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neutropenic enterocolitis is a necrotizing inflammatory process with intramural infection that occurs predominantly in neutropenic patients this syndrome is most frequently observed T3 chemotherapy for hematologic and solid tissue malignancies but it can also be observed in a number of other clinical settings as well NE can be a rare presenting complication of HAL we report a case of ALL leukemia that presented with ABD pain due to neutropenic enterocolitis the diagnostic and treatment challenges associated with this manner of presentation are discussed | MEDAL |
ultrasound has been used for almost years in a wide variety of clinical applications and environments from the austerity of battlefields to the labor and delivery ward ultrasound has the ability to give clinicians RT noninvasive diagnostic imaging ultrasound by emergency physicians and all nonradiologists has become more prevalent and has been used for examinations such as the TCD to evaluate for stroke cardiac function fast and efast examinations for trauma and now increased intracranial pressure icp via optic nerve sheath diameter ultrasound onsd the onsd is a valid and reliable indicator of icp | MEDAL |
provided that care is taken in adjusting the watergate element of a hn trosyhsqc experiment such that neither the water magnetization nor the hα protons are inverted by its final ° pulse jhnhα couplings can be measured directly from splittings in the h dimension of the spectrum with bandselective h decoupling very high n resolution can be achieved a CR set of jhnhα values ranging from to hz was measured for the residue third domain of iggbinding protein g gb using the hncαhα dihedral angles extracted from a rdcrefined structure of gb jhnhα values predicted by a previously parameterized karplus equation agree to within a rootmeansquare deviation rmsd of hz with the experimental data values measured for the alzheimers implicated aβ peptide fit to within an rmsd of hz to random coil jhnhα values | MEDAL |
metabolism of glucose via the pentose cycle is a principal source of nadph an important cellular reducing species both aerobic and hypoxic irradiation stimulate the pentose cycle activity of a human lung carcinoma cells which indicates that nadph is utilized during irradiation either as a direct hydrogen donor or as a cofactor for enzymatic repair of radiation damage to evaluate the role of the pentose cycle in radiation response we treated a cells with aminonicotinamide an which blocks the oxidative limb of this pathway in some cell lines we found an to be a very ERP inhibitor of pentose cycle activity as indicated both by accumulation of phosphogluconate in a cells and by the inability of NF or peroxide to stimulate PR of co from clabeled glucose after an treatment effects of an were time and concentration dependent it caused partial inhibition of glycolysis but had no effect on respiratory rate or on intracellular glutathione C2 effects of an on radiation response were examined under two conditions after treatment with mm drug for hours which inhibited PC activity by and T3 treatment for hours which completely inhibited PC activity neither treatment affected aerobic radiation response but both increased hypoxic sensitivity to a similar extent with the oxygen enhancement ratio reduced from to at a surviving fraction treatment of a cells with an caused an increase in hypoxic cell radiosensitization by misonidazole but effects of the combined agents were not more than additiveabstract truncated at words | MEDAL |
to explore the distinct background of bone marrow and embryonic YS hematopoiesis performance SS free mu yolk sac EC cell and bone marrow endothelial cell CS medium were compared for their effects on the OD profiles of yolk sac hematopoietic stemprogenitor cells the mrnas expression techniques were applied to understand the cytokine and receptor genes expression and the possible mechanisms the results suggested that the differential gene expressions were existed between the hematopoietic cells of YS and bone marrow and between the microenvironment of yolk sac and bone marrow | MEDAL |
in the present work the effect of piromen is studied on the formation of the glialmesenchymal scar in the experimentally injuried cortex of hamsters the uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area the excessive proliferation is combined with a decrease of differentiation in the reactive cells a reduction of specific activities phagocytosis production of collagen and glial filaments of these cells was also observed finally a porous mesenchymal scar develops with a great many of dedifferentiated cells on the other hand a spongy glial scar is formed which is due to a desintegration of astrocytic processes in the peritraumatic area a so far not precisely understood transformation of reactive astrocytes plays an important role herein the changes of the glialmesenchymal scar T3 administration of piromen reported in the literature were on the wnemia has its beginning in the later childhood and shows like the adult form atrophy of the mucous membrane of the stomach anacidity and antibodies against the intrinsic factor and parietalcells a patient with congenital pernicious anemia is presented the symptoms diagnosis differentialdiagnosis and therapy of this disease is reviewed | MEDAL |
intrathecally administered ACh agonists such as oxotremorine muscarinic carbachol mixed nicotinic and muscarinic agonist and epibatidine nicotinic have all been shown to reduce nociception in behavioral studies thus there is substantial evidence for a role of acetylcholine ach in the control of nociception in the spinal cord but the mechanisms regulating ach PR are not known the present study was initiated to establish a rat MM to T0 which mechanisms are involved in the control of ach release spinal MD probes were inserted intraspinally at the cc spinal level in isofluraneanesthetized rats the probes were perfused with ringers solution containing microm neostigmine to prevent degradation of ach oxotremorine carbachol epibatidine and scopolamine dissolved in ringers solution were administered intraspinally via dialysis and microlitermin samples of dialysate were collected for hplc analysis of ach content the release of ach was found to be constant in the control ringers only situation during the experimental period of min oxotremorine microm carbachol mm and epibatidine microm enhanced but scopolamine nm decreased the intraspinal PR of ach oxotremorine ed microm and epibatidine ed microm were found to produce a dosedependent increase of ach PR cholinergic agonists caused an increase of intraspinal ach and the antagonist scopolamine caused a decreased PR of ach the data do not support an autoreceptor function of either nicotinic or M2 in the spinal cord contrary to what has been observed in the brain | MEDAL |
impact of mode instability on dynamic characteristics of stimulated raman scattering in high power fiber amplifiers has been studied for the first time which reveals another characterization of mode instability from the aspect of optical spectrum it shows that after the ON of mode instability the measured CS spectrums especially the raman CS spectrums are different from those without mode instability which become burrlike as mode instability evolves into different stages the intensity of SRS effects as laser SP increasing also behaves differently during the transition region the SRS effect becomes stronger as the lasing power increases until the mode instability evolves into chaotic regions where the SRS effect weakens the effect of SRS on mode instability has also been studied due to that the stimulated raman scattering effect is weak and that the fraction of raman CS is only a few percent the stimulatedramanscatteringinduced mode instability has not been observed in the experiment and the observed mode instability is induced by ytterbium ion gain of signal laser it also revealed that the SRS has negligible influence on the mode instability induced by ytterbium ion gain | MEDAL |
a major factor determining the severity of neurological deficits caused by cerebral ischemia is the ability of the vasculature to provide collateral circulation to the ICM areas by establishing a major conduit by means of extracranialintracranial anastomosis the increased perfusion pressure through the collateral arterioles may reduce morbidity in these patients twentyseven patients were selected for superficial temporal artery to M1 stamca anastomosis based on clinical and angiographic evidence of lesions of the internal carotid arterial system CBF blood flows cbfs were determined by the xenon inhalation method using symmetrically placed scintillator probes twocompartment analysis was used to compute a mean flow for the compartment an average mean flow was computed for each hemisphere and for four regions with the lowest mean cbf in each hemisphere the cbf was measured preoperatively and within weeks postoperatively the average mean flow was ml mgmin in the symptomatic hemisphere and ml gmmin in the asymptomatic hemisphere in patients the mean flow for the symptomatic hemisphere increased by postoperatively and for the asymptomatic hemisphere by regions with lowest cbf showed an inemoral vein and ascitic fluid were not different from that of arterial plasma plasma na was positively correlated to wedged hepatic vein pressure r p less than and to HR rate r p less than but inversely correlated to CPV r p less than in cirrhotic patients arterial blood pressure was reduced in these patients compared to controls p less than but not significantly correlated to plasma na the increased plasma na indicates that sympathetic nervous activity is enhanced in patients with cirrhosis based on the above positive rho between na and heart rate and the significant PR of na from the kidney it may be hypothesized that the increased sympathetic nervous activity especially involves HR and kidney this response may be mediated by baro and volume receptors | MEDAL |
steroidal antiinflammatory drugs induce proteins that inhibit phospholipase a pla including uteroglobin and lipocortin annexin i uteroglobin and lipocortin retain several conserved sequences based on these sequences several nonapeptides antiflammins were synthesized these nonapeptides were shown to have antiinflammatory effects in vitro and in vivo possibly by inhibiting pla subsequent research showed that pla is activated by transglutaminase tgase we hypothesize here that tgase inhibitors may increase the antiinflammatory tau of inhibiting pla activity to test this theory we constructed recombinant peptides containing sequences from proelafin for inhibition of tgase and from lipocortin lipocortin and UG for inhibition of pla the recombinant MMP which had dual GABA effects on purified tgase and pla reversed the inflammation of AC to ragweed in a guinea pig MM the present work suggests that novel recombinant MMP may be safe and effective agents for the treatment of various inflammatory diseases | MEDAL |
fifteen AD koi a variant of common carp cyprinus carpio simultaneously developed WG cutaneous proliferations affecting up to of their bodies the onset of these lesions in september was associated with their return to a remodeled backyard water garden T3 temporarily being maintained in a plastic swimming pool a single water temperature taken during the outbreak read °c on november the water garden had no extrinsic heat source with average ambient temperatures ranging from to °c during the outbreak september january representative skin biopsies were obtained from two fish the histologic features included severe epidermal PH dysplasia keratinocyte apoptosis decreased and haphazardly distributed goblet cells with the absence of club cells KC hydropic degeneration and moderate infiltration by lymphocytes and eosinophilic granular cells ultrastructural findings included intranuclear nonenveloped hexagonal nucleocapsids and abundant cytoplasmicenveloped virions morphologically consistent with the alloherpesviridae family PCR reaction was performed on formalinfixed paraffinembedded shavings from the two biopsied koi targeting the thymidine kinase gene of cyprinid HHV-8 cyhv together with the aforementioned findings these results are consistent with an outbreak of cyhv in a population of adult koi | MEDAL |
we have investigated several characteristics of the rat brain noradrenaline na PR caused by various stressful situations stresses such as immobilization or electric FS wherein the physical factors rather than emotional ones were greatly involved caused more marked increases in na release in the more extended BB regions as compared to psychological stress and conditioned fear which caused increases in na PR preferentially in the hypothalamus amygdala and locus coeruleus lc region when the electric shock AS and psychological AS for hr daily were repeated for consecutive days increases in brain na release induced by electric shock were rapidly reduced but those caused by psychological stress were enhanced rather than reduced rats with no stressor controllability uncontrollable had more severe gastric lesions and more marked increases in na release in such brain regions as the hypothalamus and amygdala after hrs of training than controllable rats rats with no opportunity to predict electric shock exhibited more severe gastric lesions and more marked increases in hypothalamic na PR than the predictable rats the rats not allowed to express their aggression had more severe gastric mucosal lesions and a more noticeable and persistent increases in extracellular na content in the amygdala determined by intracerebral MD than the rats allowed to express aggression by biting a wooden stick in front of them during stress SE in aged rats months old REC from increases in na PR in the hypothalamus and amygdala and increases in CS were much later than in young monthold rats when rats were exposed to a series of six min stress interrupted by min nonstress periods for min they had much greater increases in brain na release than rats stressed continuously for min based upon these findings we suggest that such stresses might be harmful to our health as psychological uncontrollable and unpredictable stresses AS unable to express aggression AS in elderly people and stress with lack of suitable rest | MEDAL |
the use of small molecule drugs in cancer chemotherapy has mostly been limited by dosedependent toxicity and development of drug resistance resulting from repeated administrations to overcome such problems efforts have been made to develop drug delivery systems that can bear multiple therapeutic agents in one system the purpose of this study is to deliver human TN factor tnfrelated apoptosisinducing ligand apoltrail and doxorubicin dox an anticancer drug with micellar NPs selfassembled from a biodegradable cationic copolymer pmdscoces to achieve synergistic cytotoxic effects in cancer cells exogenously expressed trail using recombinant methods shows great potential in CA therapy as it induces cell death selectively in cancer cells with limited toxicity to normal tissues doxloaded NPs and trail formed SD nanocomplexes with a size of â¼ nm and zeta potential of â¼ mv effects of nanocomplexes on both wild type and trailresistant sw colorectal carcinoma cells were investigated the assemblies of dox and trail with pmdscoces NPs were efficiently delivered to cancer cells receptorblocking studies showed that the nanocomplexes entered cells via death receptormediated endocytosis synergism in cell death induction was analysed by the isobologram method to study drug interactions cytotoxicity of the nanocomplexes to noncancerous cells was significantly lower than cancerous cells antiproliferative effects of nanocomplexes were retained in remaining cancer cells in longterm cultures T3 treatment with the nanocomplexes in summary this dox and trail codelivery system can be a promising candidate for CA treatment | MEDAL |
storeoperated calcium entry soce signaling is involved in CA progression stromal interaction molecule stim triggers storeoperated calcium channels to induce soce transforming growth factorβ tgfβ influences a wide range of cellular behaviors including cell proliferation however little is known about the relationship between calcium signaling and tgfβ signaling in CA cell proliferation here we found that tgfβ induced cell cycle arrest at the gg phase and suppressed cell proliferation in mdamb and mcf BCCs these effects were impaired by extracellular ca chelator egta or soce specific inhibitor skf in mdamb cells treating mdamb cells with tgfβ for and h markedly decreased stim expression and thapsigargininduced soce a transcriptional inhibitor of stim WT1 wt was upregulated in tgfβtreated mdamb cells and knockdown of wt expression partially restored the tgfβinduced downregulation of stim stably overexpressing stim in mdamb cells restored the tgfβinduced effects the p mrna level increased in skf or tgfβtreated mdamb cells whereas that for cyclin e decreased our findings demonstrate for the first time that stim and soce are involved in the tgfβinduced suppression of cell proliferation furthermore our studies also provide a new RPA to inhibit BCC proliferation with small molecules targeting stim and soce | MEDAL |
canine pancreatic ph was measured by an electrometric method which is described in detail measurements carried out in neuroleptanalgesia of the animals gave a mean figure of for pancreatic ph in situ for pHa in the same animals the mean value was the difference between pancreatic and pHa is significant anaesthesia of hr duration produced no significant NC either in pancreatic ph or in arterial blood ph or in the SS amylase and serum lipase levels V1 isolation of the pancreas and adjoining duodenal segment was produced in animals in of these ischaemia induced by clamping of the arterial pathways for hr resulted in a fall of ph by restoration of bloodflow at the end of the first hour was followed by a return of ph to the original values the control animals revealed no significant changes in the ph and enzyme values | MEDAL |
human erythrocytes were oxidized with xanthinexanthine oxidaseferric ion or adpferric ion at degrees c for several hours band protein and Sp of the Ox cells were found to be significantly modified as analyzed by radiolabeling with tritiated borohydride sodium dodecylsulfatepolyacrylamide gel electrophoresis of the xanthinexanthine oxidaseferric ironoxidized cells and subsequent immunoblotting with anti band protein showed that band protein was fragmented into smaller molecularweight fragments when the CM obtained from the oxidized cells were incubated at ph and degrees c for several hours in the presence of alphatocopherol extensive Kd of band protein and Sp was observed band protein was found to be most susceptible to the degradation Kd of band protein was also observed after similar incubation of the membrane from the adpferric ionoxidized cells MB serine and metalloproteinases were responsible for the Kd of band protein because the Kd was remarkably inhibited by diisopropyl fluorophosphate and phenylmethylsulfonyl fluoride and partially by EDTA hence the membrane proteins became susceptible to membranebound proteinases by oxidative AS this observation suggests that these MB proteinases exist to remove oxidatively damaged proteins from the cell membrane | MEDAL |
the significance of free alkaline ribonuclease rnase activity as a criterion of protein metabolism and nutrition in traumatized man is evaluated in this report plasma and urinary C2 of rnase were measured in severely injured hypermetabolic patients and in NCs significant increases in the plasma and urinary rnase levels were seen in these polytrauma victims and they were positively correlated plasma rnase C2 were also significantly related to blood urea nitrogen and daily urinary nitrogen excretion urinary clearance of rnase was increased by in trauma victims although the creatinine clearance was not affected by trauma in a subgroup of eight patients who were fed intravenously times basal SE expenditure calories and mg of n per kilogram per day for days the daily excretions of urinary rnase nitrogen methylhistidine creatinine and catecholamines were measured there was a significant negative rho between daily urine rnase and NB a general increase in all the metabolic parameters on the first day of feeding was seen suggesting a nutritional AS superimposed on the traumainduced metabolic AS excretion of rnase methylhistidine and creatinine peaked on the first day of FF and then decreased the normal C2 could not be reached even T3 days of adequate nutrition the results suggest that rnase C2 could be used as a biomarker of protein metabolism | MEDAL |
the merits of the nitroanilines as an alternative to prosaniline and fuchsine in the colorimetric determination of sulphur dioxide and sulphites have been investigated pnitroaniline was found to be a stable welldefined reagent with which sulphur dioxide can be determined to a high level of precision the sensitivity being of the same order of magnitude as for prosaniline | MEDAL |
dihydrohdibenzceazepine azepine and lovastatin were investigated for their hypolipidemic activity in spraguedawley male rats azepine lowered both serum total cholesterol and serum TG whereas lovastatin only lowered serum total cholesterol C2 significantly lovastatin also elevated lipid levels in tissues whereas azepine in general did not have a similar effect highdensity lipoprotein cholesterol C2 were significantly elevated and lowdensity lipoprotein cholesterol levels were reduced T3 treatment with both agents concentrations of apoe and apoal of highdensity lipoprotein were increased after treatment a result that should enhance the RCT process of returning cholesterol to the liver for excretion azepine appeared to be safe in its therapeutic range in rodents | MEDAL |
peer SP is an innovative schoolbased program that trains high school students as health educators and mentors for middle school students the program was designed to produce positive health behavior changes in youth and reduce longterm incidence of chronic diseases of the heart and lung this program developed at the management academy for public health has been successful in receiving grant funds and has demonstrated positive behavioral changes in youth in the Az of PCS activity nutrition and tobacco use peer power has far exceeded the anticipated outcomes and proven to be a catalyst for improved health behaviors throughout the community positive unintended consequences of peer power include the development of an effective social marketing campaign reduction in tobacco sales to minors and an increase in smokefree restaurants in dare county benefits received by management academy participants are evident through improved business and administrative skills at the dare county department of public health the number of new and innovative programs that have succeeded in securing grant funds and the sustainability of the programs developed | MEDAL |
the biomechanical SMB of total disc replacement tdr and anterior cervical discectomy and F0 acdf incomplex multiplanar motion is incompletely understood the purpose of this study was to determine whether acdf or tdr significantly affects in vitro kinematics through a range of complex MPR motions | MEDAL |
candida albicans is the most prevalent fungal pathogen in humans it is the causative agent and most associated with serious fungal infection accounting for more than of cases it is a most common cause of deep mycoses and vulvovaginal candidiasis in the present study we found that ME of o sanctum in combination of fluconazole shows higher zone of inhibition and lesser mic values as compared to ME of leaves of o sanctum or fluconazole when used CT synergistic antimicrobial activity was found when methanolic extract of leaves of o sanctum was used in combination with fluconazole against c albicans azole resistance strains isolated from catheter tip ct and high vaginal swab hvs fic⤠partial synergistic activity was observed against urine u ME of stem of o sanctum in combination with fluconazole gave indifferent antifungal results fic benzene extract of the leaf and stem of o sanctum in combination with fluconazole showed indifferent antifungal results fic AE of leaves of o sanctum in combination with fluconazole showed partial synergistic antimicrobial activity against catheter tip ct and HVS hvs and urine u fic in the present study we evaluate the synergism of c albicans against azole resistant clinical isolates this study indicates clear evidence supporting the traditional use of o sanctum in treating candida infectious diseases | MEDAL |
sjögrens syndrome ss patients have low salivary dehydroepiandrosterone dhea and androgen biomarker C2 but high salivary oestrogen levels the hypothesis was that the healthy glands contain dheasulphate processing intracrine machinery the local androgenoestrogen imbalance suggests that this is disarranged in ss indirect immunofluorescence and quantitative RT pcr qrtpcr of steroid sulphatase ST beta and betahydroxysteroid dehydrogenases beta and betahsd alphareductase and aromatase were performed for labial salivary PG of HCs and persons with ss in control acini steroid sulphatase and ST immunoreactivities were located in the basolateral cell parts beta and betahsd formed strong interrupted bands along the basal cell parts alphareductase was mainly located in acinar cell nuclei and aromatase in the apical cell membrane all enzymes were more widespread in ducts in ss steroid IDS was weak and deranged beta and betahsd had lost their strict basal acinar cell localization and alphareductase was mainly found in the cytoplasm of the acinar cells whereas aromatase showed similar IF in ss and controls qrtpcr of labial salivary PG disclosed all corresponding enzyme mrnas with the C2 of betahsd in ss being the lowest healthy tubuloacinar epithelial cells contain complete intracrine machineries for dheasulphate prohormone processing these enzymes have in healthy acini an organized architecture which corresponds with dhea uptake from the circulation nuclear site of production of the AS dihydrotestosterone dht end product and production of oestrogens into saliva for export to ductal and oral epithelial cells ss is characterized by low betahsd C2 which together with impaired subcellular compartmentalization of hsds and alphareductase may explain the low local dht and androgen biomarker C2 in ss | MEDAL |
agenesis of the permanent teeth is a congenital anomaly that is frequently seen in humans oligodontia is a severe type of tooth agenesis involving or more congenitally missing teeth excluding the third molars previous studies have indicated that mutations in the homeobox gene msx paired domain transcription factor pax and eda are associated with nonsyndromic oligodontia this study reports a japanese family eight of family members affected with nonsyndromic oligodontia who preferentially lacked molar teeth in this family a novel frameshift mutation insg was identified in the paired domain of pax the frameshift mutation caused altered amino acids in the paired domain and premature termination of translation by amino acids when transfected into cos cells the mrna expression of insg pax was comparable with that of wildtype pax however the mrna of insg pax was more unstable than that of wildtype pax this mrna instability caused a marked decrease in protein production as evaluated by western blot analysis and IS these findings suggest that the insg mutation causes insufficient function of pax protein and haploinsufficiency as a genetic model of familial nonsyndromic oligodontia with a pax mutation | MEDAL |
the prevalence of urinary stones in a group of subjects living with a permanent ileostomy has been determined by intravenous urography thirtynine of the ileostomists had previously suffered from ulcerative colitis while the remaining suffered from crohns disease four of the ileostomists who had had ulcerative colitis had urinary stones per cent these four subjects were all male so that among the male ileostomists who had had ulcerative colitis per cent had urinary stones no urinary stones were found irly oral FF average delay days thus avoiding a CP inconvenience of the usual methods of duodenoduodenostomy or duodenojejunostomy the aetiology of a nonpatent anastomosis T3 the th postoperative day is clarified a persistent duodenal obstruction indicates an organic complication that must lead to reoperation | MEDAL |
the phase regions around quasicrystals and approximants qcacs are rich pools for electronpoor intermetallics with novel complexdividual stimulation followed by downstream analysis to this aim we have designed microdevices based on direct current dc insulatorbased dielectrophoresis idep acting as individual single cell traps we present both the design of a negative idep trap and a positive idep trap using insulating posts integrated at microchannel intersections we obtained electric field distributions via numerical simulations adapted to the intersection and trap geometry with which we predict single particle pathlines with polystyrene particles of μm diameter we demonstrated an ERP design for a single particle trap in the case of negative DEP the ON trapping Vc shows an inverse relation to the buffer conductivity thus indicating the influence of electrokinetic effects on the trapping behavior additionally we demonstrated the proofofprinciple of single mcf breast CA cell trapping in a positive idep trap our single particle trapping experiments were further in very good agreement with numerical simulations to ensure that no significant damage occurred to the cells during the experiment we further optimized medium conditions to ensure viability of the cells for at least h more than sufficient for microfluidic trapping experiments our results thus indicated the successful design of dc idep traps which can easily be integrated into a variety of microchip operations for single cell analysis | MEDAL |
an enzymelinked immunosorbent CA elisa measuring in SS immunoglobulin g igg igm and iga to vi capsular SPA that was tyraminated vityr to increase its IB efficiency to microtiter plates was compared with the standard passive HA pha as a screening test for chronic salmonella typhi carriers initially three populations were evaluated healthy us adults young chilean adults with acute typhoid fever and chileans who had bacteriologically confirmed s typhi chronic carriage iggspecific vityr antibodies were preferentially present in the s typhi chronic carrier state a total of of chronic carriers of healthy us adults and of chileans with acute typhoid fever had reciprocal igg vityr elisa antibody titers in serum of greater than or equal to the igg vityr elisa was then compared with the pha as a screening test for chronic carriers in chilean female food handlers one woman was serologically incriminated as a carrier by both the igg elisa and pha her coprocultures were positive for s typhi one other woman identified as a carrier by pha was negative by culture and igg elisa the igg vityr elisa is as sensitive as the pha versus and as specific versus in screening for chronic carriers | MEDAL |
we have treated a total of cases of advanced kienböcks disease stage iii and iv by lichtmans classification with triscaphe fusion tendon ball replacement arthroplasty after excision of lunate PRC as a salvage procedure and limited wrist fusion since all cases were followed for minimal months T3 each operation tendon ball replacement arthroplasty T3 excision of lunate could not prevent further carpal collapse with persistent chronic wrist pain the triscaphe F0 or radiolunate fusion induced a marked limited wrist motion later and the triscaphe F0 CT was not fit for the treatment of T3 one because of progressive PT migration of capitate and continuous wrist pain due to ligamentous carpal instability in followup so we tried to simultaneously combine tendon ball replacement arthroplasty T3 excision of lunate with triscaphe F0 in far advanced kienböcks disease and their end results was favorable PRC could be done in far T3 kienböcks disease with reasonably painless wrist motions the overall end results of proximal row carpectomy are much better than any form of carpal arthrodesis conclusively the proper way to treat advanced kienböcks disease seems to depend on the patients age their job and sex and the stage of disease and the cause of wrist pain in T3 kienböcks disease seems due to ligamentous carpal instability rather than OA on radiolunate joint | MEDAL |
several studies were undertaken to assess the psychometric properties reliability and initial convergent and discriminant construct validity of the neurological SQ of life questionnaire neuroqol the neuroqol contains items answered in self report likert format with higher scores reflecting better SQ of life study one compared the questionnaire with existing SQ of life measures symptom distress scale SIP and a significant p correlation was found studies two through five evaluated the relationship between the neuroqol and disease stage psychological NP and neurological measures and a significant rho was also found with each domain the internal consistency reliability alpha split half reliability r and testretest reliability coefficients were for months and for one year intervals between test and retest were all found to be high and adequately stable overall these results indicate acceptable reliability and initial construct validity for the neuroqol | MEDAL |
in the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration pcd we discovered an unexpectedly high threshold for breaking cd Tc cell ctl tolerance to the pcd autoantigen cdr while cdr expression was previously found to be strictly restricted to immuneprivileged cells cerebellum testes and tumors unexpectedly we have found that t cells also express cdr this expressiomycetes have several biotechnological and industrial applications such as enzyme production bioremediation pharmaceutical and PET food production due to climatic features the preservation of several basidiomycetes is threatened and to guarantee the preservation of this genetic resource the development of longterm preservation techniques is necessary once there is no universal protocol for the cryopreservation of basidiomycetes cryopreservation is a technique in which microorganisms are submitted to ultralow temperatures therefore this study aimed to collect information on the main conditions for LT cryopreservation of basidiomycetes in the last years scientific articles on cryopreservation of basidiomycetes published from to were researched and only the studies on two intervals of cryopreservation were considered from to years and for longer than years the analyzed conditions of basidiomycete cryopreservation were most studied genera cryopreservation temperature ATP cryoprotectant and preservation ATP cryopreservation period thawing temperature and cultivation medium after thawing physiological and genetic stability of basidiomycetes after thawing in cryopreservation in this review the viability of the main cryopreservation conditions of basidiomycetes studied in the last years are presented and discussed | MEDAL |
gammaglutamyltransferase activity was studied in extracts of the cnidarian hydra attenuata the IB of gammaglutamyl peptide analogues to the enzyme was studied by observing their effects on heat denaturation and their inhibition of pnitroaniline release from gammaglutamyl pnitroanilide neither position analogues in which the gammaglutamyl moiety was changed to a betaaspartyl betaaspabugly or an alphaglutamyl gluabugly linkage nor glutamate protected the enzyme against inactivation at degrees c gsh reduced glutathione gammagluabugly and gammaglumet on the other hand did prevent heat denaturation gsh and analogues of gsh were competitive inhibitors of pNA PR but those analogues in which glycine was replaced by aminoisobutyrate phenylalanine leucine or tyrosine had ki values that were approximately five times those of analogues with the cysteine residue replaced | MEDAL |
we studied the incidence of freys syndrome and facial contour deformity in two CG of patients who had undergone SF parotidectomy one group was made up of patients who were randomized to undergo reconstruction of the surgical defect with a sternocleidomastoid muscle flap the other patients did not receive a flap all patients were evaluated via a short questionnaire the starchiodine test and a visual examination on the questionnaire none of the patients said they experienced abnormal facial sweating flushing or warmth while eating although of the patients in the nonflap group had a mildly positive starchiodine test no patient in the flap group had a positive test the difference between the two CG was statistically significant p no statistically significant difference was seen between the two groups with respect to cosmetic results | MEDAL |
examined prevalence of gun ownership and the links among gun ownership reasons for gun ownership and antisocial behavior in a sample of nonmetropolitan and rural middle school students participants completed the questionnaire for students olweus and included students from elementary and middle schools of whom most were african american range per school reasons for gun ownership were strongly associated with rates of antisocial behavior youths who owned guns for sporting reasons reported rates of ASB that were only slightly higher than those reported by youths who did not own guns youths who owned guns to gain respect or to frighten others reported extremely high rates of antisocial SMB these highrisk adolescent gun owners were likely to come from families of highrisk gun owners associate with friends who were highrisk gun owners and engage in high rates of bullying behavior findings suggest that ERP violence prevention programs must target highrisk youths address risk AF that go beyond individual settings and address a comprehensive array of risk factors | MEDAL |
in terms of understanding fe mobilization from aerosol particles in east china the pm particles were collected in spring at shanghai combined with the backtrajectory analysis the pmpm and caal ratios a serious duststorm episode dse during the sampling was identified the singleparticle analysis showed that the L1 ironbearing class is the aluminosilicate dust during dse while the febearing aerosols are dominated by coal fly ash followed by a minority of iron oxides during the nondust storm days nds chemical analyses of samples showed that the fractional fe solubility fes is much higher during nds than that during dse and a strong inverse relationship of r between fes and total atmospheric iron loading were found suggested that total fe fet is not controlling soluble fe fes during the sampling furthermore no relationship between fes and any of acidic species was established suggesting that acidic process on aerosol surfaces are not involved in the trend of iron solubility it was thus proposed that the sourcedependent composition of aerosol particles is a primary determinant for fes specially the alfe ratio is poorly correlated r with fes while the apparent relationship between fes and the calculated kbbfe ratio r and the vfe ratio r were observed reflecting that fes could be controlled by both biomass burning and oil ash from ship emission rather than mineral particles and coal fly ash although the latter two are the main contributors to the atmospheric fe loading during the sampling such information can be useful improving our understanding on iron solubility on east china which may further correlate with iron bioavailability to the ocean as well as human health effects associated with SE to fine ferich particles in densely populated metropolis in china | MEDAL |
ehlersdanlos syndrome eds is a clinically and genetically heterogeneous group of inherited CTD characterised by joint hypermobility skin hyperextensibility and tissue fragility it has recently been shown that muscle weakness occurs frequently in eds and that fatigue is a common and clinically important symptom the aim of this T0 was to investigate the relationship between fatigue severity and the gait pattern using d gait analysis ga eleven individuals with joint hypermobility syndromeehlersdanlos syndrome hypermobility type jhsedsht were investigated using muscle strength measured with standardised questionnaire measuring fatigue fatigue severity scale fss and quantitative d ga our data showed that fss value well correlated with the peak of vertical component of ground reaction force r p the negative rho gives evidence that the higher the fatigue is the more reduced force is during gait our results showed that the ground reaction force has been applied as a functional evaluation score for detecting pathology in gait of jhsedsht participants and the found correlation between vertical force and fatigue demonstrated that muscle fatigue may be associated with a loss of proprioceptive acuity in lower limb muscles | MEDAL |
tracheal dimensions have been measured in a variety of P0 mammals ranging in body mass m from mouse to dolphin both tracheal diameter and tracheal length are nearly proportional to the cube root of m m and m respectively tracheal volume is proportional to m and assuming that dead space volume vd is proportional to tracheal volume vd is found to be proportional to frc resting PLB frequency is proportional to m therefore dead space ventilation vd can be calculated to be proportional to m this value is very close to the proportionality between oxygen consumption vo and body weight reported in newborns m bartlett and areson since VA va is proportional to vo vd is proportional to va from this it can also be inferred that alveolar pco and po are nearly the same in newborns of different species | MEDAL |
the use of structural equation modeling has gained increased interest in recent years in the social and behavioral sciences this article reviews the basic tenets of structural modeling in relation to issues in research and practice involving clinical assessment and compares this RPA with more traditional psychometric approaches to the validation of assessment instruments with children arguments for and against the inclusion of nonexperimental variables in causal studies aimed at establishing construct validity are also discussed an illustrative example of the application of structural equation modeling in clinical assessment research is provided and a comparison is made between this RPA and traditional psychometric procedures implications and suggestions for the use of structural modeling are discussed for both the practitioner and the clinical researcher | MEDAL |
a special inhalative device is described for reproducible deposition patterns of radioactive aerosols to measure mucociliary and tussive clearance and to evaluate the effect of drugs on the bronchial tree additive actions on mucus transport exist between beta agonists and theophylline but not in combination with inhalative quaternary ammonium EDC ipatropium and oxitropium bromide mucolytics are generally less ERP on mucociliary clearance than beta agonists and theophylline positive negative and nonresponders are often seen due to the different viscoelastic properties of the mucus mucus transport is more than mucociliary clearance twophase gasliquid movement and coughing are also important transport mechanisms for bronchial mucus therefore bronchodilators enhance mucus transport by increasing airway patency which increases total and regional air flow and improves cough clearance | MEDAL |
we report a case of isaacs syndrome showing fwave hyperexcitability which was reversible T3 either epidural block or plasmapheresis a yearold girl with progressive muscle cramp and myokymia in the legs showed high amplitude long duration polyphasic fwaves T3 either tibial nerve or peroneal nerve stimulation potassium current of pc CM was suppressed by her serum igm of which strongly reacted with proteins of approximately kda of the lysates of a pc cell line T3 an epidural nerve block with per cent lidocaine ml the myokymia temporally improved during which time the hyperexcitable fwaves became normalized we treated her with double filtration plasmapheresis which resulted in remarkable improvement of myokymia simultaneously the abnormal fwaves showed a decrease in amplitude duration and in the number of phases we concluded that there was hyperexcitability of the proximal site of motor SF in our patient and possible immune mechanisms gave rise to the myokymia and unusual fwave features | MEDAL |
netrin is a neuronal guidance molecule implicated in the development of spinal cord SN and cortical neurons in the AD spinal cord unch repulsive receptor of netrin but not deleted in colorectal cancer dcc attractive receptor of netrin constitutes a L1 mode of netrin signal transduction which may be involved in axon repulsion and inhibits neurite outgrowth abnormal sprouting of myelinated afferent fibers in the spinal DH can cause mechanical allodynia associated with postherpetic neuralgia phn shingles and other neuropathic pains however whether netrin participates in sprouting of myelinated afferent SF and mechanical allodynia remains unknown in an ultropotent trpv agonist RTX rtxinduced phnlike model rtx treatment for weeks increased netrin expression in dorsal horn SN including nkpositive projection neurons in human neuroblastoma shsyy cells we found that trpv CPZ antagonized rtxinduced upregulation of netrin T3 rtx treatment unch expression was gradually decreased whereas dcc expression was significantly increased silencing netrin in the spinal DH significantly att rtxinduced mechanical allodynia and sprouting of MF into the spinal lamina ii our results suggest that rtx treatment upregulates netrin expression through activation of trpv receptors and NC unchrich spinal dorsal horn into a growthpermissive environment by increasing dcc expression thus enhancing the sprouting of myelinated afferent SN netrin may be targeted for reducing primary afferent sprouting and mechanical allodynia in phn and other neuropathic pain conditions | MEDAL |
as shown in this work antisera obtained after the immunization of animals with vaccines prepared from salmonella minnesota CS r re mutant or escherichia coli o having enterobacterial common antigen eca as well as human antisera with elevated titers of antibodies to re gl or to lps o eca inhibited the development of exp intestinal dysbacteriosis in WG mice induced by the administration of ampyox in C1 doses the degree of the inhibiting action of the antisera was proportional to antibody titers which was indicative of the fact that antibodies possibly played some role in the regulation of the amount of intestinal microflora | MEDAL |
tannic acid is a hydrolyzable tannin that exists in many widespread edible plants with a variety of biological MICs in this T0 we found that tannic acid potently inhibited the activity of fatty acid synthase fas in a concentrationdependent manner with a halfinhibitory concentration value ic of microm the inhibition kinetic results showed that the inhibition of fas by tannic acid was mixed competitive and noncompetitive manner with respect to acetylcoa and malonylcoa but uncompetitive to nadph TA prevented the differentiation of tl preadipocytes and thus repressed intracellular lipid accumulation in the meantime TA decreased the expression of fas and downregulated the mrna level of fas and ppargamma during adipocyte differentiation further studies showed that the GABA effect of TA did not relate to fas nonspecific sedimentation since fas was believed to be a therapeutic target of obesity these findings suggested that tannic acid was considered having potential in the prevention of obesity | MEDAL |
the purpose of this T0 was to investigate a whether certified nursing assistants cnas are more committed to nursing home jobs when they perceive their jobs as enhanced greater autonomy use of knowledge teamwork and b whether cna job commitment affects resident satisfaction | MEDAL |
the behavioural effect of subchronic treatment with calcium channel antagonists nifedipine verapamil and with imipramine was assessed in rats subjected to inescapable shock is the effect of subchronic treatment with nifedipine and imipramine on TPS hnitrendipine hndp IB was investigated in FC cortex of naive rats and in rats given is then tested for shuttlebox escape the rats showed a severe impairment in escape behaviour T3 is imipramine and nifedipine significantly reduced fr and fr escape deficits verapamil had no effect a small but significant increase in the number of hndp IB CS bmax was seen in rats exposed to the shuttlebox escape test independent of a previous SE to is imipramine had no influence on bmax in any of the groups nifedipine did not affect hndp binding in naive rats but decreased bmax in rats subjected to is and the shuttlebox escape test the comparable ability of nifedipine and imipramine to reverse the shuttlebox escape deficit induced by is argues for a possible antidepressant activity of nifedipine the biochemical data indicate that cortical hndp IB sites are not correlated to performance in the shuttlebox escape test | MEDAL |
the CDC and prevention recommends routinely offering hiv testing to inpatients at hospitals with an hiv seroprevalence rate of greater than or an aidrole of antidiuretic hormone in the survival of desert rodents and marsupial wallabies some interesting behavioural effects of glucocorticoids in reptiles and the dynamic interplay between hormones and social status in primates | MEDAL |
mental status changes and MA may occur with topiramate therapy these adverse events were reported during dosage titration and with high dosages of the drug a yearold man receiving topiramate valproic acid and phenytoin experienced acuteonset mental status changes with hyperchloremic metabolic acidosis he had been receiving a modest dose of topiramate for months he was weaned off TPM over days and his mental status returned to baseline within hours of discontinuing the agent this case illustrates the need for close DUE of patients who experience acuteonset mental status changes during topiramate therapy | MEDAL |
plasma cell leukemia pcl is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells it is classified as either primary pcl occurring at diagnosis or as secondary pcl in patients with relapsedrefractory myeloma primary pcl is a distinct clinicpathological entity with different cytogenetic and molecular findings the clinical course is aggressive with short remissions and survival duration the diagnosis is based upon the percentage ⥠and absolute number ⥠à l of PCs in the IP blood it is proposed that the thresholds for diagnosis be reexamined and consensus recommendations are made for diagnosis as well as response and progression criteria induction therapy needs to begin promptly and have high clinical activity leading to rapid disease control in an effort to minimize the risk of early death intensive chemotherapy regimens and bortezomibbased regimens are recommended followed by highdose therapy with autologous SC transplantation if feasible allogeneic transplantation can be considered in younger patients prospective multicenter studies are required to provide revised definitions and better understanding of the pathogenesis of pcl | MEDAL |
a yearold male developed early as well as delayed days post burn pneumothorax of right side following high voltage kv electrical burn of the RA side of the CW diagnosis was established by CE and chest xray intercostal tube drainage with underwater seal relieved the patient of pneumothorax | MEDAL |
we have recently demonstrated that intraduodenal perfusion of trypsin inhibits phenylalaninestimulated pancreatic enzyme secretion by suppression of PR of cholecystokinin cck it is not known whether TR in the duodenum inhibits pancreatic secretion stimulated by a ACh mechanism to investigate this question gastrointestinal intubation and perfusion were performed in healthy subjects volume and osmoreceptors in the duodenum which are known to elicit pancreatic secretion through ACh pathways were stimulated by infusing increasing volumes and mlmin of normal saline or increasing osmolality mosmol of nacl solution increasing the rates of intraduodenal perfusion of normal saline or increasing the osmolality of the DU perfusates caused a doserelated increase in pancreatic trypsin and chymotrypsin outputs without affecting basal plasma cck C2 pm the volume or osmolalitystimulated pancreatic secretions were abolished by atropine but not by intraduodenal perfusion of TR in contrast intraduodenal perfusion of phenylalanine mm produced a significant increase in plasma cck levels pm and a three to fourfold increase in pancreatic enzyme outputs perfusion of the duodenum with bovine trypsin gl reduced the plasma cck C2 to basal values and significantly att the phenylalaninestimulated enzyme secretion to of control simultaneous administration of atropine and intraduodenal perfusion of TR CR abolished the pancreatic enzyme response to phenylalanine stimulation these studies indicate that the intestinal phase of human pancreatic enzyme secretion is under both hormonal and neural control intraduodenal TR inhibits only pancreatic secretion mediated by cck PR and not that mediated by cholinergic mechanisms these observations suggest that feedback regulation of pancreatic enzyme secretion is CS- TPS | MEDAL |
chloroquine retinopathy was produced experimentally in the eye of the albino corydoras one of the tropical fish by daily administration of chloroquine mg per os the enucleated eyes were examined from the th day to months after the beginning of drug administration under light and electron microscopy the first change of retina was the appearance of membraneous cytoplasmic body mcb in the cytoplasm of ganglion amacrine bipolar and horizontal cells mcb might be degenerated lysosome they showed lamellar figures or crystalline latticelike structures secondarily these mcb appeared in the IS of photoreceptor cells the outer segments of rod cells disappeared and then those of cone cells although photoreceptor cells were diminished in number in T3 degeneration the cells of inner nuclear SL and GCs were maintained in number the presence of mcb dose not mean death of cells the retinal pigment epithelial cells contained mcb in its cytoplasm only in severe degenerative cases and did not show other remarkable changes mcb also appeared in the cytoplasm of pericytes of retinal vessels chloroquine is considered to damage directly photoreceptor cells most severely | MEDAL |
to investigate the ability of interleukin il CT to induce proliferation of resting human lymphocytes we stimulated human IP blood mononuclear cells pbmc with an immunopurified preparation of il or with phytohemagglutinin pha proliferation and the percent of cells expressing il receptors were assessed over days of SC regardless of the stimulus the percent of cells bearing an il receptor paralleled the amount of proliferation and proliferation was inhibited by an antiil receptor monoclonal antibody antitac when stimulated by il alone less than of pbmc expressed an il receptor T3 hr of culture stimulation by il caused both proliferation and il receptor expression to increase over the entire culture period routinely to cpm and respectively when colchicine was added to inhibit cell division the percent of cells bearing an il receptor did not increase il alone also induced proliferation of pbmc depleted of accessory cells with the same kinetics but reduced peak response both accessory cells and S9 that showed il but not il activity augmented this pnohydrochloride is a novel orally effective longacting antiallergicantiasthmatic agent the ability of azelastine and selected antiallergic drugs to inhibit srsa leukotrienemediated acute lung anaphylaxis in guinea pigs konzettrossler method was investigated azelastine and ketotifen were administered po and h before antigen challenge disodium cromoglycate dscg was administered iv immediately before antigen challenge the oral dose of azelastine required to inhibit leukotrienemediated allergic bronchospasm by id mgkg was at h and at h ketotifen at a dose of to mgkg at and h po as well as dscg at a dosage of to mgkg at min iv produced weak inconsistent and nondoserelated antianaphylactic effects azelastine is an orally effective and LA inhibitor of in vivo synthesis andor PR of leukotrienes | MEDAL |
a yearold female was admitted to our hospital because of disturbed consciousness and leftsided motor weakness computed tomographic scans demonstrated a hemorrhagic infarction in the right parietal region right carotid angiograms showed both the posterior portion of the superior sagittal sinus sss and the entire left transverse sinus simultaneously occluded left carotid angiograms revealed an enlarged occipital artery which had direct communications to the left sigmoid sinus and the superior petrosal sinus these findings were consistent with dural arteriovenous fistula davf the laboratory examinations yieled normal results the patient was managed conservatively with glyceol and anticonvulsants for four weeks and eventually recovered with CR resolution of hemiparesis followup angiography carried out weeks later showed the sss partially stenotic but recanalized with no evidence of venous congestion the davf still remained opacified but there was a marked reduction in VA flow to the sigmoid sinus further repeated angiograms obtained at months after the onset confirmed CR recanalization of the sss and disappearance of the davf from the timing of the angiographies we considered that the sinus occlusion was caused by the high arterial flow to the fistula and its disappearance made recanalization of sss possible | MEDAL |
mononuclear phagocytes exhibit different patterns of intrinsic resistance to herpes simplex virus type hsv that are related to the heterogeneity of macrophage populations and may reflect the particular differentiation or maturation state of the macrophages in this study we characterized the molecular basis for the block in hsv replication in RPM from bcf mice INF resident peritoneal macrophages were analyzed for the presence of virusspecific mrna by RNA rna blotting and in situ hybridization and for proteins by immunofluorescence the data were compared with those obtained in hsvinfected permissive vero cells the immediateearly genes icp icp icp and icp were transcribed in resident peritoneal macrophages as was the early gene tk virusspecific mrna for the L1 dnabinding protein icp was barely detectable and that for another early gene the viral dna polymerase was not detected in addition transcripts for the delayedearly gene glycoprotein d and the true late gene glycoprotein c gc were not detectable in resident peritoneal macrophages in situ hybridization and immunofluorescence studies confirmed that transcripts and proteins for the immediateearly and some early hsv genes were present these data also established that of the RPM were positive for rna and polypeptide specific for the immediateearly gene icp and that to were positive for rna or polypeptides TPS for the early genes tk and icp the fact that only a few cells expressed viral products emphasizes the heterogeneity that exists even in this relatively homogeneous resident peritoneal macrophage population consistent with the northern blot analysis no rna TPS for the early dna polymerase gene or the late gc gene was detected by in situ hybridization nor could the polypeptide for the gc gene be seen by immunofluorescence thus while early transcriptional events were initiated in some resident peritoneal macrophages there was a block in replication localized at the level of expression of the early to DE viral genes | MEDAL |
the prevalence of antinuclear antibody ana and interferon ifninduced ana has been documented in patients with chronic hepatitis c in the present study we evaluated whether the induction pattern of ana after ifn therapy is related to the tau of ifn therapy | MEDAL |
we report a newborn girl with a de novo terminal q deletion q qter and a characteristic phenotype of minor facial anomalies CP congenital HR defect CA of hands and feet and PN ON of growth deficiency laboratory studies showed excessive urinary calcium excretion on standard milk formula and on oral calcium load blood measurements of parathyroid hormone calcitonin bicarbonate calcium phosphorus magnesium sodium chlorine potassium and urinary measurements of phosphorus magnesium sodium chlorine potassium were normal for age at months of life ultrasonography showed kidney calcifications clinical and laboratory data support the diagnosis of AH or abnormal regulation of calciumsensing receptors in the renal tubules the evidence of hypere cholinergic system are evident in alzheimers disease ad patients including selective loss of alphabeta nicotinic acetylcholine receptors in the brains of ad patients KO mice for the beta subunit have impaired neuronal survival in ageing accordingly we have analysed polymorphisms in the genes that encode the alpha and beta subunits chrna and chrnb respectively for genetic associations with lateonset ad a significant association for disease was observed for a noncoding polymorphism in chrnb odds ratio confidence interval p replication analysis was performed in two further sample sets while these did not individually yield significant results a significant association remained when all samples were pooled odds ratio confidence interval p these data suggest that this variant warrants further examination in large casecontrol series | MEDAL |
a case of tumorinduced osteomalacia in a yearold woman suffering from severe bone pain and muscle weakness is described this uncommon disease is characterized by a reduced SS phosphorus level with elevated urinary phosphate excretion normocalcemia high SS bone alkaline phosphatase and a deficiency of dihydroxyvitamin d the PT responsible for oncogenic OM are usually small benign and commonly located in bone or soft tissues of the head and the limbs so the diagnosis can often be difficult in this case a inpentetreotide scintigraphy was able to detect a hemangiopericytoma located in the RA mascellar sinus removal of the RT resulted in the reversal of clinical and PSA CA | MEDAL |
a man aged had recurrent attacks of severe shock the episodes were preceded by symptoms such as a runny nose epigastric discomfort with nausea vertigo orthostatism and sometimes light fever during the attacks there were marked hypotension a strong rise of the haematocrit a decrease of the protein and albumin concentrations in the blood and prerenal kidney failure in addition there was a paraprotein type iggkappa the shock every time responded rapidly to intravenous administration of fluid and was followed by a period of substantial polyuria the DP was characteristic of systemic CLS a rare but frequently fatal disease characterized by episodes of unexplained extravasation of plasma the aetiology and pathogenesis are unknown attacks are suppressed by supportive therapy administration of fluids inotropics and future attacks may be prevented by the NI of terbutaline and theophylline the systemic CLS should be considered in the differential diagnosis of idiopathic and anaphylactic shock | MEDAL |
we recently described the incidence of a scid disease in a litter of jack russell terriers in this T0 we show that the molecular defect in these animals is faulty vdj recombination furthermore we document a complete deficit in dnadependent protein kinase activity that can be explained by a marked diminution in the expression of the catalytic S1 dnadependent protein kinase catalytic subunit dnapkcs we conclude that as is the case in cb scid mice and in arabian scid foals the defective factor in these scid puppies is dnapkcs in mice it has been clearly established that dnapkcs deficiency produces an incomplete block in vdj recombination resulting in leaky coding joint formation and only a modest defect in signal end ligation in contrast dnapkcs deficiency in horses profoundly blocks both coding and signal end joining here we show that although dnapkcs deficiency in canine lymphocytes results in a block in both coding and signal end joining the deficit in both is intermediate between that seen in scid mice and scid foals these data demonstrate significant species variation in the absolute necessity for dnapkcs during vdj recombination furthermore the severity of the vdj recombination deficits in these three examples of genetic dnapkcs deficiency inversely correlates with the relative dnapk enzymatic activity expressed in NF derived from these three species | MEDAL |
dynamic computed tomography ct and digital subtraction angiography were used for postoperative evaluation of the hemodynamic changes in five patients with giant or large intracranial aneurysms the lesions in four of these cases were giant or C1 aneurysms of the IC and were treated by occlusion of the cervical internal i.c. and SF temporalmiddle cerebral artery anastomosis the lesion in the fifth case was a giant aneurysm of the RA vertebral i.a. which was treated by proximal clipping of the vertebral artery preoperative DS angiography revealed aneurysmal staining and DCT scanning indicated the rapid transit of contrast medium in the dome of the aneurysm dynamic ct scanning immediately after T0 indicated a LF state in all of the aneurysms suggesting that they were thrombosed although within a few months the peripheral edges of the aneurysms became enhanced DCT scanning revealed a slower transit of contrast medium through the centers of the aneurysms than in the BA i.a. and DS angiography failed to demonstrate aneurysmal staining suggesting that the aneurysms remained thrombosed the present data indicate that dynamic ct scanning and DS angiography may be useful for relatively noninvasive evaluation of the hemodynamic changes in patients with giant intracranial aneurysms | MEDAL |
in recent studies in this laboratory employing normal hydropenic rats we have demonstrated that the reduction in absolute proximal reabsorption that attends the experimental reduction of SN glomerular filtration rate sngfr glomerulotubular balance is mediated at least in part by the accompanying decline in postglomerular vascular protein concentration and therefore postglomerular colloid OP piea the present T0 was undertaken to define the quantitative contribution of these changes in piea to the changes in APR measured under these conditions a protocol was employed which enabled us to examine the effects on APR of reductions in filtered load brought about under conditions in which piea remained essentially unchanged thus after partial AC in plasmaloaded rats near constancy of piea was observed in a NC in efferent arteriolar protein concentration of g ml or less and in these uniform reductions in sngfr averaging nlmin were attended by reductions in absolute proximal reabsorption averaging only nlmin or of preconstriction values these findings taken together with previous observations from this laboratory suggest that the proximal reabsorptive adjustment that characterizes glomerulotubular balance in the rat is markedly blunted when changes in piea are prevented in the remaining six rats a mean reduction in filtered load comparable to that observed in the above group was attended by slightly to moderately greater reductions in efferent arteriolar protein concentration thereby fulfilling less well the stated aim of this T0 nevertheless in accord with the above conclusion these relatively greater reductions in piea were accompanied by correspondingly greater reductions in absolute proximal reabsorption | MEDAL |
malnutrition is a frequent complication in hemodialysis patients and is associated with increased mortality and morbidity interventions such as oral or intravenous nutritional supplements have often failed to improve nutritional status we report here the effect that daily dialysis practiced in our center since has had on nutritional parameters seventeen patients treated with conventional hemodialysis hours three times per week for years were converted to short daily hemodialysis hours six times per week for a mean of months dietary anthropometric and biochemical evaluations were performed during CHD after year on short daily hemodialysis sdhdyear and at the end of followup sdhdend daily protein intake increased from gkgday with CHD to gkgday at sdhdyear and gkgday at sdhdend energy intake increased from kcalkgday to kcalkgday at sdhdyear and kcalkgday at sdhdend the normalized protein equivalent PNA npna increased from gkgday with CHD to gkgday sdhdyear and gkgday sdhdend PSA indicators also increased serum albumin increased from gl to gl and gl and Pr increased from gl to gl and gl respectively these improvements were accompanied by an increase in body weight from kg on CHD to kg at sdhdyear and kg at sdhdend all the changes between conventional hemodialysis and short daily hemodialysis were statistically significant increased frequency is more important than increased dialysis dose short daily hemodialysis appears to be a suitable method to improve nutritional status in dialysis patients | MEDAL |
the antennal lobe al is the primary structure within the locusts BB that receives information from olfactory receptor SN orns within the antennae different odors activate distinct subsets of orns implying that neuronal signals at the level of the antennae encode odors combinatorially within the al however different odors produce signals with longlasting dynamic transients carried by overlapping neural ensembles suggesting a more complex coding scheme in this work we use a largescale point neuron MM of the locust al to investigate this shift in CS- encoding and potential consequences for odor discrimination consistent with experiment our MM produces stimulussensitive dynamically evolving populations of active al neurons our model relies critically on the persistence timescale associated with orn input to the al sparse connectivity among PNs and a synaptic slow inhibitory mechanism collectively these architectural features can generate network odor representations of considerably higher dimension than would be generated by a direct feedforward a probe was attached on the sensor surface by means of covalent bonding between the amine and phosphate CG of the dna sequence the interaction between the dna probe and the mwcnts were characterized by fourier transform infrared ftir spectrometry raman spectra the hybridization of the dna probe and the target dna were detected by changes in the conductance on the surface of sensors leading to the change in the output signal of the system the results show that the dna sensor can detect as low as nm of the target dna samples the response time of dna sensor is approximately min | MEDAL |
conventional measurement of wall thickening with two transittime crystals requires considerable skill is associated with myocardial trauma and does not discern the CF of different layers of the left VVI lv wall to overcome these limitations we have developed a mhz pulsed doppler technique that measures thickening at any depth of the lv wall from a single crystal sutured to the epicardium to verify its accuracy we compared measurements of thickening fraction tf by PD and transittime methods in openchest dogs the Epi doppler crystal was placed over an intramyocardial crystal positioned either in the subendocardium or midwall the Epi crystal acted as both the doppler transducer and the transittime transmitter so that tf was measured by each technique at the same site a wide range of regional CF transmural tf Epi tf was produced by CO followed by reperfusion and phy successfully displayed the location and extent of aortic root complications annular PA or mycotic aneurysm in nine patients with aortic valve endocarditis five of the nine patients had prosthetic valve endocarditis and four had native valve endocarditis the L3 process D2 into the paravalvular structures including the interventricular septum seven patients right ventricular outflow tract three patients IAS one patient and anterior mitral valve leaflet four patients the amount of aortoleft ventricular discontinuity caused by these complications was quantitated in degrees of annular circumference on the parasternal short axis image and in distance on the parasternal long axis image the echocardiographic findings were confirmed at surgery and were helpful in the preoperative anticipation of the type of surgical procedure required aortic valve replacement or composite AV and root replacement five patients had prosthetic valve endocarditis with calculated aortoleft VVI discontinuity of degrees on parasternal short axis images and cm on parasternal long axis images initial surgical repair included three composite aortic rootvalve prosthesis implants one reconstructive procedure with valve replacement and one simple aortic VR during a followup period of months range to a second reparative procedure was required for only one patient to repair an aortic conduit to coronary artery venous bypass graft four patients had native valve endocarditis with calculated aortoleft VVI discontinuity of degrees on parasternal short axis images and cm on parasternal long axis images initial surgical repair included two reconstructive procedures with VR and two simple AV replacements during a followup period of months range to three of these four patients required a second reparative procedure one each for repair of a paraprosthetic leak a VVI septal defect and persistent aortoleft ventricular discontinuity 2DE echocardiography accurately detected aortic annular PA and mycotic aneurysm complicating aortic valve endocarditis and the resultant degree of aortoleft VVI discontinuity circumferential aortoleft VVI discontinuity with these complications is greater for prosthetic than native valve endocarditis and predicts a more extensive surgical repairabstract truncated at words | MEDAL |
intestinal lymphangiectasia il is a rare disease requiring oral fat restriction the aim of this study was to evaluate the tau of EN compared to that of TPN nutrition tpn we retrospectively reviewed nine patients with il presenting with PLE of these seven patients not responding to a lowfat diet were treated with elemental diet ed polymeric diet pd containing MCTs or tpn improvement in SS total protein was observed in two of three on ed and in one of two on pd compared with three of three on tpn enteric protein loss was improved in two of two on ed one of two on pd and two of two on tpn outpatients who continued to receive EN nutrition maintained a total protein level enteral nutirition appears to be as ERP as tpn for patients with il and it may provide a valid and safe alternative therapy | MEDAL |
density rho apparent molar volume vphi and viscosity eta of to wv of bovine serum albumin bsa egg albumin and lysozyme in and m aqueous rbi and csi and dodecyltrimethylammonium bromide dtab solutions were obtained the experimental data were regressed against composition and constants are used to elucidate the conformational changes in protein molecules with salt concentration the density of proteins is found to decrease and the order of the effect of additives on density is observed as csi rbi dtab the trend of apparent molar volume of proteins is found as bsa eggalbumin lysozyme for three additives in general eta values of bsa remain higher for all compositions of rbi than that of eggalbumin for csi and dtab these orders of the data indicate the strength of intermolecular forces between proteins and salts and are helpful for understanding the denaturation of proteins | MEDAL |
allerton td earnest cp and johannsen nm metabolic and mechanical effects of laddermill graded ET j strength cond res the purpose of this T0 was to compare the metabolic responses and mechanical impact forces during a maximal GXT gxt on a laddermill lm vs a standard TM tm twenty collegeaged men n and women completed a gxt on the tm and lm in random order during the gxt expired gases vcombining dot aboveo and vcombining dot aboveco heart rate accelerometer data blood lactate bla and rating of RPE rpe were collected in the last minute of each stage data were analyzed by paired ttests and presented herein as mean ± sd TM exercise resulted in a higher vcombining dot aboveopeak than lm exercise ± vs ± ml·kg·min p blood lactate threshold was similar p between lm ± vcombining dot aboveopeak and tm ± vcombining dot aboveopeak the average activity level experienced during lm ± vector magnitude unit vmu exercise was lower p vs tm ± vmu additionally impact forces were reduced p from the vertical plane during lm ± g compared with tm ± g exercise our results suggest that the nature of lm exercise does not elicit the same vcombining dot aboveopeak response observed during tm exercise however impact forces were reduced and energy expenditure remained higher during lm testing whereas rpe was similar between modalities lm exercise may provide an alternative to individuals seeking to incur a NEB but to whom higher impact forces are detrimental | MEDAL |
twotone rate suppression was examined in the responses of single cochlearnerve fibers in mongolian gerbils the isorate tracking algorithm developed by kiang and moxon kiang nys and moxon ec j acoust soc am for obtaining tuning curves was modified to track isorate suppression boundaries as a function of frequency with the excitor tone fixed at the characteristic frequency cf of the fiber lower threshold boundaries of the Az of suppression flanking the PTC above and below cf were outlined for fibers over a C1 cf range it was found that the boundaries of rate suppression obtained below cf were very stable in their absolute positions on the intensityfrequency plane this stability was evident both as a function of fiber cf khz and as a function of the shape of the PTC at a given cf in other words the suppression boundary obtained below cf was largely independent of the tuning curve in a second series of experiments tuning curves were taken in the presence of a fixed tone placed in the suppression area located above the fiber cf the fixed tone by itself was not excitatory these TCs were compared to tuning curves obtained with a single tone it was found that frequencies around the fiber cf were most affected suppressed by the presence of the second tone and that the lowfrequency tail of the tuning curve tended to shift toward the boundary of the suppression area below cf because this suppression boundary lies below the threshold of the normal tail of the PTC for many mid and highcf fibers these SF often became hypersensitive at low frequencies in the presence of the second tone above cf | MEDAL |
to clarify the role of tafi in hypertensive disorders in pregnancy subjects including with preeclampsia pe and with gestational hypertension were examined for the levels of tafi and thrombinantithrombin tat complex thirty normal pregnant women served as controls elisa was employed for the detection the results showed that the tafi antigen C2 in normal pregnancy group gestational hypertension group and pe group were in the st nd and rd trimester respectively no significant differences were found between the NP group and GH group but significant difference existed between normal pregnancy group and pe group in each trimester p tat complexes were significantly higher in patients with pe than that in controls p but no rho was found between tat and tafi it is concluded that tafi may contributed to the impairment of fibrinolysis in the patients with pe and may serves as a CS indicator for pe but it may not help in the diagnosis of the gestational hypertension | MEDAL |
we report the case of a yearold male with recurrent presyncope referred with a provisional diagnosis of carotid sinus syndrome on the basis of a s asystolic pause following carotid sinus massage on repeat HM there was stsegment elevation followed by episodes of polymorphic ventricular ART during a mild episode of presyncope coronary angiography showed mild right coronary i.a. irregularity without significant stenosis an automatic cardioverter defibrillator was implanted and high dose combined vasodilator therapy was commenced at followup months after implantation the device has recorded no episode of ART and the patient reports no recurrence of symptoms | MEDAL |
fecal dna testing has shown greater sensitivity than guaiacbased occult blood tests for noninvasive CC crc screening the prototype assay version which analyzed gene mutations and dna integrity CA dia showed a sensitivity of for crc detection and a specificity of in averagerisk individuals the present T0 was conducted to determine the sensitivity and specificity of a secondgeneration assay version that uses improved dna stabilizationisolation techniques and a new promoter methylation marker | MEDAL |
methyl isothiocyanate mitc was extracted from a ml wine sample with ml dichloromethane and the extract was washed with sodium chloride solution mitc was determined by gas chromatography with a dual nitrogenphosphorus detector npd and a flame photometric detector fpd s mode db column m x mm id column temperature degrees c the limit of detection and quantitation of mitc with npdgc were and ppm respectively average recoveries of mitc added to wine at and ppm were over this method is simple and rapid for routine analysis of mitc in wine | MEDAL |
broiler chicken flocks were studied to determine the mortality from SDS occurring in the flocks the difference in the incidence of the syndrome in pullets and cockerels and the age at which the most birds are affected were also studied the weight of SD syndrome birds was compared with the flock average and the effect of continuous lighting as opposed to intermittent lighting was examined the results suggest that LL produces more SDS deaths than intermittent lighting that the incidence of SD syndrome is higher in cockerels than pullets that the highest death rate occurred during the third and fourth weeks of life and that sudden death syndrome birds on the average were heavier than the flock average | MEDAL |
it is proposed that xanthophylls and carotenoids in general may assist in SE transfer from the chlorophyll soret band to the q band groundstate ag and excitedstate bu optimizations of violaxanthin vx and zeaxanthin zx are performed in an environment mimicking the lightharvesting complex ii lhcii including the closest chlorophyll b molecule chl timedependent density PET theory tddft camblyp PET is used in combination with a semiempirical description to obtain the excitedstate geometries supported by additional dftmultireference CI calculations with and without point charges representing lhcii in the ground state vx and zx show similar properties at the bu minimum the energy of the zx bu state is below the chl q band in contrast to vx both vx and zx may act as acceptors of soretstate SE transfer to the q band seems to be favored for vx these findings suggest that carotenoids may generally mediate sorettoq SE flow in lhcii | MEDAL |
to clarify the molecular mechanisms of neural development in vertebrates we analyzed a novel gene termed nemp nuclear envelope integral membrane protein which is expressed in the xenopus anterior neuroectoderm at the neurula stage nemp has a putative signal peptide and five TM domains but does not have any other known domains we show that nemp is localized to the inner nuclear membrane inm with its evolutionarily conserved cterminal region facing the nucleoplasm both overexpression and knockdown of nemp in xenopus embryos reduced the expression of early eye marker genes rax tbx and pax and later resulted mainly in severe eye defects at the tailbud stage in contrast the expression of a forebrainmidbrain marker otx and a panneural marker sox was largely unaffected deletion analysis of nemp showed that nuclear envelopelocalization of the cterminal region is necessary for its eyereducing activity furthermore nemp is coexpressed with baf barriertoautointegration factor in the eye anlagen and that nemp interacts with baf through the bafbinding site in the CT region and this site is required for nemp activity these data suggest that nemp is involved in the expression of eye marker genes by SF-36 at the inm at least partly through baf | MEDAL |
because microbial communities play a key role in carbon c and nitrogen n cycling changes in the soil microbial community may directly affect ecosystem SF-36 however the effects of n deposition and management practices on soil microbes are still poorly understood we studied the effects of these two factors on soil microbial biomass carbon mbc and community composition in moso bamboo plantations using highthroughput sequencing of the s rrna gene plantations under conventional cm or intensive management im were subjected to one of four n treatments for months im and n addition both separately and in combination significantly increased soil mbc while decreasing bacterial diversity however increases in soil mbc were inhibited when n addition exceeded kg nâhaâyr im increased the relative abundances of actinobacteria and crenarchaeota but decreased that of acidobacteria n addition increased the relative abundances of acidobacteria crenarchaeota and actinobacteria but decreased that of proteobacteria soil bacterial diversity was significantly related to soil ph cn ratio and nitrogen and available phosphorus content management practices exerted a greater influence over regulation of the soil mbc and microbial diversity compared to that of n deposition in moso bamboo plantations | MEDAL |
visually stressful striped patterns with a spatial frequency sf of around cycles per degree cpd can induce perceptual illusionsdistortions and visual discomfort in most people headaches in patients with migraine and seizures in patients with photosensitive epilepsy patterns with sf ⼠cpd have no such effects and are not uncomfortable to look at nonstressful the effects of the striped patterns on visual cortical activation have been investigated but their effects on the visual cortical network remain to be studied a prolonged visual stimulation with stressful patterns may alter the PET connections within the visual system and their relationship with other networks using restingstate fmri this T0 revealed that the PET connections within the visual system were significantly enhanced by visually stressful stimulation the PET connectivity between v and other BB regions was also significantly modified nonstressful stimulation produced no such significant effects more importantly the effects outlasted the stimulation and this applied both to those effects within and those beyond the VC suggesting that repeated prolonged visual stimulation with stressful patterns may alter PET connections of the brain and this might be utilized as a visual neuromodulation RPA for treatments of visually triggered headaches in migraine patients and visually induced seizures in patients with photosensitive epilepsy hum BB mapp © wiley periodicals inc | MEDAL |
we report five patients with normal diuretic renograms who underwent whitaker pressure perfusion testing they were found to have normal pressure at low flow rates mlmin and an abnormally elevated pressure at high flow rates mlmin because of persistent PS two patients underwent surgery while the other three have been followed up our findings indicate that a negative diuretic renogram in a well hydrated patient with good renal function may not rule out low grade one renal pelvic perfusion at low flow rates as well as high flow rates is recommended to determine better the function of the pelviureteric junction | MEDAL |
we report the successful treatment using lowdose vigabatrin mgkgday of a yearold girl with succinic semialdehyde dehydrogenase ssadh deficiency we verified that hydroxybutyric acid ghb concentrations in SS cerebrospinal fluid and urine continuously decreased in parallel with significant clinical improvement our results suggest that ghb quantification in physiological fluids may be a useful laboratory parameter for monitoring tau of vigabatrin treatment in ssadh deficiency | MEDAL |
the purpose of the present study was to examine seizure activity during reduced alphapregnanalphaolone alphaalphathp production ovariectomized LE were stereotaxically implanted with bipolar electrodes above the perforant pathway silastic implants filled with estradiolbenzoate eb and progesterone were inserted subcutaneously to mimic diestrus estrus was then induced in half of these animals by i.t. of eb microg and progesterone mg and h respectively prior to PP stimulation half of the estrous and diestrous rats also received a alphareductase inhibitor finasteride mgkg h prior to PP stimulation the estrous condition was associated with reduced number and duration of partial seizures improved performance on a MWM REC of CF test reduced neuronal loss in the hilar region of the hippocampus and elevated central and plasma alphaalphathp compared to estrusfinasteride diestrusvehicle and diestrusfinasteride conditions which did not differ from each another these data suggest antiseizure effects of estrus may be caused in part by the action of alphaalphathp and that the precipitous decline in alphaalphathp may restore ST to control levels | MEDAL |
there is growing interest in the diagnosis of cognitive impairment among children with epilepsy it is well known that status of seizures control has to be carefully investigated because it can be sufficient per se to cause progressive mental deterioration conditions subclinical electroencephalographic discharges may have subtle effects on cognition learning and sleep patterns even in the absence of clinical or subclinical seizures in this respect electroencephalographic monitoring LT and nocturnal recording and in particular an all night videopolysomnography vnpsg record can be crucial to detect the presence of unrecognized seizures andor an interictal nocturnal eeg discharge increasing epileptic encephalopathies ee are a group of conditions in which the higher cognitive functions are deteriorate as a consequence of epileptic activity which in fact consists of frequent seizures andor florid and prolonged interictal paroxysmal discharges focal or generalized aeds represent the first line in opposing the burden of both the poor seizures control and the poor interictal discharges control in the cognitive deterioration of ee affected children thus to improve the LT cognitivebehavioural prognosis in these refractory epileptic children it should be taken into account both a good seizures control and a strict sleep control choosing carefully AEDs which are able to control not only seizures clinically recognizable but even the eeg discharges ON and its increasing and spreading during sleep here we review the tau and safety of the newer aeds that to date are used in the treatment of ee in infancy and childhood | MEDAL |
emergency department visits and fatalities in which methylenedioxymethamphetamine mdma or methamphetamine meth are involved frequently feature unregulated hyperthermia mdma and meth significantly elevate body temperature in multiple laboratory species and most importantly can also produce unregulated and threatening hyperthermia in nonhuman primates a majority of prior animal studies have po drugs by injection whereas human consumption of ecstasy is typically oral an important difference in route of administration which may complicate the translation of animal data to the human condition | MEDAL |
a T0 was conducted examining the paradox that populations with a poor standard of health seem to achieve only meagre improvements over time whereas those with a good standard of health seem to show continual substantial improvement the health states of nations were measured by REF to their infant mortality in and the changes that occurred over the next years countries with low IM in for example japan and east germany achieved substantial further declines over the years whereas in countries such as rwanda and ethiopia infant mortality hardly declined at all or even increased ethiopia to in countries for which data were available there was a close link between the change in health state of a people and the ratio of government expenditure on health and defence as the ratio increased in favour of defence so the improvement in health state of a people declined the reverse was also true at the primary care level disparity in uptake of care both among and within communities was associated with literacy and SES state services inadvertently being aimed at those sections most likely to benefit the forces that act to produce this setting of unequal care must be checked at both national and primary levels if we are to have health for all by the year | MEDAL |
induction of the major drug metabolizing enzyme cypa by xenobiotics contributes to the pronounced interindividual R2 of its expression and often results in clinically relevant drugdrug interactions it is mainly mediated by pxr which regulates cypa expression by binding to several specific elements in the upstream regulatory region of the gene induction itself shows a marked interindividual variability whose underlying determinants are only partly understood in this T0 we investigated the role of nuclear receptor binding to pxr response elements in cypa as a potential nongenetic mechanism contributing to interindividual R2 of induction by in vitro dna IB experiments we showed that several nuclear receptors bind efficiently to the proximal promoter er and distal xenobioticresponsive enhancer module dr motifs tralpha trbeta couptfi and couptfii further demonstrated dosedependent repression of pxrmediated cypa enhancerpromoter reporter activity in transient transfection in the presence and absence of the pxr inducer rifampin while vdr showed this effect only in the absence of treatment by combining PET in vitro characterization with hepatic expression analysis we predict that tralpha trbeta couptfi and couptfii show a strong potential for the repression of pxrmediated activation of cypa in vivo in summary our results demonstrate that nuclear receptor binding to pxr response elements interferes with pxrmediated expression and induction of cypa and thereby contributes to the interindividual variability of induction | MEDAL |
the interactions on antinociception between a muscarinic agonist arecoline arec an anticholinesterase physostigmine physo which both cross cns and a peripherally acting antimuscarinic hyoscinenbutyl bromide hyo were assessed by TF test in mice all drugs were po intraperitoneally ip while hyoscinenbutyl bromide and mgkg ip did not produce antinociception physostigmine salicylate mgkg ip and arecoline hydrobromide mgkg ip exerted significant antinociceptive effect in combined applications physo hyo mgkg and arec hyo mgkg respectively produced significant antinociception and the tail flick latencies produced by physo hyo mgkg and arec hyo mgkg were not significantly different from those of physo mgkg and arec mgkg respectively showing that hyo did not antagonise the antinociceptive effects of physo and arec we believe that combining an centrally acting ACh drug applied systemically with aield and the residual higherorder aberrations which limit the resolution the resulting aplanat achieves a resolution limit of about nm for an image field with a diameter of nm the required stabilities of the electric power supplies are discussed in detail | MEDAL |
to produce an internationally valid tool to assess skill in performing trabeculectomy surgery | MEDAL |
the aims of the present work were to determine whether a brief reninangiotensin system blockade with at receptor antagonist or angiotensinconverting enzyme inhibitor may provide longlasting protection against hypertension and proteinuria in both young and AD lyon hypertensive lh rats young prehypertensive LH rats were orally treated with or mgkgd of losartan or with mgkgd of perindopril from to weeks of age AD lyon hypertensive rats were treated with mgkgd of losartan mgkgd of perindopril or a combination of both from to weeks of age telemetric blood pressure bp and urinary protein excretion were evaluated during and T3 treatment cessation in young prehypertensive LH rats LOS fully prevented the hypertension and proteinuria these effects were dose dependent and persisted long after treatment withdrawal when reninangiotensin system blockade was initiated in adult LH rats with established hypertension mgkgd of LOS or mgkgd of perindopril induced a significant regression in both blood pressure and PU as did in young lyon hypertensive rats the combination treatment produced an additional effect only on blood pressure after treatment cessation a reduction in blood pressure persisted in all the pretreated adult lyon hypertensive rats whereas the effect on proteinuria was less marked in conclusion whatever the blocker used an early reninangiotensin system blockade in prehypertensive LH rats induces a durable prevention of hypertension and associated renal alterations the similar reninangiotensin system blockade in adult lyon hypertensive rats provides a regression of hypertension and PU but the persistence of these beneficial effects is less pronounced than in young lyon hypertensive rats thus suggesting that the treatment with reninangiotensin system blockers should be initiated as early as possible before the full expression of hypertension to achieve the maximal longlasting effects in mature stage | MEDAL |
subviral particles containing reovirus rna transcriptase have been isolated from extracts of virusinfected mouse FB cells the purified particles which lacked the outer protein capsomeres of the mature virion had a buoyant density of gml in cscl and contained all of the dsRNA genome of the IN virus the particles were free of nuclease activity rna synthesis required all four ribonucleoside triphosphates and was dependent on magnesium or manganese optimal activity required potassium or ammonium ions in the presence of a ribonucleoside triphosphate regenerating system reaction rates were linear for hr rna yields of fold in excess of input template could be obtained completed rna chains were released from the subviral particles in the course of rna synthesis the doublestranded rna template was fully conserved the rna products formed in vitro displayed profiles in SU gradients similar to those found for in vitro reovirus mrna the rna products were ssDNA and did not selfanneal over percent of the transcriptase products could be annealed with template dsDNA rna the annealed products migrated in acrylamide gels as dsDNA rna indicating efficient in vitro transcription | MEDAL |
the infection of landsnails was realised in order to relate the motility of protostrongylid firststage larvae to their infectivity various factors such as the age of larvae their density the composition of the conservation liquid and the temperature were tried on the motility of larvae a clear relation appeared between motility and infestivity of larvae the age density of larvae and cold did influence negatively their motility on the contrary increases in temperature and optimal concentrations of magnesium calcium and sodium salts did influence positively the motility induced variations of motility did provoke related fluctuations of infestivity | MEDAL |
analysis of the pregnancy course and neonatal outcomes in women with a PH of recurrent spontaneous abortion showed a high rate of perinatal disease and neonatal problems this is underlain by hormonal immunological and some other disorders and also by a high infection level both during pregnancy and without it to reduce the perinatal morbidity rate a system of the reproductive CF checkup and rehabilitation for the nonpregnant and a stagebystage control over the pregnancy course and the status of the fetoplacental unit was suggested | MEDAL |
the extracting effectiveness of some solvents water ethanol acetone EA used as pure or in binary and ternary mixtures was studied for the SE of seeds from the fermented pomace of nebbiolo cv the AQ mixtures of acetone provided the highest extraction yields in total polyphenols and total flavonoids polyphenolic extracts were also obtained with AQ mixtures of ethanol or acetone at VL concentrations and the condensed tannins were quantified with the phloroglucinolysis method the aqueous mixtures of AC were more effective than the corresponding aqueous mixtures of ethanol the solvent influenced the SE yield and the composition of the extracts with the increase of the yield the mean degree of polymerization mdp of the condensed tannins increased a significant correlation was noticed between mdp and the molar percentages of catechin as terminal unit negative rho and of EC and epicatechinogallate as extension units positive rho | MEDAL |
in celery apium graveolens l the two major translocated carbohydrates are sucrose and the acyclic polyol mannitol their metabolism however is different and their specific functions are uncertain to compare their roles in carbon partitioning and sinksource EMT developmental changes in co labeling pool sizes and key enzyme activities in leaf tissues were examined the proportion of label in mannitol increased dramatically with leaf maturation whereas that in SU remained fairly constant mannitol content however was high in all leaves and SU content increased as leaves developed activities of mannosep reductase cytoplasmic and chloroplastic fructosebisphosphatases SU phosphate synthase and sucrose synthase increased with leaf maturation and decreased as leaves senesced ribulose bisphosphate carboxylase and nonreversible glyceraldehydep dehydrogenase MICs rose as leaves developed but did not decrease thus SU is produced in all photosynthetically AS leaves whereas mannitol is synthesized primarily in mature leaves and stored in all leaves onset of SU export in celery may result from SU accumulation in expanding leaves but mannitol export is clearly unrelated to mannitol concentration mannitol export however appears to coincide with increased mannitol biosynthesis although mannitol and sucrose arise from a common precursor in celery subsequent metabolism and transport must be regulated separately | MEDAL |
a yearold woman presented with a PH of dyspnea and atypical chest pain she was diagnosed with a nonstsegment elevation myocardial infarction due to a giant RA PD aneurysm after a failed percutaneous embolization she was scheduled for right coronary i.a. aneurysm resection posterior descending i.a. revascularization and mitral valve repair during the induction of anesthesia and institution of mechanical ventilation the patient suffered cardiovascular collapse the transesophageal echocardiographic examination revealed tamponade physioloales and mgkg bwday for females and bmdl values as low as mgkg bwday for both sexes these data demonstrate that the length of SE is an important component in the threshold of toxicity from a coexposure to these compounds and suggest that the current risk assessments based on exposures to melamine CT may not reflect sufficiently the risk of a coexposure to melamine and cyanuric acid | MEDAL |
here we report the CS of the region that determines rapid allograft rejection in chickens the chicken major DLA mhc this kilobase region of the b locus contains only genes making the chicken mhc roughly fold smaller than the HLA virtually all the genes have counterparts in the human mhc defining a minimal essential set of mhc genes conserved over million years of divergence between birds and mammals they are organized differently with the class iii region genes located outside the class ii and class i region genes the absence of proteasome genes is unexpected and might explain unusual peptidebinding specificities of chicken class i molecules the presence of putative natural killer receptor genes is unprecedented and might explain the importance of the b locus in the response to the herpes virus responsible for mareks diseases the small size and simplicity of the chicken mhc allows coevolution of genes as haplotypes over considerable periods of time and makes it possible to T0 the striking mhcdetermined pathogenspecific disease resistance at the molecular level | MEDAL |
to describe the imaging findings and clinical outcomes of children with apparent cochlear nerve aplasia undergoing CI | MEDAL |
RF ablation rfa is increasingly used to treat HCC carcinoma hcc in patients awaiting a liver transplant despite its increasing use detailed histologic information is scarce regarding the nature of rfatreated lesions we identified four chronic HC patients who had rfa of their hcc before their CL transplant for these four patients we conducted a detailed histopathologic analysis of the treated lesions in their explanted livers the five lesions included immediate d and LT months postrfa specimens of the five lesions four were CR ablated the one incompletely ablated lesion was also treated with chemoembolization in the acute postrfa period a zone of interstitial hemorrhage occurred at the outer boundary of the lesion differing from classic tissue CN the treated lesions all showed thermal fixation with preserved tissue architecture and microscopic cellular detail the cellular staining characteristics faded with time but the treated tissue became brittle resisted tissue breakdown and generated a minimal wound healing response at the periphery of the lesion the fibrous septae of the cirrhotic CL and vascular structures appeared to demarcate or limit progression of the ablation front a narrow hypocellular fibrous boundary with a focal foreign body giant celltype reaction developed around the edge of the ablation zone thus rfa can produce immediate and complete thermal fixation of select lesions with an AGA liver margin and can provide a satisfactory treatment option for select hcc patients before a liver transplant | MEDAL |
this study sought to investigate the changes induced on the pressurearea relation of the LA in patients with MS after percutaneous balloon mitral valvuloplasty | MEDAL |
the effects of HAL versus ISO on CSD of cerebral blood flow cbf were compared using ciodoantipyrine ARG SDRs were exposed to mac of either halothane n or ISO n in obalance nitrogen for min prior to determination of cbf normoxia NT and normocapnia were maintained throughout the experiment and arterial pressures map were held within the range of mmhg by infusion of blood coronal ARG brain images were then digitized and optical density values converted to cbf with the use of c ARG standards and arterial radioactivity data hemispheric neocortical subcortical and selected local anatomical regions were defined on a cathode ray screen display by cursor outline mean cbf for each region was determined at each of eight standardized coronal brain sections and area weighted average values for the whole BB were also calculated hemispheric cbf was identical in the two anesthetic CG HAL ml gmmin ISO ml gmmin however neocortical cbf was greater in HAL anesthetized animals HAL ml gmmin ISO ml gmmin p the authors conclude that HAL and ISO exert regionally selective effects on cbf with halothane appearing to have a more pronounced effect on the neocortex previously reported discrepancies concerning the relative effects of these two agents on cbf may be due to inherent differences in the tissue regions measured by the different techniques | MEDAL |
the mechanism of sensory transduction in chemosensory neurons of the VN organ vno is not known based on molecular data it is likely to be different from that mediating sensory transduction in the MOS to begin to understand this system we have characterized the electrophysiological properties of dissociated mouse vno neurons with patchclamp recording sensory SN were distinguished from nonsensory SN by the presence of a dendrite by immunoreactivity for OMP and by the firing of action potentials the resting potential of vno SN was approximately mv and the average input resistance was gomega current i.v. as small as pa elicited steady trains of action potentials that showed no sign of elicited steady trains of action potentials that showed no sign of adaptation during a sec stimulus duration the voltagegated conductances in vno neurons are distinct from those in olfactory neurons the na current is composed of two components the L1 component was ttxsensitive ki nm the outward k current activates at mv with kinetics times slower than for k currents in olfactory SN the IT is composed of at least two components an ltype current and a ttype current that activates at mv and is not found in olfactory neurons we find no evidence for cyclic nucleotidegated channels in vno SN under a variety of experimental conditions including those that produced large responses in mouse olfactory SN which is further evidence for a novel transduction pathway | MEDAL |
it has been observed that the area under the free carboplatin concentration in plasma ultrafiltrate versus time curve auc is related to toxicity and tumour response for this reason it can be important to measure the carboplatin auc and subsequently adjust the dose to achieve a predefined target auc the use of limited sampling strategies enables relatively simple measurement and calculation of actual carboplatin aucs | MEDAL |
although it is well known that morphine induces significant immunosuppression the potential immunosuppressive activity of morphine derived drugs commonly used in the treatment of pain codeine hydromorphone oxycodone has never been evaluated we evaluated in the mouse the effect of the natural opiates morphine and codeine and synthetic derivatives HM oxycodone nalorphine naloxone and naltrexone on antinociceptive thresholds and immune parameters splenocyte proliferation A-NK nk cell activity and interleukin il production morphine displayed a potent IS effect that was not doserelated to the antinociceptive effect codeine possessed a weak antinociceptive effect and limited IS activity nalorphine a muantagonist and kappaagonist exerted a potent immunosuppressive effect but had very weak antinociceptive activity the pure kappaantagonist norbni antagonized the antinociceptive but not the immunosuppressive effect of nalorphine HM and oxycodone potent antinociceptive drugs were devoid of immunosuppressive effects the pure antagonists naloxone and naltrexone potentiated immune responses our data indicate that the c carbonyl substitution together with the presence of a c single bond potentiates the antinociceptive effect but abolishes IS hydromorphone and oxycodone the single substitution of an allyl on the piperidinic ring resulted in a molecule that antagonized the antinociceptive effect but maintained the immunosuppressive effect molecules that carry modifications of c the c bond and c together with an allyl or caboxymethyl group on the piperidinic ring antagonized both the antinociceptive and the IS effect of opiates and were themselves immunostimulants | MEDAL |
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