensive state and cerebral V1 accident cva years prior to consultation the diagnosis was GO associated with nifedipine no other risk factors being identified the patient had been taking nifedipine for months but T3 the consultation with the patients doctor nifedipine was suspended as the hypertension was controlled treatment consisted of meticulous oral hygiene instruction scaling root surface instrumentation and prophylaxis six months T3 the first MI clinical parameters revealed a significant improvement with a considerable reduction in GO demonstrating the effect of nonsurgical periodontal therapy in severe cases of GO nonsurgical treatment of digo is a far less invasive technique than surgical approaches and has demonstrated an impressively positive treatment response it should therefore be considered as a first treatment option for digo
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growing interest in complementary and alternative medicine in the united states has been paralleled by increased use of SMT in an attempt to manage PS of LBP spinal stenosis and spondylolisthesis chiropractors have been the main practitioners of spinal manipulative therapy with osteopaths and physical therapists providing a smaller fraction of these services theories explaining the mode of action of spinal manipulative therapy are largely preliminary and have focused on the mechanical effects of manipulative forces on the spine and neurologic responses to manipulation the effects of spinal manipulation on patients with both acute and chronic LBP have been investigated in randomized clinical trials most reviews of these trials indicate that SMT provides some shortterm benefit to patients especially with acute LBP
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this study investigated the influence of modulated photoactivation on axial polymerization shrinkage shrinkage force and hardening of light and dualcuring resinbased composites three lightcuring resin composites sdr bulkfill esthet x flow and esthet x hd and one dualcuring material rebilda dc were subjected to different irradiation protocols with MZ ED j cm highintensity continuous CS hic lowintensity continuous CS lic softstart ss and pulsedelay curing pd axial shrinkage and shrinkage force of mmthick specimens were recorded in real time for min using custommade devices KHN was determined at the end of the observation period statistical analysis revealed no significant differences among the curing protocols for both knoop hardness and axial shrinkage irrespective of the composite material pulsedelay curing generated the significantly lowest shrinkage forces within the three lightcuring materials sdr bulkfill esthet x flow and esthet x hd highintensity continuous CS created the significantly highest shrinkage forces within esthet x hd and rebilda dc and caused significantly higher forces than lic within esthet x flow in conclusion both the composite material and the applied curing protocol control shrinkage force formation pulsedelay curing decreases shrinkage forces compared with highintensity continuous irradiation without affecting hardening and axial polymerization shrinkage
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on i.v. of tlcl mbq mci initial transit of it through the HR as well as subsequent uptake by the chest were recorded in the SP using a scintillation camera coupling to a small digital computer and remaining the patient in the same position perfusion scintigram with mtcmacroaggregated Al maa or transmission scintigram with a point source of mtco too the radioactivity of total injected dose of tl t was calculated from the entire region on the initial transit of the tracer bolus through the HR and that of unilateral lung l was done from the anterior image of tl on which isocount map of the perfusion image or transmission one was superimposed by these procedures the lung uptake ratio of tl was calculated by ratio of lt and expressed as percentage per entire unilateral lung and mean value per pixel the average values of the lung uptake ratio in circulatory diseases were in the right lung in the left lung and in respiratory diseases and respectively this technique sma CM rupture of the basement CM and separation of the cells from the BMs rupture of tubular BMs tubulorrhexis and mitochondrial dark bodies suggest an atn due to ischemia or induced by vasoconstrictor substances glomerular lesions were infrequent one in five and therefore do not seem to have contributed to renal failure all cases terminally had extremely low urinary sodium meqliter high urinary potassium meqliter a remarkably low urinary sodiumpotassium ratio normal and a low urinary osmolality less than mosmkg from this study we conclude that an atn of VL severity may be associated with the hepatorenal syndrome since this atn developed without preceding shock sepsis or hypotension it is possible that this atn like that in ischemic ARF may be due to reduced RBF and intense cortical vasoconstriction which has been reported in HRS finally our data imply that low urinary sodium is consistent with this pathologic lesion in this clinical setting
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aims to evaluate whether reduced waiting time influences survival of patients treated with wholebrain radiotherapy wbrt for BM materials and methods retrospective intentiontotreat study including patients treated with primary wbrt typically fractions of gy no other treatment between diagnosis and wbrt uni and multivariate tests were performed results median delay between imaging diagnosis and wbrt was days range days wbrt started within week in during the second week in and during the third week in of patients no significant rho between waiting time and survival was evident except for one subgroup of patients those without extracranial metastases potentially more threatened by worse intracranial disease control survived for a median of months from wbrt if waiting time was weeks or longer as compared to months if waiting time was shorter than weeks p the same rho was seen if survival was computed from imaging diagnosis conclusion if departmental resources are not sufficient to provide immediate wbrt within weeks to all patients those without extracranial metastases should be prioritised this T0 did not address the impact of waiting time on quality of life or symptom palliation
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knowledge of the exact spatial CSD of BB tissues in images acquired by magnetic resonance imaging mri is necessary to measure and compare the performance of segmentation algorithms currently available physical phantoms do not satisfy this requirement stateoftheart digital BB phantoms also fall short because they do not handle separately anatomical structures eg basal ganglia and provide relatively Rg simulations of tissue fine structure and inhomogeneity we present a software procedure for the construction of a realistic mri digital brain phantom the phantom consists of hydrogen nuclear magnetic resonance spinlattice relaxation rate r spinspin relaxation rate r and proton density pd values for a à à cm volume of a normal head the phantom includes normal tissues each characterized by both mean value and variations in r r and pd in addition an optional tissue class for multiple sclerosis ms lesions is simulated the phantom was used to create realistic magnetic resonance mr images of the brain using simulated SE cse and fast fieldecho ffe sequences results of monoparametric segmentation of simulations of sequences with different noise and slice thickness are presented as an example of possible applications of the phantom the phantom data and simulated images are available online at httplabibbcnrit
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the endoscopic findings and the surgical results of resected cases of SF oesophageal CA are described of these cases had mucosal CA twentyone of cases of mucosal cancer of the oesophagus had neither nodal involvement nor V1 invasion and therefore excellent longterm results can be anticipated in order to obtain good results in the treatment of mucosal cancer of the CLO the role of oesophagoscopy is extremely important in the early diagnosis of this CA
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arecoline is an alkaloid of betel nut of areca catechu betel nut is chewed by millions of people in the world and it causes oral and hepatic cancers in human it has therapeutic value for the treatment of alzheimer and schizophrenia arecoline has IS mutagenic and genotoxic effects in laboratory animals it also affects endocrine functions the objective of this study was to investigate the effects of arecoline on pinealtesticular axis in rats since pineal activity is different between day and night the current T0 is undertaken in both the photophase and scotophase the findings were evaluated by ultrastructural and hormonal studies of pineal and testicular leydig cells with quantitations of fructose and sialic acid of sex accessories arecoline treatment mgkg body weight daily for days caused suppression of pineal activity at ultrastructural level by showing dilatation of the cisternae of the RER rer large autophagosomelike HB with swollen mitochondrial cristae numerous lysosomes degenerated SR and reduced number of synapticlike microvesicles moreover pineal and serum nacetylserotonin and melatonin C2 were decreased with increased serotonin levels in both the gland and SS in contrast testicular leydig cell activity was stimulated with abundance of SER ser electrondense core LDV and vacuolated secretory LDV and increased testosterone level in the arecoline recipients consequently the testosterone target like prostate was ultrastructurally stimulated with abundance of rer and accumulation of secretory LDV fructose and sialic acid concentrations were also significantly increased respectively in the CG and seminal vesicle these results were more significant in the scotophase than the photophase the findings suggest that arecoline inhibits pineal activity but stimulates testicular function testosterone level and its target organs presumably via mACh receptor in rats
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TN factor tnf is first identified as a mediator of lethal endotoxin poisoning the antitnf therapy in the treatment of rheumatoid ICA is based on the recognition of the role of tnf as the master regulator type ii diabetes is characterized with altered stem cells and reduced vasculogenesis therefore we aimed to determine if tnf inhibitor would improve vasculogenesis in ischemic hindlimbs of diabetic mice fifty male type diabetic and their control weeks old mice were used and ischemia was induced in the hindlimbs of all mice for days vessel density was assessed by highdefinition microangiography at the end of the treatment period after weeks vessel density displayed no difference between the ischemic and the nonischemic legs in control mice however in diabetic mice the ischemic hindlimb vessel density was significantly decreased interestingly diabetic mice displayed a significant improved vasculogenesis when treated with tnf inhibitor moreover this data was confirmed by capillary density determined by IS tnf inhibitors are able to improve the formation of MV in response to ischemia in type diabetes
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this T0 was aimed to demonstrate the morphological and histochemical properties of the harderian gland in the angora rabbit ten healthy adult angora rabbits obtained from private breeders constituted the material of the T0 the HG which is composed of the pink and WG lobes consists of cells that produce a secretion of lipid character the pink lobe contained type i cells with C1 lipid vacuoles cells with small lipid vacuoles type ii were found in the WG lobe type iii cells containing both large and small lipid vacuoles were not observed while type i cells reacted strongly to IF with oil red o type ii cells reacted weakly to this stain the number of PCs was greater in the WG lobe when compared to the pink lobe the apical granules within the epithelial cells lining the intralobular and interlobular excretory ducts of the gland were positive for periodic acidschiff pas periodic acidschiffalcian blue pasab AB ab and performic acidalcian blue paab electron microscopic examination revealed that type i cells contain large electronlight lipid vacuoles and an eccentric heterochromatic nucleus due to the presence of these vacuoles the cells which were connected by tight junctions possessed apically located microfolds the nucleus of ATII was situated basally and had an oval shape ATII had apical microvillilike cytoplasmic protrusions longer than those of type i cells oval shaped ME cells were observed between the glandular epithelial cells and their BL the epithelium lining the excretory ducts of the gland contained two types of granules which were dark and lightly coloured histochemical and ultrastructural examinations revealed no difference in the structure of the harderian gland between female and male angora rabbits
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we conducted a multiinstitutional assessment of a recently developed endtoend monthly SQ assurance qa protocol for EBRT treatment chains this protocol validates the entire treatment chain against a baseline to detect the presence of complex PE not easily found in standard componentbased qa methods participating physicists from institutions ran the EE protocol on treatment chains that include imaging and radiation oncology core iroccredentialed linacs results were analyzed in the form of american association of physicists in medicine aapm task group tg so that they may be referenced by future test participants optically stimulated luminescent dosimeter osld ebt radiochromic film and asl ion chamber readings were accumulated across test runs confidence limits were calculated to determine where of measurements should fall from calculated confidence limits of measurements should be within error for oslds error for ionization chambers and error for relative gamma pass rate radiochromic film at agreement mm distance to agreement data were separated by institution MM of linac and treatment protocol intensitymodulated radiation therapy imrt vs volumetric modulated arc therapy vmat a total of of oslds o and strategies toward it among indonesian women particularly in yogyakarta province were still unsatisfied efforts should be improved for supporting CC prevention and control in indonesia through such as education on CC disease and strategies toward it
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a yearold woman with pulmonary AM proteinosis was treated by repeated unilateral bronchopulmonary lavages over years the effectiveness of the treatment was assessed by xe scintigraphy as well as lung function tests and chest roentgenograms xe scintigraphy clearly demonstrated improvement of regional ventilation and perfusion and equalization of the ventilation and perfusion ratio therefore xe scintigraphy was found to be useful in the analysis of changes in regional aeration ventilation and perfusion before and T3 bronchopulmonary lavage in pulmonary alveolar proteinosis
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preoperative discrimination between benign and malignant soft tissue tumors is critical for the prevention of excess application of magnetic resonance imaging and biopsy as well as unplanned resection although ultrasound including PD imaging is an easy noninvasive and costeffective modality for screening soft tissue PT few studies have investigated reliable discrimination between benign and malignant soft tissue tumors
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we describe an angiotensin ang iicontaining innervation of the kidney cryosections of rat pig and human kidneys were investigated for the presence of ang iicontaining nerve SF using a mouse monoclonal antibody against ang ii b costaining was performed with antibodies against synaptophysin tyrosine hydroxylase and dopamine betahydroxylase to detect catecholaminergic efferent fibers and against CGRP-LI to detect sensory SF tagged secondary antibodies and confocal CS or laser scanning microscopy were used for immunofluorescence PCD ang iicontaining nerve SF were densely present in the renal pelvis the subepithelial layer of the urothelium the arterial nervous plexus and the peritubular interstitium of the cortex and OM they were infrequent in CE veins and the renal capsule and absent within glomeruli and the renal papilla ang iipositive fibers represented phenotypic subgroups of CA postganglionic or sensory fibers with different morphology and intrarenal distribution compared to their ang iinegative counterparts the ang iipositive postganglionic fibers were thicker produced typically fusiform varicosities and preferentially innervated the OM and periglomerular arterioles ang iinegative sensory SF were highly varicose prevailing in the pelvis and scarce in the renal periphery compared to the rarely varicose ang iipositive fibers neurons within renal microganglia displayed angiotensinergic catecholaminergic or combined phenotypes our results suggest that autonomic fibers may be an independent source of intrarenal ang ii acting as a neuropeptide cotransmitter or neuromodulator the angiotensinergic renal innervation may play a distinct role in the neuronal control of renal sodium reabsorption vasomotion and renin secretion
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as health care provision in the united states shifts to primary care settings it is vital that new models of occupational CHS be developed that link clinical care to prevention the model program described in this paper was developed at the union health center uhc a comprehensive health care center supported by the international ladies garment workers union now the union of needletrades industrial and textile employees serving a population of approximately primarily minority female garment workers in new york city the objective of this paper is to describe a MM OM program in a unionbased comprehensive health center linking accessible clinical care with primary and AA disease prevention efforts to assess the presence of PS suggestive of occupational disease a health status questionnaire was po to female workers attending the uhc for routine health maintenance based on the results of this survey an OM clinic was developed that integrated direct clinical care with worker and employer education and workplace hazard abatement to assess the success of this new approach selected cases of sentinel health events were tracked and a chart review was conducted T3 years of clinic T0 prior to initiation of the occupational medicine clinic of the workers surveyed reported PS indicative of occupational illnesses however only reported having been told by a physician that they had an occupational illness and only reported having field a WC claim for an occupational disease in the occupational medicine clinic established at the uhc a health and safety specialist acts as a case manager coordinating worker and employer education as well as workplace hazard abatement focused on disease prevention ensuring that every case of occupational disease is treated as a potential sentinel health event as examples of the success of this RPA index cases of rotator cuff tendonitis lead poisoning and formaldehyde overexposure in three patients and their preventative workplace followup affecting approximately workers at three worksites are described workrelated conditions diagnosed during the first years of clinic operation included cumulative trauma disorders cases carpal tunnel syndrome cases LB disorders cases lead poisoning cases and respiratory disease cases this pilot project represents a new MM for effective integration of clinical care and occupational disease prevention efforts within a PCC it could serve as a prototype for OD of such services in other managed and primary care settings
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the most frequently used measures in behavioral research are distributiondetermined measures that provide a quantitative determination of the relative frequency of a specified behavior these measures are however insensitive to the CS of behaviors complexity measures address this deficiency several sequencesensitive measures including the topological entropy metric entropy algorithmic complexity and stochastic model complexity will be described several applications to psychiatric research will also be discussed these applications include the characterization of changes in animal SMB in response to cnsactivide exchange on rangtp ranbp binds directly to nuclear pore complexes where it competes for IB sites with importinbeta transportin and apparently also with the mediators of mrna and u snrna export furthermore we provide evidence for a randependent transport cycle of ranbp and demonstrate that ranbp can cross the NE rapidly and in both directions on the basis of these results we propose that ranbp might represent a nuclear transport factor that carries an as yet unknown cargo which could apply as well for this entire class of related rangtpbinding proteins
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we report here the existence of a crystalline molecular packing of type ii collagen in the fibrils of the lamprey notochord sheath this is the first finding of a crystalline structure in any collagen other than type i the lamprey notochord sheath has a composition similar to that of cartilage with type ii collagen a minor collagen component with alpha alpha and alpha chains and cartilagelike proteoglycan the high degree of orientation of fibrils in the notochord makes it possible to use xray diffraction to determine collagen fibril organization in this type iicontaining tissue the low angle equatorial scattering shows the fibrils are all about nm in diameter and have an average centertocenter separation of nm these results are supported by EM observations a set of broad equatorial diffraction maxima at higher angles represents the sampling of the collagen molecular transform by a limited crystalline lattice extending over a lateral dimension close to the diameter of one fibril this indicates that each nm fibril contains a crystalline array of molecules and although a unit cell is difficult to determine because of the broad overlapping reflections it is clear that the quasihexagonal triclinic unit cell of type i collagen in rat tail tendon is not consistent with the data the meridional diffraction pattern showed orders with the characteristic nm periodicity found for tendon however the intensities of these reflections differ markedly from those found for tendon and cannot be explained by an unmodified gapoverlap model within each nm period both xray diffraction and electron microscope data indicate a low degree of contrast along the fibril axis and are consistent with a periodic binding of a noncollagenous component in such a way as to obscure the gap region
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the analytical quality of SM of blood glucose smbg is not satisfactory and the need for standardized control routines for smbg has been underscored the objective of this study was to investigate whether an external quality assesated to the degree of myocardial fibrosis and is the hemodynamic hallmark of hypertensive heart disease when DD is present left VVI EDV pressure increases outofproportion to volume and may be elevated at rest or with exertion leading to clinical HF at least one third of HF patients in the united states can be considered to have HF related to diastolic dysfunction compared to HF patients with systolic dysfunction DHF patients are more likely to be older female and to be hypertensive at the time of presentation although it has been assumed that lvh may lead to systolic dysfunction evidence is lacking that lvh resulting from hypertension is a L1 risk factor for systolic HF independent of coronary artery disease treatment of hypertension greatly attenuates the development of lvh and significantly decreases the incidence of heart failure in patients with established lvh regression is both possible and desirable and results in a significant reduction in adverse clinical endpoints
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this study was to test safety and tau of mixture of gadoliniumnonionic contrast media in avoiding contrast nephropathy during coronary angiography in patients with renal dysfunction although off label for xray angiography gadolinium has drawn attention for its potential to avoid CN during coronary angiography initial data seem promising patients with a baseline creatinine of mgdl or more were included in order to minimize contrast nephropathy risk all patients were thoroughly hydrated and treated by NAC T3 coronary angiography andor percutaneous coronary MI renal function tests were remeasured on days and a rise of mgdl or more in creatinine value in the following days or the need for dialysis were considered as a contrast nephropathy event twentysix patients were enrolled in this study ten were women and were men the mean age was baseline creatinine value was mgdl the total amount of contrast medium used on fashion was ml no procedurerelated cardiac complication or CN event occurred in this T0 although there was a slight loss in image quality we felt that the results were adequate for interpretation although off label using gadolinium contrast media in a mixture with standard nonionic low osmolar contrast media seems to be a viable option in decreasing the likelihood of CN further DUE appears to be warranted
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FAP fap is a neurodegenerative disorder associated with extracellular deposition of mutant TTR ttr amyloid fibrils particularly in the peripheral nervous system we have hypothesized that binding of ttr fibrils to the receptor for T3 glycation end products rage on critical cellular targets is associated with a destructive AS response underlying PN dysfunction analysis of nerve biopsy samples from patients with fap n at different stages of disease compared with AMC n by semiquantitative immunohistology and in situ hybridization showed increased C2 of rage beginning at the earliest stages of the disease fap p and especially localized in axons upregulation of Th1 cytokines TN factoralpha and interleukinbeta approximately threefold p and the inducible form of nitric oxide synthase inos approximately fold p was also observed in a CSD overlapping rage expression IMT nitration and increased G1 caspase in axons from fap patients p were apparent although these data suggest the presence of ongoing neuronal AS there was no upregulation of NTs nerve growth factor and neurotrophin in fap SN studies on cultured neuronallike schwann and EC cells incubated with ttr fibrils displayed ragedependent expression of cytokines and inos at early times and hr respectively followed by later hr activation of ICE and dna fragmentation we propose that the interaction of ttr fibrils with rage may contribute to cellular AS and toxicity in fap furthermore there is an apparent lack of responsiveness of SCs in fap nerve to provide neurotrophic factors
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mozambique had been ranked among the countries with the highest global incidence of hcc with chronic hepatitis b infection and high SE to aflatoxinb afb being L1 risk AF indeed hcc remains one of the most frequent CA in maputo on the other hand mozambique has a high prevalence of infection with human immunodeficiency virus hiv our T0 aims to describe the epidemiology clinicopathological and serological features of patients with hcc in maputo CE hospital and its relationship with hiv
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to evaluate fecal continence anorectal manometry am and profilometry p in patients operated for congenital megacolon using either the modified duhamel technique mdt or the modified transanal rectosigmoidectomy mtr technique
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in this study we have investigated the role of cd an early inducible leukocyte activation receptor in mu dendritic cell dc differentiation maturation and migration skin dcs and dc subsets present in mouse lymphoid organs express cd in response to maturation stimuli using a contact sensitization model we show that skin dcs migrated more efficiently to draining CL NO lns in the absence of cd this was confirmed by subcutaneous transfer of cd dcs which presented an increased migration to peripheral lns twophoton microscopy analysis showed that once dcs reached the lns cd deficiency did not alter dc interstitial motility in the lns CTX to sphingosinephosphate sp was enhanced in cd dcs compared with wildtype dcs accordingly we detected a higher expression of sp receptor type sp by cd dcs whereas sp expression levels were similar in wildtype and cd dcs moreover in vivo treatment with sp analogs sew and fty during skin sensitization reduced skin dc migration to IP lns these results suggest that cd regulates spinduced skin dc migration by modulating sp function together our findings increase our knowledge on dc trafficking patterns in the skin enabling the OD of new directed therapies using dcs for antigen ag delivery
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the aim of this simulation study was to present a systemapproach method for adjustment of continuous drug infusions at timevarying rates aimed at achieving and then maintaining required drug concentrationtime profiles in patients the method presented can be used for safe and costeffective individualization of drug dosing by computercontrolled infusion pumps utilization of this method is exemplified by simulation experiments aimed at adjusting continuous infusions of factor viii fviii at timevarying rates which would theoretically yield required AUC of fviii in hemophilia a patients over several days
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to identify the preoperative risk AF associated with increased prevalence of AS lesions of the ascending aorta among patients undergoing offpump coronary artery bypass surgery opcab
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conventional methods for identifying gastroenteritis pathogens are time consuming more likely to result in a falsenegative rely on personnel with diagnostic expertise and are dependent on the specimen status alternatively molecular diagnostic methods permit the rapid simultaneous detection of multiple pathogens with high sensitivity and specificity the present T0 compared conventional methods with the luminex xtag gastrointestinal pathogen panel xtag gpp for the diagnosis of infectious gastroenteritis in RNA taiwan from july to april clinical fecal samples were collected from patients with suspected infectious gastroenteritis all specimens were tested using conventional diagnostic techniques following physicians orders as well as with the xtag gpp the multiplex PCR reaction pcr RPA detected significantly more positive samples with bacterial viral andor parasitic infections as compared to conventional analysis vs respectively p moreover multiplex pcr could detect escherichia coli o enterotoxigenic e coli shigalike toxinproducing e coli cryptosporidium and giardia which were undetectable by conventional methods furthermore pathogens in patients with coinfections were identified only using the multiplex pcr approach of which were from pediatric patients because the detection rates using multiplex pcr are higher than conventional methods and some pediatric pathogens could only be detected by multiplex pcr this RPA may be useful in rapidly diagnosing diarrheal disease in children and facilitating treatment initiation further studies are necessary to determine if multiplex pcr improves patient outcomes and reduces costs
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advantages and pharmacy applications of computerized hospital managementcontrol and planning systems are described hospitals must define their product lines patient cases nas a single bolus injection was comparable with the inhibition by mg as a single oral dose repeated once daily administration of mg intravenously and mg orally also resulted in comparable reductions in pao the reduction in pao T3 repeated once daily oral administration of mg was comparable with the effect of a single intravenous dose of mg terminal t1/2 were short but significantly p less than prolonged after a single intravenous i.t. of mg repeated once daily intravenous administration of and mg did not result in prolongation of terminal half lives it is concluded that intravenous administration of omeprazole causes a potent and long acting inhibition of pentagastrin stimulated gastric acid secretion in man its potency is augmented after repeated once daily administration
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the effect of RL in alteration of the phototropic sensitivity of corn coleoptiles zea mays l cultivar burpee barbecue hybrid is investigated phototropic dosageresponse curves for etiolated coleoptiles are compared with those for coleoptiles receiving hour of continuous red light immediately prior to phototropic induction in the former case only curvature comparable to the first positive curvature of oat coleoptiles is obtained there is no evidence for first negative curvature and only minimal second positive curvature the reciprocity law proved valid for all curvatures obtained with RL the sensitivity of the first positive curvature was decreased over tenfold and there was clear appearance of second positive curvature for which the reciprocity law was not valid once again there was no evidence for negative curvature time course studies indicated that within hour of the beginning of red light treatment at degrees reactions leading to the decrease in phototropic sensitivity of the first positive component had gone to completion whether the RL was continuous or consisted of a single second SE followed by a hour dark period an action spectrum for the redinduced NC in phototropic sensitivity showed a marked peak near mmu with a small broad shoulder between and mmu characteristic of phytochromemediated responses the effect of red light could be fully reversed by low dosages of FR but longer doses of far red were less effective C1 dosages of farred light alone induced the same alteration in phototropic sensitivity as did RL
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in a total of patients had undergone extracapsular tonsillectomies te and a tonsillotomy tt procedure in germany while the latter is increasingly performed the number of the former is continually decreasing however a constant number of approximately surgical procedures in terms of abscesstonsillectomies or incision and drainage are annually performed in germany to treat patients with a PTA the purpose of this part of the clinical guideline is to provide clinicians in any setting with a clinically focused multidisciplinary guidance through the surgical treatment options to reduce inappropriate variation in clinical care improve clinical outcome and reduce harm surgical treatment options encompass intracapsular as well as extracapsular tonsil surgery and are related to three distinct entities recurrent episodes of acute tonsillitis peritonsillar abscess and IM conservative management of these entities is subject of part i of this guideline the quality of evidence for te to resolve recurrent episodes of tonsillitis is moderate for children and low for adults conclusions concerning the tau of te on the number of sore throat episodes per year are limited to postoperative months in children and months in adults the impact of te on the number of sore throat episodes per year in children is modest due to the heterogeneity of data no firm conclusions on the effectiveness of te in adults can be drawn there is still an urgent need for further research to reliably estimate the value of te compared to nonsurgical therapy of tonsillitistonsillopharyngitis the impact of te on quality of life is considered as being positive but further research is mandatory to establish AGA inventories and standardized DUE procedures especially in children in contrast to te tt or comparable procedures are characterized by a substantially lower postoperative morbidity in terms of pain and one although tonsillar tissue remains along the capsule the outcome appears not to differ from te at least in the pediatric population and young adults age and a history of tonsillitis are not a contraindication abscess formation in the tonsillar remnants is an extremely rare finding the volume of the tonsils should be graded according to brodsky and a grade is considered to be eligible for tt the number of episodes during months prior to presentation is crucial to indicate either te or tt while surgery is not indicated in patients with less than three episodes a waitandsee policy for months is justified to include the potential of a spontaneous healing before surgery is considered six or more episodes appear to justify tonsil surgery needle aspiration incision and drainage and abscess tonsillectomy are effective methods to treat patients with peritonsillar abscess compliance and ability of the patient to cooperate must be taken into account when choosing the surgical method simultaneous antibiotic therapy is recommended but still subject of scientific research PA tonsillectomy should be preferred if complications have occurred or if alternative therapeutic procedures had failed simultaneous te of the CL side should only be performed when criteria for elective te are matched or in cases of BL PTA needle aspiration or incision and drainage should be preferred if comorbidities exist or an increased surgical risk or coagulation disorders are present recurrences of peritonsillar abscesses after needle aspiration or incision and drainage are rare interval te should not be performed the RPA is not supported by contemporary clinical studies in patients lioma whereas the prostate was found to be free of tumor
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as part of a phase ii chemotherapy trial using mitomycinc adriamycin and vindesine patients with adenocarcinoma of unknown primary site were assessed for prognostic variables predictive of response and survival they were also evaluated for response and toxicity usefulness of screening techniques and eventual definition of primary site and DP of progression only gender predicted response with women being more likely to respond than men visceral metastases below the diaphragm or the presence of LM predicted poor survival responding patients were highly likely to relapse first at sites of initial disease hemolyticuremic syndrome was the most severe toxicity other SE were moderate the response rate was three CR responders which is similar to other current regimens this T0 suggests that patients with better prognosis characteristics of single site of disease and without intraabdominal tumor may benefit from a policy of expectant observation after local control has been established patients with multiple sites of disease andor intraabdominal tumor are AGA candidates for investigational chemotherapy
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changes in gl tolerance and the CF of the antiinsulin system after a L1 resection of the canine pancreas were divided into three types immediately T3 the removal of per cent or more of the pancreas diabetes developed and the CF of the antiinsulin system was depressed showing a poor response of glucagon secretion to hypoglycemia T3 insulin load and degeneration or destruction of the islet cells and both a and b cells and the dosage of insulin required to control blood sugar was close to that of a total pancreatectomy to weeks T3 the removal of to per cent of the pancreas socalled sandmeyers diabetes occurred in which gl tolerance and the CF of the antiinsulin system were within the normal range during the early postoperative periods but the CF of the antiinsulin system was highly G1 later se hypoglycemia and its neurologic consequences
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